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Protein
Submitted name:

Aspartic protease PM4

Gene
N/A
Organism
Plasmodium vivax
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl proteaseUniRule annotationSAAS annotation, Hydrolase, Protease

Enzyme and pathway databases

BRENDAi3.4.23.B14. 4894.

Protein family/group databases

MEROPSiA01.021.

Names & Taxonomyi

Protein namesi
Submitted name:
Aspartic protease PM4Imported
Submitted name:
PlasmepsinImported
OrganismiPlasmodium vivaxImported
Taxonomic identifieri5855 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Plasmodium)

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 63HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL6198.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi170 ↔ 175Combined sources
Disulfide bondi372 ↔ 408Combined sources

Interactioni

Protein-protein interaction databases

STRINGi5855.PVX_086040.

Chemistry databases

BindingDBiO60989.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MIQX-ray2.50A/B76-450[»]
1QS8X-ray2.50A/B122-450[»]
ProteinModelPortaliO60989.
SMRiO60989.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 446Peptidase A1InterPro annotationAdd BLAST308

Sequence similaritiesi

Belongs to the peptidase A1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
HOGENOMiHOG000114910.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60989-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIAVKEQDY SNGLIKNSAA FENLKFSNIK NFKVQKRFQI LYYILFVFVT
60 70 80 90 100
GIFFFFLIST YFFTPNYKVN KIVQNTEHLT LAFKIERPYD KVLKTISKKN
110 120 130 140 150
LKNYIKETFN FFKSGYMKQN YLGSENDVIE LDDVANIMFY GEGEVGDNHQ
160 170 180 190 200
KFMLIFDTGS ANLWVPSKKC NSSGCSIKNL YDSSKSKSYE KDGTKVDITY
210 220 230 240 250
GSGTVKGFFS KDLVTLGHLS MPYKFIEVTD TDDLEPIYSS VEFDGILGLG
260 270 280 290 300
WKDLSIGSID PIVVELKNQN KIDNALFTFY LPVHDVHAGY LTIGGIEEKF
310 320 330 340 350
YEGNITYEKL NHDLYWQIDL DVHFGKQTME KANVIVDSGT TTITAPSEFL
360 370 380 390 400
NKFFANLNVI KVPFLPFYVT TCDNKEMPTL EFKSANNTYT LEPEYYMNPI
410 420 430 440 450
LEVDDTLCMI TMLPVDIDSN TFILGDPFMR KYFTVFDYDK ESVGFAIAKN
Length:450
Mass (Da):51,667
Last modified:August 1, 1998 - v1
Checksum:i0CC8062FE9E5E0B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001208 Genomic DNA. Translation: AAC15792.1.
AY584069 mRNA. Translation: AAS99507.1.
AY584070 mRNA. Translation: AAS99508.1.
AY584071 mRNA. Translation: AAS99509.1.
AY584072 mRNA. Translation: AAS99510.1.
AY584073 mRNA. Translation: AAS99511.1.
AY584074 mRNA. Translation: AAS99512.1.
AY584075 mRNA. Translation: AAS99513.1.
AY584076 mRNA. Translation: AAS99514.1.
AY584077 mRNA. Translation: AAS99515.1.
AY584078 mRNA. Translation: AAS99516.1.
AY584079 mRNA. Translation: AAS99517.1.
AY584080 mRNA. Translation: AAS99518.1.
AY584081 mRNA. Translation: AAS99519.1.
AY584082 mRNA. Translation: AAS99520.1.
AY584083 mRNA. Translation: AAS99521.1.
AY584084 mRNA. Translation: AAS99522.1.
AY584085 mRNA. Translation: AAS99523.1.
AY584086 mRNA. Translation: AAS99524.1.
AY584087 mRNA. Translation: AAS99525.1.
AY584088 mRNA. Translation: AAS99526.1.
AY584089 mRNA. Translation: AAS99527.1.

Genome annotation databases

EnsemblProtistsiPVX_086040; PVX_086040; PVX_086040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001208 Genomic DNA. Translation: AAC15792.1.
AY584069 mRNA. Translation: AAS99507.1.
AY584070 mRNA. Translation: AAS99508.1.
AY584071 mRNA. Translation: AAS99509.1.
AY584072 mRNA. Translation: AAS99510.1.
AY584073 mRNA. Translation: AAS99511.1.
AY584074 mRNA. Translation: AAS99512.1.
AY584075 mRNA. Translation: AAS99513.1.
AY584076 mRNA. Translation: AAS99514.1.
AY584077 mRNA. Translation: AAS99515.1.
AY584078 mRNA. Translation: AAS99516.1.
AY584079 mRNA. Translation: AAS99517.1.
AY584080 mRNA. Translation: AAS99518.1.
AY584081 mRNA. Translation: AAS99519.1.
AY584082 mRNA. Translation: AAS99520.1.
AY584083 mRNA. Translation: AAS99521.1.
AY584084 mRNA. Translation: AAS99522.1.
AY584085 mRNA. Translation: AAS99523.1.
AY584086 mRNA. Translation: AAS99524.1.
AY584087 mRNA. Translation: AAS99525.1.
AY584088 mRNA. Translation: AAS99526.1.
AY584089 mRNA. Translation: AAS99527.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MIQX-ray2.50A/B76-450[»]
1QS8X-ray2.50A/B122-450[»]
ProteinModelPortaliO60989.
SMRiO60989.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5855.PVX_086040.

Chemistry databases

BindingDBiO60989.
ChEMBLiCHEMBL6198.

Protein family/group databases

MEROPSiA01.021.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPVX_086040; PVX_086040; PVX_086040.

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
HOGENOMiHOG000114910.

Enzyme and pathway databases

BRENDAi3.4.23.B14. 4894.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO60989_PLAVI
AccessioniPrimary (citable) accession number: O60989
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.