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Protein

DEAD-box helicase Dbp80

Gene

Dbp80

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent RNA helicase involved in mRNA export from the nucleus.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi119 – 126ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processmRNA transport, Protein transport, Translocation, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DEAD-box helicase Dbp80 (EC:3.6.4.13)
Gene namesi
Name:Dbp80
Synonyms:Hel40, HEL80
ORF Names:CG17023
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0024804. Dbp80.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550241 – 460DEAD-box helicase Dbp80Add BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26Phosphoserine1 Publication1
Modified residuei30Phosphothreonine2 Publications1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO61305.
PRIDEiO61305.

PTM databases

iPTMnetiO61305.

Expressioni

Gene expression databases

BgeeiFBgn0024804.
ExpressionAtlasiO61305. differential.
GenevisibleiO61305. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0304166.

Structurei

3D structure databases

ProteinModelPortaliO61305.
SMRiO61305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 276Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST171
Domaini287 – 455Helicase C-terminalPROSITE-ProRule annotationAdd BLAST169

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi73 – 101Q motifAdd BLAST29
Motifi223 – 226DEAD box4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0332. Eukaryota.
ENOG410XRGX. LUCA.
OrthoDBiEOG091G03PS.
PhylomeDBiO61305.

Family and domain databases

InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.

Sequencei

Sequence statusi: Complete.

O61305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWAKKSED QEVSKLVDKL NLDSKSGEET DFDVADPAET SLLIKILGKG
60 70 80 90 100
LVNTKLSLDL QQKNPNSPLH SVKTFEALHL KASLLKGIYA MGFNTPSKIQ
110 120 130 140 150
ETALPTLLAD PPQNMIAQSQ SGTGKTAAFV LAMLSRVNVC LNHPQVLCLS
160 170 180 190 200
PTYELAIQTG EVAARMGQFC REIKLRFAVR GEEVDRSKKI EEHILIGTPG
210 220 230 240 250
KLLDWGIKFR LFDMKKISVF VLDEADVMIA TQGHHDQCIR IHKMLNPHCQ
260 270 280 290 300
MLFFSATYGK EVMDFARLIV ADPTIIRLMR EEESLENIKQ YYVKCKNEEG
310 320 330 340 350
KYNAIQNIYG CISVGQAIIF CHTKRTAAWL AAKMTSDGHS VAVLTGDLTV
360 370 380 390 400
VQRLDVLDRF RSGLEKVLIT TNILSRGIDI EQLQVVVNFD LPVDLDGMAD
410 420 430 440 450
CETYLHRIGR TGRFGKSGIA INLITDEKTM KVCSDIEKHF NKKIEVLNTD
460
SADDIEKIGT
Length:460
Mass (Da):51,315
Last modified:August 1, 1998 - v1
Checksum:i380DE3A9A0100AB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. No translation available.
AF005239 mRNA. Translation: AAC23709.1.

Similar proteinsi

Entry informationi

Entry nameiDDX19_DROME
AccessioniPrimary (citable) accession number: O61305
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: July 5, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families