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Protein

Glycylpeptide N-tetradecanoyltransferase

Gene

Nmt

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.

Catalytic activityi

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.

GO - Molecular functioni

  • glycylpeptide N-tetradecanoyltransferase activity Source: FlyBase

GO - Biological processi

  • dorsal closure Source: FlyBase
  • N-terminal peptidyl-glycine N-myristoylation Source: GO_Central
  • N-terminal protein myristoylation Source: FlyBase

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-DME-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferase (EC:2.3.1.97)
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase
Short name:
NMT
Peptide N-myristoyltransferase
dNMT
Gene namesi
Name:Nmt
ORF Names:CG7436
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0020392. Nmt.

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642281 – 472Glycylpeptide N-tetradecanoyltransferaseAdd BLAST472

Proteomic databases

PaxDbiO61613.
PRIDEiO61613.

Expressioni

Gene expression databases

BgeeiFBgn0020392.
GenevisibleiO61613. DM.

Interactioni

Protein-protein interaction databases

BioGridi64329. 3 interactors.
MINTiMINT-818590.
STRINGi7227.FBpp0076451.

Structurei

3D structure databases

ProteinModelPortaliO61613.
SMRiO61613.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni92 – 94Myristoyl-CoA bindingBy similarity3
Regioni224 – 226Myristoyl-CoA bindingBy similarity3
Regioni232 – 236Myristoyl-CoA bindingBy similarity5

Sequence similaritiesi

Belongs to the NMT family.Curated

Phylogenomic databases

eggNOGiKOG2779. Eukaryota.
COG5092. LUCA.
GeneTreeiENSGT00390000017837.
InParanoidiO61613.
KOiK00671.
OMAiYNWRCPG.
OrthoDBiEOG091G06JB.
PhylomeDBiO61613.

Family and domain databases

InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiView protein in Pfam
PF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiView protein in PROSITE
PS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O61613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNENAEDLS GQELKQKAKE VADASEAMLE KVVAGLNIQD TASTNAAGNE
60 70 80 90 100
DAEQPDGAKN EASVSANASK QALLQAVSDA MASTRQMAKK FAFWSTQPVT
110 120 130 140 150
KLDEQVTTNE CIEPNKEISE IRALPYTLPG GFKWVTLDLN DANDLKELYT
160 170 180 190 200
LLNENYVEDD DAMFRFDYQP EFLKWSLQPP GWKRDWHVGV RVEKSGKLVG
210 220 230 240 250
FISAIPSKLK SYDKVLKVVD INFLCVHKKL RSKRVAPVLI REITRRVNLT
260 270 280 290 300
GIFQAAYTAG VVLPTPVATC RYWHRSLNPK KLVDVRFSHL ARNMTMQRTM
310 320 330 340 350
KLYKLPDQPK TKGYRRITAK DMDKAHKLLE DYLKRFQLSP VFSKEEFRHW
360 370 380 390 400
FTPKEGIIDC FVVADEKGNI TDLTSYYCLP SSVMHHPVHK TVRAAYSFYN
410 420 430 440 450
VSTKTPWLDL MNDALISARN VQMDVYNALD LMENKKYFAP LKFGAGDGNL
460 470
QYYLYNWRCP SMQPEEIALI LM
Length:472
Mass (Da):53,833
Last modified:June 7, 2005 - v2
Checksum:i21A0961A9127A7FA
GO

Sequence cautioni

The sequence AAC08578 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130Missing in AAC08578 (PubMed:9044045).Curated1
Sequence conflicti244T → S in AAC08578 (PubMed:9044045).Curated1
Sequence conflicti412N → G in AAC08578 (PubMed:9044045).Curated1
Sequence conflicti466 – 472EIALILM → RLL in AAC08578 (PubMed:9044045).Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053725 Genomic DNA. Translation: AAC08578.1. Sequence problems.
AE014296 Genomic DNA. Translation: AAF50476.1.
AF132556 mRNA. Translation: AAD27855.1.
AY118963 mRNA. Translation: AAM50823.1.
RefSeqiNP_523969.1. NM_079245.3.
UniGeneiDm.7798.

Genome annotation databases

EnsemblMetazoaiFBtr0076728; FBpp0076451; FBgn0020392.
GeneIDi38909.
KEGGidme:Dmel_CG7436.

Similar proteinsi

Entry informationi

Entry nameiNMT_DROME
AccessioniPrimary (citable) accession number: O61613
Secondary accession number(s): Q9XZ55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 7, 2005
Last modified: November 22, 2017
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families