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Protein

60S ribosomal protein L10

Gene

RpL10

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • ribosomal large subunit assembly Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L10
Alternative name(s):
QM protein homolog
dQM
Gene namesi
Name:RpL10
Synonyms:Qm
ORF Names:CG17521
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0024733 RpL10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001471141 – 21860S ribosomal protein L10Add BLAST218

Proteomic databases

PaxDbiO61231
PRIDEiO61231

Expressioni

Gene expression databases

BgeeiFBgn0024733
ExpressionAtlasiO61231 differential
GenevisibleiO61231 DM

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (By similarity).By similarity

Protein-protein interaction databases

BioGridi68678, 26 interactors
DIPiDIP-18809N
IntActiO61231, 13 interactors
MINTiO61231
STRINGi7227.FBpp0306039

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CI1-218[»]
ProteinModelPortaliO61231
SMRiO61231
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0857 Eukaryota
COG0197 LUCA
GeneTreeiENSGT00390000003897
InParanoidiO61231
KOiK02866
OMAiPYTRKEY
OrthoDBiEOG091G0H9M
PhylomeDBiO61231

Family and domain databases

CDDicd01433 Ribosomal_L16_L10e, 1 hit
Gene3Di3.90.1170.10, 1 hit
InterProiView protein in InterPro
IPR001197 Ribosomal_L10e
IPR016180 Ribosomal_L10e/L16
IPR036920 Ribosomal_L10e/L16_sf
IPR018255 Ribosomal_L10e_CS
PANTHERiPTHR11726 PTHR11726, 1 hit
PfamiView protein in Pfam
PF00252 Ribosomal_L16, 1 hit
PIRSFiPIRSF005590 Ribosomal_L10, 1 hit
SUPFAMiSSF54686 SSF54686, 1 hit
TIGRFAMsiTIGR00279 uL16_euk_arch, 1 hit
PROSITEiView protein in PROSITE
PS01257 RIBOSOMAL_L10E, 1 hit

Sequencei

Sequence statusi: Complete.

O61231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRPARCYR YCKNKPYPKS RFCRGVPDPK IRIFDLGRKK ATVEDFPLCV
60 70 80 90 100
HLVSDEYEQL SSEALEAGRI CCNKYLVKYC GKDQFHIRMR LHPFHVIRIN
110 120 130 140 150
KMLSCAGADR LQTGMRGAFG KPQGTVARVR IGQPIMSVRS SDRYKAQVIE
160 170 180 190 200
ALRRAKFKFP GRQKIYVSKK WGFTKYERER YEELRDDNRL EPDGCNVKYR
210
PEHGPIAAWE KAQRDVYA
Length:218
Mass (Da):25,528
Last modified:August 1, 1998 - v1
Checksum:i2EFC207CEB832BE4
GO

Sequence cautioni

The sequence AAO39584 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73 – 99Missing in AAO39584 (Ref. 5) CuratedAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49721 mRNA Translation: AAC16108.1
AE014296 Genomic DNA Translation: AAF45440.3
AE014296 Genomic DNA Translation: AAG22453.4
AY070910 mRNA Translation: AAL48532.1
BT003580 mRNA Translation: AAO39584.1 Different initiation.
RefSeqiNP_001262233.1, NM_001275304.1
NP_651954.3, NM_143697.5
NP_730773.4, NM_168984.5
UniGeneiDm.1411

Genome annotation databases

EnsemblMetazoaiFBtr0299869; FBpp0289147; FBgn0024733
FBtr0299870; FBpp0289148; FBgn0024733
FBtr0333910; FBpp0306039; FBgn0024733
GeneIDi43864
KEGGidme:Dmel_CG17521

Similar proteinsi

Entry informationi

Entry nameiRL10_DROME
AccessioniPrimary (citable) accession number: O61231
Secondary accession number(s): Q0E8B5
, Q86NY2, Q9I813, Q9W5T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health