O61137 (O61137_LEIDO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Aminophospholipid translocase EMBL AAC19127.1

Gene names

Name:

APLT1 EMBL AAC19127.1

Organism

Leishmania donovani EMBL AAC19127.1

Taxonomic identifier

5661 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania

Protein attributes

Sequence length	1156 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity

ATP + H2O + phospholipid(In) = ADP + phosphate + phospholipid(Out). SAAS SAAS023299

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS023306
Ligand	ATP-binding SAAS SAAS023306 Magnesium SAAS SAAS023299 Nucleotide-binding
Molecular function	Hydrolase SAAS SAAS023299
Gene Ontology (GO)
Biological process	cation transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro phospholipid-translocating ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O61137 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 1E48F6D83DC9D120	FASTA	1,156	129,297
	10 20 30 40 50 60 MRQIRYRALH NGADEDARSR NSSTPNISTS SAHGPQLPQR HCCRPRDFVF DDSLSTGAAV 70 80 90 100 110 120 SVLAIPQQKK HSVRRWLQEM LHLPIAPSLD NRQIPFGYFP GEWSPVGYPS NAVSNRRYTL 130 140 150 160 170 180 STFLPLALLR QFQNFFNLFY LFLAFSQVIP VLKVGFIFTY FSPLVMVVCL SLMKDALDEW 190 200 210 220 230 240 KRFRRDRIAN VEVFEKLTGG GDVVTVRSSH IRVGDLLILH QDQRVPADCV VLHTSEKSGT 250 260 270 280 290 300 TFIRTDQLDG ETDWKLRYPL NSTKGLGYAE LGACASTCTV ARLTKTSTAS PAPSNWPTDR 310 320 330 340 350 360 ASRSRWRMPS GRRVWWRRGR WWLPSYTRVG RRAALNSTSP RNKLGLIERE LNLIAVLCFA 370 380 390 400 410 420 LLLILSFLLV AQQQFRGDFA VMFVRFFILL SSMIPISMRV NVDVGRLWYS YDMSHDPNIP 430 440 450 460 470 480 GAVARNANLP EELGRLRYLF SDKTGTLTKN KMKFRVMQVG PDTVLTDRFT DQLAGALQEY 490 500 510 520 530 540 FGTGNWGAGA RLMLSNVSAR VSVRNSKQWS RDVQRVGDLI RAIVLCHNVS PVVMEEPLAL 550 560 570 580 590 600 GTDDETTALG RGAAAAVPAT TDMRSQPTDY QASSPDEVAL VKFCGSLGIV LTYRDLTTIA 610 620 630 640 650 660 FTVGGGAQLH TCTIVKTFPF SSERKCMGII LRERTGSCSG GSSQETVKFY MKGADVKMAS 670 680 690 700 710 720 VVRQSEWLEE CCQELAQMGL RTLVFASRTL SEEMLGAFLQ QYEAAISILG EGRAAAIEAA 730 740 750 760 770 780 MKLLETDMTL TGVTGVEDEL QDDVVVCLET LGMCGIKVWM LTGDKVETAI TIGRSTRLIP 790 800 810 820 830 840 RHCRIEYLCG MAPADIGHRL HELQEEFCWG VTCGSIVPPW TLVLDGNALA YCLSHASFFA 850 860 870 880 890 900 DVARTAYSVI VARCSPTQKA AVVTVMRDSC RDARVAAIGD GGNDVSMIQA ANVGIGIEGL 910 920 930 940 950 960 EGKQASMAAD FSITKFSHCL RLIMWHGRNS YQRTCRLSQF IMHRGIVYSV VQTVFSVLFA 970 980 990 1000 1010 1020 GTTMSVFNGY LLMGYSTVFT MAPAFALVLD EDFNESDVHE YPFLYKDLLK ARSMNTRTFL 1030 1040 1050 1060 1070 1080 QWVWASFFQG GVMMLMALQL FKSDMFQIVT IAYTSLLITE LAIVGATAHL RILWRERRAR 1090 1100 1110 1120 1130 1140 FFLFLCSEVV SLLMFFLAVV VLPDTFDRDF FFSWSCWWRV AVICLASIAP LMIFQMVGKY 1150 ILFNPRIAVS CMGCRT

References

[1]	"Leishmania donovani contains a family of P-type ion motive ATPase genes." Meade J.C., Xue L., Case S.T. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Ethiopian L82 EMBL AAC19127.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF067496 Genomic DNA. Translation: AAC19127.1.
PIR	T14899.
3D structure databases
ProteinModelPortal	O61137.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR023306. ATPase_cation_domN. IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR006539. ATPase_P-typ_Plipid-transl. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 2 hits. G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
Pfam	PF00122. E1-E2_ATPase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01652. ATPase-Plipid. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O61137_LEIDO

Accession

Primary (citable) accession number: O61137

Entry history

Integrated into UniProtKB/TrEMBL:	August 1, 1998
Last sequence update:	August 1, 1998
Last modified:	December 14, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)