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O61199 (ODO1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase, mitochondrial

EC=1.2.4.2
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name=OGDC-E1
Alpha-ketoglutarate dehydrogenase
Gene names
Name:ogdh-1
ORF Names:T22B11.5
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length1029 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. UniProtKB Q02218

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. UniProtKB Q02218

Cofactor

Thiamine pyrophosphate By similarity. UniProtKB Q02218

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion
Chain? – 10292-oxoglutarate dehydrogenase, mitochondrialPRO_0000234100

Sequences

Sequence LengthMass (Da)Tools
O61199 [UniParc].

Last modified October 1, 2001. Version 2.
Checksum: 71ECB0F4236135F4

FASTA1,029115,661
        10         20         30         40         50         60 
MHRASLICRL ASPSRINAIR NASSGKSHIS ASTLVQHRNQ SVAAAVKHEP FLNGSSSIYI 

        70         80         90        100        110        120 
EQMYEAWLQD PSSVHTSWDA YFRNVEAGAG PGQAFQAPPA TAYAGALGVS PAAAQVTTSS 

       130        140        150        160        170        180 
APATRLDTNA SVQSISDHLK IQLLIRSYQT RGHNIADLDP LGINSADLDD TIPPELELSF 

       190        200        210        220        230        240 
YGLGERDLDR EFLLPPTTFI SEKKSLTLRE ILQRLKDIYC TSTGVEYMHL NNLEQQDWIR 

       250        260        270        280        290        300 
RRFEAPRVTE LSHDQKKVLF KRLIRSTKFE EFLAKKWPSE KRFGLEGCEV LIPAMKQVID 

       310        320        330        340        350        360 
SSSTLGVDSF VIGMPHRGRL NVLANVCRQP LATILSQFST LEPADEGSGD VKYHLGVCIE 

       370        380        390        400        410        420 
RLNRQSQKNV KIAVVANPSH LEAVDPVVMG KVRAEAFYAG DEKCDRTMAI LLHGDAAFAG 

       430        440        450        460        470        480 
QGVVLETFNL DDLPSYTTHG AIHIVVNNQI GFTTDPRSSR SSPYCTDVGR VVGCPIFHVN 

       490        500        510        520        530        540 
VDDPEAVMHV CNVAADWRKT FKKDVIVDLV CYRRHGHNEL DEPMFTQPLM YQRIKQTKTA 

       550        560        570        580        590        600 
LEKYQEKILN EGVANEQYVK EELTKYGSIL EDAYENAQKV TYVRNRDWLD SPWDDFFKKR 

       610        620        630        640        650        660 
DPLKLPSTGI EQENIEQIIG KFSQYPEGFN LHRGLERTLK GRQQMLKDNS LDWACGEALA 

       670        680        690        700        710        720 
FGSLLKEGIH VRLSGQDVQR GTFSHRHHVL HDQKVDQKIY NPLNDLSEGQ GEYTVCNSSL 

       730        740        750        760        770        780 
SEYAVLGFEL GYSMVDPNSL VIWEAQFGDF SNTAQCIIDQ FISSGQSKWI RQSGLVMLLP 

       790        800        810        820        830        840 
HGYEGMGPEH SSARPERFLQ MCNEDDEIDL EKIAFEGTFE AQQLHDTNWI VANCTTPANI 

       850        860        870        880        890        900 
YHLLRRQVTM PFRKPAVVFS PKSLLRHPMA RSPVEDFQSG SNFQRVIPET GAPSQNPPDV 

       910        920        930        940        950        960 
KRVVFCTGKV YYDMVAARKH VGKENDVALV RVEQLSPFPY DLVQQECRKY QGAEILWAQE 

       970        980        990       1000       1010       1020 
EHKNMGAWSF VQPRINSLLS IDGRATKYAG RLPSSSPATG NKFTHMQEQK EMMSKVFGVP 


KSKLEGFKA 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]Bienvenut W.V.
Submitted (MAR-2006) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 126-146; 297-317; 320-328; 372-391; 504-514; 548-565; 622-633; 673-680; 910-918; 975-984 AND 992-1002, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO081256 Genomic DNA. Translation: CCD70240.1.
PIRT15098.
RefSeqNP_500617.1. NM_068216.4.
UniGeneCel.17820.

3D structure databases

ProteinModelPortalO61199.
SMRO61199. Positions 138-1019.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid42364. 1 interaction.
IntActO61199. 1 interaction.
STRING6239.T22B11.5.

Proteomic databases

PaxDbO61199.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaT22B11.5a; T22B11.5a; WBGene00020679.
GeneID177235.
KEGGcel:CELE_T22B11.5.
UCSCT22B11.5. c. elegans.

Organism-specific databases

CTD177235.
WormBaseT22B11.5a; CE28486; WBGene00020679; ogdh-1.

Phylogenomic databases

eggNOGCOG0567.
GeneTreeENSGT00530000063092.
HOGENOMHOG000259586.
InParanoidO61199.
KOK00164.
OMAMLSGTHF.
PhylomeDBO61199.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Other

NextBio895922.
PROO61199.

Entry information

Entry nameODO1_CAEEL
AccessionPrimary (citable) accession number: O61199
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2001
Last modified: June 11, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase