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O60941 (DTNB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dystrobrevin beta

Short name=DTN-B
Alternative name(s):
Beta-dystrobrevin
Gene names
Name:DTNB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length627 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with dystrophin short form DP71 and syntrophins SNTG1 and SNTG2. Binds dystrobrevin binding protein 1 By similarity. Ref.9

Subcellular location

Cytoplasm.

Tissue specificity

Highly expressed in brain, kidney and pancreas.

Domain

The coiled coil domain may mediate the interaction with dystrophin.

Sequence similarities

Belongs to the dystrophin family. Dystrobrevin subfamily.

Contains 1 ZZ-type zinc finger.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

synapse

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: O60941-1)

Also known as: DTN-B1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O60941-2)

Also known as: Dystrophin-associated protein A0;

The sequence of this isoform differs from the canonical sequence as follows:
     360-390: RLQYSQDIPSHLADEHALIASYVARLQHCAR → S
     579-608: Missing.
Isoform 3 (identifier: O60941-3)

Also known as: DTN-B2;

The sequence of this isoform differs from the canonical sequence as follows:
     526-558: AQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPT → VSELRNFPPDSRSFARSSFPHINVSPLLPAHHL
     559-627: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 4 (identifier: O60941-4)

The sequence of this isoform differs from the canonical sequence as follows:
     579-608: Missing.
Isoform 5 (identifier: O60941-5)

The sequence of this isoform differs from the canonical sequence as follows:
     360-390: RLQYSQDIPSHLADEHALIASYVARLQHCAR → S
     519-525: Missing.
     579-608: Missing.
Isoform 6 (identifier: O60941-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.
     519-525: Missing.
     609-626: Missing.
Note: No experimental confirmation available.
Isoform 7 (identifier: O60941-7)

The sequence of this isoform differs from the canonical sequence as follows:
     609-626: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 627627Dystrobrevin beta
PRO_0000086878

Regions

Zinc finger237 – 28448ZZ-type
Region399 – 44850Syntrophin-binding region
Coiled coil428 – 529102 Potential

Natural variations

Alternative sequence1 – 5757Missing in isoform 6.
VSP_045534
Alternative sequence360 – 39031RLQYS…QHCAR → S in isoform 2 and isoform 5.
VSP_004223
Alternative sequence519 – 5257Missing in isoform 5 and isoform 6.
VSP_043445
Alternative sequence526 – 55833AQATG…GSTPT → VSELRNFPPDSRSFARSSFP HINVSPLLPAHHL in isoform 3.
VSP_004224
Alternative sequence559 – 62769Missing in isoform 3.
VSP_004225
Alternative sequence579 – 60830Missing in isoform 2, isoform 4 and isoform 5.
VSP_004226
Alternative sequence609 – 62618Missing in isoform 6 and isoform 7.
VSP_045535
Natural variant971P → H. Ref.7
Corresponds to variant rs17854576 [ dbSNP | Ensembl ].
VAR_069146
Natural variant1161I → T. Ref.7
Corresponds to variant rs17854577 [ dbSNP | Ensembl ].
VAR_069147

Experimental info

Sequence conflict1021I → T in BAH13469. Ref.4
Sequence conflict1721K → T in BAH13469. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (DTN-B1) [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 6927EC0BD86D375C

FASTA62771,356
        10         20         30         40         50         60 
MIEESGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL HLVDIWNMIE 

        70         80         90        100        110        120 
AFRDNGLNTL DHTTEISVSR LETVISSIYY QLNKRLPSTH QISVEQSISL LLNFMIAAYD 

       130        140        150        160        170        180 
SEGRGKLTVF SVKAMLATMC GGKMLDKLRY VFSQMSDSNG LMIFSKFDQF LKEVLKLPTA 

       190        200        210        220        230        240 
VFEGPSFGYT EHSVRTCFPQ QRKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP 

       250        260        270        280        290        300 
VECSYCRCES MMGFRYRCQQ CHNYQLCQNC FWRGHAGGPH SNQHQMKEHS SWKSPAKKLS 

       310        320        330        340        350        360 
HAISKSLGCV PTREPPHPVF PEQPEKPLDL AHIVPPRPLT NMNDTMVSHM SSGVPTPTKR 

       370        380        390        400        410        420 
LQYSQDIPSH LADEHALIAS YVARLQHCAR VLDSPSRLDE EHRLIARYAA RLAAEAGNVT 

       430        440        450        460        470        480 
RPPTDLSFNF DANKQQRQLI AELENKNREI LQEIQRLRLE HEQASQPTPE KAQQNPTLLA 

       490        500        510        520        530        540 
ELRLLRQRKD ELEQRMSALQ ESRRELMVQL EELMKLLKEE EQKQAAQATG SPHTSPTHGG 

       550        560        570        580        590        600 
GRPMPMPVRS TSAGSTPTHC PQDSLSGVGG DVQEAFAQGT RRNLRNDLLV AADSITNTMS 

       610        620 
SLVKELHSAE EGAEEEEEKM QNGKDRG 

« Hide

Isoform 2 (Dystrophin-associated protein A0) [UniParc].

Checksum: FCE6EA264E0288AC
Show »

FASTA56764,603
Isoform 3 (DTN-B2) [UniParc].

Checksum: 503AE1161728764C
Show »

FASTA55864,424
Isoform 4 [UniParc].

Checksum: D6B8F6824D9ADA5E
Show »

FASTA59768,061
Isoform 5 [UniParc].

