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Protein
Submitted name:

Plasmepsin

Gene

PmUG01_13050400

Organism
Plasmodium malariae
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei158PROSITE-ProRule annotation1
Active sitei338PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteasePROSITE-ProRule annotationSAAS annotation, Hydrolase, Protease

Enzyme and pathway databases

BRENDAi3.4.23.B14 7305

Protein family/group databases

MEROPSiA01.021

Names & Taxonomyi

Protein namesi
Submitted name:
PlasmepsinImported
Submitted name:
Plasmepsin IV, putative (PM4)Imported
Submitted name:
Plasmepsin, putativeImported
Gene namesi
Name:PmUG01_13050400Imported
Synonyms:PmlGA01_130044400Imported
ORF Names:PMALA_027650Imported, PMLGA01_130044400Imported, PMUG01_13050400Imported
OrganismiPlasmodium malariaeImported
Taxonomic identifieri5858 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Plasmodium)
Proteomesi
  • UP000219813 Componenti: Chromosome 13
  • UP000078597 Componenti: Unassembled WGS sequence
  • UP000219799 Componenti: Chromosome 13

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 64HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi171 ↔ 176Combined sources
Disulfide bondi373 ↔ 409Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ANLX-ray3.30A/B125-451[»]
SMRiO60990
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60990

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini140 – 447Peptidase A1InterPro annotationAdd BLAST308

Sequence similaritiesi

Belongs to the peptidase A1 family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

CDDicd05471 pepsin_like, 1 hit
Gene3Di2.40.70.10, 3 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR034164 Pepsin-like_dom
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

O60990-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDITVKEQEF SNGLIKNSSA FENIKFSNIK NNFKVQKKFQ ILYFILFIFV
60 70 80 90 100
TGVFFFFLIG NYFFSPNYKV NKIVQNTEHL TIGFKIERPH DKVLKTIVEK
110 120 130 140 150
NLKNYIKETV KFFQSGYVKQ NYLGSENDVI ELDDVANLMF YGEGEVGDNH
160 170 180 190 200
QKFMLIFDTG SANLWVPSKK CNSIGCSTKH LYDSSKSKSY EKDGTKVEIT
210 220 230 240 250
YGSGTVRGFF SKDLVTLGYL SLPYKFIEVT DTDDLEPLYT AAEFDGILGL
260 270 280 290 300
GWKDLSIGSI DPIVVELKNQ NKIDQALFTF YLPVHDKHSG YLTIGGIEEK
310 320 330 340 350
FYEGELTYEK LNHDLFWQVD LDVNFGKTSM EKANVIVDSG TSTITAPTSF
360 370 380 390 400
INKFFKDLNV IKVPFLPFYI TTCNNKDMPT LEFKSANNTY TLEPEYYMEP
410 420 430 440 450
LLDIDDTLCM LYILPVDIDK NTFILGDPFM RKYFTVFDYD KESIGFAVAK

N
Length:451
Mass (Da):51,809
Last modified:August 1, 1998 - v1
Checksum:i0A47921D087F50B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001210 Genomic DNA Translation: AAC15794.1
FLQW01001494 Genomic DNA Translation: SBS89857.1
LT594501 Genomic DNA Translation: SBT72504.1
LT594634 Genomic DNA Translation: SCP02857.1

Genome annotation databases

EnsemblProtistsiSBS89857; SBS89857; PMALA_027650

Similar proteinsi

Entry informationi

Entry nameiO60990_PLAMA
AccessioniPrimary (citable) accession number: O60990
Secondary accession number(s): A0A1C3KFU2
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

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