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Protein

Glucose-6-phosphate isomerase

Gene

TcC31.19

Organism
Trypanosoma cruzi
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (TcC31.19), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

GluconeogenesisUniRule annotation, GlycolysisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Gene namesi
Name:TcC31.19Imported
OrganismiTrypanosoma cruziImported
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

PTM / Processingi

Proteomic databases

PaxDbiO61113.

Interactioni

Protein-protein interaction databases

STRINGi353153.XP_821969.1.

Structurei

3D structure databases

ProteinModelPortaliO61113.
SMRiO61113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2446. Eukaryota.
COG0166. LUCA.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O61113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDQYLKDLT VHLNESNAAP ANTSMAVASF NMPHEITRRM RPLGVDADTS
60 70 80 90 100
LTSCPSWRRL QELYEIHGSE SILKNFDECK DRFQRYSLEV DLRSSDKNFV
110 120 130 140 150
FLDYSKTHIN DEIKDVLFKL VEERGIRAFM RALFAGEKVN TAENRSVLHI
160 170 180 190 200
ALRNRSNRPI FVNGHDVMPL VNKVLEQMKK LSEKVRRGEW KGQSGKPIRH
210 220 230 240 250
VVNIGIGGSD LGPMMACEAL RPFSDRRISM HFVSNIDGTH LSEVLNLVDL
260 270 280 290 300
ESTLFIIASK TFTTQETITN ALSARNEFLK FLSSRGISEA GAVAKHFVAL
310 320 330 340 350
STNAEKVKEF GIDEENMFQF WDWVGGRYSL WSAIGLSVMI SIGYDNFVEL
360 370 380 390 400
LTGAHIMDEH FINAPTENNL PIILALVGIW YNNFFGSETQ AILPYDQYLW
410 420 430 440 450
RLPAYLQQLD MESNGKGATK NGRMVSTHTG PIIFGEAGTN GQHAFYQLIH
460 470 480 490 500
QGTKLIPCDF IGAIQTQNYI GEHHRILMSN FFAQTEALMI GKTPEEVKRE
510 520 530 540 550
LESAGGKSED EIQLLIPQKT FTGGRPSNSL LVKALTPRAL GAIIAMYEHK
560 570 580 590 600
VLVQGAIWGI NSYDQWGVEL GKLLAKSILL QLQPGQKVTN HDSSTNGLIE

LFNERSHL
Length:608
Mass (Da):68,366
Last modified:March 1, 2003 - v2
Checksum:i2374C5AC2600B237
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC137988 Genomic DNA. Translation: AAN78341.1.
PIRiT14631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC137988 Genomic DNA. Translation: AAN78341.1.
PIRiT14631.

3D structure databases

ProteinModelPortaliO61113.
SMRiO61113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi353153.XP_821969.1.

Proteomic databases

PaxDbiO61113.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG2446. Eukaryota.
COG0166. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO61113_TRYCR
AccessioniPrimary (citable) accession number: O61113
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.