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Unreviewed, UniProtKB/TrEMBL O61380 (O61380_DROME)

Last modified June 16, 2009. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    Eukaryotic translation initiation factor 4G, isoform A EMBL AAF59403.3
Submitted name:
    Eukaryotic translation initiation factor 4G, isoform C EMBL ACL82868.1
    FI02056p EMBL ACK77586.1
    Translation initiation factor eIF4G EMBL AAC38985.1
Gene names
Name: eIF4G FlyBase FBgn0023213
Synonyms: eIF-4G FlyBase FBgn0023213, eIF4G-RA EMBL ACK77586.1
ORF Names: Dmel_CG10811 EMBL AAF59403.3
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length1666 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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Ontologies

Keywords
   Biological processProtein biosynthesis
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processRNA metabolic process

Inferred from electronic annotation. Source: InterPro

mitotic spindle elongation

Inferred from mutant phenotype. Source: FlyBase

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequences

Sequence LengthMass (Da)Tools
O61380-1 [UniParc].

Last modified November 13, 2007. Version 3.
Checksum: 6BBA557A1ACE251A

FASTA1,666183,942
        10         20         30         40         50         60 
MQQAIPTLPT QSDIDKAMQP HSAQNMYVST GNNNSGNTRS NPQSGGIFRG PPSTPNAPRG 

        70         80         90        100        110        120 
ASGGATRHVH VQPMYSQPLH QNMVLQQYTQ YNPRQQTFPA SHLQYAPAPM PYYQYQYVPT 

       130        140        150        160        170        180 
LQQQPPHTRS AVTVNTNVNV GNNLQPVQSG PNGPLPVPGA SSSQIQLLTS TVQPGASTVM 

       190        200        210        220        230        240 
GVGGPGSTMG QVGVPPMVGV GVMTTSVQPQ PVQVQPASRR RHQHRLQIID PTTKKNILDD 

       250        260        270        280        290        300 
FDKTKSNTDN EFSDQVTSTN TPATVLSEGP IRIPQQESVG LNNLTSTSSQ GSESRTNAPY 

       310        320        330        340        350        360 
IPIETTPISR TDVGPTPIVS AMTDAPSVEI LPTPQRGRSK KIPIVSPKNV SESIVAPITD 

       370        380        390        400        410        420 
ETDDAGSTPI SRATEESMPP NQTHPNLLIS DSSKHKQAVS NSEISKDAPT GLKEMHVAEL 

       430        440        450        460        470        480 
ESSVASENHP AGILDVNVNK SSQSLDFSAD PEIDSIGAIS PTSPNAVSPI LHEVLDNTEL 

       490        500        510        520        530        540 
SKKLENSTTE RFKDSQSVEK PTHQELSLRN ATDETEISAM ALQDVNSLDN NQIEKTYPSK 

       550        560        570        580        590        600 
PKLNVDVSED ISSRESAIKS TSTKNTGVDV GLQSDSKPET TLNDKQDSTD LKVKVSAKIS 

       610        620        630        640        650        660 
SIINYNEGQW SPNNPSGKKQ YDREQLLQLR EVKASRIQPE VKNVSILPQP NLMPSFIRNN 

       670        680        690        700        710        720 
NNNKRVQSMV GIIGNRSNES AGNYIGKQMS MSGVQSGGGR SSMKGMIHVN LSLNQDVKLS 

       730        740        750        760        770        780 
ENENAWRPRV LNKSDGDSDA KSALEKDELV RRVRGILNKL TPERFDTLVE EIIKLKIDTP 

       790        800        810        820        830        840 
DKVDEVIVLV FEKAIDEPNF SVSYARLCQR LAAEVKVIDE RMESETKSNS AHFRNALLDK 

       850        860        870        880        890        900 
TEQEFTQNVS QSTAKEKKLQ PIVDKIKKCT DANEKAELEA FLEEEERKIR RRSGGTVRFI 

       910        920        930        940        950        960 
GELFKISMLT GKIIYSCIDT LLNPHSEDML ECLCKLLTTV GAKFEKTPVN SKDPSRCYSL 

