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Protein

Dystrobrevin beta

Gene

DTNB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 284ZZ-typePROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Dystrobrevin beta
Short name:
DTN-B
Alternative name(s):
Beta-dystrobrevin
Gene namesi
Name:DTNB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000138101.18.
HGNCiHGNC:3058. DTNB.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi1838.
OpenTargetsiENSG00000138101.
PharmGKBiPA27511.

Polymorphism and mutation databases

BioMutaiDTNB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000868781 – 627Dystrobrevin betaAdd BLAST627

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei394PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60941.
MaxQBiO60941.
PaxDbiO60941.
PeptideAtlasiO60941.
PRIDEiO60941.

PTM databases

iPTMnetiO60941.
PhosphoSitePlusiO60941.

Expressioni

Tissue specificityi

Highly expressed in brain, kidney and pancreas.

Gene expression databases

BgeeiENSG00000138101.
CleanExiHS_DTNB.
ExpressionAtlasiO60941. baseline and differential.
GenevisibleiO60941. HS.

Organism-specific databases

HPAiHPA061357.

Interactioni

Subunit structurei

Interacts with dystrophin short form DP71 and syntrophins SNTG1 and SNTG2. Binds dystrobrevin binding protein 1 (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi108171. 51 interactors.
IntActiO60941. 62 interactors.
MINTiMINT-109678.
STRINGi9606.ENSP00000384084.

Structurei

3D structure databases

ProteinModelPortaliO60941.
SMRiO60941.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni399 – 448Syntrophin-binding regionAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili428 – 529Sequence analysisAdd BLAST102

Domaini

The coiled coil domain may mediate the interaction with dystrophin.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 284ZZ-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG4301. Eukaryota.
ENOG410XP3C. LUCA.
GeneTreeiENSGT00760000119237.
HOGENOMiHOG000230684.
HOVERGENiHBG005539.
InParanoidiO60941.
OMAiPLTNMND.
OrthoDBiEOG091G02RL.
PhylomeDBiO60941.
TreeFamiTF343849.

Family and domain databases

InterProiView protein in InterPro
IPR017432. Distrobrevin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR000433. Znf_ZZ.
PfamiView protein in Pfam
PF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00569. ZZ. 1 hit.
PIRSFiPIRSF038204. Distrobrevin. 1 hit.
SMARTiView protein in SMART
SM00291. ZnF_ZZ. 1 hit.
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiView protein in PROSITE
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: O60941-1) [UniParc]FASTAAdd to basket
Also known as: DTN-B1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIEESGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL
60 70 80 90 100
HLVDIWNMIE AFRDNGLNTL DHTTEISVSR LETVISSIYY QLNKRLPSTH
110 120 130 140 150
QISVEQSISL LLNFMIAAYD SEGRGKLTVF SVKAMLATMC GGKMLDKLRY
160 170 180 190 200
VFSQMSDSNG LMIFSKFDQF LKEVLKLPTA VFEGPSFGYT EHSVRTCFPQ
210 220 230 240 250
QRKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP VECSYCRCES
260 270 280 290 300
MMGFRYRCQQ CHNYQLCQNC FWRGHAGGPH SNQHQMKEHS SWKSPAKKLS
310 320 330 340 350
HAISKSLGCV PTREPPHPVF PEQPEKPLDL AHIVPPRPLT NMNDTMVSHM
360 370 380 390 400
SSGVPTPTKR LQYSQDIPSH LADEHALIAS YVARLQHCAR VLDSPSRLDE
410 420 430 440 450
EHRLIARYAA RLAAEAGNVT RPPTDLSFNF DANKQQRQLI AELENKNREI
460 470 480 490 500
LQEIQRLRLE HEQASQPTPE KAQQNPTLLA ELRLLRQRKD ELEQRMSALQ
510 520 530 540 550
ESRRELMVQL EELMKLLKEE EQKQAAQATG SPHTSPTHGG GRPMPMPVRS
560 570 580 590 600
TSAGSTPTHC PQDSLSGVGG DVQEAFAQGT RRNLRNDLLV AADSITNTMS
610 620
SLVKELHSAE EGAEEEEEKM QNGKDRG
Length:627
Mass (Da):71,356
Last modified:August 1, 1998 - v1
Checksum:i6927EC0BD86D375C
GO
Isoform 2 (identifier: O60941-2) [UniParc]FASTAAdd to basket
Also known as: Dystrophin-associated protein A0

The sequence of this isoform differs from the canonical sequence as follows:
     360-390: RLQYSQDIPSHLADEHALIASYVARLQHCAR → S
     579-608: Missing.

Show »
Length:567
Mass (Da):64,603
Checksum:iFCE6EA264E0288AC
GO
Isoform 3 (identifier: O60941-3) [UniParc]FASTAAdd to basket
Also known as: DTN-B2

The sequence of this isoform differs from the canonical sequence as follows:
     526-558: AQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPT → VSELRNFPPDSRSFARSSFPHINVSPLLPAHHL
     559-627: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:558
Mass (Da):64,424
Checksum:i503AE1161728764C
GO
Isoform 4 (identifier: O60941-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     579-608: Missing.

