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O61471

- PGK_APLCA

UniProt

O61471 - PGK_APLCA

Protein

Phosphoglycerate kinase

Gene

PGK

Organism
Aplysia californica (California sea hare)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361SubstrateBy similarity
    Binding sitei119 – 1191SubstrateBy similarity
    Binding sitei167 – 1671SubstrateBy similarity
    Binding sitei216 – 2161ATPBy similarity
    Binding sitei308 – 3081ATP; via carbonyl oxygenBy similarity
    Binding sitei339 – 3391ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi368 – 3714ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. phosphoglycerate kinase activity Source: UniProtKB

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway
    2. phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:PGK
    OrganismiAplysia californica (California sea hare)
    Taxonomic identifieri6500 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 412412Phosphoglycerate kinasePRO_0000145842Add
    BLAST

    Proteomic databases

    PRIDEiO61471.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO61471.
    SMRiO61471. Positions 2-410.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 233Substrate bindingBy similarity
    Regioni60 – 634Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O61471-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKLSINDVD VRDKRVLIRV DFNVPLKNGQ ISNNQRIAAA LPTIKLALEK    50
    GAKSVVLMSH LGRPDGRPIH AASMKPVVAE LENLLGKKIM FLEDCVGSKV 100
    EAACANPEPG SVILLENLRF HVEKEGKGKD AQGNKAKADD AAVAAFRASL 150
    SKLGDVYVND AFGTAHRAHS SMVGVDLPVK ACGLLMKKEL DYFAKALENP 200
    ARPFLAILGG AKVADKIQLI ENLMDKVNEM IIGGGMAFTF LKVLNNMDIG 250
    GSLFDEGAKI VGRLVDKAKE KGVKLHLPSD FITGDKFADV AKSATASVAS 300
    GIPEGWMGLD VGTKTNEVFQ KVIEGAKTIV WNGPPGVFEF ENFSTGSKQM 350
    MDSVVRATEA GTITIIGGCD TATCAKNSNA TEKVSHVSTG SGTSLELLEG 400
    KILPGVAALS QP 412
    Length:412
    Mass (Da):43,653
    Last modified:August 1, 1998 - v1
    Checksum:i99B63AA7A2CC2D02
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042738 mRNA. Translation: AAC13267.1.
    RefSeqiNP_001191644.1. NM_001204715.1.
    UniGeneiAcl.505.

    Genome annotation databases

    GeneIDi100533438.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042738 mRNA. Translation: AAC13267.1 .
    RefSeqi NP_001191644.1. NM_001204715.1.
    UniGenei Acl.505.

    3D structure databases

    ProteinModelPortali O61471.
    SMRi O61471. Positions 2-410.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O61471.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100533438.

    Organism-specific databases

    CTDi 33461.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of specific mRNAs affected by treatments producing long-term facilitation in Aplysia."
      Zwartjes R.E., West H., Hattar S., Ren X., Noel F., Nunez-Regueiro M., Macphee K., Homayouni R., Crow M.T., Byrne J.H., Eskin A.
      Learn. Memory 4:478-495(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPGK_APLCA
    AccessioniPrimary (citable) accession number: O61471
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3