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Protein
Submitted name:

Ligand-Gated ion Channel

Gene

lgc-30

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Ligand-Gated ion ChannelImported
Gene namesi
Name:lgc-30Imported
ORF Names:CELE_F58H7.3Imported, F58H7.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF58H7.3; CE41140; WBGene00019069; lgc-30.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei274 – 29926HelicalSequence analysisAdd
BLAST
Transmembranei311 – 33222HelicalSequence analysisAdd
BLAST
Transmembranei352 – 37423HelicalSequence analysisAdd
BLAST
Transmembranei506 – 52419HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 529512Sequence analysisPRO_5004159370Add
BLAST

Proteomic databases

PaxDbiO61216.
PRIDEiO61216.

Structurei

3D structure databases

ProteinModelPortaliO61216.
SMRiO61216. Positions 82-395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 272199Neur_chan_LBDInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000020122.
InParanoidiO61216.
OMAiVAMFMCH.
OrthoDBiEOG73541M.
PhylomeDBiO61216.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O61216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLLSIFFMA TIWSCWGAQE SEGFIPKKLI KKPPAIDDTA FHRRRALDKE
60 70 80 90 100
DGGQVIADPD ADGDPHGRLA TWIRSHARHH IPLKHPHTRI DVFISAGLYQ
110 120 130 140 150
IVDLDQRNNL ATVSAYLDVH WNDDFIKWKP EIFGGIERIF VPIKWIWKPE
160 170 180 190 200
FYMYHSVYGR VPDYAPDASA ELHYNGLVRM FVSISSKSFC PINFKRFPFD
210 220 230 240 250
SQTCSFSCGS WAYQSNIVNL VAAKQEIALE DFYDNQEWLL TDARLFNGTT
260 270 280 290 300
RNVSAANESF SMVYMQLDLK RQSFYYVFNL VFPTTLVSLV AVIGFHAPIN
310 320 330 340 350
ATGRRESKFR LGIMTLLSMS VMLLMLVGEM KFAMESVPGQ RGSFSDVPLM
360 370 380 390 400
GIYYMTLICI VSIATCTSSI FVHLEKFALR NPSWQSVPWY IRWLAAKKLF
410 420 430 440 450
CCYVPKSFRY DKDAYSRNNN VQAISLHSTP DRNVAKNLIP KEINFTEVNQ
460 470 480 490 500
DAPLHDVLEG PSAEKTQKID LIVSLLREII HLKERIGASG QLAPYWDQII
510 520
SRCEKVSLSF YLFLITINVL MFLYPELWY
Length:529
Mass (Da):60,825
Last modified:September 11, 2007 - v3
Checksum:iA36FB739BD1CF460
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD67289.1.
RefSeqiNP_500015.3. NM_067614.3.
UniGeneiCel.12781.

Genome annotation databases

EnsemblMetazoaiF58H7.3; F58H7.3; WBGene00019069.
GeneIDi186551.
KEGGicel:CELE_F58H7.3.
UCSCiF58H7.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD67289.1.
RefSeqiNP_500015.3. NM_067614.3.
UniGeneiCel.12781.

3D structure databases

ProteinModelPortaliO61216.
SMRiO61216. Positions 82-395.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiO61216.
PRIDEiO61216.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF58H7.3; F58H7.3; WBGene00019069.
GeneIDi186551.
KEGGicel:CELE_F58H7.3.
UCSCiF58H7.3. c. elegans.

Organism-specific databases

CTDi186551.
WormBaseiF58H7.3; CE41140; WBGene00019069; lgc-30.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000020122.
InParanoidiO61216.
OMAiVAMFMCH.
OrthoDBiEOG73541M.
PhylomeDBiO61216.

Miscellaneous databases

NextBioi932244.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO61216_CAEEL
AccessioniPrimary (citable) accession number: O61216
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: September 11, 2007
Last modified: May 11, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.