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Protein

Mitogen-activated protein kinase p38b

Gene

p38b

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Kinase involved in dpp signal transduction pathway in the process of wing morphogenesis when the levels of dpp are enhanced or inhibited. May down-regulate insect immunity gene expression after prolonged infection.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation by Mkk3.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53ATPPROSITE-ProRule annotation1
Active sitei153Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 38ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase activity Source: FlyBase
  • protein serine/threonine kinase activity Source: FlyBase
  • SAP kinase activity Source: FlyBase

GO - Biological processi

  • cellular response to arsenic-containing substance Source: FlyBase
  • cellular response to cadmium ion Source: FlyBase
  • cellular response to reactive oxygen species Source: FlyBase
  • circadian rhythm Source: FlyBase
  • defense response to bacterium Source: FlyBase
  • defense response to fungus Source: FlyBase
  • determination of adult lifespan Source: FlyBase
  • heart morphogenesis Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: UniProtKB
  • immune response Source: FlyBase
  • MAPK cascade Source: FlyBase
  • paracrine signaling Source: FlyBase
  • positive regulation of cell size Source: FlyBase
  • positive regulation of multicellular organism growth Source: FlyBase
  • positive regulation of protein phosphorylation Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • reactive oxygen species metabolic process Source: FlyBase
  • regulation of adult chitin-containing cuticle pigmentation Source: FlyBase
  • regulation of BMP signaling pathway Source: UniProtKB
  • regulation of cellular response to oxidative stress Source: FlyBase
  • regulation of innate immune response Source: UniProtKB
  • regulation of terminal button organization Source: FlyBase
  • response to bacterium Source: FlyBase
  • response to heat Source: FlyBase
  • response to hydrogen peroxide Source: FlyBase
  • response to salt stress Source: FlyBase
  • response to starvation Source: FlyBase

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.24 1994
ReactomeiR-DME-168638 NOD1/2 Signaling Pathway
R-DME-171007 p38MAPK events
R-DME-198753 ERK/MAPK targets
R-DME-2559580 Oxidative Stress Induced Senescence
R-DME-375170 CDO in myogenesis
R-DME-376172 DSCAM interactions
R-DME-418592 ADP signalling through P2Y purinoceptor 1
R-DME-432142 Platelet sensitization by LDL
R-DME-4420097 VEGFA-VEGFR2 Pathway
R-DME-450302 activated TAK1 mediates p38 MAPK activation
R-DME-6798695 Neutrophil degranulation
SignaLinkiO61443

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase p38b1 Publication (EC:2.7.11.24)
Short name:
MAP kinase p38b1 Publication
Short name:
MAPK p38b1 Publication
Gene namesi
Name:p38b1 PublicationImported
ORF Names:CG7393Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0024846 p38b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001863011 – 365Mitogen-activated protein kinase p38bAdd BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei183Phosphothreonine1 Publication1
Modified residuei185Phosphotyrosine1 Publication1

Post-translational modificationi

Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO61443
PRIDEiO61443

PTM databases

iPTMnetiO61443

Expressioni

Tissue specificityi

At mid-embryogenesis, highest expression is seen in developing anterior and posterior midguts. Almost ubiquitous expression throughout all development.

Developmental stagei

Expressed both maternally and zygotically in the embryo, expression seen in all developmental stages.

Gene expression databases

BgeeiFBgn0024846
GenevisibleiO61443 DM

Interactioni

Protein-protein interaction databases

BioGridi60814, 50 interactors
DIPiDIP-22779N
IntActiO61443, 6 interactors
STRINGi7227.FBpp0080111

Structurei

3D structure databases

ProteinModelPortaliO61443
SMRiO61443
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 311Protein kinasePROSITE-ProRule annotationAdd BLAST288

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi183 – 185TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
GeneTreeiENSGT00550000074271
InParanoidiO61443
KOiK04441
OMAiDVIDTIC
OrthoDBiEOG091G08QL
PhylomeDBiO61443

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR008352 MAPK_p38-like
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PRINTSiPR01773 P38MAPKINASE
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

O61443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKMAKFYK LDINRTEWEI PETYQNLQPV GQGAYGQVCK AVVRGTSTKV
60 70 80 90 100
AIKKLARPFQ SAVHAKRTYR ELRLLKHMDH ENVIGLLDVF HPGQPADSLD
110 120 130 140 150
QFQQVYMVTH LMDADLNNII RTQKLSDDHV QFLVYQILRG LKYIHSAGVI
160 170 180 190 200
HRDLKPSNIA VNEDCELRIL DFGLARPAES EMTGYVATRW YRAPEIMLNW
210 220 230 240 250
MHYNQTADIW SVGCIMAELL TGRTLFPGTD HIHQLNLIME VLGTPADEFM
260 270 280 290 300
SRISSESARN YIRSLPVMPR RNFRDIFRGA NPLAIDLLEK MLELDADKRI
310 320 330 340 350
TAEQALAHPY MEKYHDPTDE QTAALYDQSF EENELPVEKW REMVFSEVTA
360
FKPTAAFAEL LPKEQ
Length:365
Mass (Da):42,098
Last modified:August 1, 1998 - v1
Checksum:i3B3F217E467BAD53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035548 mRNA Translation: AAC39032.1
AB006364 mRNA Translation: BAA35141.1
AE014134 Genomic DNA Translation: AAF53326.1
AY058548 mRNA Translation: AAL13777.1
RefSeqiNP_477361.1, NM_058013.5
UniGeneiDm.2953

Genome annotation databases

EnsemblMetazoaiFBtr0080534; FBpp0080111; FBgn0024846
GeneIDi34780
KEGGidme:Dmel_CG7393

Similar proteinsi

Entry informationi

Entry nameiMK38B_DROME
AccessioniPrimary (citable) accession number: O61443
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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