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Protein

Phosphoglycerate kinase

Gene

PGK

Organism
Aplysia californica (California sea hare)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361SubstrateBy similarity
Binding sitei119 – 1191SubstrateBy similarity
Binding sitei167 – 1671SubstrateBy similarity
Binding sitei216 – 2161ATPBy similarity
Binding sitei308 – 3081ATP; via carbonyl oxygenBy similarity
Binding sitei339 – 3391ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi368 – 3714ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. phosphoglycerate kinase activity Source: UniProtKB

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
  2. phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:PGK
OrganismiAplysia californica (California sea hare)
Taxonomic identifieri6500 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Phosphoglycerate kinasePRO_0000145842Add
BLAST

Proteomic databases

PRIDEiO61471.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO61471.
SMRiO61471. Positions 2-410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 233Substrate bindingBy similarity
Regioni60 – 634Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O61471-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKLSINDVD VRDKRVLIRV DFNVPLKNGQ ISNNQRIAAA LPTIKLALEK
60 70 80 90 100
GAKSVVLMSH LGRPDGRPIH AASMKPVVAE LENLLGKKIM FLEDCVGSKV
110 120 130 140 150
EAACANPEPG SVILLENLRF HVEKEGKGKD AQGNKAKADD AAVAAFRASL
160 170 180 190 200
SKLGDVYVND AFGTAHRAHS SMVGVDLPVK ACGLLMKKEL DYFAKALENP
210 220 230 240 250
ARPFLAILGG AKVADKIQLI ENLMDKVNEM IIGGGMAFTF LKVLNNMDIG
260 270 280 290 300
GSLFDEGAKI VGRLVDKAKE KGVKLHLPSD FITGDKFADV AKSATASVAS
310 320 330 340 350
GIPEGWMGLD VGTKTNEVFQ KVIEGAKTIV WNGPPGVFEF ENFSTGSKQM
360 370 380 390 400
MDSVVRATEA GTITIIGGCD TATCAKNSNA TEKVSHVSTG SGTSLELLEG
410
KILPGVAALS QP
Length:412
Mass (Da):43,653
Last modified:July 31, 1998 - v1
Checksum:i99B63AA7A2CC2D02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042738 mRNA. Translation: AAC13267.1.
RefSeqiNP_001191644.1. NM_001204715.1.
UniGeneiAcl.505.

Genome annotation databases

GeneIDi100533438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042738 mRNA. Translation: AAC13267.1.
RefSeqiNP_001191644.1. NM_001204715.1.
UniGeneiAcl.505.

3D structure databases

ProteinModelPortaliO61471.
SMRiO61471. Positions 2-410.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO61471.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100533438.

Organism-specific databases

CTDi33461.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of specific mRNAs affected by treatments producing long-term facilitation in Aplysia."
    Zwartjes R.E., West H., Hattar S., Ren X., Noel F., Nunez-Regueiro M., Macphee K., Homayouni R., Crow M.T., Byrne J.H., Eskin A.
    Learn. Memory 4:478-495(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPGK_APLCA
AccessioniPrimary (citable) accession number: O61471
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 1998
Last sequence update: July 31, 1998
Last modified: January 6, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.