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Protein

Katanin p80 WD40 repeat-containing subunit B1

Gene

KATNB1

Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.UniRule annotation2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Katanin p80 WD40 repeat-containing subunit B1UniRule annotation
Short name:
Katanin p80 subunit B1UniRule annotation
Alternative name(s):
p80 kataninUniRule annotation
Gene namesi
Name:KATNB1UniRule annotation
OrganismiStrongylocentrotus purpuratus (Purple sea urchin)
Taxonomic identifieri7668 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
Proteomesi
  • UP000007110 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation1 Publication
  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosome UniRule annotation1 Publication
  • Cytoplasmcytoskeletonspindle pole UniRule annotation1 Publication
  • Cytoplasmcytoskeleton UniRule annotation1 Publication

  • Note: Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510531 – 690Katanin p80 WD40 repeat-containing subunit B1Add BLAST690

Interactioni

Subunit structurei

Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi7668.SPU_014392tr.

Structurei

3D structure databases

ProteinModelPortaliO61585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 54WD 1Add BLAST41
Repeati57 – 96WD 2Add BLAST40
Repeati99 – 138WD 3Add BLAST40
Repeati141 – 182WD 4Add BLAST42
Repeati184 – 222WD 5Add BLAST39
Repeati225 – 265WD 6Add BLAST41

Sequence similaritiesi

Belongs to the WD repeat KATNB1 family.UniRule annotation
Contains 6 WD repeats.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0267. Eukaryota.
ENOG410XQAC. LUCA.
InParanoidiO61585.
KOiK18643.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03022. Katanin_p80_B1. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR026962. Katanin_bsu1.
IPR028021. Katanin_C-terminal.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19845:SF0. PTHR19845:SF0. 1 hit.
PfamiPF13925. Katanin_con80. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O61585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKRAWKLQ ELVAHSSNVN CLALGPMSGR VMVTGGEDKK VNLWAVGKQN
60 70 80 90 100
CIISLSGHTS PVDSVKFNSS EELVVAGSQS GTMKIYDLEP AKIVRTLTGH
110 120 130 140 150
RNSIRCMDFH PFGEFVASGS TDTNVKLWDV RRKGCIYTYK GHSDQVNMIK
160 170 180 190 200
FSPDGKWLVT ASEDTTIKLW DLTMGKLFQE FKNHTGGVTG IEFHPNEFLL
210 220 230 240 250
ASGSSDRTVQ FWDLETFQLV SSTSPGASAV RSISFHPDGS YLFCSSQDML
260 270 280 290 300
HAFGWEPIRC FDTFSVGWGK VADTVIASTQ LIGASFNATN VSVYVADLSR
310 320 330 340 350
MSTTGIAQEP QSQPSKTPSG GAEEVPSKPL TASGRKNFVR ERPHTTSSKQ
360 370 380 390 400
RQPDVKSEPE RQSPTQDEGV KDDDATDIKD PDSYAKIFSP KTRVDHSPER
410 420 430 440 450
NAQPFPAPLD VPGAQEPEPF KHPPKPAAAA AVAPVSRAPA PSASDWQPAQ
460 470 480 490 500
ANPAPNRVPA ATKPVPAQEV APSRKPDPIS TIIPSDRNKP ANLDMDAFLP
510 520 530 540 550
PAHAQQAPRV NAPASRKQSD SERIEGLRKG HDSMCQVLSS RHRNLDVVRA
560 570 580 590 600
IWTAGDAKTS VESVVNMKDQ AILVDILNIM LLKKSLWNLD MCVVVLPRLK
610 620 630 640 650
ELLSSKYENY VHTSCACLKL ILKNFTSLFN QNIKCPPSGI DITREERYNK
660 670 680 690
CSKCYSYLIA TRGYVEEKQH VSGKLGSSFR ELHLLLDQLE
Length:690
Mass (Da):75,814
Last modified:August 1, 1998 - v1
Checksum:iF4404CD6206971DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052433 mRNA. Translation: AAC09329.1.
RefSeqiNP_999734.1. NM_214569.1.
UniGeneiSpu.64.

Genome annotation databases

GeneIDi373369.
KEGGispu:373369.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052433 mRNA. Translation: AAC09329.1.
RefSeqiNP_999734.1. NM_214569.1.
UniGeneiSpu.64.

3D structure databases

ProteinModelPortaliO61585.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7668.SPU_014392tr.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373369.
KEGGispu:373369.

Organism-specific databases

CTDi10300.

Phylogenomic databases

eggNOGiKOG0267. Eukaryota.
ENOG410XQAC. LUCA.
InParanoidiO61585.
KOiK18643.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03022. Katanin_p80_B1. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR026962. Katanin_bsu1.
IPR028021. Katanin_C-terminal.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19845:SF0. PTHR19845:SF0. 1 hit.
PfamiPF13925. Katanin_con80. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKTNB1_STRPU
AccessioniPrimary (citable) accession number: O61585
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.