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Protein
Submitted name:

Aspartic protease PM4

Gene

PVC01_130047600

Organism
Plasmodium vivax
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei157PROSITE-ProRule annotation1
Active sitei337PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteasePROSITE-ProRule annotationSAAS annotation, Hydrolase, Protease

Enzyme and pathway databases

BRENDAi3.4.23.B14. 4894.

Protein family/group databases

MEROPSiA01.021.

Names & Taxonomyi

Protein namesi
Submitted name:
Aspartic protease PM4Imported
Submitted name:
PlasmepsinImported
Submitted name:
Plasmepsin IV, putativeImported
Gene namesi
ORF Names:PVC01_130047600Imported, PVT01_130045800Imported
OrganismiPlasmodium vivaxImported
Taxonomic identifieri5855 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Plasmodium)
Proteomesi
  • UP000196402 Componenti: Chromosome 13

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 63HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL6198.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi170 ↔ 175Combined sources
Disulfide bondi372 ↔ 408Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MIQX-ray2.50A/B76-450[»]
1QS8X-ray2.50A/B122-450[»]
SMRiO60989.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 446Peptidase A1InterPro annotationAdd BLAST308

Sequence similaritiesi

Belongs to the peptidase A1 family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
HOGENOMiHOG000114910.

Family and domain databases

CDDicd05471. pepsin_like. 1 hit.
Gene3Di2.40.70.10. 3 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR034164. Pepsin-like_dom.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom_sf.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiView protein in Pfam
PF00026. Asp. 1 hit.
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.

Sequencei

Sequence statusi: Complete.

O60989-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIAVKEQDY SNGLIKNSAA FENLKFSNIK NFKVQKRFQI LYYILFVFVT
60 70 80 90 100
GIFFFFLIST YFFTPNYKVN KIVQNTEHLT LAFKIERPYD KVLKTISKKN
110 120 130 140 150
LKNYIKETFN FFKSGYMKQN YLGSENDVIE LDDVANIMFY GEGEVGDNHQ
160 170 180 190 200
KFMLIFDTGS ANLWVPSKKC NSSGCSIKNL YDSSKSKSYE KDGTKVDITY
210 220 230 240 250
GSGTVKGFFS KDLVTLGHLS MPYKFIEVTD TDDLEPIYSS VEFDGILGLG
260 270 280 290 300
WKDLSIGSID PIVVELKNQN KIDNALFTFY LPVHDVHAGY LTIGGIEEKF
310 320 330 340 350
YEGNITYEKL NHDLYWQIDL DVHFGKQTME KANVIVDSGT TTITAPSEFL
360 370 380 390 400
NKFFANLNVI KVPFLPFYVT TCDNKEMPTL EFKSANNTYT LEPEYYMNPI
410 420 430 440 450
LEVDDTLCMI TMLPVDIDSN TFILGDPFMR KYFTVFDYDK ESVGFAIAKN
Length:450
Mass (Da):51,667
Last modified:August 1, 1998 - v1
Checksum:i0CC8062FE9E5E0B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001208 Genomic DNA. Translation: AAC15792.1.
AY584069 mRNA. Translation: AAS99507.1.
AY584070 mRNA. Translation: AAS99508.1.
AY584071 mRNA. Translation: AAS99509.1.
AY584072 mRNA. Translation: AAS99510.1.
AY584073 mRNA. Translation: AAS99511.1.
AY584074 mRNA. Translation: AAS99512.1.
AY584075 mRNA. Translation: AAS99513.1.
AY584076 mRNA. Translation: AAS99514.1.
AY584077 mRNA. Translation: AAS99515.1.
AY584078 mRNA. Translation: AAS99516.1.
AY584079 mRNA. Translation: AAS99517.1.
AY584080 mRNA. Translation: AAS99518.1.
AY584081 mRNA. Translation: AAS99519.1.
AY584082 mRNA. Translation: AAS99520.1.
AY584083 mRNA. Translation: AAS99521.1.
AY584084 mRNA. Translation: AAS99522.1.
AY584085 mRNA. Translation: AAS99523.1.
AY584086 mRNA. Translation: AAS99524.1.
AY584087 mRNA. Translation: AAS99525.1.
AY584088 mRNA. Translation: AAS99526.1.
AY584089 mRNA. Translation: AAS99527.1.
LT615251 Genomic DNA. Translation: SCO69511.1.
LT615268 Genomic DNA. Translation: SCO74986.1.

Similar proteinsi

Entry informationi

Entry nameiO60989_PLAVI
AccessioniPrimary (citable) accession number: O60989
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 22, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported