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Protein
Submitted name:

CROL GAMMA

Gene

crol

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • lateral inhibition Source: FlyBase
  • negative regulation of transcription, DNA-templated Source: FlyBase
  • negative regulation of Wnt signaling pathway Source: FlyBase
  • positive regulation of mitotic cell cycle Source: FlyBase
  • regulation of chromatin silencing Source: FlyBase
  • regulation of transcription from RNA polymerase II promoter Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
CROL GAMMAImported
Submitted name:
Crooked legs, isoform CImported
Gene namesi
Name:crolImported
Synonyms:crol gammaImported
ORF Names:CG14938Imported, Dmel_CG14938Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0020309. crol.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0079845.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini183 – 21028C2H2-typeInterPro annotationAdd
BLAST
Domaini211 – 23828C2H2-typeInterPro annotationAdd
BLAST
Domaini239 – 26628C2H2-typeInterPro annotationAdd
BLAST
Domaini267 – 29428C2H2-typeInterPro annotationAdd
BLAST
Domaini295 – 32228C2H2-typeInterPro annotationAdd
BLAST
Domaini323 – 35028C2H2-typeInterPro annotationAdd
BLAST
Domaini351 – 37828C2H2-typeInterPro annotationAdd
BLAST
Domaini379 – 40628C2H2-typeInterPro annotationAdd
BLAST
Domaini407 – 43529C2H2-typeInterPro annotationAdd
BLAST
Domaini436 – 46328C2H2-typeInterPro annotationAdd
BLAST
Domaini468 – 49528C2H2-typeInterPro annotationAdd
BLAST
Domaini496 – 51924C2H2-typeInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili647 – 67731Sequence analysisAdd
BLAST
Coiled coili681 – 70828Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129692.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O61362-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHVSAASSV PSVVTPVVTT GGTTITLGGP PPLPKSEHKE DGKPPHGIEM
60 70 80 90 100
YKVNIEDISQ LFTYHEVFGK IHGDVVNHQL AAAHGGQLPP PPPLPPQVTS
110 120 130 140 150
HAASAAAAAA AASTNNAAVA AVMASANAAA AAAAAASAGG GLPPATSGNG
160 170 180 190 200
GQQVTVTTTS SSTSSGGSTT SGGTTTTAGQ TPHQCDVCGK KYTRKEHLAN
210 220 230 240 250
HMRSHTNETP FRCEICGKSF SRKEHFTNHI LWHTGETPHR CDFCSKTFTR
260 270 280 290 300
KEHLLNHVRQ HTGESPHRCS YCMKTFTRKE HLVNHIRQHT GETPFKCTYC
310 320 330 340 350
TKAFTRKDHM VNHVRQHTGE SPHKCTYCTK TFTRKEHLTN HVRQHTGDSP
360 370 380 390 400
HRCSYCKKTF TRKEHLTNHV RLHTGDSPHK CEYCQKTFTR KEHLNNHMRQ
410 420 430 440 450
HSSDNPHCCN VCNKPFTRKE HLINHMSRCH TGDRPFTCET CGKSFPLKGN
460 470 480 490 500
LLFHQRSHTK GQEMERPFAC EKCPKNFICK GHLVSHMRSH SGEKPHACTL
510 520 530 540 550
CSKAFVERGN LKRHMKMNHP DAMMPPPPVH PHPQIPAGVL TQVKQEVKPI
560 570 580 590 600
IIPHHSATTT MHTIQQITAG AAGGAGAVQL TPGLVPLVTS TLISHNAAAQ
610 620 630 640 650
QQSQKQQAAA AAAAQQQAAA AAAAQQQAAQ QQAAAAHQQH QQQVAAQHQQ
660 670 680 690 700
QAAVAAHQQQ QQQLQQQQQL LQLSIQQAAH HHQQEQHRQQ QQQQHQQQQQ
710 720 730 740 750
QQHHQQQQQG HPQAPPPQQQ QQPPPIALIS DPSALARAAI QLQHLPANVE

QHPVVY
Length:756
Mass (Da):82,883
Last modified:August 1, 1998 - v1
Checksum:iFA5DF25B09B74642
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020349 mRNA. Translation: AAC15518.1.
AE014134 Genomic DNA. Translation: AAN10784.1.
RefSeqiNP_477244.1. NM_057896.4.
UniGeneiDm.3562.

Genome annotation databases

EnsemblMetazoaiFBtr0080263; FBpp0079847; FBgn0020309.
GeneIDi34592.
UCSCiCG14938-RC. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020349 mRNA. Translation: AAC15518.1.
AE014134 Genomic DNA. Translation: AAN10784.1.
RefSeqiNP_477244.1. NM_057896.4.
UniGeneiDm.3562.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0079845.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080263; FBpp0079847; FBgn0020309.
GeneIDi34592.
UCSCiCG14938-RC. d. melanogaster.

Organism-specific databases

CTDi34592.
FlyBaseiFBgn0020309. crol.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129692.

Enzyme and pathway databases

ReactomeiR-DME-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSicrol. fly.
GenomeRNAii34592.
NextBioi789202.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "crooked legs encodes a family of zinc finger proteins required for leg morphogenesis and ecdysone-regulated gene expression during Drosophila metamorphosis."
    D'Avino P.P., Thummel C.S.
    Development 125:1733-1745(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Canton SImported.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  4. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. Millard Andrew
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO61362_DROME
AccessioniPrimary (citable) accession number: O61362
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.