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Protein

Calcium-transporting ATPase

Gene
N/A
Organism
Trypanosoma cruzi
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
OrganismiTrypanosoma cruziImported
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei125 – 144HelicalUniRule annotationAdd BLAST20
Transmembranei156 – 176HelicalUniRule annotationAdd BLAST21
Transmembranei312 – 334HelicalUniRule annotationAdd BLAST23
Transmembranei354 – 380HelicalUniRule annotationAdd BLAST27
Transmembranei875 – 892HelicalUniRule annotationAdd BLAST18
Transmembranei912 – 929HelicalUniRule annotationAdd BLAST18
Transmembranei950 – 970HelicalUniRule annotationAdd BLAST21
Transmembranei982 – 1003HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliO60948.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 141Cation_ATPase_NInterPro annotationAdd BLAST73

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60948-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRSSFSYGS CDEMEEETKM RRSRLMESVR RRTSIRVNFT DGDDVGVSIR
60 70 80 90 100
TDLENIFARA NEGMPLYEKL GRAEGIAAKL QMDLNNGVRS ETVERRRTVF
110 120 130 140 150
GRNELPEEEE LSFWRIYKAA WSDQMILLLS GAAFVSLVLG LTVPEPGRDK
160 170 180 190 200
ADTGTGWIEG FAILVSVLIV TTVSSVNDYR KELKFRQLME ENSAQPIAVI
210 220 230 240 250
RGGREQVIDV TEIVVGDIVS LSTGLVVPVD GFYVRGLSVV IDESSVTGEN
260 270 280 290 300
DPKKKGVQAP ILLTGTVVNT AEDAYMLACA VGESSFGGKL LMESRQEGGP
310 320 330 340 350
RMTPLQERLD ELAGLIGRFG MGSAVLLFSL LSLLEVFRII RGTDEFHMKT
360 370 380 390 400
FLDHFLLCVT IVVVAVPEGL PLAVTIALAY SQKKMQEDNN QVRRLCACET
410 420 430 440 450
MGCATQICSD KTGTLTQNLM SVVQGYIGLQ RFNVRDPGDV PTPIVLRNVP
460 470 480 490 500
AASRDLLVEG LSLNSSSEKV VCRTGRDGES VARPYWQWRA DKGNKTDNAL
510 520 530 540 550
LDFVDRVLLQ DGDPTDMTSR PHQRVRAGSR HGFAIFPFTS ERKFMSVVVA
560 570 580 590 600
GPGGVLTAAR EGRVGPRAGN VRPLRFRFGC GGGATDGCDA DKDRCADPFP
610 620 630 640 650
PLTTRTARSV WLMGVSMAKA FPRASYGAAG VGCARGHSGP SAAGGTRRGA
660 670 680 690 700
EVQQAGVTVR MCTGDNLDTA VAISRSAHLQ PFTWRCGNDR KEFRSLVYDA
710 720 730 740 750
YGSSANMEKF WPILDRMVVM ARSQPLDKQL LVLMLMMRGE VVAVTGDGTN
760 770 780 790 800
DAPALRLANV GFVMRSGTDI AVKSSDIVLL DDNFRSVQRA VVWGRTVNDN
810 820 830 840 850
IRKFLQLQLT VNVSSVVLTF LGSFLSSSHT SPLSTVQLLW VNLIMDTLAA
860 870 880 890 900
LALATEEPSE ACLDRGPIPR KAPLVSRRMW CTILAIAGYQ TVSTLLVERF
910 920 930 940 950
GGSWFDVSGG EMQTIVFNVF LLSVIFHMFN ARKLYEEMNC FEGLWKRSRI
960 970 980 990 1000
FVCIVGFCFA FQVFSVEMLG SFMQVVSLRG EQWVGCLALS FLTLVFGAVA
1010 1020 1030 1040 1050
RLVPVEELPL PEAEMDDMEP EARRMAMKLT ADVEAHAARE GAGGHLLLGR
1060 1070 1080 1090 1100
RLLAQAMWQQ VREHHIAVRS VNAFRRARID RDMHTSVAKD IYCRLASTMQ
Length:1,100
Mass (Da):121,126
Last modified:August 1, 1998 - v1
Checksum:i032018BAA40B70EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70620 Genomic DNA. Translation: AAC38969.1.
PIRiT30303.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70620 Genomic DNA. Translation: AAC38969.1.
PIRiT30303.

3D structure databases

ProteinModelPortaliO60948.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO60948_TRYCR
AccessioniPrimary (citable) accession number: O60948
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.