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Protein

Phospholipid-transporting ATPase

Gene

APLT1

Organism
Leishmania donovani
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).UniRule annotationSAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPaseUniRule annotation (EC:3.6.3.1UniRule annotation)
Gene namesi
Name:APLT1Imported
OrganismiLeishmania donovaniImported
Taxonomic identifieri5661 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei135 – 15218HelicalUniRule annotationAdd
BLAST
Transmembranei351 – 37323HelicalUniRule annotationAdd
BLAST
Transmembranei379 – 39820HelicalUniRule annotationAdd
BLAST
Transmembranei946 – 96419HelicalUniRule annotationAdd
BLAST
Transmembranei1019 – 104123HelicalUniRule annotationAdd
BLAST
Transmembranei1047 – 107024HelicalUniRule annotationAdd
BLAST
Transmembranei1082 – 110221HelicalUniRule annotationAdd
BLAST
Transmembranei1117 – 113721HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliO61137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini107 – 15448PhoLip_ATPase_NInterPro annotationAdd
BLAST
Domaini199 – 25355E1-E2_ATPaseInterPro annotationAdd
BLAST
Domaini907 – 1140234PhoLip_ATPase_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 2 hits.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 3 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O61137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQIRYRALH NGADEDARSR NSSTPNISTS SAHGPQLPQR HCCRPRDFVF
60 70 80 90 100
DDSLSTGAAV SVLAIPQQKK HSVRRWLQEM LHLPIAPSLD NRQIPFGYFP
110 120 130 140 150
GEWSPVGYPS NAVSNRRYTL STFLPLALLR QFQNFFNLFY LFLAFSQVIP
160 170 180 190 200
VLKVGFIFTY FSPLVMVVCL SLMKDALDEW KRFRRDRIAN VEVFEKLTGG
210 220 230 240 250
GDVVTVRSSH IRVGDLLILH QDQRVPADCV VLHTSEKSGT TFIRTDQLDG
260 270 280 290 300
ETDWKLRYPL NSTKGLGYAE LGACASTCTV ARLTKTSTAS PAPSNWPTDR
310 320 330 340 350
ASRSRWRMPS GRRVWWRRGR WWLPSYTRVG RRAALNSTSP RNKLGLIERE
360 370 380 390 400
LNLIAVLCFA LLLILSFLLV AQQQFRGDFA VMFVRFFILL SSMIPISMRV
410 420 430 440 450
NVDVGRLWYS YDMSHDPNIP GAVARNANLP EELGRLRYLF SDKTGTLTKN
460 470 480 490 500
KMKFRVMQVG PDTVLTDRFT DQLAGALQEY FGTGNWGAGA RLMLSNVSAR
510 520 530 540 550
VSVRNSKQWS RDVQRVGDLI RAIVLCHNVS PVVMEEPLAL GTDDETTALG
560 570 580 590 600
RGAAAAVPAT TDMRSQPTDY QASSPDEVAL VKFCGSLGIV LTYRDLTTIA
610 620 630 640 650
FTVGGGAQLH TCTIVKTFPF SSERKCMGII LRERTGSCSG GSSQETVKFY
660 670 680 690 700
MKGADVKMAS VVRQSEWLEE CCQELAQMGL RTLVFASRTL SEEMLGAFLQ
710 720 730 740 750
QYEAAISILG EGRAAAIEAA MKLLETDMTL TGVTGVEDEL QDDVVVCLET
760 770 780 790 800
LGMCGIKVWM LTGDKVETAI TIGRSTRLIP RHCRIEYLCG MAPADIGHRL
810 820 830 840 850
HELQEEFCWG VTCGSIVPPW TLVLDGNALA YCLSHASFFA DVARTAYSVI
860 870 880 890 900
VARCSPTQKA AVVTVMRDSC RDARVAAIGD GGNDVSMIQA ANVGIGIEGL
910 920 930 940 950
EGKQASMAAD FSITKFSHCL RLIMWHGRNS YQRTCRLSQF IMHRGIVYSV
960 970 980 990 1000
VQTVFSVLFA GTTMSVFNGY LLMGYSTVFT MAPAFALVLD EDFNESDVHE
1010 1020 1030 1040 1050
YPFLYKDLLK ARSMNTRTFL QWVWASFFQG GVMMLMALQL FKSDMFQIVT
1060 1070 1080 1090 1100
IAYTSLLITE LAIVGATAHL RILWRERRAR FFLFLCSEVV SLLMFFLAVV
1110 1120 1130 1140 1150
VLPDTFDRDF FFSWSCWWRV AVICLASIAP LMIFQMVGKY ILFNPRIAVS

CMGCRT
Length:1,156
Mass (Da):129,297
Last modified:August 1, 1998 - v1
Checksum:i1E48F6D83DC9D120
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067496 Genomic DNA. Translation: AAC19127.1.
PIRiT14899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067496 Genomic DNA. Translation: AAC19127.1.
PIRiT14899.

3D structure databases

ProteinModelPortaliO61137.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 2 hits.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 3 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO61137_LEIDO
AccessioniPrimary (citable) accession number: O61137
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.