Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O61199

- ODO1_CAEEL

UniProt

O61199 - ODO1_CAEEL

Protein

2-oxoglutarate dehydrogenase, mitochondrial

Gene

ogdh-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (01 Oct 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.By similarity

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. generation of precursor metabolites and energy Source: UniProtKB
    2. glycolytic process Source: UniProtKB-KW
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
    Alternative name(s):
    2-oxoglutarate dehydrogenase complex component E1
    Short name:
    OGDC-E1
    Alpha-ketoglutarate dehydrogenase
    Gene namesi
    Name:ogdh-1
    ORF Names:T22B11.5
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiT22B11.5a; CE28486; WBGene00020679; ogdh-1.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. mitochondrial membrane Source: UniProtKB
    3. mitochondrion Source: WormBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 10292-oxoglutarate dehydrogenase, mitochondrialPRO_0000234100
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PaxDbiO61199.

    Interactioni

    Protein-protein interaction databases

    BioGridi42364. 1 interaction.
    IntActiO61199. 1 interaction.
    STRINGi6239.T22B11.5.

    Structurei

    3D structure databases

    ProteinModelPortaliO61199.
    SMRiO61199. Positions 138-1019.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0567.
    GeneTreeiENSGT00530000063092.
    HOGENOMiHOG000259586.
    InParanoidiO61199.
    KOiK00164.
    OMAiMLSGTHF.
    PhylomeDBiO61199.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O61199-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHRASLICRL ASPSRINAIR NASSGKSHIS ASTLVQHRNQ SVAAAVKHEP     50
    FLNGSSSIYI EQMYEAWLQD PSSVHTSWDA YFRNVEAGAG PGQAFQAPPA 100
    TAYAGALGVS PAAAQVTTSS APATRLDTNA SVQSISDHLK IQLLIRSYQT 150
    RGHNIADLDP LGINSADLDD TIPPELELSF YGLGERDLDR EFLLPPTTFI 200
    SEKKSLTLRE ILQRLKDIYC TSTGVEYMHL NNLEQQDWIR RRFEAPRVTE 250
    LSHDQKKVLF KRLIRSTKFE EFLAKKWPSE KRFGLEGCEV LIPAMKQVID 300
    SSSTLGVDSF VIGMPHRGRL NVLANVCRQP LATILSQFST LEPADEGSGD 350
    VKYHLGVCIE RLNRQSQKNV KIAVVANPSH LEAVDPVVMG KVRAEAFYAG 400
    DEKCDRTMAI LLHGDAAFAG QGVVLETFNL DDLPSYTTHG AIHIVVNNQI 450
    GFTTDPRSSR SSPYCTDVGR VVGCPIFHVN VDDPEAVMHV CNVAADWRKT 500
    FKKDVIVDLV CYRRHGHNEL DEPMFTQPLM YQRIKQTKTA LEKYQEKILN 550
    EGVANEQYVK EELTKYGSIL EDAYENAQKV TYVRNRDWLD SPWDDFFKKR 600
    DPLKLPSTGI EQENIEQIIG KFSQYPEGFN LHRGLERTLK GRQQMLKDNS 650
    LDWACGEALA FGSLLKEGIH VRLSGQDVQR GTFSHRHHVL HDQKVDQKIY 700
    NPLNDLSEGQ GEYTVCNSSL SEYAVLGFEL GYSMVDPNSL VIWEAQFGDF 750
    SNTAQCIIDQ FISSGQSKWI RQSGLVMLLP HGYEGMGPEH SSARPERFLQ 800
    MCNEDDEIDL EKIAFEGTFE AQQLHDTNWI VANCTTPANI YHLLRRQVTM 850
    PFRKPAVVFS PKSLLRHPMA RSPVEDFQSG SNFQRVIPET GAPSQNPPDV 900
    KRVVFCTGKV YYDMVAARKH VGKENDVALV RVEQLSPFPY DLVQQECRKY 950
    QGAEILWAQE EHKNMGAWSF VQPRINSLLS IDGRATKYAG RLPSSSPATG 1000
    NKFTHMQEQK EMMSKVFGVP KSKLEGFKA 1029
    Length:1,029
    Mass (Da):115,661
    Last modified:October 1, 2001 - v2
    Checksum:i71ECB0F4236135F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081256 Genomic DNA. Translation: CCD70240.1.
    PIRiT15098.
    RefSeqiNP_500617.1. NM_068216.4.
    UniGeneiCel.17820.

    Genome annotation databases

    EnsemblMetazoaiT22B11.5a; T22B11.5a; WBGene00020679.
    GeneIDi177235.
    KEGGicel:CELE_T22B11.5.
    UCSCiT22B11.5. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081256 Genomic DNA. Translation: CCD70240.1 .
    PIRi T15098.
    RefSeqi NP_500617.1. NM_068216.4.
    UniGenei Cel.17820.

    3D structure databases

    ProteinModelPortali O61199.
    SMRi O61199. Positions 138-1019.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 42364. 1 interaction.
    IntActi O61199. 1 interaction.
    STRINGi 6239.T22B11.5.

    Proteomic databases

    PaxDbi O61199.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T22B11.5a ; T22B11.5a ; WBGene00020679 .
    GeneIDi 177235.
    KEGGi cel:CELE_T22B11.5.
    UCSCi T22B11.5. c. elegans.

    Organism-specific databases

    CTDi 177235.
    WormBasei T22B11.5a ; CE28486 ; WBGene00020679 ; ogdh-1.

    Phylogenomic databases

    eggNOGi COG0567.
    GeneTreei ENSGT00530000063092.
    HOGENOMi HOG000259586.
    InParanoidi O61199.
    KOi K00164.
    OMAi MLSGTHF.
    PhylomeDBi O61199.

    Miscellaneous databases

    NextBioi 895922.
    PROi O61199.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. Bienvenut W.V.
      Submitted (MAR-2006) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 126-146; 297-317; 320-328; 372-391; 504-514; 548-565; 622-633; 673-680; 910-918; 975-984 AND 992-1002, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiODO1_CAEEL
    AccessioniPrimary (citable) accession number: O61199
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3