Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium channel protein Nach

Gene

Nach

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Part of a complex that plays a role in tracheal liquid clearance. Probable role in sodium transport.1 Publication1 Publication

GO - Molecular functioni

  • sodium channel activity Source: UniProtKB

GO - Biological processi

  • liquid clearance, open tracheal system Source: UniProtKB
  • sodium ion transport Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi1.A.6.4.3. the epithelial na(+) channel (enac) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel protein Nach
Alternative name(s):
Pickpocket protein 4
Gene namesi
Name:Nach
Synonyms:PPK4
ORF Names:CG8178
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0024319. Nach.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 471ExtracellularSequence analysisAdd BLAST401
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Topological domaini493 – 535CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001813101 – 535Sodium channel protein NachAdd BLAST535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi165N-linked (GlcNAc...)Sequence analysis1
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Glycosylationi367N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO61365.
PRIDEiO61365.

Expressioni

Tissue specificityi

Embryonic and larval tracheal system; dorsal trunk (but not at fusion with transverse connective), several branches and terminal cells. Also expressed in adult tracheal system; dorsal trunk, but not at the spiracles.1 Publication

Gene expression databases

BgeeiFBgn0024319.
GenevisibleiO61365. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0088959.

Structurei

3D structure databases

ProteinModelPortaliO61365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4294. Eukaryota.
ENOG410ZNFK. LUCA.
InParanoidiO61365.
KOiK03440.
OMAiNCDEILY.
OrthoDBiEOG091G08X0.
PhylomeDBiO61365.

Family and domain databases

InterProiIPR001873. Na+channel_ASC.
IPR020903. Na+channel_ASC_CS.
[Graphical view]
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiPF00858. ASC. 1 hit.
[Graphical view]
PRINTSiPR01078. AMINACHANNEL.
PROSITEiPS01206. ASC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B1 Publication (identifier: O61365-1) [UniParc]FASTAAdd to basket
Also known as: PPK4L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGHQEELKPE QVDLKVTPFV GYLRRTWSDF CATSSIHGLK YTRDEDTNKI
60 70 80 90 100
VHLVWLLISV VMFICAVVMA RTFYMDYRSS PTRMNVESDN TPVNRLYFPP
110 120 130 140 150
VTICPDVLFN MQKSEAFLNT LRLPKGAELR GILRKLHIFY GFMLDDERYS
160 170 180 190 200
AEDIEQMEAL LFLNNLTIPE FVEHLRWNCD EILYRCRFNG EIMDCSKIFQ
210 220 230 240 250
LSKTFFGHCC SFNLRQKGWV NNKLNNLESF KVFHLNSLNF TAQRAIGGLR
260 270 280 290 300
YGLSVVVRYK DDNYDPLQSY SYGVKLLIQE ADAFPSAHSA AKFIAFNSET
310 320 330 340 350
FAAVRPQETF CSSAVKALII EERNCVFQNE FPMRYFSDYV YPNCELNCRV
360 370 380 390 400
TNMVKFCGCH TYFFDFNRTS DRICTFRDIP CLVDNFANII TRKKSTQCYC
410 420 430 440 450
PLTCEHIDYD VQLTNFPLEL NMPVADKFYS GLAKNDGVLH VFINSFSYRR
460 470 480 490 500
LRRDLLSNMV TLVSNLGSAF SLFVGMSMLS VVEIIYYFSV ILRKNYKLEC
510 520 530
ETRSQMLHKK PKFAWPKAND THSKEQKSVF IIHKS
Length:535
Mass (Da):62,330
Last modified:October 10, 2003 - v2
Checksum:i63C88935FAD62161
GO
Isoform ACurated (identifier: O61365-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-237: Missing.

Show »
Length:516
Mass (Da):60,044
Checksum:iD9C23ABAFBFD1AE9
GO
Isoform C (identifier: O61365-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-386: F → FGRLLLICSKYSDFNRLLS

Note: No experimental confirmation available.
Show »
Length:553
Mass (Da):64,410
Checksum:iC1A686DF887970AB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22Y → S in AAD09149 (Ref. 1) Curated1
Sequence conflicti269S → L in AAD09149 (Ref. 1) Curated1
Sequence conflicti289S → F in AAD09149 (Ref. 1) Curated1
Sequence conflicti312 – 313SS → FF in AAD09149 (Ref. 1) Curated2
Sequence conflicti365D → A in AAD09149 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008551219 – 237Missing in isoform A. CuratedAdd BLAST19
Alternative sequenceiVSP_011421386F → FGRLLLICSKYSDFNRLLS in isoform C. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022713 Genomic DNA. Translation: AAD09149.1.
AY226538 mRNA. Translation: AAO47364.1.
AE013599 Genomic DNA. Translation: AAF57970.1.
AE013599 Genomic DNA. Translation: AAS64839.1.
AE013599 Genomic DNA. Translation: AAS64840.1.
RefSeqiNP_611145.1. NM_137301.1. [O61365-2]
UniGeneiDm.12422.

Genome annotation databases

GeneIDi36864.
KEGGidme:Dmel_CG8178.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022713 Genomic DNA. Translation: AAD09149.1.
AY226538 mRNA. Translation: AAO47364.1.
AE013599 Genomic DNA. Translation: AAF57970.1.
AE013599 Genomic DNA. Translation: AAS64839.1.
AE013599 Genomic DNA. Translation: AAS64840.1.
RefSeqiNP_611145.1. NM_137301.1. [O61365-2]
UniGeneiDm.12422.

3D structure databases

ProteinModelPortaliO61365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0088959.

Protein family/group databases

TCDBi1.A.6.4.3. the epithelial na(+) channel (enac) family.

Proteomic databases

PaxDbiO61365.
PRIDEiO61365.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi36864.
KEGGidme:Dmel_CG8178.

Organism-specific databases

CTDi36864.
FlyBaseiFBgn0024319. Nach.

Phylogenomic databases

eggNOGiKOG4294. Eukaryota.
ENOG410ZNFK. LUCA.
InParanoidiO61365.
KOiK03440.
OMAiNCDEILY.
OrthoDBiEOG091G08X0.
PhylomeDBiO61365.

Miscellaneous databases

GenomeRNAii36864.
PROiO61365.

Gene expression databases

BgeeiFBgn0024319.
GenevisibleiO61365. DM.

Family and domain databases

InterProiIPR001873. Na+channel_ASC.
IPR020903. Na+channel_ASC_CS.
[Graphical view]
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiPF00858. ASC. 1 hit.
[Graphical view]
PRINTSiPR01078. AMINACHANNEL.
PROSITEiPS01206. ASC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNACH_DROME
AccessioniPrimary (citable) accession number: O61365
Secondary accession number(s): Q7KRC7, Q86LH4, Q9V7S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: November 2, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.