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O61387

- CP6B7_HELAM

UniProt

O61387 - CP6B7_HELAM

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Protein
Cytochrome P450 6B7
Gene
CYP6B7
Organism
Helicoverpa armigera (Cotton bollworm) (Heliothis armigera)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi445 – 4451Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 6B7 (EC:1.14.14.1)
    Alternative name(s):
    CYPVIB7
    Gene namesi
    Name:CYP6B7
    OrganismiHelicoverpa armigera (Cotton bollworm) (Heliothis armigera)
    Taxonomic identifieri29058 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaeHeliothinaeHelicoverpa

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Cytochrome P450 6B7
    PRO_0000051899Add
    BLAST

    Expressioni

    Inductioni

    By treatment with the monoterpene, alpha-pinene.

    Structurei

    3D structure databases

    ProteinModelPortaliO61387.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O61387-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWVLYLPAVL SVLIVTLYLY FTRTFNYWKK RNVRGPEPTV FFGNLKDSTL    50
    RKKNIGIVME EIYNQFPYEK VVGMYRMTTP CLLVRDFHVI KHIMIKDFEA 100
    FRDRGVEFSK EGLGQNLFHA DGETWRALRN RFTPIFTSGK LKNMFYLMHE 150
    GADNFIDHVS KECEKKQEFE VHSLLQTYTM STISSCAFGV SYNSISDKVQ 200
    TLEIVDKIIS EPSYAIELDY MYPKLLAKLN LSIIPTPVQH FFKSLVDNII 250
    SQRNGKPAGR NDFMDLILEL RQMGEVTSNK YLDGVTSLEI TDEVICAQAF 300
    VFYVAGYETS ATTMSYLIYQ LSLNQDVQNK LIAEVDEAIK ASDGKVTYDT 350
    VKEMKYLNKV FDETLRMYSI VEPLQRKATR DYQIPGTDVV IEKDTMVLIS 400
    PRGIHYDPKY YDNPKQFNPD RFDAEEVGKR HPCAYLPFGL GQRNCIGMRF 450
    GRLQSLLCIT KILSKFRIEP SKNTDRNLQV EPRRVTIGPK GGIRVNIVPR 500
    KIVS 504
    Length:504
    Mass (Da):58,218
    Last modified:August 1, 1998 - v1
    Checksum:i9EC92687CF4A0A4A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031468 mRNA. Translation: AAC09227.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031468 mRNA. Translation: AAC09227.1 .

    3D structure databases

    ProteinModelPortali O61387.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of two cytochrome P450 cDNA clones for CYP6B6 and CYP6B7 from Helicoverpa armigera (Hubner): possible involvement of CYP6B7 in pyrethroid resistance."
      Ranasinghe C., Hobbs A.A.
      Insect Biochem. Mol. Biol. 28:571-580(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCP6B7_HELAM
    AccessioniPrimary (citable) accession number: O61387
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: August 1, 1998
    Last modified: December 11, 2013
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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