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Protein
Submitted name:

CROL BETA

Gene

crol

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • lateral inhibition Source: FlyBase
  • negative regulation of transcription, DNA-templated Source: FlyBase
  • negative regulation of Wnt signaling pathway Source: FlyBase
  • positive regulation of mitotic cell cycle Source: FlyBase
  • regulation of chromatin silencing Source: FlyBase
  • regulation of transcription from RNA polymerase II promoter Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
CROL BETAImported
Submitted name:
Crooked legs, isoform BImported
Gene namesi
Name:crolImported
Synonyms:crol betaImported
ORF Names:CG14938Imported, Dmel_CG14938Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0020309. crol.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0079845.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini221 – 24828C2H2-typeInterPro annotationAdd
BLAST
Domaini249 – 27628C2H2-typeInterPro annotationAdd
BLAST
Domaini277 – 30428C2H2-typeInterPro annotationAdd
BLAST
Domaini305 – 33228C2H2-typeInterPro annotationAdd
BLAST
Domaini333 – 36028C2H2-typeInterPro annotationAdd
BLAST
Domaini361 – 38828C2H2-typeInterPro annotationAdd
BLAST
Domaini389 – 41628C2H2-typeInterPro annotationAdd
BLAST
Domaini417 – 44428C2H2-typeInterPro annotationAdd
BLAST
Domaini445 – 47228C2H2-typeInterPro annotationAdd
BLAST
Domaini473 – 50028C2H2-typeInterPro annotationAdd
BLAST
Domaini501 – 52828C2H2-typeInterPro annotationAdd
BLAST
Domaini529 – 55628C2H2-typeInterPro annotationAdd
BLAST
Domaini557 – 58428C2H2-typeInterPro annotationAdd
BLAST
Domaini585 – 61228C2H2-typeInterPro annotationAdd
BLAST
Domaini613 – 64129C2H2-typeInterPro annotationAdd
BLAST
Domaini642 – 66928C2H2-typeInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili782 – 81231Sequence analysisAdd
BLAST
Coiled coili816 – 84328Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129692.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 16 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O61361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHVSAASSV PSVVTPVVTT GGTTITLGGP PPLPKSEHKE DGKPPHGIEM
60 70 80 90 100
YKVNIEDISQ LFTYHEVFGK IHGDVVNHQL AAAHGGQLPP PPPLPPQVTS
110 120 130 140 150
HAASAAAAAA AASTNNAAVA AVMASANAAA AAAAAASAGG GLPPATSGNG
160 170 180 190 200
GQQVTVTTTS SSTSSGGSTT SGGTTTTAGE LLMPKMEGGI HGVDGSGNGG
210 220 230 240 250
NGGGQNVALA PDGTPIATGT HVCDICGKMF QFRYQLIVHR RYHSERKPFM
260 270 280 290 300
CQVCGQGFTT SQDLTRHGKI HIGGPMFTCI VCFNVFANNT SLERHMKRHS
310 320 330 340 350
TDKPFACTIC QKTFARKEHL DNHFRSHTGE TPFRCQYCAK TFTRKEHMVN
360 370 380 390 400
HVRKHTGETP HRCDICKKSF TRKEHYVNHY MWHTGQTPHQ CDVCGKKYTR
410 420 430 440 450
KEHLANHMRS HTNETPFRCE ICGKSFSRKE HFTNHILWHT GETPHRCDFC
460 470 480 490 500
SKTFTRKEHL LNHVRQHTGE SPHRCSYCMK TFTRKEHLVN HIRQHTGETP
510 520 530 540 550
FKCTYCTKAF TRKDHMVNHV RQHTGESPHK CTYCTKTFTR KEHLTNHVRQ
560 570 580 590 600
HTGDSPHRCS YCKKTFTRKE HLTNHVRLHT GDSPHKCEYC QKTFTRKEHL
610 620 630 640 650
NNHMRQHSSD NPHCCNVCNK PFTRKEHLIN HMSRCHTGDR PFTCETCGKS
660 670 680 690 700
FPLKGNLLFH QRSHTKGQEM ERPFACEKCP KNFICKVPHH SATTTMHTIQ
710 720 730 740 750
QITAGAAGGA GAVQLTPGLV PLVTSTLISH NAAAQQQSQK QQAAAAAAAQ
760 770 780 790 800
QQAAAAAAAQ QQAAQQQAAA AHQQHQQQVA AQHQQQAAVA AHQQQQQQLQ
810 820 830 840 850
QQQQLLQLSI QQAAHHHQQE QHRQQQQQQH QQQQQQQHHQ QQQQGHPQAP
860 870 880 890
PPQQQQQPPP IALISDPSAL ARAAIQLQHL PANVEQHPVV Y
Length:891
Mass (Da):98,466
Last modified:August 1, 1998 - v1
Checksum:i3B436CAB5DEC4FEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020348 mRNA. Translation: AAC15517.1.
AE014134 Genomic DNA. Translation: AAN10786.1.
RefSeqiNP_477245.1. NM_057897.4.
UniGeneiDm.3562.

Genome annotation databases

EnsemblMetazoaiFBtr0080262; FBpp0079846; FBgn0020309.
GeneIDi34592.
UCSCiCG14938-RB. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020348 mRNA. Translation: AAC15517.1.
AE014134 Genomic DNA. Translation: AAN10786.1.
RefSeqiNP_477245.1. NM_057897.4.
UniGeneiDm.3562.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0079845.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080262; FBpp0079846; FBgn0020309.
GeneIDi34592.
UCSCiCG14938-RB. d. melanogaster.

Organism-specific databases

CTDi34592.
FlyBaseiFBgn0020309. crol.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129692.

Enzyme and pathway databases

ReactomeiR-DME-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSicrol. fly.
GenomeRNAii34592.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 16 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "crooked legs encodes a family of zinc finger proteins required for leg morphogenesis and ecdysone-regulated gene expression during Drosophila metamorphosis."
    D'Avino P.P., Thummel C.S.
    Development 125:1733-1745(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Canton SImported.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  4. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. Millard Andrew
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO61361_DROME
AccessioniPrimary (citable) accession number: O61361
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.