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Protein

2-oxoglutarate dehydrogenase, mitochondrial

Gene

ogdh-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.By similarity

Cofactori

thiamine diphosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

ReactomeiREACT_287541. Citric acid cycle (TCA cycle).
REACT_338081. Lysine catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name:
OGDC-E1
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:ogdh-1
ORF Names:T22B11.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiT22B11.5a; CE28486; WBGene00020679; ogdh-1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrial membrane Source: UniProtKB
  • mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 10292-oxoglutarate dehydrogenase, mitochondrialPRO_0000234100
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PaxDbiO61199.

Expressioni

Gene expression databases

ExpressionAtlasiO61199. baseline.

Interactioni

Protein-protein interaction databases

BioGridi42364. 1 interaction.
IntActiO61199. 1 interaction.
STRINGi6239.T22B11.5.1.

Structurei

3D structure databases

ProteinModelPortaliO61199.
SMRiO61199. Positions 138-1019.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0567.
GeneTreeiENSGT00530000063092.
HOGENOMiHOG000259586.
InParanoidiO61199.
KOiK00164.
OMAiQNQGAWF.
PhylomeDBiO61199.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O61199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRASLICRL ASPSRINAIR NASSGKSHIS ASTLVQHRNQ SVAAAVKHEP
60 70 80 90 100
FLNGSSSIYI EQMYEAWLQD PSSVHTSWDA YFRNVEAGAG PGQAFQAPPA
110 120 130 140 150
TAYAGALGVS PAAAQVTTSS APATRLDTNA SVQSISDHLK IQLLIRSYQT
160 170 180 190 200
RGHNIADLDP LGINSADLDD TIPPELELSF YGLGERDLDR EFLLPPTTFI
210 220 230 240 250
SEKKSLTLRE ILQRLKDIYC TSTGVEYMHL NNLEQQDWIR RRFEAPRVTE
260 270 280 290 300
LSHDQKKVLF KRLIRSTKFE EFLAKKWPSE KRFGLEGCEV LIPAMKQVID
310 320 330 340 350
SSSTLGVDSF VIGMPHRGRL NVLANVCRQP LATILSQFST LEPADEGSGD
360 370 380 390 400
VKYHLGVCIE RLNRQSQKNV KIAVVANPSH LEAVDPVVMG KVRAEAFYAG
410 420 430 440 450
DEKCDRTMAI LLHGDAAFAG QGVVLETFNL DDLPSYTTHG AIHIVVNNQI
460 470 480 490 500
GFTTDPRSSR SSPYCTDVGR VVGCPIFHVN VDDPEAVMHV CNVAADWRKT
510 520 530 540 550
FKKDVIVDLV CYRRHGHNEL DEPMFTQPLM YQRIKQTKTA LEKYQEKILN
560 570 580 590 600
EGVANEQYVK EELTKYGSIL EDAYENAQKV TYVRNRDWLD SPWDDFFKKR
610 620 630 640 650
DPLKLPSTGI EQENIEQIIG KFSQYPEGFN LHRGLERTLK GRQQMLKDNS
660 670 680 690 700
LDWACGEALA FGSLLKEGIH VRLSGQDVQR GTFSHRHHVL HDQKVDQKIY
710 720 730 740 750
NPLNDLSEGQ GEYTVCNSSL SEYAVLGFEL GYSMVDPNSL VIWEAQFGDF
760 770 780 790 800
SNTAQCIIDQ FISSGQSKWI RQSGLVMLLP HGYEGMGPEH SSARPERFLQ
810 820 830 840 850
MCNEDDEIDL EKIAFEGTFE AQQLHDTNWI VANCTTPANI YHLLRRQVTM
860 870 880 890 900
PFRKPAVVFS PKSLLRHPMA RSPVEDFQSG SNFQRVIPET GAPSQNPPDV
910 920 930 940 950
KRVVFCTGKV YYDMVAARKH VGKENDVALV RVEQLSPFPY DLVQQECRKY
960 970 980 990 1000
QGAEILWAQE EHKNMGAWSF VQPRINSLLS IDGRATKYAG RLPSSSPATG
1010 1020
NKFTHMQEQK EMMSKVFGVP KSKLEGFKA
Length:1,029
Mass (Da):115,661
Last modified:October 1, 2001 - v2
Checksum:i71ECB0F4236135F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081256 Genomic DNA. Translation: CCD70240.1.
PIRiT15098.
RefSeqiNP_500617.1. NM_068216.4.
UniGeneiCel.17820.

Genome annotation databases

EnsemblMetazoaiT22B11.5a; T22B11.5a; WBGene00020679.
GeneIDi177235.
KEGGicel:CELE_T22B11.5.
UCSCiT22B11.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081256 Genomic DNA. Translation: CCD70240.1.
PIRiT15098.
RefSeqiNP_500617.1. NM_068216.4.
UniGeneiCel.17820.

3D structure databases

ProteinModelPortaliO61199.
SMRiO61199. Positions 138-1019.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi42364. 1 interaction.
IntActiO61199. 1 interaction.
STRINGi6239.T22B11.5.1.

Proteomic databases

PaxDbiO61199.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT22B11.5a; T22B11.5a; WBGene00020679.
GeneIDi177235.
KEGGicel:CELE_T22B11.5.
UCSCiT22B11.5. c. elegans.

Organism-specific databases

CTDi177235.
WormBaseiT22B11.5a; CE28486; WBGene00020679; ogdh-1.

Phylogenomic databases

eggNOGiCOG0567.
GeneTreeiENSGT00530000063092.
HOGENOMiHOG000259586.
InParanoidiO61199.
KOiK00164.
OMAiQNQGAWF.
PhylomeDBiO61199.

Enzyme and pathway databases

ReactomeiREACT_287541. Citric acid cycle (TCA cycle).
REACT_338081. Lysine catabolism.

Miscellaneous databases

NextBioi895922.
PROiO61199.

Gene expression databases

ExpressionAtlasiO61199. baseline.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. Bienvenut W.V.
    Submitted (MAR-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 126-146; 297-317; 320-328; 372-391; 504-514; 548-565; 622-633; 673-680; 910-918; 975-984 AND 992-1002, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiODO1_CAEEL
AccessioniPrimary (citable) accession number: O61199
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2001
Last modified: June 24, 2015
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.