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O61379 (TPM_PANST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tropomyosin
Alternative name(s):
Allergen Pan s I
Allergen=Pan s 1
OrganismPanulirus stimpsoni (Chinese spiny lobster)
Taxonomic identifier71578 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAchelataPalinuroideaPalinuridaePanulirus

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

Subunit structure

Homodimer By similarity.

Domain

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Belongs to the tropomyosin family.

Ontologies

Keywords
   DiseaseAllergen
   DomainCoiled coil
Repeat
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Tropomyosin
PRO_0000205676

Regions

Coiled coil1 – 274274 By similarity

Sequences

Sequence LengthMass (Da)Tools
O61379 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 886FACBE8CF1E81E

FASTA27431,739
        10         20         30         40         50         60 
MKLEKDNAMD RADTLEQQNK EANIRAEKAE EEVHNLQKRM QQLENDLDQV QESLLKANTQ 

        70         80         90        100        110        120 
LEEKDKALSN AEGEVAALNR RIQLLEEDLE RSEERLNTAT TKLAEASQAA DESERMRKVL 

       130        140        150        160        170        180 
ENRSLSDEER MDALENQLKE ARFLAEEADR KYDEVARKLA MVEADLERAE ERAETGESKF 

       190        200        210        220        230        240 
VELEEELRVV GNNLKSLEVS EEKANQREEA YKEQIKTLTN KLKAAEARAE FAERSVQKLQ 

       250        260        270 
KEVDRLEDEL VNEKEKYKSI TDELDQTFSE LSGY 

« Hide

References

[1]"Molecular identification of the lobster muscle protein tropomyosin as a seafood allergen."
Leung P.S.C., Chen Y.C., Mykles D.L., Chow W.K., Li C.P., Chu K.H.
Mol. Mar. Biol. Biotechnol. 7:12-20(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF030063 mRNA. Translation: AAC38996.1.

3D structure databases

ProteinModelPortalO61379.
SMRO61379. Positions 1-273.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3396. Pan s 1.0101.
500. Pan s 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000533. Tropomyosin.
[Graphical view]
PfamPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSPR00194. TROPOMYOSIN.
PROSITEPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTPM_PANST
AccessionPrimary (citable) accession number: O61379
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: August 1, 1998
Last modified: April 3, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries