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Protein
Submitted name:

Hsp70/Hsp90 organizing protein homolog

Gene

Hop

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiR-DME-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR).

Names & Taxonomyi

Protein namesi
Submitted name:
Hsp70/Hsp90 organizing protein homologImported
Gene namesi
Name:HopImported
ORF Names:CG2720Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0024352. Hop.

PTM / Processingi

Proteomic databases

PaxDbiO61650.
PeptideAtlasiO61650.
PRIDEiO61650.

Expressioni

Gene expression databases

BgeeiFBgn0024352.

Interactioni

Protein-protein interaction databases

IntActiO61650. 1 interactor.
STRINGi7227.FBpp0077790.

Structurei

3D structure databases

ProteinModelPortaliO61650.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 410TPR_REGIONInterPro annotationAdd BLAST407
Repeati4 – 37TPRPROSITE-ProRule annotationAdd BLAST34
Repeati38 – 71TPRPROSITE-ProRule annotationAdd BLAST34
Repeati72 – 105TPRPROSITE-ProRule annotationAdd BLAST34
Repeati174 – 207TPRPROSITE-ProRule annotationAdd BLAST34
Repeati208 – 241TPRPROSITE-ProRule annotationAdd BLAST34
Repeati249 – 282TPRPROSITE-ProRule annotationAdd BLAST34
Repeati309 – 342TPRPROSITE-ProRule annotationAdd BLAST34
Repeati343 – 376TPRPROSITE-ProRule annotationAdd BLAST34
Repeati377 – 410TPRPROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

RepeatSAAS annotation, TPR repeatPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0548. Eukaryota.
ENOG410XTCJ. LUCA.
HOGENOMiHOG000241380.
OrthoDBiEOG091G0E5W.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiView protein in InterPro
IPR006636. STI1_HS-bd.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
PfamiView protein in Pfam
PF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
SMARTiView protein in SMART
SM00727. STI1. 1 hit.
SM00028. TPR. 9 hits.
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiView protein in PROSITE
PS50005. TPR. 9 hits.
PS50293. TPR_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

O61650-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKVNELKEK GNQALSAEKF DEAVAAYTEA IALDDQNHVL YSNRSAAFAK
60 70 80 90 100
AGKFQEALED AEKTIQLNPT WPKGYSRKGA AAAGLNDFMK AFEAYNEGLK
110 120 130 140 150
YDPTNAILLQ GRMETTASAL SFMQSQGDIP MDVDPQQARS RRAPSPPPKP
160 170 180 190 200
AEPPKPAEPR VEDMTEEQKN KYFARKEKEL GNAAYKKKDF ETALKHYHAA
210 220 230 240 250
IEHDPTDITF YNNIAAVHFE RKEYEECIKQ CEKGIEVGRE SRADFKLIAK
260 270 280 290 300
SFARIGNTYR KLENYKQAKV YYEKAMSEHR TPEIKTSLSE VEAKIKEEER
310 320 330 340 350
MAYINPEKAE EEKEQGNLFF KNGDYSTAVK HYTEAIKRNP DDPKLYSNRA
360 370 380 390 400
ACYTKLAAFD LGLKDCDTCI KLDEKFIKGY IRKGKILQGM QQQSKAQAAY
410 420 430 440 450
QKALELDPNN AEAIEGYRQC SMNFQRNPQE VLKNAMSDPE IQQILKDPAM
460 470 480
RMILEQMQSD PNAVKEHLQN PAIADKIMKL LESGIIQIH
Length:489
Mass (Da):55,613
Last modified:August 1, 1998 - v1
Checksum:iD086D5699DB0AB70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056198 mRNA. Translation: AAC12945.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056198 mRNA. Translation: AAC12945.1.

3D structure databases

ProteinModelPortaliO61650.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO61650. 1 interactor.
STRINGi7227.FBpp0077790.

Proteomic databases

PaxDbiO61650.
PeptideAtlasiO61650.
PRIDEiO61650.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0024352. Hop.

Phylogenomic databases

eggNOGiKOG0548. Eukaryota.
ENOG410XTCJ. LUCA.
HOGENOMiHOG000241380.
OrthoDBiEOG091G0E5W.

Enzyme and pathway databases

ReactomeiR-DME-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR).

Gene expression databases

BgeeiFBgn0024352.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiView protein in InterPro
IPR006636. STI1_HS-bd.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
PfamiView protein in Pfam
PF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
SMARTiView protein in SMART
SM00727. STI1. 1 hit.
SM00028. TPR. 9 hits.
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiView protein in PROSITE
PS50005. TPR. 9 hits.
PS50293. TPR_REGION. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO61650_DROME
AccessioniPrimary (citable) accession number: O61650
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: June 7, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.