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Protein
Submitted name:

Ligand-Gated ion Channel

Gene

lgc-30

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-975298. Ligand-gated ion channel transport.

Names & Taxonomyi

Protein namesi
Submitted name:
Ligand-Gated ion ChannelImported
Gene namesi
Name:lgc-30Imported
ORF Names:CELE_F58H7.3Imported, F58H7.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF58H7.3; CE41140; WBGene00019069; lgc-30.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei274 – 299HelicalSequence analysisAdd BLAST26
Transmembranei311 – 332HelicalSequence analysisAdd BLAST22
Transmembranei352 – 374HelicalSequence analysisAdd BLAST23
Transmembranei506 – 524HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_500415937018 – 529Sequence analysisAdd BLAST512

Proteomic databases

PaxDbiO61216.

Expressioni

Gene expression databases

BgeeiWBGene00019069.

Structurei

3D structure databases

ProteinModelPortaliO61216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 272Neur_chan_LBDInterPro annotationAdd BLAST199

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000020122.
InParanoidiO61216.
OMAiVAMFMCH.
OrthoDBiEOG091G06H0.
PhylomeDBiO61216.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O61216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLLSIFFMA TIWSCWGAQE SEGFIPKKLI KKPPAIDDTA FHRRRALDKE
60 70 80 90 100
DGGQVIADPD ADGDPHGRLA TWIRSHARHH IPLKHPHTRI DVFISAGLYQ
110 120 130 140 150
IVDLDQRNNL ATVSAYLDVH WNDDFIKWKP EIFGGIERIF VPIKWIWKPE
160 170 180 190 200
FYMYHSVYGR VPDYAPDASA ELHYNGLVRM FVSISSKSFC PINFKRFPFD
210 220 230 240 250
SQTCSFSCGS WAYQSNIVNL VAAKQEIALE DFYDNQEWLL TDARLFNGTT
260 270 280 290 300
RNVSAANESF SMVYMQLDLK RQSFYYVFNL VFPTTLVSLV AVIGFHAPIN
310 320 330 340 350
ATGRRESKFR LGIMTLLSMS VMLLMLVGEM KFAMESVPGQ RGSFSDVPLM
360 370 380 390 400
GIYYMTLICI VSIATCTSSI FVHLEKFALR NPSWQSVPWY IRWLAAKKLF
410 420 430 440 450
CCYVPKSFRY DKDAYSRNNN VQAISLHSTP DRNVAKNLIP KEINFTEVNQ
460 470 480 490 500
DAPLHDVLEG PSAEKTQKID LIVSLLREII HLKERIGASG QLAPYWDQII
510 520
SRCEKVSLSF YLFLITINVL MFLYPELWY
Length:529
Mass (Da):60,825
Last modified:September 11, 2007 - v3
Checksum:iA36FB739BD1CF460
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD67289.1.
RefSeqiNP_500015.3. NM_067614.3.
UniGeneiCel.12781.

Genome annotation databases

EnsemblMetazoaiF58H7.3; F58H7.3; WBGene00019069.
GeneIDi186551.
KEGGicel:CELE_F58H7.3.
UCSCiF58H7.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD67289.1.
RefSeqiNP_500015.3. NM_067614.3.
UniGeneiCel.12781.

3D structure databases

ProteinModelPortaliO61216.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiO61216.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF58H7.3; F58H7.3; WBGene00019069.
GeneIDi186551.
KEGGicel:CELE_F58H7.3.
UCSCiF58H7.3. c. elegans.

Organism-specific databases

CTDi186551.
WormBaseiF58H7.3; CE41140; WBGene00019069; lgc-30.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000020122.
InParanoidiO61216.
OMAiVAMFMCH.
OrthoDBiEOG091G06H0.
PhylomeDBiO61216.

Enzyme and pathway databases

ReactomeiR-CEL-975298. Ligand-gated ion channel transport.

Gene expression databases

BgeeiWBGene00019069.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO61216_CAEEL
AccessioniPrimary (citable) accession number: O61216
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: September 11, 2007
Last modified: November 2, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.