O61380 (O61380_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Eukaryotic translation initiation factor 4G, isoform A EMBL AAF59403.3

Submitted name:
Eukaryotic translation initiation factor 4G, isoform C EMBL ACL82868.1
Submitted name:
FI02056p EMBL ACK77586.1
Submitted name:
Translation initiation factor eIF4G EMBL AAC38985.1

Gene names

Name:	eIF4G EMBL AAF59403.3 FlyBase FBgn0023213
Synonyms:	eIF-4G FlyBase FBgn0023213, eIF4G-RA EMBL ACK77586.1
ORF Names:	Dmel_CG10811 EMBL AAF59403.3

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome] EMBL AAF59403.3

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	1666 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Biological process	Protein biosynthesis
Molecular function	Initiation factor EMBL AAF59403.3
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G1/S transition of mitotic cell cycle Inferred from mutant phenotype PubMed 17611222. Source: FlyBase RNA metabolic process Inferred from electronic annotation. Source: InterPro mitosis Inferred from mutant phenotype PubMed 18463163. Source: FlyBase mitotic G2 DNA damage checkpoint Inferred from genetic interaction PubMed 21205937. Source: FlyBase mitotic spindle elongation Inferred from mutant phenotype PubMed 17412918. Source: FlyBase
Cellular_component	cytosol Inferred from sequence or structural similarity PubMed 10908586. Source: FlyBase eukaryotic translation initiation factor 4F complex Inferred from direct assay PubMed 8027064. Source: FlyBase
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro RNA 7-methylguanosine cap binding Inferred from direct assay PubMed 17611222. Source: FlyBase translation initiation factor activity Inferred from sequence or structural similarity PubMed 10908586Ref.1. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O61380 [UniParc]. Last modified November 13, 2007. Version 3. Checksum: 6BBA557A1ACE251A	FASTA	1,666	183,942
	10 20 30 40 50 60 MQQAIPTLPT QSDIDKAMQP HSAQNMYVST GNNNSGNTRS NPQSGGIFRG PPSTPNAPRG 70 80 90 100 110 120 ASGGATRHVH VQPMYSQPLH QNMVLQQYTQ YNPRQQTFPA SHLQYAPAPM PYYQYQYVPT 130 140 150 160 170 180 LQQQPPHTRS AVTVNTNVNV GNNLQPVQSG PNGPLPVPGA SSSQIQLLTS TVQPGASTVM 190 200 210 220 230 240 GVGGPGSTMG QVGVPPMVGV GVMTTSVQPQ PVQVQPASRR RHQHRLQIID PTTKKNILDD 250 260 270 280 290 300 FDKTKSNTDN EFSDQVTSTN TPATVLSEGP IRIPQQESVG LNNLTSTSSQ GSESRTNAPY 310 320 330 340 350 360 IPIETTPISR TDVGPTPIVS AMTDAPSVEI LPTPQRGRSK KIPIVSPKNV SESIVAPITD 370 380 390 400 410 420 ETDDAGSTPI SRATEESMPP NQTHPNLLIS DSSKHKQAVS NSEISKDAPT GLKEMHVAEL 430 440 450 460 470 480 ESSVASENHP AGILDVNVNK SSQSLDFSAD PEIDSIGAIS PTSPNAVSPI LHEVLDNTEL 490 500 510 520 530 540 SKKLENSTTE RFKDSQSVEK PTHQELSLRN ATDETEISAM ALQDVNSLDN NQIEKTYPSK 550 560 570 580 590 600 PKLNVDVSED ISSRESAIKS TSTKNTGVDV GLQSDSKPET TLNDKQDSTD LKVKVSAKIS 610 620 630 640 650 660 SIINYNEGQW SPNNPSGKKQ YDREQLLQLR EVKASRIQPE VKNVSILPQP NLMPSFIRNN 670 680 690 700 710 720 NNNKRVQSMV GIIGNRSNES AGNYIGKQMS MSGVQSGGGR SSMKGMIHVN LSLNQDVKLS 730 740 750 760 770 780 ENENAWRPRV LNKSDGDSDA KSALEKDELV RRVRGILNKL TPERFDTLVE EIIKLKIDTP 790 800 810 820 830 840 DKVDEVIVLV FEKAIDEPNF SVSYARLCQR LAAEVKVIDE RMESETKSNS AHFRNALLDK 850 860 870 880 890 900 TEQEFTQNVS QSTAKEKKLQ PIVDKIKKCT DANEKAELEA FLEEEERKIR RRSGGTVRFI 910 920 930 940 950 960 GELFKISMLT GKIIYSCIDT LLNPHSEDML ECLCKLLTTV GAKFEKTPVN SKDPSRCYSL 970 980 990 1000 1010 1020 EKSITRMQAI ASKTDKDGAR VSSRVRFMLQ DVIDLRKNKW QTSRNEAPKT MGQIEKEAKN 1030 1040 1050 1060 1070 1080 EQLSAQYFGT LSSTTPGGSQ GGSGKRDDRG NSRYGESRSS SAYGGSHSQR GDNGNLRHQQ 1090 1100 1110 1120 1130 1140 QNNVGGNVSG GAGHSNGNND ENTWHVQTSK GSRSLAVDSN KLEGLSKLSD QNLETKKMGG 1150 1160 1170 1180 1190 1200 LTQFIWISSD TTRLSSAPTP TPSNPFAVLS SLIDKNSNER DRDRSGPRNK GSYNKGSMER 1210 1220 1230 1240 1250 1260 DRYDRGMHSR TGSSQGSREN SSSRGGQQGR TLLSSSVQKS TSHSKYTQQA PPTRHTVKAQ 1270 1280 1290 1300 1310 1320 SSVGSSNVNT GPLYRGSEQQ TSATFSQTTR SVAPVAVFIE ASETDLKLIK SVVSEIVDLS 1330 1340 1350 1360 1370 1380 AASKEVTPGA VSCIKRVPEK LRCSFIYYIL TDYLHLANVG KQYRRYLSIA VSQLIQQNYI 1390 1400 1410 1420 1430 1440 SADHLRLAYN EFTVYANDLI