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Protein
Submitted name:

Fimbrin

Gene

Fim

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi27 – 38PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin binding Source: FlyBase
  • calcium ion binding Source: InterPro

GO - Biological processi

  • female meiosis chromosome segregation Source: FlyBase

Keywordsi

Molecular functionActin-bindingSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
FimbrinImported
Submitted name:
Fimbrin, isoform AImported
Submitted name:
LD05347pImported
Gene namesi
Name:FimImported
ORF Names:CG8649Imported, Dmel_CG8649Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0024238. Fim.

Subcellular locationi

GO - Cellular componenti

  • apical cortex Source: FlyBase
  • cytosol Source: FlyBase

Expressioni

Gene expression databases

BgeeiFBgn0024238.

Interactioni

GO - Molecular functioni

  • actin binding Source: FlyBase

Protein-protein interaction databases

MINTiMINT-918155.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 49EF-handInterPro annotationAdd BLAST36
Domaini72 – 89EF-handInterPro annotationAdd BLAST18
Domaini125 – 241Actin-bindingInterPro annotationAdd BLAST117
Domaini269 – 374Actin-bindingInterPro annotationAdd BLAST106
Domaini391 – 499Actin-bindingInterPro annotationAdd BLAST109
Domaini512 – 620Actin-bindingInterPro annotationAdd BLAST109

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
KOiK17336.
OrthoDBiEOG091G03YP.

Family and domain databases

CDDicd00014. CH. 1 hit.
cd00051. EFh. 1 hit.
Gene3Di1.10.418.10. 4 hits.
InterProiView protein in InterPro
IPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF00307. CH. 4 hits.
PF13405. EF-hand_6. 1 hit.
SMARTiView protein in SMART
SM00033. CH. 4 hits.
SM00054. EFh. 1 hit.
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF47576. SSF47576. 1 hit.
PROSITEiView protein in PROSITE
PS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.

Sequencei

Sequence statusi: Complete.

O61604-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLNKFTKT LSIDEKAEIK EKFIELDANK DGFIDLHELK DALNQVGFKL
60 70 80 90 100
AGYQVREMID EYKGKQLTAF QGKLNLEEFE ALCLDLKSKD VASTFKTVVS
110 120 130 140 150
KKENLETLGG MSSISSEGTT HSVRLEEQLA FSDWINSNLG HDKDLQHLLP
160 170 180 190 200
IDSEGKRLYL SIKDGILLCK IINHSCPDTI DERAINKKNL TVYREFENLT
210 220 230 240 250
LALVSSQAIG CNIVNIDAHD LAKGKPHLVL GLLWQIIRIG LFSHITLDSC
260 270 280 290 300
PGLAGLLFDN ERLEDLMKMS PEAILLRWVN HHLERAGISR RCTNFQSDIV
310 320 330 340 350
DSEIYSHLLK QIAGNDADVN LDALRESDLQ SRAEIMLQQA AKLNCRSFLT
360 370 380 390 400
PQDVVNGVYK LNLAFVANLF NNHPGLDKPE QIEGLESIEE TREEKTYRNW
410 420 430 440 450
MNSMGVAPHV NWLYSDLADG LVIFQLFDVI KPGIVNWSRV HKRFSPLRKF
460 470 480 490 500
MEKLENCNYA VDLGKQLKFS LVGIAGQDLN DGNATLTLAL IWQLMRAYTL
510 520 530 540 550
SILSRLANTG NPIIEKEIVQ WVNNRLSEAG KQSQLRNFND PAIADGKIVI
560 570 580 590 600
DLIDAIKEGS INYELVRTSG TQEDNLANAK YAISMARKIG ARVYALPEDI
610 620 630 640
TEVKPKMVMT VFACMMALDY VPNMDSVDQN NHNSSANNSN
Length:640
Mass (Da):71,914
Last modified:August 1, 1998 - v1
Checksum:i96F770F7F51A4F8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053225 mRNA. Translation: AAC06256.1.
AE014298 Genomic DNA. Translation: AAF48722.1.
AY069342 mRNA. Translation: AAL39487.1.
RefSeqiNP_523385.1. NM_078661.4.
UniGeneiDm.2171.

Genome annotation databases

EnsemblMetazoaiFBtr0074441; FBpp0074215; FBgn0024238.
GeneIDi32721.
KEGGidme:Dmel_CG8649.
UCSCiCG8649-RA. d. melanogaster.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiO61604_DROME
AccessioniPrimary (citable) accession number: O61604
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: July 5, 2017
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported