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Protein

Dystrobrevin beta

Gene

DTNB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri237 – 28448ZZ-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Dystrobrevin beta
Short name:
DTN-B
Alternative name(s):
Beta-dystrobrevin
Gene namesi
Name:DTNB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:3058. DTNB.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. synapse Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27511.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 627627Dystrobrevin betaPRO_0000086878Add
BLAST

Proteomic databases

MaxQBiO60941.
PaxDbiO60941.
PRIDEiO60941.

PTM databases

PhosphoSiteiO60941.

Expressioni

Tissue specificityi

Highly expressed in brain, kidney and pancreas.

Gene expression databases

BgeeiO60941.
CleanExiHS_DTNB.
ExpressionAtlasiO60941. baseline and differential.
GenevestigatoriO60941.

Organism-specific databases

HPAiHPA061357.
HPA064517.

Interactioni

Subunit structurei

Interacts with dystrophin short form DP71 and syntrophins SNTG1 and SNTG2. Binds dystrobrevin binding protein 1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi108171. 32 interactions.
IntActiO60941. 15 interactions.
MINTiMINT-109678.
STRINGi9606.ENSP00000384084.

Structurei

3D structure databases

ProteinModelPortaliO60941.
SMRiO60941. Positions 26-235, 237-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni399 – 44850Syntrophin-binding regionAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili428 – 529102Sequence AnalysisAdd
BLAST

Domaini

The coiled coil domain may mediate the interaction with dystrophin.

Sequence similaritiesi

Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri237 – 28448ZZ-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG251970.
GeneTreeiENSGT00760000119237.
HOGENOMiHOG000230684.
HOVERGENiHBG005539.
InParanoidiO60941.
OMAiNTLEPQS.
OrthoDBiEOG7N8ZV0.
PhylomeDBiO60941.
TreeFamiTF343849.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR017432. Distrobrevin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
PIRSFiPIRSF038204. Distrobrevin. 1 hit.
SMARTiSM00291. ZnF_ZZ. 1 hit.
[Graphical view]
PROSITEiPS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: O60941-1) [UniParc]FASTAAdd to basket

Also known as: DTN-B1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIEESGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL
60 70 80 90 100
HLVDIWNMIE AFRDNGLNTL DHTTEISVSR LETVISSIYY QLNKRLPSTH
110 120 130 140 150
QISVEQSISL LLNFMIAAYD SEGRGKLTVF SVKAMLATMC GGKMLDKLRY
160 170 180 190 200
VFSQMSDSNG LMIFSKFDQF LKEVLKLPTA VFEGPSFGYT EHSVRTCFPQ
210 220 230 240 250
QRKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP VECSYCRCES
260 270 280 290 300
MMGFRYRCQQ CHNYQLCQNC FWRGHAGGPH SNQHQMKEHS SWKSPAKKLS
310 320 330 340 350
HAISKSLGCV PTREPPHPVF PEQPEKPLDL AHIVPPRPLT NMNDTMVSHM
360 370 380 390 400
SSGVPTPTKR LQYSQDIPSH LADEHALIAS YVARLQHCAR VLDSPSRLDE
410 420 430 440 450
EHRLIARYAA RLAAEAGNVT RPPTDLSFNF DANKQQRQLI AELENKNREI
460 470 480 490 500
LQEIQRLRLE HEQASQPTPE KAQQNPTLLA ELRLLRQRKD ELEQRMSALQ
510 520 530 540 550
ESRRELMVQL EELMKLLKEE EQKQAAQATG SPHTSPTHGG GRPMPMPVRS
560 570 580 590 600
TSAGSTPTHC PQDSLSGVGG DVQEAFAQGT RRNLRNDLLV AADSITNTMS
610 620
SLVKELHSAE EGAEEEEEKM QNGKDRG
Length:627
Mass (Da):71,356
Last modified:August 1, 1998 - v1
Checksum:i6927EC0BD86D375C
GO
Isoform 2 (identifier: O60941-2) [UniParc]FASTAAdd to basket

Also known as: Dystrophin-associated protein A0

The sequence of this isoform differs from the canonical sequence as follows:
     360-390: RLQYSQDIPSHLADEHALIASYVARLQHCAR → S
     579-608: Missing.

Show »
Length:567
Mass (Da):64,603
Checksum:iFCE6EA264E0288AC
GO
Isoform 3 (identifier: O60941-3) [UniParc]FASTAAdd to basket

Also known as: DTN-B2

The sequence of this isoform differs from the canonical sequence as follows:
     526-558: AQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPT → VSELRNFPPDSRSFARSSFPHINVSPLLPAHHL
     559-627: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:558
Mass (Da):64,424
Checksum:i503AE1161728764C
GO
Isoform 4 (identifier: O60941-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     579-608: Missing.

Show »
Length:597
Mass (Da):68,061
Checksum:iD6B8F6824D9ADA5E
GO
Isoform 5 (identifier: O60941-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-390: RLQYSQDIPSHLADEHALIASYVARLQHCAR → S
     519-525: Missing.
     579-608: Missing.