Show »
Length:597
Mass (Da):68,061
Checksum:iD6B8F6824D9ADA5E
GO
Isoform 5 (identifier: O60941-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-390: RLQYSQDIPSHLADEHALIASYVARLQHCAR → S
     519-525: Missing.
     579-608: Missing.

Show »
Length:560
Mass (Da):63,760
Checksum:i7E690DC33BBC1CE2
GO
Isoform 6 (identifier: O60941-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.
     519-525: Missing.
     609-626: Missing.

Note: No experimental confirmation available.
Show »
Length:545
Mass (Da):61,538
Checksum:iE80E4844A6FE8689
GO
Isoform 7 (identifier: O60941-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     609-626: Missing.

Note: No experimental confirmation available.
Show »
Length:609
Mass (Da):69,294
Checksum:iF1FE02EF941A8F9D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102I → T in BAH13469 (PubMed:14702039).Curated1
Sequence conflicti172K → T in BAH13469 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06914697P → H1 PublicationCorresponds to variant dbSNP:rs17854576Ensembl.1
Natural variantiVAR_069147116I → T1 PublicationCorresponds to variant dbSNP:rs17854577Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0455341 – 57Missing in isoform 6. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_004223360 – 390RLQYS…QHCAR → S in isoform 2 and isoform 5. 3 PublicationsAdd BLAST31
Alternative sequenceiVSP_043445519 – 525Missing in isoform 5 and isoform 6. 3 Publications7
Alternative sequenceiVSP_004224526 – 558AQATG…GSTPT → VSELRNFPPDSRSFARSSFP HINVSPLLPAHHL in isoform 3. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_004225559 – 627Missing in isoform 3. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_004226579 – 608Missing in isoform 2, isoform 4 and isoform 5. 4 PublicationsAdd BLAST30
Alternative sequenceiVSP_045535609 – 626Missing in isoform 6 and isoform 7. 2 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022728 mRNA. Translation: AAC05082.1.
Y15722 mRNA. Translation: CAA75737.1.
Y12712 mRNA. Translation: CAA73249.1.
Y15718 mRNA. Translation: CAA75733.1.
Y15719 mRNA. Translation: CAA75734.1.
Y15720 mRNA. Translation: CAA75735.1.
Y15721 mRNA. Translation: CAA75736.1.
BT009805 mRNA. Translation: AAP88807.1.
AK301386 mRNA. Translation: BAH13469.1.
AC010150 Genomic DNA. No translation available.
AC012074 Genomic DNA. No translation available.
AC019144 Genomic DNA. No translation available.
AC104699 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00719.1.
CH471053 Genomic DNA. Translation: EAX00722.1.
BC016655 mRNA. Translation: AAH16655.1.
BC049366 mRNA. Translation: AAH49366.1.
AF070567 mRNA. Translation: AAC28643.1.
CCDSiCCDS46233.1. [O60941-5]
CCDS46234.1. [O60941-2]
CCDS46235.1. [O60941-4]
CCDS46236.1. [O60941-7]
CCDS46237.1. [O60941-1]
CCDS58702.1. [O60941-6]
RefSeqiNP_001243232.1. NM_001256303.1.
NP_001243237.1. NM_001256308.2. [O60941-6]
NP_001307861.1. NM_001320932.1.
NP_001307862.1. NM_001320933.1.
NP_001307863.1. NM_001320934.1.
NP_001307864.1. NM_001320935.1.
NP_001307865.1. NM_001320936.1.
NP_068707.1. NM_021907.4. [O60941-1]
NP_149159.2. NM_033147.3. [O60941-4]
NP_149160.1. NM_033148.3. [O60941-2]
NP_899204.1. NM_183360.2. [O60941-7]
NP_899205.1. NM_183361.2. [O60941-5]
UniGeneiHs.307720.

Genome annotation databases

EnsembliENST00000404103; ENSP00000385482; ENSG00000138101. [O60941-4]
ENST00000405222; ENSP00000384787; ENSG00000138101. [O60941-5]
ENST00000406818; ENSP00000384084; ENSG00000138101. [O60941-1]
ENST00000407038; ENSP00000384767; ENSG00000138101. [O60941-2]
ENST00000407661; ENSP00000385193; ENSG00000138101. [O60941-7]
ENST00000496972; ENSP00000444463; ENSG00000138101. [O60941-6]
GeneIDi1838.
KEGGihsa:1838.
UCSCiuc002rgh.5. human. [O60941-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDTNB_HUMAN
AccessioniPrimary (citable) accession number: O60941
Secondary accession number(s): B7Z733
, F5GZG4, G5E9F6, O43782, O60881, O75538, Q86VR4, Q96AW0, Q9UE14, Q9UE15, Q9UE16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: October 25, 2017
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families