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O61387

- CP6B7_HELAM

UniProt

O61387 - CP6B7_HELAM

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Protein

Cytochrome P450 6B7

Gene

CYP6B7

Organism
Helicoverpa armigera (Cotton bollworm) (Heliothis armigera)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi445 – 4451Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 6B7 (EC:1.14.14.1)
Alternative name(s):
CYPVIB7
Gene namesi
Name:CYP6B7
OrganismiHelicoverpa armigera (Cotton bollworm) (Heliothis armigera)
Taxonomic identifieri29058 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaeHeliothinaeHelicoverpa

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Cytochrome P450 6B7PRO_0000051899Add
BLAST

Expressioni

Inductioni

By treatment with the monoterpene, alpha-pinene.

Structurei

3D structure databases

ProteinModelPortaliO61387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O61387-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWVLYLPAVL SVLIVTLYLY FTRTFNYWKK RNVRGPEPTV FFGNLKDSTL
60 70 80 90 100
RKKNIGIVME EIYNQFPYEK VVGMYRMTTP CLLVRDFHVI KHIMIKDFEA
110 120 130 140 150
FRDRGVEFSK EGLGQNLFHA DGETWRALRN RFTPIFTSGK LKNMFYLMHE
160 170 180 190 200
GADNFIDHVS KECEKKQEFE VHSLLQTYTM STISSCAFGV SYNSISDKVQ
210 220 230 240 250
TLEIVDKIIS EPSYAIELDY MYPKLLAKLN LSIIPTPVQH FFKSLVDNII
260 270 280 290 300
SQRNGKPAGR NDFMDLILEL RQMGEVTSNK YLDGVTSLEI TDEVICAQAF
310 320 330 340 350
VFYVAGYETS ATTMSYLIYQ LSLNQDVQNK LIAEVDEAIK ASDGKVTYDT
360 370 380 390 400
VKEMKYLNKV FDETLRMYSI VEPLQRKATR DYQIPGTDVV IEKDTMVLIS
410 420 430 440 450
PRGIHYDPKY YDNPKQFNPD RFDAEEVGKR HPCAYLPFGL GQRNCIGMRF
460 470 480 490 500
GRLQSLLCIT KILSKFRIEP SKNTDRNLQV EPRRVTIGPK GGIRVNIVPR

KIVS
Length:504
Mass (Da):58,218
Last modified:August 1, 1998 - v1
Checksum:i9EC92687CF4A0A4A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031468 mRNA. Translation: AAC09227.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031468 mRNA. Translation: AAC09227.1 .

3D structure databases

ProteinModelPortali O61387.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of two cytochrome P450 cDNA clones for CYP6B6 and CYP6B7 from Helicoverpa armigera (Hubner): possible involvement of CYP6B7 in pyrethroid resistance."
    Ranasinghe C., Hobbs A.A.
    Insect Biochem. Mol. Biol. 28:571-580(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP6B7_HELAM
AccessioniPrimary (citable) accession number: O61387
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3