Checksum: 7E690DC33BBC1CE2
Show »

FASTA56063,760
Isoform 6 [UniParc].

Checksum: E80E4844A6FE8689
Show »

FASTA54561,538
Isoform 7 [UniParc].

Checksum: F1FE02EF941A8F9D
Show »

FASTA60969,294

References

« Hide 'large scale' references
[1]"Beta-dystrobrevin, a new member of the dystrophin family. Identification, cloning, and protein associations."
Peters M.F., O'Brien K.F., Sadoulet-Puccio H.M., Kunkel L.M., Adams M.E., Froehner S.C.
J. Biol. Chem. 272:31561-31569(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Identification and characterization of a novel member of the dystrobrevin gene family."
Puca A.A., Piluso V.N.G., Belsito A., Sampaolo S., Quaderi N., Rossi E., Di Iorio G., Ballabio A., Franco B.
FEBS Lett. 425:7-13(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Skeletal muscle.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
Tissue: Synovium.
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 7), VARIANTS HIS-97 AND THR-116.
Tissue: Brain and Eye.
[8]Yu W., Gibbs R.A.
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 200-627 (ISOFORM 4).
Tissue: Brain.
[9]"Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells."
Piluso G., Mirabella M., Ricci E., Belsito A., Abbondanza C., Servidei S., Puca A.A., Tonali P., Puca G.A., Nigro V.
J. Biol. Chem. 275:15851-15860(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SNTG1 AND SNTG2.
[10]"An unappreciated role for RNA surveillance."
Hillman R.T., Green R.E., Brenner S.E.
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[11]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF022728 mRNA. Translation: AAC05082.1.
Y15722 mRNA. Translation: CAA75737.1.
Y12712 mRNA. Translation: CAA73249.1.
Y15718 mRNA. Translation: CAA75733.1.
Y15719 mRNA. Translation: CAA75734.1.
Y15720 mRNA. Translation: CAA75735.1.
Y15721 mRNA. Translation: CAA75736.1.
BT009805 mRNA. Translation: AAP88807.1.
AK301386 mRNA. Translation: BAH13469.1.
AC010150 Genomic DNA. No translation available.
AC012074 Genomic DNA. No translation available.
AC019144 Genomic DNA. No translation available.
AC104699 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00719.1.
CH471053 Genomic DNA. Translation: EAX00722.1.
BC016655 mRNA. Translation: AAH16655.1.
BC049366 mRNA. Translation: AAH49366.1.
AF070567 mRNA. Translation: AAC28643.1.
RefSeqNP_001243232.1. NM_001256303.1.
NP_001243233.1. NM_001256304.1.
NP_001243237.1. NM_001256308.1.
NP_068707.1. NM_021907.4.
NP_149159.2. NM_033147.3.
NP_149160.1. NM_033148.3.
NP_899204.1. NM_183360.2.
NP_899205.1. NM_183361.2.
UniGeneHs.307720.

3D structure databases

ProteinModelPortalO60941.
SMRO60941. Positions 26-235, 237-292.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108171. 14 interactions.
IntActO60941. 15 interactions.
MINTMINT-109678.
STRING9606.ENSP00000384084.

PTM databases

PhosphoSiteO60941.

Proteomic databases

PaxDbO60941.
PRIDEO60941.

Protocols and materials databases

DNASU1838.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000404103; ENSP00000385482; ENSG00000138101. [O60941-4]
ENST00000405222; ENSP00000384787; ENSG00000138101. [O60941-5]
ENST00000406818; ENSP00000384084; ENSG00000138101. [O60941-1]
ENST00000407038; ENSP00000384767; ENSG00000138101. [O60941-2]
ENST00000407661; ENSP00000385193; ENSG00000138101. [O60941-7]
ENST00000496972; ENSP00000444463; ENSG00000138101. [O60941-6]
GeneID1838.
KEGGhsa:1838.
UCSCuc002rgh.4. human. [O60941-1]
uc002rgi.4. human.
uc002rgj.4. human. [O60941-4]
uc002rgk.4. human. [O60941-2]
uc002rgl.4. human. [O60941-5]
uc002rgr.1. human. [O60941-3]

Organism-specific databases

CTD1838.
GeneCardsGC02M025600.
HGNCHGNC:3058. DTNB.
MIM602415. gene.
neXtProtNX_O60941.
PharmGKBPA27511.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG251970.
HOGENOMHOG000230684.
HOVERGENHBG005539.
InParanoidO60941.
OMAPQELTHT.
OrthoDBEOG7N8ZV0.
PhylomeDBO60941.
TreeFamTF343849.

Gene expression databases

ArrayExpressO60941.
BgeeO60941.
CleanExHS_DTNB.
GenevestigatorO60941.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR017432. Distrobrevin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR000433. Znf_ZZ.
[Graphical view]
PfamPF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
PIRSFPIRSF038204. Distrobrevin. 1 hit.
SMARTSM00291. ZnF_ZZ. 1 hit.
[Graphical view]
PROSITEPS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDTNB. human.
GeneWikiDTNB.
GenomeRNAi1838.
NextBio7517.
PROO60941.
SOURCESearch...

Entry information

Entry nameDTNB_HUMAN
AccessionPrimary (citable) accession number: O60941
Secondary accession number(s): B7Z733 expand/collapse secondary AC list , F5GZG4, G5E9F6, O43782, O60881, O75538, Q86VR4, Q96AW0, Q9UE14, Q9UE15, Q9UE16
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: April 16, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM