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Protein

Molt-inhibiting hormone

Gene
N/A
Organism
Metacarcinus magister (Dungeness crab) (Cancer magister)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Inhibits Y-organs where molting hormone (ecdysteroid) is secreted. A molting cycle is initiated when MIH secretion diminishes or stops (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone, Neuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Molt-inhibiting hormone
Short name:
MIH
OrganismiMetacarcinus magister (Dungeness crab) (Cancer magister)
Taxonomic identifieri29965 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataBrachyuraEubrachyuraCancroideaCancridaeMetacarcinus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35By similarityAdd BLAST35
PeptideiPRO_000001907736 – 113Molt-inhibiting hormoneAdd BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 79By similarity
Disulfide bondi59 ↔ 75By similarity
Disulfide bondi62 ↔ 88By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliO61389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.10.2010.10. 1 hit.
InterProiIPR001166. Arthropod_neurhormone.
IPR031098. Arthropod_neuro/LMWP.
IPR018251. Crust_neurhormone_CS.
IPR001262. Crust_neurhormone_MIH/MOIH/GIH.
[Graphical view]
PfamiPF01147. Crust_neurohorm. 1 hit.
[Graphical view]
PRINTSiPR00549. HYPRGLYCEMC2.
PR00550. HYPRGLYCEMIC.
SUPFAMiSSF81778. SSF81778. 1 hit.
PROSITEiPS01250. CHH_MIH_GIH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O61389-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSRTESRYS SQRTWLLSMV VLAALWSISV QRATARVIND DCPNLIGNRD
60 70 80 90 100
LYKRVEWICE DCSNIFRNTG MATLCRKNCF FNEDFLWCVY ATERTEEMSQ
110
LRQWVGILGA GRE
Length:113
Mass (Da):13,228
Last modified:August 1, 1998 - v1
Checksum:i02D0AAB1A53838F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031493 mRNA. Translation: AAC38984.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031493 mRNA. Translation: AAC38984.1.

3D structure databases

ProteinModelPortaliO61389.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.2010.10. 1 hit.
InterProiIPR001166. Arthropod_neurhormone.
IPR031098. Arthropod_neuro/LMWP.
IPR018251. Crust_neurhormone_CS.
IPR001262. Crust_neurhormone_MIH/MOIH/GIH.
[Graphical view]
PfamiPF01147. Crust_neurohorm. 1 hit.
[Graphical view]
PRINTSiPR00549. HYPRGLYCEMC2.
PR00550. HYPRGLYCEMIC.
SUPFAMiSSF81778. SSF81778. 1 hit.
PROSITEiPS01250. CHH_MIH_GIH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIH_METMG
AccessioniPrimary (citable) accession number: O61389
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: June 24, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.