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Protein
Submitted name:

Ligand-Gated ion Channel

Gene

lgc-6

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-975298. Ligand-gated ion channel transport.

Names & Taxonomyi

Protein namesi
Submitted name:
Ligand-Gated ion ChannelImported
Gene namesi
Name:lgc-6Imported
ORF Names:CELE_F17E9.8Imported, F17E9.8Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF17E9.8; CE47516; WBGene00017544; lgc-6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei228 – 25124HelicalSequence analysisAdd
BLAST
Transmembranei293 – 31422HelicalSequence analysisAdd
BLAST
Transmembranei406 – 42419HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 425406Sequence analysisPRO_5004159043Add
BLAST

Proteomic databases

PaxDbiO61519.

Structurei

3D structure databases

ProteinModelPortaliO61519.
SMRiO61519. Positions 18-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 227208Neur_chan_LBDInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000016482.
InParanoidiO61519.
OMAiVHTSAIR.
OrthoDBiEOG7P5T4W.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O61519-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWILRFLTA VAFLETSNTE TLLQQLFNQT YDVDMKPSDD LTMVTITPNT
60 70 80 90 100
FILLSMDQTQ ETIQYSEEFL LRWYDPILHW NQSAVSYEND WIKISASRAW
110 120 130 140 150
IPDVIFTNGI DMDPLLDKDM QMADLRYNGE IRTSRPAVVS SPCPLEIDNF
160 170 180 190 200
PYDVQKCNIS MGSWAFDRRF LSVQSSTIEI LPQKGRFEGN SEWELISILT
210 220 230 240 250
VRSDSYDTLL EEWFSEITYV VTLKRKPVYY VLVIQAPTFI LCTITIFGLF
260 270 280 290 300
TPNSNEDERL SKVELCLNMF AAISMMLQLV SDMMPKASRL PLLGNYIIAE
310 320 330 340 350
IFVVTAATIA SIIIQQTHHH VHTSAIRPRR WLRCLVLCEC RRRRFSISEA
360 370 380 390 400
STVSSVDVPE HAIQSFSILK SSLHQTAVLV RDTLQRMSLI SENQLLWLKI
410 420
LDKTDLMCLF LFQVANIVVT AVFWR
Length:425
Mass (Da):49,075
Last modified:July 11, 2012 - v3
Checksum:iC63C238C06DD3BD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD68536.2.
RefSeqiNP_501410.3. NM_069009.3.

Genome annotation databases

EnsemblMetazoaiF17E9.8; F17E9.8; WBGene00017544.
GeneIDi184621.
KEGGicel:CELE_F17E9.8.
UCSCiF17E9.8. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD68536.2.
RefSeqiNP_501410.3. NM_069009.3.

3D structure databases

ProteinModelPortaliO61519.
SMRiO61519. Positions 18-314.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiO61519.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF17E9.8; F17E9.8; WBGene00017544.
GeneIDi184621.
KEGGicel:CELE_F17E9.8.
UCSCiF17E9.8. c. elegans.

Organism-specific databases

CTDi184621.
WormBaseiF17E9.8; CE47516; WBGene00017544; lgc-6.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000016482.
InParanoidiO61519.
OMAiVHTSAIR.
OrthoDBiEOG7P5T4W.

Enzyme and pathway databases

ReactomeiR-CEL-975298. Ligand-gated ion channel transport.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO61519_CAEEL
AccessioniPrimary (citable) accession number: O61519
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: July 11, 2012
Last modified: July 6, 2016
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.