Show »
Length:560
Mass (Da):63,760
Checksum:i7E690DC33BBC1CE2
GO
Isoform 6 (identifier: O60941-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.
     519-525: Missing.
     609-626: Missing.

Note: No experimental confirmation available.

Show »
Length:545
Mass (Da):61,538
Checksum:iE80E4844A6FE8689
GO
Isoform 7 (identifier: O60941-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     609-626: Missing.

Note: No experimental confirmation available.

Show »
Length:609
Mass (Da):69,294
Checksum:iF1FE02EF941A8F9D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021I → T in BAH13469 (PubMed:14702039).Curated
Sequence conflicti172 – 1721K → T in BAH13469 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971P → H.1 Publication
Corresponds to variant rs17854576 [ dbSNP | Ensembl ].
VAR_069146
Natural varianti116 – 1161I → T.1 Publication
Corresponds to variant rs17854577 [ dbSNP | Ensembl ].
VAR_069147

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5757Missing in isoform 6. 1 PublicationVSP_045534Add
BLAST
Alternative sequencei360 – 39031RLQYS…QHCAR → S in isoform 2 and isoform 5. 3 PublicationsVSP_004223Add
BLAST
Alternative sequencei519 – 5257Missing in isoform 5 and isoform 6. 3 PublicationsVSP_043445
Alternative sequencei526 – 55833AQATG…GSTPT → VSELRNFPPDSRSFARSSFP HINVSPLLPAHHL in isoform 3. 1 PublicationVSP_004224Add
BLAST
Alternative sequencei559 – 62769Missing in isoform 3. 1 PublicationVSP_004225Add
BLAST
Alternative sequencei579 – 60830Missing in isoform 2, isoform 4 and isoform 5. 4 PublicationsVSP_004226Add
BLAST
Alternative sequencei609 – 62618Missing in isoform 6 and isoform 7. 2 PublicationsVSP_045535Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022728 mRNA. Translation: AAC05082.1.
Y15722 mRNA. Translation: CAA75737.1.
Y12712 mRNA. Translation: CAA73249.1.
Y15718 mRNA. Translation: CAA75733.1.
Y15719 mRNA. Translation: CAA75734.1.
Y15720 mRNA. Translation: CAA75735.1.
Y15721 mRNA. Translation: CAA75736.1.
BT009805 mRNA. Translation: AAP88807.1.
AK301386 mRNA. Translation: BAH13469.1.
AC010150 Genomic DNA. No translation available.
AC012074 Genomic DNA. No translation available.
AC019144 Genomic DNA. No translation available.
AC104699 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00719.1.
CH471053 Genomic DNA. Translation: EAX00722.1.
BC016655 mRNA. Translation: AAH16655.1.
BC049366 mRNA. Translation: AAH49366.1.
AF070567 mRNA. Translation: AAC28643.1.
CCDSiCCDS46233.1. [O60941-5]
CCDS46234.1. [O60941-2]
CCDS46235.1. [O60941-4]
CCDS46236.1. [O60941-7]
CCDS46237.1. [O60941-1]
CCDS58702.1. [O60941-6]
RefSeqiNP_001243232.1. NM_001256303.1.
NP_001243233.1. NM_001256304.1.
NP_001243237.1. NM_001256308.1. [O60941-6]
NP_068707.1. NM_021907.4. [O60941-1]
NP_149159.2. NM_033147.3. [O60941-4]
NP_149160.1. NM_033148.3. [O60941-2]
NP_899204.1. NM_183360.2. [O60941-7]
NP_899205.1. NM_183361.2. [O60941-5]
UniGeneiHs.307720.

Genome annotation databases

EnsembliENST00000404103; ENSP00000385482; ENSG00000138101. [O60941-4]
ENST00000405222; ENSP00000384787; ENSG00000138101. [O60941-5]
ENST00000406818; ENSP00000384084; ENSG00000138101. [O60941-1]
ENST00000407038; ENSP00000384767; ENSG00000138101. [O60941-2]
ENST00000407661; ENSP00000385193; ENSG00000138101. [O60941-7]
ENST00000496972; ENSP00000444463; ENSG00000138101. [O60941-6]
GeneIDi1838.
KEGGihsa:1838.
UCSCiuc002rgh.4. human. [O60941-1]
uc002rgi.4. human.
uc002rgj.4. human. [O60941-4]
uc002rgk.4. human. [O60941-2]
uc002rgl.4. human. [O60941-5]
uc002rgr.1. human. [O60941-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022728 mRNA. Translation: AAC05082.1.
Y15722 mRNA. Translation: CAA75737.1.
Y12712 mRNA. Translation: CAA73249.1.
Y15718 mRNA. Translation: CAA75733.1.
Y15719 mRNA. Translation: CAA75734.1.
Y15720 mRNA. Translation: CAA75735.1.
Y15721 mRNA. Translation: CAA75736.1.
BT009805 mRNA. Translation: AAP88807.1.
AK301386 mRNA. Translation: BAH13469.1.
AC010150 Genomic DNA. No translation available.
AC012074 Genomic DNA. No translation available.
AC019144 Genomic DNA. No translation available.
AC104699 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00719.1.
CH471053 Genomic DNA. Translation: EAX00722.1.
BC016655 mRNA. Translation: AAH16655.1.
BC049366 mRNA. Translation: AAH49366.1.
AF070567 mRNA. Translation: AAC28643.1.
CCDSiCCDS46233.1. [O60941-5]
CCDS46234.1. [O60941-2]
CCDS46235.1. [O60941-4]
CCDS46236.1. [O60941-7]
CCDS46237.1. [O60941-1]
CCDS58702.1. [O60941-6]
RefSeqiNP_001243232.1. NM_001256303.1.
NP_001243233.1. NM_001256304.1.
NP_001243237.1. NM_001256308.1. [O60941-6]
NP_068707.1. NM_021907.4. [O60941-1]
NP_149159.2. NM_033147.3. [O60941-4]
NP_149160.1. NM_033148.3. [O60941-2]
NP_899204.1. NM_183360.2. [O60941-7]
NP_899205.1. NM_183361.2. [O60941-5]
UniGeneiHs.307720.

