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Protein

Sodium channel protein Nach

Gene

Nach

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of a complex that plays a role in tracheal liquid clearance. Probable role in sodium transport (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel protein Nach
Gene namesi
Name:Nach
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0024473. Dana\Nach.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949CytoplasmicSequence analysisAdd
BLAST
Transmembranei50 – 7021HelicalSequence analysisAdd
BLAST
Topological domaini71 – 452382ExtracellularSequence analysisAdd
BLAST
Transmembranei453 – 47321HelicalSequence analysisAdd
BLAST
Topological domaini474 – 51643CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Sodium channel protein NachPRO_0000181309Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence analysis
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence analysis
Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi7217.FBpp0116649.

Structurei

3D structure databases

ProteinModelPortaliO61370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4294. Eukaryota.
ENOG410ZNFK. LUCA.
OrthoDBiEOG091G08X0.

Family and domain databases

InterProiIPR001873. Na+channel_ASC.
IPR020903. Na+channel_ASC_CS.
[Graphical view]
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiPF00858. ASC. 1 hit.
[Graphical view]
PRINTSiPR01078. AMINACHANNEL.
PROSITEiPS01206. ASC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O61370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHEEELSPE QVDLKVSPLM GSLKRTWNDF CATSSIHGLR YTRDEDTNRI
60 70 80 90 100
VHFVWLLISL VMFICAVVMA RTFYIDFRSN PTRMNVESDN TPVNTLYFPP
110 120 130 140 150
VTICPDVLFN MQKSEAFLQT LQLPQGTNQS VILRKLHIFY GFMLDDEKYS
160 170 180 190 200
EQDTSLMESL LSLNNLTLQQ LVEHLRWNCD EILYRCRFNG QIRDCLELFQ
210 220 230 240 250
LSKTFFGHCC SFNLRQTGLN FTAERAVGGL KYGLSVILRY KDDSYDPVQS
260 270 280 290 300
YSFGVKLLIQ ESDAFPSAHS SSKFIAFNSE VFAAIRPQET FCSPAVKALS
310 320 330 340 350
IEDRNCVFRN EFKMRYFKNY VYPNCELNCR VTNMVKFCNC HTYFFDFNRT
360 370 380 390 400
TDRICTFKDI PCLVDNFANI ISRKRSTQCY CPLTCEHLDY DVQISDFPLK
410 420 430 440 450
LNMPVGDQFY SGINKNDGIL HVFINSFGYR RLRHDLLSNM VTLVSNLGSA
460 470 480 490 500
FSLFVGMSML SVVEIMYYFS VILRKNYVLE CEARKKMLHK GPKFAWPKAN
510
DSHSKHQKSV FIIHKM
Length:516
Mass (Da):59,941
Last modified:August 1, 1998 - v1
Checksum:i1EA6FDC2509EF40A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024691 Genomic DNA. Translation: AAC39089.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024691 Genomic DNA. Translation: AAC39089.1.

3D structure databases

ProteinModelPortaliO61370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7217.FBpp0116649.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0024473. Dana\Nach.

Phylogenomic databases

eggNOGiKOG4294. Eukaryota.
ENOG410ZNFK. LUCA.
OrthoDBiEOG091G08X0.

Family and domain databases

InterProiIPR001873. Na+channel_ASC.
IPR020903. Na+channel_ASC_CS.
[Graphical view]
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiPF00858. ASC. 1 hit.
[Graphical view]
PRINTSiPR01078. AMINACHANNEL.
PROSITEiPS01206. ASC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNACH_DROAN
AccessioniPrimary (citable) accession number: O61370
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.