O60948 (O60948_TRYCR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Ca2+-ATPase EMBL AAC38969.1
Organism	Trypanosoma cruzi EMBL AAC38969.1
Taxonomic identifier	5693 [NCBI]
Taxonomic lineage	Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Schizotrypanum

Protein attributes

Sequence length	1100 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the cation transport ATPase (P-type) family. RuleBase RU000653

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS004014
Ligand	ATP-binding SAAS SAAS004014 RuleBase RU000653 Nucleotide-binding
Molecular function	Hydrolase SAAS SAAS006068 RuleBase RU000653
PTM	Phosphoprotein SAAS SAAS004014 RuleBase RU000653
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-transporting ATPase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O60948 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 032018BAA40B70EF	FASTA	1,100	121,126
	10 20 30 40 50 60 MRRSSFSYGS CDEMEEETKM RRSRLMESVR RRTSIRVNFT DGDDVGVSIR TDLENIFARA 70 80 90 100 110 120 NEGMPLYEKL GRAEGIAAKL QMDLNNGVRS ETVERRRTVF GRNELPEEEE LSFWRIYKAA 130 140 150 160 170 180 WSDQMILLLS GAAFVSLVLG LTVPEPGRDK ADTGTGWIEG FAILVSVLIV TTVSSVNDYR 190 200 210 220 230 240 KELKFRQLME ENSAQPIAVI RGGREQVIDV TEIVVGDIVS LSTGLVVPVD GFYVRGLSVV 250 260 270 280 290 300 IDESSVTGEN DPKKKGVQAP ILLTGTVVNT AEDAYMLACA VGESSFGGKL LMESRQEGGP 310 320 330 340 350 360 RMTPLQERLD ELAGLIGRFG MGSAVLLFSL LSLLEVFRII RGTDEFHMKT FLDHFLLCVT 370 380 390 400 410 420 IVVVAVPEGL PLAVTIALAY SQKKMQEDNN QVRRLCACET MGCATQICSD KTGTLTQNLM 430 440 450 460 470 480 SVVQGYIGLQ RFNVRDPGDV PTPIVLRNVP AASRDLLVEG LSLNSSSEKV VCRTGRDGES 490 500 510 520 530 540 VARPYWQWRA DKGNKTDNAL LDFVDRVLLQ DGDPTDMTSR PHQRVRAGSR HGFAIFPFTS 550 560 570 580 590 600 ERKFMSVVVA GPGGVLTAAR EGRVGPRAGN VRPLRFRFGC GGGATDGCDA DKDRCADPFP 610 620 630 640 650 660 PLTTRTARSV WLMGVSMAKA FPRASYGAAG VGCARGHSGP SAAGGTRRGA EVQQAGVTVR 670 680 690 700 710 720 MCTGDNLDTA VAISRSAHLQ PFTWRCGNDR KEFRSLVYDA YGSSANMEKF WPILDRMVVM 730 740 750 760 770 780 ARSQPLDKQL LVLMLMMRGE VVAVTGDGTN DAPALRLANV GFVMRSGTDI AVKSSDIVLL 790 800 810 820 830 840 DDNFRSVQRA VVWGRTVNDN IRKFLQLQLT VNVSSVVLTF LGSFLSSSHT SPLSTVQLLW 850 860 870 880 890 900 VNLIMDTLAA LALATEEPSE ACLDRGPIPR KAPLVSRRMW CTILAIAGYQ TVSTLLVERF 910 920 930 940 950 960 GGSWFDVSGG EMQTIVFNVF LLSVIFHMFN ARKLYEEMNC FEGLWKRSRI FVCIVGFCFA 970 980 990 1000 1010 1020 FQVFSVEMLG SFMQVVSLRG EQWVGCLALS FLTLVFGAVA RLVPVEELPL PEAEMDDMEP 1030 1040 1050 1060 1070 1080 EARRMAMKLT ADVEAHAARE GAGGHLLLGR RLLAQAMWQQ VREHHIAVRS VNAFRRARID 1090 1100 RDMHTSVAKD IYCRLASTMQ

References

[1]

"Ca2+ content and expression of an acidocalcisomal calcium pump are elevated in intracellular forms of Trypanosoma cruzi." Lu H.G., Zhong L., de Souza W., Benchimol M., Moreno S., Docampo R. Mol. Cell. Biol. 18:2309-2323(1998) [PubMed: 9528801] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAC38969.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U70620 Genomic DNA. Translation: AAC38969.1.
PIR	T30303.
3D structure databases
ProteinModelPortal	O60948.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR023306. ATPase_cation_domN. IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006408. ATPase_P-typ_Ca-transp_PMCA. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR000695. ATPase_P-typ_H-transp. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00120. HATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01517. ATPase-IIB_Ca. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O60948_TRYCR

Accession

Primary (citable) accession number: O60948

Entry history

Integrated into UniProtKB/TrEMBL:	August 1, 1998
Last sequence update:	August 1, 1998
Last modified:	July 27, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)