VDIPELWLYI LQFAGPLIVK KILTISDLWN NNLKENSPSN 1450 1460 1470 1480 1490 1500 VAKKFLKTYL IYCTQEVGPN FARNMWIKFN LKWSDFMPES EVADFIKFNR LEYVENESKS 1510 1520 1530 1540 1550 1560 PVIDHRETPE KHVKNVIDHI EHLLKEGTTA DCIIDYSNGN IMVVDKLFIR GLTETLSNFS 1570 1580 1590 1600 1610 1620 IHYKDNSYKL ESETFQKFCI PVLQRYIDSN EDHQLECLYT LQLLVHGLEH PRGLLSELIG 1630 1640 1650 1660 ELYDAFVIQK ESLCKWRDSK DQSAGKGVAV KSLNPFFNSL LNDDAN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of the cDNA and the gene for eukaryotic translation initiation factor 4G from Drosophila melanogaster." Hernandez G., del Mar Castellano M., Agudo M., Sierra J.M. Eur. J. Biochem. 253:27-35(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Oregon R EMBL AAC38985.1.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence." Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., Pacleb J.M., Park S. , Pfeiffer B.D., Richards S., Sodergren E.J., Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M. Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[5]	"The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective." Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E. Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[6]	"Heterochromatic sequences in a Drosophila whole-genome shotgun assembly." Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H. Genome Biol. 3:RESEARCH0085.1-RESEARCH0085.16(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[7]	"Combined evidence annotation of transposable elements in genome sequences." Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D. PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[8]	"Drosophila melanogaster release 4 sequence." Berkeley Drosophila Genome Project Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[9]	Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[10]	"The Release 5.1 annotation of Drosophila melanogaster heterochromatin." Smith C.D., Shu S., Mungall C.J., Karpen G.H. Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[11]	"Sequence finishing and mapping of Drosophila melanogaster heterochromatin." Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., Dimitri P., Karpen G.H., Celniker S.E. Science 316:1625-1628(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[12]	Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[13]	FlyBase Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF030155 mRNA. Translation: AAC38985.1. AE014135 Genomic DNA. Translation: AAF59403.3. BT053671 mRNA. Translation: ACK77586.1. AE014135 Genomic DNA. Translation: ACL82868.1.
RefSeq	NP_001137857.1. NM_001144385.2. NP_524640.3. NM_079901.4.
UniGene	Dm.7136.
3D structure databases
SMR	O61380. Positions 744-1000, 1302-1660.
ModBase	Search...
Protein-protein interaction databases
IntAct	O61380. 5 interactions.
MINT	MINT-974303.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0089243; FBpp0088303; FBgn0023213. FBtr0289951; FBpp0288389; FBgn0023213.
GeneID	43839.
KEGG	dme:Dmel_CG10811.
UCSC	CG10811-RA. d. melanogaster.
Organism-specific databases
CTD	43839.
FlyBase	FBgn0023213. eIF4G.
Phylogenomic databases
GeneTree	ENSGT00530000063038.
InParanoid	O61380.
KO	K03260.
Family and domain databases
Gene3D	1.25.40.180. 3 hits.
InterPro	IPR016024. ARM-type_fold. IPR003891. Initiation_fac_eIF4g_MI. IPR016021. MIF4-like_typ_1/2/3. IPR003890. MIF4G-like_typ-3. IPR003307. W2_domain. [Graphical view]
Pfam	PF02847. MA3. 1 hit. PF02854. MIF4G. 1 hit. [Graphical view]
SMART	SM00515. eIF5C. 1 hit. SM00544. MA3. 1 hit. SM00543. MIF4G. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 3 hits.
PROSITE	PS51366. MI. 1 hit. PS51363. W2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	EIF4G. drosophila.
GenomeRNAi	43839.
NextBio	836177.

Entry information

Entry name

O61380_DROME

Accession

Primary (citable) accession number: O61380
Secondary accession number(s): Q7KQ11

Entry history

Integrated into UniProtKB/TrEMBL:	August 1, 1998
Last sequence update:	November 13, 2007
Last modified:	May 1, 2013
This is version 105 of the entry and version 3 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)