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Protein
Submitted name:

Hemoglobin chain d1

Gene
N/A
Organism
Lumbricus terrestris (Common earthworm)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi112 – 1121Iron (heme axial ligand); via tele nitrogenCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transportUniRule annotation, Transport

Keywords - Ligandi

HemeUniRule annotationCombined sources, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Hemoglobin chain d1Imported
OrganismiLumbricus terrestris (Common earthworm)Imported
Taxonomic identifieri6398 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataOligochaetaHaplotaxidaLumbricinaLumbricidaeLumbricinaeLumbricus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 158140Sequence analysisPRO_5004159241Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi20 ↔ 149Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X9FX-ray2.60D/H/L19-158[»]
2GTLX-ray3.50D/H/L19-158[»]
4V93electron microscopy8.10A1/A6/AD/AI/AN/AS/AX/Ac/Ah/Am/Ar/Aw19-158[»]
B0/B5/BC/BH/BM/BR/BW/Bb/Bg/Bl/Bq/Bv/C4/CB/CG/CL/CQ/CV/Ca/Cf/Ck/Cp/Cu/Cz1-158[»]
ProteinModelPortaliO61233.
SMRiO61233. Positions 19-158.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO61233.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 153130GLOBINInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the globin family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR014610. Haemoglobin_extracell.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PIRSFiPIRSF036517. Ext_hemo. 1 hit.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O61233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVFVAVFLL AFATYVSAEC LVTESLKVKL QWASAFGHAH ERVAFGLELW
60 70 80 90 100
RDIIDDHPEI KAPFSRVRGD NIYSPEFGAH SQRVLSGLDI TISMLDTPDM
110 120 130 140 150
LAAQLAHLKV QHVERNLKPE FFDIFLKHLL HVLGDRLGTH FDFGAWHDCV

DQIIDGIK
Length:158
Mass (Da):17,924
Last modified:August 1, 1998 - v1
Checksum:i6AFD81C772D4FAC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55073 Genomic DNA. Translation: AAC14535.1.
PIRiS65728.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55073 Genomic DNA. Translation: AAC14535.1.
PIRiS65728.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X9FX-ray2.60D/H/L19-158[»]
2GTLX-ray3.50D/H/L19-158[»]
4V93electron microscopy8.10A1/A6/AD/AI/AN/AS/AX/Ac/Ah/Am/Ar/Aw19-158[»]
B0/B5/BC/BH/BM/BR/BW/Bb/Bg/Bl/Bq/Bv/C4/CB/CG/CL/CQ/CV/Ca/Cf/Ck/Cp/Cu/Cz1-158[»]
ProteinModelPortaliO61233.
SMRiO61233. Positions 19-158.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO61233.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR014610. Haemoglobin_extracell.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PIRSFiPIRSF036517. Ext_hemo. 1 hit.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "Crystal structure of the hemoglobin dodecamer from Lumbricus erythrocruorin: allosteric core of giant annelid respiratory complexes."
    Strand K., Knapp J.E., Bhyravbhatla B., Royer W.E.
    J. Mol. Biol. 344:119-134(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 19-158 IN COMPLEX WITH HEME, DISULFIDE BONDS.
  3. "Lumbricus erythrocruorin at 3.5 A resolution: architecture of a megadalton respiratory complex."
    Royer W.E., Sharma H., Strand K., Knapp J.E., Bhyravbhatla B.
    Structure 14:1167-1177(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.50 ANGSTROMS) OF 19-158 IN COMPLEX WITH HEME, DISULFIDE BONDS.
  4. "Structural Basis for Cooperative Oxygen Binding and Bracelet-Assisted Assembly of Lumbricus Terrestris Hemoglobin."
    Chen W.T., Chen Y.C., Liou H.H., Chao C.Y.
    Submitted (APR-2014) to the PDB data bank
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (8.10 ANGSTROMS) OF 19-158 AND 1-158.

Entry informationi

Entry nameiO61233_LUMTE
AccessioniPrimary (citable) accession number: O61233
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: March 16, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.