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Reviewed, UniProtKB/Swiss-Prot O61235 (CATA2_CAEEL)

Last modified November 3, 2009. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Catalase-2
    EC=1.11.1.6
Gene names
Name: ctl-1
Synonyms: cat-2
ORF Names: Y54G11A.6
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Responsible for the increase in catalase activity detected in dauer larvae. May act as a general scavenger of hydrogen peroxide in the cytosol, or it may protect cells from the effects of an unknown, dauer-specific metabolic process. Expression may be directly regulated by daf-16. Ref.1

Catalytic activity

2 H2O2 = O2 + 2 H2O.

Cofactor

Heme group.

Subcellular location

Cytoplasm. Ref.1

Developmental stage

With abundant food, the amount of ctl-1 decreases slightly as worms mature.

Induction

Overcrowding and depletion of food.

Sequence similarities

Belongs to the catalase family.

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Ontologies

Keywords
   Biological processHydrogen peroxide
   Cellular componentCytoplasm
   LigandHeme
Iron
Metal-binding
   Molecular functionOxidoreductase
Peroxidase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdetermination of adult lifespan Ref.1

Inferred from mutant phenotype. Source: UniProtKB

hydrogen peroxide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm Ref.1

Non-traceable author statement. Source: UniProtKB

   Molecular functioncatalase activity Ref.1

Inferred from mutant phenotype. Source: UniProtKB

heme binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Catalase-2
PRO_0000084910

Sites

Active site711 By similarity
Active site1441 By similarity
Metal binding3541Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict911C → G in AAC14537. Ref.1
Sequence conflict971N → H in AAC14537. Ref.1
Sequence conflict1901Missing in AAC14537. Ref.1
Sequence conflict2371G → P in AAC14537. Ref.1
Sequence conflict2701F → L in AAC14537. Ref.1
Sequence conflict2821F → I in AAC14537. Ref.1
Sequence conflict3101G → A in AAC14537. Ref.1
Sequence conflict3131V → L in AAC14537. Ref.1
Sequence conflict385 – 3862DG → EV in CAA74394. Ref.2
Sequence conflict385 – 3862DG → EV in CAA74392. Ref.2
Sequence conflict394 – 3952GD → EN in CAA74394. Ref.2
Sequence conflict394 – 3952GD → EN in CAA74392. Ref.2
Sequence conflict3991Y → S in CAA74394. Ref.2
Sequence conflict3991Y → S in CAA74392. Ref.2
Sequence conflict425 – 4284DRYE → GSLW in AAC14537. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
O61235-1 [UniParc].

Last modified November 25, 2002. Version 3.
Checksum: 26662FE6EF38CCE5

FASTA49757,305
        10         20         30         40         50         60 
MPNDPSDNQL KTYKETYPKP QVITTSNGAP IYSKTAVLTA GRRGPMLMQD VVYMDEMAHF 

        70         80         90        100        110        120 
DRERIPERVV HAKGAGAHGY FEVTHDITKY CKADMFNKVG KQTPLLVRFS TVAGESGSAD 

       130        140        150        160        170        180 
TVRDPRGFSL KFYTEEGNWD LVGNNTPIFF IRDAIHFPNF IHALKRNPQT HMRDPNALFD 

       190        200        210        220        230        240 
FWMNRPESIH QVMFLYSDRG IPDGFRFMNG YGAHTFKMVN KEGNPIYCKF HFKPAQGSKN 

       250        260        270        280        290        300 
LDPTDAGKLA SSDPDYAIRD LFNAIESRNF PEWKMFIQVM TFEQAEKWEF NPFDVTKVWP 

       310        320        330        340        350        360 
HGDYPLIEVG KMVLNRNVKN YFAEVEQAAF CPAHIVPGIE FSPDKMLQGR IFSYTDTHYH 

       370        380        390        400        410        420 
RLGPNYIQLP VNCPYRSRAH TTQRDGAMAY ESQGDAPNYF PNSFRGYRTR DDVKESTFQT 

       430        440        450        460        470        480 
TGDVDRYETG DDHNYEQPRQ FWEKVLKEEE RDRLVGNLAS DLGGCLEEIQ NGMVKEFTKV 

       490 
HPDFGNALRH QLCQKKH

« Hide

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References

« Hide 'large scale' references
[1]"A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants."
Taub J., Lau J.F., Ma C., Hahn J.H., Hoque R., Rothblatt J., Chalfie M.
Nature 399:162-166(1999) [PubMed: 10335847] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
Strain: Bristol N2.
[2]Eckelt V.H.O.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: Bristol N2.
[3]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U55384 mRNA. Translation: AAC14537.1.
Y14066 mRNA. Translation: CAA74394.1.
Y14065 Genomic DNA. Translation: CAA74392.1.
AL034488 Genomic DNA. Translation: CAA22458.2.
PIRT37477.
T42443.
RefSeqNP_496979.2.
UniGeneCel.34211
Cel.34268

3D structure databases

HSSPHSSP built from PDB template 1F4J based on UniProtKB P04040.
ModBaseSearch...

Protein-protein interaction databases

STRINGO61235.

Genome annotation databases

EnsemblY54G11A.6; Y54G11A.6; Y54G11A.6; Caenorhabditis elegans. [Genome view]
GeneID259738.
KEGGcel:Y54G11A.6.
NMPDRfig|6239.3.peg.8173.
UCSCB0432.5a. c. elegans.

Organism-specific databases

CTD259738.
WormBaseWBGene00000830. ctl-1.
WormPepY54G11A.6. CE30713. [WorfDB]

Phylogenomic databases

OMANENEQLA.

Enzyme and pathway databases

BRENDA1.11.1.6. 672.

Gene expression databases

ArrayExpressO61235.

Family and domain databases

InterProIPR002226. Catalase.
IPR010582. Catalase-rel_immune_responsive.
IPR011614. Catalase_N.
IPR018028. Catalase_rel_subgroup.
[Graphical view]
Gene3DG3DSA:2.40.180.10. Catalase_N. 1 hit.
PANTHERPTHR11465. Catalase. 1 hit.
PfamPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PRINTSPR00067. CATALASE.
ProDomPD000510. Catalase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio952568.

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Entry information

Entry nameCATA2_CAEEL
AccessionPrimary (citable) accession number: O61235
Secondary accession number(s): O18193, Q9XVZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 25, 2002
Last modified: November 3, 2009
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents