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O61387 (CP6B7_HELAM) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 6B7

EC=1.14.14.1
Alternative name(s):
CYPVIB7
Gene names
Name:CYP6B7
OrganismHelicoverpa armigera (Cotton bollworm) (Heliothis armigera)
Taxonomic identifier29058 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaeHeliothinaeHelicoverpa

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein Potential. Microsome membrane; Peripheral membrane protein Potential.

Induction

By treatment with the monoterpene, alpha-pinene.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Cytochrome P450 6B7
PRO_0000051899

Sites

Metal binding4451Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
O61387 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 9EC92687CF4A0A4A

FASTA50458,218
        10         20         30         40         50         60 
MWVLYLPAVL SVLIVTLYLY FTRTFNYWKK RNVRGPEPTV FFGNLKDSTL RKKNIGIVME 

        70         80         90        100        110        120 
EIYNQFPYEK VVGMYRMTTP CLLVRDFHVI KHIMIKDFEA FRDRGVEFSK EGLGQNLFHA 

       130        140        150        160        170        180 
DGETWRALRN RFTPIFTSGK LKNMFYLMHE GADNFIDHVS KECEKKQEFE VHSLLQTYTM 

       190        200        210        220        230        240 
STISSCAFGV SYNSISDKVQ TLEIVDKIIS EPSYAIELDY MYPKLLAKLN LSIIPTPVQH 

       250        260        270        280        290        300 
FFKSLVDNII SQRNGKPAGR NDFMDLILEL RQMGEVTSNK YLDGVTSLEI TDEVICAQAF 

       310        320        330        340        350        360 
VFYVAGYETS ATTMSYLIYQ LSLNQDVQNK LIAEVDEAIK ASDGKVTYDT VKEMKYLNKV 

       370        380        390        400        410        420 
FDETLRMYSI VEPLQRKATR DYQIPGTDVV IEKDTMVLIS PRGIHYDPKY YDNPKQFNPD 

       430        440        450        460        470        480 
RFDAEEVGKR HPCAYLPFGL GQRNCIGMRF GRLQSLLCIT KILSKFRIEP SKNTDRNLQV 

       490        500 
EPRRVTIGPK GGIRVNIVPR KIVS 

« Hide

References

[1]"Isolation and characterization of two cytochrome P450 cDNA clones for CYP6B6 and CYP6B7 from Helicoverpa armigera (Hubner): possible involvement of CYP6B7 in pyrethroid resistance."
Ranasinghe C., Hobbs A.A.
Insect Biochem. Mol. Biol. 28:571-580(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF031468 mRNA. Translation: AAC09227.1.

3D structure databases

ProteinModelPortalO61387.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP6B7_HELAM
AccessionPrimary (citable) accession number: O61387
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: December 11, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families