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Protein

Sex-lethal homolog

Gene

SXL

Organism
Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Unknown; apparently not involved in somatic sex determination.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sex-lethal homolog
Alternative name(s):
CCSXL
Gene namesi
Name:SXL
OrganismiCeratitis capitata (Mediterranean fruit fly) (Tephritis capitata)
Taxonomic identifieri7213 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaTephritoideaTephritidaeCeratitisCeratitis

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Sex-lethal homologPRO_0000081965Add
BLAST

Expressioni

Developmental stagei

Expressed in embryos of both sexes. Also expressed in the progenitor cells of the germline.

Structurei

3D structure databases

ProteinModelPortaliO61374.
SMRiO61374. Positions 108-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini110 – 18879RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini196 – 27681RRM 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 2727Asn/Gly-richAdd
BLAST
Compositional biasi68 – 758Poly-Gly
Compositional biasi95 – 995Poly-Gly
Compositional biasi293 – 31119Poly-GlyAdd
BLAST
Compositional biasi312 – 3165Poly-Pro

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR006546. Sxl.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
TIGRFAMsiTIGR01659. sex-lethal. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform E3 (identifier: O61374-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYGNMNNGGH APYGYNGYRP SGGRMWGMSH SLPSGMSRYA FSPEDTDFTS
60 70 80 90 100
SYPGPSMNRR GGYNDFSGGG GGGGGTMGSM NNMVNAASTN SLNCGGGGGR
110 120 130 140 150
DGHGGGSNGT NLIVNYLPQD MTDRELYALF RTIGPINTCR IMRDYKTGYS
160 170 180 190 200
FGYAFVDFAA ETDSQRAIKS LNGITVRNKR LKVSYARPGG ESIKDTNLYV
210 220 230 240 250
TNLPRTITDD QLDTIFGKYG MIVQKNILRD KLTGKPRGVA FVRFNKREEA
260 270 280 290 300
QEAISALNNV IPEGASQPLT VRLAEEHGKA KAQHYMSQLG LIGGGGGGGG
310 320 330 340
GGGGGGGGMG GPPPPPMNMG YNNMVHRGRQ NKSRFQKMHP YHNAQKFI
Note: Embryo specific.
Length:348
Mass (Da):37,188
Last modified:May 30, 2000 - v2
Checksum:iCABA3DA5C2C8874A
GO
Isoform A1 (identifier: O61374-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-44: Missing.

Note: Adult specific.
Show »
Length:340
Mass (Da):36,250
Checksum:iF13597D22896141E
GO
Isoform A2 (identifier: O61374-3)
Sequence is not available
Note: Adult specific.
Length:
Mass (Da):
Isoform A3 (identifier: O61374-4)
Sequence is not available
Note: Adult specific.
Length:
Mass (Da):
Isoform A4 (identifier: O61374-5)
Sequence is not available
Note: Adult specific.
Length:
Mass (Da):
Isoform E1 (identifier: O61374-6)
Sequence is not available
Note: Embryo specific.
Length:
Mass (Da):
Isoform E2 (identifier: O61374-7)
Sequence is not available
Note: Embryo specific.
Length:
Mass (Da):

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei37 – 448Missing in isoform A1. 1 PublicationVSP_005880

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026145 mRNA. Translation: AAC38968.1.
RefSeqiNP_001266336.1. NM_001279407.1. [O61374-2]

Genome annotation databases

GeneIDi101454489.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026145 mRNA. Translation: AAC38968.1.
RefSeqiNP_001266336.1. NM_001279407.1. [O61374-2]

3D structure databases

ProteinModelPortaliO61374.
SMRiO61374. Positions 108-274.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101454489.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR006546. Sxl.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
TIGRFAMsiTIGR01659. sex-lethal. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSXL_CERCA
AccessioniPrimary (citable) accession number: O61374
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: January 20, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.