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Protein
Submitted name:

MAP kinase kinase 4, isoform A

Gene

Mkk4

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • activation of JUN kinase activity Source: FlyBase
  • JNK cascade Source: FlyBase
  • neuron development Source: FlyBase
  • neuron projection morphogenesis Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • regulation of adult chitin-containing cuticle pigmentation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-2559580. Oxidative Stress Induced Senescence.
R-DME-2871796. FCERI mediated MAPK activation.
R-DME-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.

Names & Taxonomyi

Protein namesi
Submitted name:
MAP kinase kinase 4, isoform AImported
Submitted name:
MAP kinase kinase 4, isoform BImported
Submitted name:
MAP kinase kinase 4, isoform CImported (EC:2.7.11.-Imported, EC:2.7.11.13Imported)
Submitted name:
RE70055pImported
Submitted name:
Stress activated MAP kinase kinase 4Imported
Gene namesi
Name:Mkk4Imported
ORF Names:CG9738Imported, Dmel_CG9738Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0024326. Mkk4.

Subcellular locationi

GO - Cellular componenti

  • axon Source: FlyBase
  • cytoplasm Source: GO_Central
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiFBgn0024326.

Interactioni

Protein-protein interaction databases

IntActiO61444. 2 interactors.
MINTiMINT-1710570.
STRINGi7227.FBpp0081378.

Structurei

3D structure databases

ProteinModelPortaliO61444.
SMRiO61444.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 387Protein kinaseInterPro annotationAdd BLAST266

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0984. Eukaryota.
ENOG410XT3F. LUCA.
GeneTreeiENSGT00760000119199.
KOiK04430.
OMAiKFYKFIC.
OrthoDBiEOG091G0A9H.
PhylomeDBiO61444.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O61444-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERPKNLFA TGSSRSRNPP DQLSLNNLSI RHPPSSTSST SSGSTSSGSS
60 70 80 90 100
SSSQHNHVTR CFGAQQPQQT PPVASSQVPP VPAASSSSAA DRHRERIRQQ
110 120 130 140 150
ACGKLQFGEG GANTHTFTSD DLEDEGEIGR GAFGAVNKMT FKKLDKVMAV
160 170 180 190 200
KRIRSTVDEK EQKQLLMDLE VVMKSNECIY IVQFYGALFK EGDCWICMEL
210 220 230 240 250
MDTSLDKFYK YIYEKQQRHI PESILAKITV ATVNALNYLK EELKIIHRDV
260 270 280 290 300
KPSNILLHRR GDIKLCDFGI SGQLVDSIAK TKDAGCRPYM APERIDPERA
310 320 330 340 350
KGYDVRSDVW SLGITLMEVA TGNFPYRKWD SVFEQLCQVV QGEPPRLLTS
360 370 380 390 400
YNGMEFSKEF VDFVNTCLIK KESDRPKYSR LLEMPFIRRG ETSHTDVAVY
410 420
VADILESMEK DGITQFTANQ QAES
Length:424
Mass (Da):47,534
Last modified:August 1, 1998 - v1
Checksum:i260C29A569A38DAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035551 Genomic DNA. Translation: AAC39035.1.
AE014297 Genomic DNA. Translation: AAF54258.1.
AY070600 mRNA. Translation: AAL48071.1.
AE014297 Genomic DNA. Translation: ACZ94848.1.
AE014297 Genomic DNA. Translation: AGB95757.1.
RefSeqiNP_001163551.1. NM_001170080.2.
NP_001262375.1. NM_001275446.1.
NP_477353.1. NM_058005.5.
UniGeneiDm.2942.

Genome annotation databases

EnsemblMetazoaiFBtr0081892; FBpp0081378; FBgn0024326.
FBtr0300443; FBpp0289672; FBgn0024326.
FBtr0334320; FBpp0306434; FBgn0024326.
GeneIDi41020.
KEGGidme:Dmel_CG9738.
UCSCiCG9738-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035551 Genomic DNA. Translation: AAC39035.1.
AE014297 Genomic DNA. Translation: AAF54258.1.
AY070600 mRNA. Translation: AAL48071.1.
AE014297 Genomic DNA. Translation: ACZ94848.1.
AE014297 Genomic DNA. Translation: AGB95757.1.
RefSeqiNP_001163551.1. NM_001170080.2.
NP_001262375.1. NM_001275446.1.
NP_477353.1. NM_058005.5.
UniGeneiDm.2942.

3D structure databases

ProteinModelPortaliO61444.
SMRiO61444.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO61444. 2 interactors.
MINTiMINT-1710570.
STRINGi7227.FBpp0081378.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0081892; FBpp0081378; FBgn0024326.
FBtr0300443; FBpp0289672; FBgn0024326.
FBtr0334320; FBpp0306434; FBgn0024326.
GeneIDi41020.
KEGGidme:Dmel_CG9738.
UCSCiCG9738-RA. d. melanogaster.

Organism-specific databases

CTDi41020.
FlyBaseiFBgn0024326. Mkk4.

Phylogenomic databases

eggNOGiKOG0984. Eukaryota.
ENOG410XT3F. LUCA.
GeneTreeiENSGT00760000119199.
KOiK04430.
OMAiKFYKFIC.
OrthoDBiEOG091G0A9H.
PhylomeDBiO61444.

Enzyme and pathway databases

ReactomeiR-DME-2559580. Oxidative Stress Induced Senescence.
R-DME-2871796. FCERI mediated MAPK activation.
R-DME-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.

Miscellaneous databases

GenomeRNAii41020.

Gene expression databases

BgeeiFBgn0024326.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO61444_DROME
AccessioniPrimary (citable) accession number: O61444
Secondary accession number(s): O61445
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.