O61573 (GCH1_OSTOS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1
EC=3.5.4.16

Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I

Gene names

Name:

gch

Organism

Ostertagia ostertagi (Brown stomach worm)

Taxonomic identifier

6317 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Strongylida › Trichostrongyloidea › Trichostrongylidae › Trichostrongylinae › Ostertagia

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.
Subunit structure	Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	Tetrahydrobiopterin biosynthesis
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Allosteric enzyme
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway tetrahydrobiopterin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	GTP cyclohydrolase 1		PRO_0000119483
Sites
	Metal binding	104	1	Zinc By similarity
	Metal binding	107	1	Zinc By similarity
	Metal binding	175	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	O61573 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 2B5170D1902C32E9	FASTA	213	23,843
	10 20 30 40 50 60 MASESGFLSS DSSSEDCDQK IIAFSKKTSN LDKMTAAYSS IISHVGEDVN RQGLLKTPDR 70 80 90 100 110 120 AAKAMLYFTK GYEQQLDDIL NDAVFDENHD EMVIVRDIEM FSLCEHHLVP FNGKVHIGYI 130 140 150 160 170 180 PNKKVLGLSK LARIVEMFSR RLQVQERLTK QIATAMVQAV QPAGVAVVIE ASHMCMVMRG 190 200 210 VQKINATTST SCMLGVFRDD PKTREEFLNL IHK

References

[1]	"Identification of abundant mRNAs from the third stage larvae of the parasitic nematode, Ostertagia ostertagi." Moore J., Tetley L., Devaney E. Biochem. J. 347:763-770(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF052048 mRNA. Translation: AAC06296.1.
3D structure databases
ProteinModelPortal	O61573.
SMR	O61573. Positions 30-211.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00848; UER00151.
Family and domain databases
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
PANTHER	PTHR11109. PTHR11109. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. folE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH1_OSTOS

Accession

Primary (citable) accession number: O61573

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	August 1, 1998
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)