3D structure databases

ProteinModelPortaliO60941.
SMRiO60941. Positions 26-235, 237-292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108171. 32 interactions.
IntActiO60941. 15 interactions.
MINTiMINT-109678.
STRINGi9606.ENSP00000384084.

PTM databases

PhosphoSiteiO60941.

Proteomic databases

MaxQBiO60941.
PaxDbiO60941.
PRIDEiO60941.

Protocols and materials databases

DNASUi1838.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000404103; ENSP00000385482; ENSG00000138101. [O60941-4]
ENST00000405222; ENSP00000384787; ENSG00000138101. [O60941-5]
ENST00000406818; ENSP00000384084; ENSG00000138101. [O60941-1]
ENST00000407038; ENSP00000384767; ENSG00000138101. [O60941-2]
ENST00000407661; ENSP00000385193; ENSG00000138101. [O60941-7]
ENST00000496972; ENSP00000444463; ENSG00000138101. [O60941-6]
GeneIDi1838.
KEGGihsa:1838.
UCSCiuc002rgh.4. human. [O60941-1]
uc002rgi.4. human.
uc002rgj.4. human. [O60941-4]
uc002rgk.4. human. [O60941-2]
uc002rgl.4. human. [O60941-5]
uc002rgr.1. human. [O60941-3]

Organism-specific databases

CTDi1838.
GeneCardsiGC02M025600.
HGNCiHGNC:3058. DTNB.
HPAiHPA061357.
HPA064517.
MIMi602415. gene.
neXtProtiNX_O60941.
PharmGKBiPA27511.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG251970.
GeneTreeiENSGT00760000119237.
HOGENOMiHOG000230684.
HOVERGENiHBG005539.
InParanoidiO60941.
OMAiNTLEPQS.
OrthoDBiEOG7N8ZV0.
PhylomeDBiO60941.
TreeFamiTF343849.

Miscellaneous databases

ChiTaRSiDTNB. human.
GeneWikiiDTNB.
GenomeRNAii1838.
NextBioi7517.
PROiO60941.
SOURCEiSearch...

Gene expression databases

BgeeiO60941.
CleanExiHS_DTNB.
ExpressionAtlasiO60941. baseline and differential.
GenevestigatoriO60941.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR017432. Distrobrevin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
PIRSFiPIRSF038204. Distrobrevin. 1 hit.
SMARTiSM00291. ZnF_ZZ. 1 hit.
[Graphical view]
PROSITEiPS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Beta-dystrobrevin, a new member of the dystrophin family. Identification, cloning, and protein associations."
    Peters M.F., O'Brien K.F., Sadoulet-Puccio H.M., Kunkel L.M., Adams M.E., Froehner S.C.
    J. Biol. Chem. 272:31561-31569(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Identification and characterization of a novel member of the dystrobrevin gene family."
    Puca A.A., Piluso V.N.G., Belsito A., Sampaolo S., Quaderi N., Rossi E., Di Iorio G., Ballabio A., Franco B.
    FEBS Lett. 425:7-13(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Skeletal muscle.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
    Tissue: Synovium.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 7), VARIANTS HIS-97 AND THR-116.
    Tissue: Brain and Eye.
  8. Yu W., Gibbs R.A.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 200-627 (ISOFORM 4).
    Tissue: Brain.
  9. "Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells."
    Piluso G., Mirabella M., Ricci E., Belsito A., Abbondanza C., Servidei S., Puca A.A., Tonali P., Puca G.A., Nigro V.
    J. Biol. Chem. 275:15851-15860(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNTG1 AND SNTG2.
  10. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDTNB_HUMAN
AccessioniPrimary (citable) accession number: O60941
Secondary accession number(s): B7Z733
, F5GZG4, G5E9F6, O43782, O60881, O75538, Q86VR4, Q96AW0, Q9UE14, Q9UE15, Q9UE16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: March 4, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.