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Protein

Glucose-6-phosphate isomerase

Gene

TcC31.19

Organism
Trypanosoma cruzi
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (TcC31.19), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotation
Biological processGluconeogenesisUniRule annotation, GlycolysisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Gene namesi
Name:TcC31.19Imported
OrganismiTrypanosoma cruziImported
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Structurei

3D structure databases

ProteinModelPortaliO61113
SMRiO61113
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2446 Eukaryota
COG0166 LUCA

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

O61113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDQYLKDLT VHLNESNAAP ANTSMAVASF NMPHEITRRM RPLGVDADTS
60 70 80 90 100
LTSCPSWRRL QELYEIHGSE SILKNFDECK DRFQRYSLEV DLRSSDKNFV
110 120 130 140 150
FLDYSKTHIN DEIKDVLFKL VEERGIRAFM RALFAGEKVN TAENRSVLHI
160 170 180 190 200
ALRNRSNRPI FVNGHDVMPL VNKVLEQMKK LSEKVRRGEW KGQSGKPIRH
210 220 230 240 250
VVNIGIGGSD LGPMMACEAL RPFSDRRISM HFVSNIDGTH LSEVLNLVDL
260 270 280 290 300
ESTLFIIASK TFTTQETITN ALSARNEFLK FLSSRGISEA GAVAKHFVAL
310 320 330 340 350
STNAEKVKEF GIDEENMFQF WDWVGGRYSL WSAIGLSVMI SIGYDNFVEL
360 370 380 390 400
LTGAHIMDEH FINAPTENNL PIILALVGIW YNNFFGSETQ AILPYDQYLW
410 420 430 440 450
RLPAYLQQLD MESNGKGATK NGRMVSTHTG PIIFGEAGTN GQHAFYQLIH
460 470 480 490 500
QGTKLIPCDF IGAIQTQNYI GEHHRILMSN FFAQTEALMI GKTPEEVKRE
510 520 530 540 550
LESAGGKSED EIQLLIPQKT FTGGRPSNSL LVKALTPRAL GAIIAMYEHK
560 570 580 590 600
VLVQGAIWGI NSYDQWGVEL GKLLAKSILL QLQPGQKVTN HDSSTNGLIE

LFNERSHL
Length:608
Mass (Da):68,366
Last modified:March 1, 2003 - v2
Checksum:i2374C5AC2600B237
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC137988 Genomic DNA Translation: AAN78341.1
PIRiT14631

Similar proteinsi

Entry informationi

Entry nameiO61113_TRYCR
AccessioniPrimary (citable) accession number: O61113
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: March 1, 2003
Last modified: January 31, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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