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Protein

DNA repair protein RAD51 homolog

Gene

RAD51

Organism
Leishmania major
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.UniRule annotation

GO - Molecular functioni

  • ATPase activity Source: GeneDB
  • ATP binding Source: UniProtKB-KW
  • DNA-dependent ATPase activity Source: GO_Central
  • double-stranded DNA binding Source: GeneDB
  • double-stranded DNA-dependent ATPase activity Source: GeneDB
  • four-way junction DNA binding Source: GO_Central
  • recombinase activity Source: GO_Central
  • single-stranded DNA binding Source: GeneDB
  • single-stranded DNA-dependent ATPase activity Source: GeneDB

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein RAD51 homologUniRule annotation
Gene namesi
Name:RAD51Imported
ORF Names:LMJF_28_0550Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 28

Organism-specific databases

EuPathDBiTriTrypDB:LmjF.28.0550

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi5664.LmjF.28.0550

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 306RECA_2InterPro annotationAdd BLAST172
Domaini314 – 377RECA_3InterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the RecA family. RAD51 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1433 Eukaryota
COG0468 LUCA
HOGENOMiHOG000227426
KOiK04482
OMAiYNTDHQT

Family and domain databases

CDDicd01123 Rad51_DMC1_radA, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011941 DNA_recomb/repair_Rad51
IPR013632 DNA_recomb/repair_Rad51_C
IPR016467 DNA_recomb/repair_RecA-like
IPR010995 DNA_repair_Rad51/TF_NusA_a-hlx
IPR027417 P-loop_NTPase
IPR033925 Rad51_DMC1_RadA
IPR020588 RecA_ATP-bd
IPR020587 RecA_monomer-monomer_interface
PfamiView protein in Pfam
PF08423 Rad51, 1 hit
PIRSFiPIRSF005856 Rad51, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF47794 SSF47794, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02239 recomb_RAD51, 1 hit
PROSITEiView protein in PROSITE
PS50162 RECA_2, 1 hit
PS50163 RECA_3, 1 hit

Sequencei

Sequence statusi: Complete.

O61127-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTRSKAKGR RGRPSARPSE EVEVVESQPQ EVLQNEEQEP QQQQQQQSTD
60 70 80 90 100
MAEPNASGFR VIQILENYGV ASSDIKKLME CGFYTVESAA YAPKKAILAV
110 120 130 140 150
KGISENKAEK IMAECAKLVP MGFTSAVAYH EARKEIIMVT TGSREVDKLL
160 170 180 190 200
GGGIETGSIT ELFGEFRTGK TQLCHTLCVT CQLPISQGGA EGMALYIDTE
210 220 230 240 250
GTFRPERLVA VAERYKLDPE DVLANVACAR AFNTDHQQQL LLQASAMMAE
260 270 280 290 300
NRFALIIVDS ATALYRTDYS GRNELAARQM HLGKFLRSLH NLAEEYGVAV
310 320 330 340 350
VVTNQVVANV DGSAQMFQAD SKKPIGGHIM AHASTTRLSL RKGRGEQRII
360 370
KVYDSPCLAE AEAIFGIYDD GVGDARD
Length:377
Mass (Da):41,286
Last modified:August 1, 1998 - v1
Checksum:i71DCB64335BD2915
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062379 Genomic DNA Translation: AAC16334.1
FR796424 Genomic DNA Translation: CAJ05032.1
RefSeqiXP_001684333.1, XM_001684281.1

Genome annotation databases

EnsemblProtistsiLmjF.28.0550:mRNA; LmjF.28.0550:pep; LmjF.28.0550
GeneDBiLmjF.28.0550:pep
GeneIDi5653261
KEGGilma:LMJF_28_0550

Similar proteinsi

Entry informationi

Entry nameiO61127_LEIMA
AccessioniPrimary (citable) accession number: O61127
Secondary accession number(s): Q4Q8L5
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health