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O61471 (PGK_APLCA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:PGK
OrganismAplysia californica (California sea hare)
Taxonomic identifier6500 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from sequence or structural similarity. Source: UniProtKB

phosphoglycerate kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 412412Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145842

Regions

Nucleotide binding368 – 3714ATP By similarity
Region21 – 233Substrate binding By similarity
Region60 – 634Substrate binding By similarity

Sites

Binding site361Substrate By similarity
Binding site1191Substrate By similarity
Binding site1671Substrate By similarity
Binding site2161ATP By similarity
Binding site3081ATP; via carbonyl oxygen By similarity
Binding site3391ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
O61471 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 99B63AA7A2CC2D02

FASTA41243,653
        10         20         30         40         50         60 
MNKLSINDVD VRDKRVLIRV DFNVPLKNGQ ISNNQRIAAA LPTIKLALEK GAKSVVLMSH 

        70         80         90        100        110        120 
LGRPDGRPIH AASMKPVVAE LENLLGKKIM FLEDCVGSKV EAACANPEPG SVILLENLRF 

       130        140        150        160        170        180 
HVEKEGKGKD AQGNKAKADD AAVAAFRASL SKLGDVYVND AFGTAHRAHS SMVGVDLPVK 

       190        200        210        220        230        240 
ACGLLMKKEL DYFAKALENP ARPFLAILGG AKVADKIQLI ENLMDKVNEM IIGGGMAFTF 

       250        260        270        280        290        300 
LKVLNNMDIG GSLFDEGAKI VGRLVDKAKE KGVKLHLPSD FITGDKFADV AKSATASVAS 

       310        320        330        340        350        360 
GIPEGWMGLD VGTKTNEVFQ KVIEGAKTIV WNGPPGVFEF ENFSTGSKQM MDSVVRATEA 

       370        380        390        400        410 
GTITIIGGCD TATCAKNSNA TEKVSHVSTG SGTSLELLEG KILPGVAALS QP 

« Hide

References

[1]"Identification of specific mRNAs affected by treatments producing long-term facilitation in Aplysia."
Zwartjes R.E., West H., Hattar S., Ren X., Noel F., Nunez-Regueiro M., Macphee K., Homayouni R., Crow M.T., Byrne J.H., Eskin A.
Learn. Memory 4:478-495(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF042738 mRNA. Translation: AAC13267.1.
RefSeqNP_001191644.1. NM_001204715.1.
UniGeneAcl.505.

3D structure databases

ProteinModelPortalO61471.
SMRO61471. Positions 2-410.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEO61471.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100533438.

Organism-specific databases

CTD33461.

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_APLCA
AccessionPrimary (citable) accession number: O61471
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways