O61199 (ODO1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-oxoglutarate dehydrogenase, mitochondrial
EC=1.2.4.2

Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name=OGDC-E1
Alpha-ketoglutarate dehydrogenase

Gene names

ORF Names:

T22B11.5

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	1029 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. UniProtKB Q02218
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. UniProtKB Q02218
Cofactor	Thiamine pyrophosphate By similarity. UniProtKB Q02218
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	generation of precursor metabolites and energy Inferred from sequence or structural similarity. Source: UniProtKB glycolysis Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from sequence or structural similarity. Source: UniProtKB thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion
	Chain	? – 1029		2-oxoglutarate dehydrogenase, mitochondrial		PRO_0000234100

Sequences

	Sequence		Length	Mass (Da)
	O61199 [UniParc]. Last modified October 1, 2001. Version 2. Checksum: 71ECB0F4236135F4	FASTA	1,029	115,661
	10 20 30 40 50 60 MHRASLICRL ASPSRINAIR NASSGKSHIS ASTLVQHRNQ SVAAAVKHEP FLNGSSSIYI 70 80 90 100 110 120 EQMYEAWLQD PSSVHTSWDA YFRNVEAGAG PGQAFQAPPA TAYAGALGVS PAAAQVTTSS 130 140 150 160 170 180 APATRLDTNA SVQSISDHLK IQLLIRSYQT RGHNIADLDP LGINSADLDD TIPPELELSF 190 200 210 220 230 240 YGLGERDLDR EFLLPPTTFI SEKKSLTLRE ILQRLKDIYC TSTGVEYMHL NNLEQQDWIR 250 260 270 280 290 300 RRFEAPRVTE LSHDQKKVLF KRLIRSTKFE EFLAKKWPSE KRFGLEGCEV LIPAMKQVID 310 320 330 340 350 360 SSSTLGVDSF VIGMPHRGRL NVLANVCRQP LATILSQFST LEPADEGSGD VKYHLGVCIE 370 380 390 400 410 420 RLNRQSQKNV KIAVVANPSH LEAVDPVVMG KVRAEAFYAG DEKCDRTMAI LLHGDAAFAG 430 440 450 460 470 480 QGVVLETFNL DDLPSYTTHG AIHIVVNNQI GFTTDPRSSR SSPYCTDVGR VVGCPIFHVN 490 500 510 520 530 540 VDDPEAVMHV CNVAADWRKT FKKDVIVDLV CYRRHGHNEL DEPMFTQPLM YQRIKQTKTA 550 560 570 580 590 600 LEKYQEKILN EGVANEQYVK EELTKYGSIL EDAYENAQKV TYVRNRDWLD SPWDDFFKKR 610 620 630 640 650 660 DPLKLPSTGI EQENIEQIIG KFSQYPEGFN LHRGLERTLK GRQQMLKDNS LDWACGEALA 670 680 690 700 710 720 FGSLLKEGIH VRLSGQDVQR GTFSHRHHVL HDQKVDQKIY NPLNDLSEGQ GEYTVCNSSL 730 740 750 760 770 780 SEYAVLGFEL GYSMVDPNSL VIWEAQFGDF SNTAQCIIDQ FISSGQSKWI RQSGLVMLLP 790 800 810 820 830 840 HGYEGMGPEH SSARPERFLQ MCNEDDEIDL EKIAFEGTFE AQQLHDTNWI VANCTTPANI 850 860 870 880 890 900 YHLLRRQVTM PFRKPAVVFS PKSLLRHPMA RSPVEDFQSG SNFQRVIPET GAPSQNPPDV 910 920 930 940 950 960 KRVVFCTGKV YYDMVAARKH VGKENDVALV RVEQLSPFPY DLVQQECRKY QGAEILWAQE 970 980 990 1000 1010 1020 EHKNMGAWSF VQPRINSLLS IDGRATKYAG RLPSSSPATG NKFTHMQEQK EMMSKVFGVP KSKLEGFKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	Bienvenut W.V. Submitted (MAR-2006) to UniProtKB Cited for: PROTEIN SEQUENCE OF 126-146; 297-317; 320-328; 372-391; 504-514; 548-565; 622-633; 673-680; 910-918; 975-984 AND 992-1002, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO081256 Genomic DNA. Translation: CCD70240.1.
PIR	T15098.
RefSeq	NP_500617.1. NM_068216.4.
UniGene	Cel.17820.
3D structure databases
ProteinModelPortal	O61199.
SMR	O61199. Positions 138-1019.
ModBase	Search...
Protein-protein interaction databases
IntAct	O61199. 1 interaction.
STRING	6239.T22B11.5.
Proteomic databases
PaxDb	O61199.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	T22B11.5.1; T22B11.5.1; T22B11.5. T22B11.5.2; T22B11.5.2; T22B11.5.
GeneID	177235.
KEGG	cel:CELE_T22B11.5.
UCSC	T22B11.5. c. elegans.
Organism-specific databases
CTD	177235.
WormBase	T22B11.5; CE28486; WBGene00020679.
Phylogenomic databases
eggNOG	COG0567.
GeneTree	ENSGT00530000063092.
HOGENOM	HOG000259586.
InParanoid	O61199.
KO	K00164.
OMA	IIKRGGA.
Family and domain databases
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
PANTHER	PTHR23152. PTHR23152. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...
Other
NextBio	895922.

Entry information

Entry name

ODO1_CAEEL

Accession

Primary (citable) accession number: O61199

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	October 1, 2001
Last modified:	May 29, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project