       970        980        990       1000       1010       1020 
EKSITRMQAI ASKTDKDGAR VSSRVRFMLQ DVIDLRKNKW QTSRNEAPKT MGQIEKEAKN 

      1030       1040       1050       1060       1070       1080 
EQLSAQYFGT LSSTTPGGSQ GGSGKRDDRG NSRYGESRSS SAYGGSHSQR GDNGNLRHQQ 

      1090       1100       1110       1120       1130       1140 
QNNVGGNVSG GAGHSNGNND ENTWHVQTSK GSRSLAVDSN KLEGLSKLSD QNLETKKMGG 

      1150       1160       1170       1180       1190       1200 
LTQFIWISSD TTRLSSAPTP TPSNPFAVLS SLIDKNSNER DRDRSGPRNK GSYNKGSMER 

      1210       1220       1230       1240       1250       1260 
DRYDRGMHSR TGSSQGSREN SSSRGGQQGR TLLSSSVQKS TSHSKYTQQA PPTRHTVKAQ 

      1270       1280       1290       1300       1310       1320 
SSVGSSNVNT GPLYRGSEQQ TSATFSQTTR SVAPVAVFIE ASETDLKLIK SVVSEIVDLS 

      1330       1340       1350       1360       1370       1380 
AASKEVTPGA VSCIKRVPEK LRCSFIYYIL TDYLHLANVG KQYRRYLSIA VSQLIQQNYI 

      1390       1400       1410       1420       1430       1440 
SADHLRLAYN EFTVYANDLI VDIPELWLYI LQFAGPLIVK KILTISDLWN NNLKENSPSN 

      1450       1460       1470       1480       1490       1500 
VAKKFLKTYL IYCTQEVGPN FARNMWIKFN LKWSDFMPES EVADFIKFNR LEYVENESKS 

      1510       1520       1530       1540       1550       1560 
PVIDHRETPE KHVKNVIDHI EHLLKEGTTA DCIIDYSNGN IMVVDKLFIR GLTETLSNFS 

      1570       1580       1590       1600       1610       1620 
IHYKDNSYKL ESETFQKFCI PVLQRYIDSN EDHQLECLYT LQLLVHGLEH PRGLLSELIG 

      1630       1640       1650       1660 
ELYDAFVIQK ESLCKWRDSK DQSAGKGVAV KSLNPFFNSL LNDDAN

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References

« Hide 'large scale' references
[1]"Isolation and characterization of the cDNA and the gene for eukaryotic translation initiation factor 4G from Drosophila melanogaster."
Hernandez G., del Mar Castellano M., Agudo M., Sierra J.M.
Eur. J. Biochem. 253:27-35(1998) [PubMed: 9578457] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Oregon R EMBL AAC38985.1.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[4]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[5]Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[6]"An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
Mol. Biosyst. 3:275-286(2007) [PubMed: 17372656] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF030155 mRNA. Translation: AAC38985.1.
AE014135 Genomic DNA. Translation: AAF59403.3.
BT053671 mRNA. Translation: ACK77586.1.
AE014135 Genomic DNA. Translation: ACL82868.1.
RefSeqNP_001137857.1.
NP_524640.3.
UniGeneDm.7136

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActO61380. 5 interactions.

Proteomic databases

PRIDEO61380.

Genome annotation databases

EnsemblFBgn0023213. Drosophila melanogaster. [Contig view]
GeneID43839.

Organism-specific databases

FlyBaseFBgn0023213. eIF4G.

Phylogenomic databases

HOGENOMQ7KQ11.

Gene expression databases

ArrayExpressO61380.
Q7KQ11.

Family and domain databases

InterProIPR003307. eIF5C.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
[Graphical view]
Gene3DG3DSA:1.25.40.230. eIF5C. 1 hit.
G3DSA:1.25.40.180. MIF4-like_typ_1/2/3. 1 hit.
PfamPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTSM00515. eIF5C. 1 hit.
SM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view]
PROSITEPS51366. MI. 1 hit.
PS51363. W2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio836177.

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Entry information

Entry nameO61380_DROME
AccessionPrimary (citable) accession number: O61380
Secondary accession number(s): Q7KQ11
Entry history
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: November 13, 2007
Last modified: June 16, 2009
This is version 63 of the entry and version 3 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information