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Protein

Dystrobrevin beta

Gene

DTNB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 284ZZ-typePROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Dystrobrevin beta
Short name:
DTN-B
Alternative name(s):
Beta-dystrobrevin
Gene namesi
Name:DTNB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000138101.18
HGNCiHGNC:3058 DTNB
MIMi602415 gene
neXtProtiNX_O60941

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi1838
OpenTargetsiENSG00000138101
PharmGKBiPA27511

Polymorphism and mutation databases

BioMutaiDTNB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000868781 – 627Dystrobrevin betaAdd BLAST627

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei394PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60941
MaxQBiO60941
PaxDbiO60941
PeptideAtlasiO60941
PRIDEiO60941
ProteomicsDBi49683
49684 [O60941-2]
49685 [O60941-3]
49686 [O60941-4]
49687 [O60941-5]

PTM databases

iPTMnetiO60941
PhosphoSitePlusiO60941

Expressioni

Tissue specificityi

Highly expressed in brain, kidney and pancreas.

Gene expression databases

BgeeiENSG00000138101
CleanExiHS_DTNB
ExpressionAtlasiO60941 baseline and differential
GenevisibleiO60941 HS

Organism-specific databases

HPAiHPA061357

Interactioni

Subunit structurei

Interacts with dystrophin short form DP71 and syntrophins SNTG1 and SNTG2. Binds dystrobrevin binding protein 1 (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi108171, 51 interactors
IntActiO60941, 62 interactors
MINTiO60941
STRINGi9606.ENSP00000384084

Structurei

3D structure databases

ProteinModelPortaliO60941
SMRiO60941
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni399 – 448Syntrophin-binding regionAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili428 – 529Sequence analysisAdd BLAST102

Domaini

The coiled coil domain may mediate the interaction with dystrophin.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 284ZZ-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG4301 Eukaryota
ENOG410XP3C LUCA
GeneTreeiENSGT00760000119237
HOGENOMiHOG000230684
HOVERGENiHBG005539
InParanoidiO60941
OMAiPLTNMND
OrthoDBiEOG091G02RL
PhylomeDBiO60941
TreeFamiTF343849

Family and domain databases

InterProiView protein in InterPro
IPR017432 Distrobrevin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR000433 Znf_ZZ
PfamiView protein in Pfam
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00569 ZZ, 1 hit
PIRSFiPIRSF038204 Distrobrevin, 1 hit
SMARTiView protein in SMART
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: O60941-1) [UniParc]FASTAAdd to basket
Also known as: DTN-B1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIEESGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL
60 70 80 90 100
HLVDIWNMIE AFRDNGLNTL DHTTEISVSR LETVISSIYY QLNKRLPSTH
110 120 130 140 150
QISVEQSISL LLNFMIAAYD SEGRGKLTVF SVKAMLATMC GGKMLDKLRY
160 170 180 190 200
VFSQMSDSNG LMIFSKFDQF LKEVLKLPTA VFEGPSFGYT EHSVRTCFPQ
210 220 230 240 250
QRKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP VECSYCRCES
260 270 280 290 300
MMGFRYRCQQ CHNYQLCQNC FWRGHAGGPH SNQHQMKEHS SWKSPAKKLS
310 320 330 340 350
HAISKSLGCV PTREPPHPVF PEQPEKPLDL AHIVPPRPLT NMNDTMVSHM
360 370 380 390 400
SSGVPTPTKR LQYSQDIPSH LADEHALIAS YVARLQHCAR VLDSPSRLDE
410 420 430 440 450
EHRLIARYAA RLAAEAGNVT RPPTDLSFNF DANKQQRQLI AELENKNREI
460 470 480 490 500
LQEIQRLRLE HEQASQPTPE KAQQNPTLLA ELRLLRQRKD ELEQRMSALQ
510 520 530 540 550
ESRRELMVQL EELMKLLKEE EQKQAAQATG SPHTSPTHGG GRPMPMPVRS
560 570 580 590 600
TSAGSTPTHC PQDSLSGVGG DVQEAFAQGT RRNLRNDLLV AADSITNTMS
610 620
SLVKELHSAE EGAEEEEEKM QNGKDRG
Length:627
Mass (Da):71,356
Last modified:August 1, 1998 - v1
Checksum:i6927EC0BD86D375C
GO
Isoform 2 (identifier: O60941-2) [UniParc]FASTAAdd to basket
Also known as: Dystrophin-associated protein A0

The sequence of this isoform differs from the canonical sequence as follows:
     360-390: RLQYSQDIPSHLADEHALIASYVARLQHCAR → S
     579-608: Missing.

Show »
Length:567
Mass (Da):64,603
Checksum:iFCE6EA264E0288AC
GO
Isoform 3 (identifier: O60941-3) [UniParc]FASTAAdd to basket
Also known as: DTN-B2

The sequence of this isoform differs from the canonical sequence as follows:
     526-558: AQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPT → VSELRNFPPDSRSFARSSFPHINVSPLLPAHHL
     559-627: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:558
Mass (Da):64,424
Checksum:i503AE1161728764C
GO
Isoform 4 (identifier: O60941-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     579-608: Missing.

Show »
Length:597
Mass (Da):68,061
Checksum:iD6B8F6824D9ADA5E
GO
Isoform 5 (identifier: O60941-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-390: RLQYSQDIPSHLADEHALIASYVARLQHCAR → S
     519-525: Missing.
     579-608: Missing.

Show »
Length:560
Mass (Da):63,760
Checksum:i7E690DC33BBC1CE2
GO
Isoform 6 (identifier: O60941-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.
     519-525: Missing.
     609-626: Missing.

Note: No experimental confirmation available.
Show »
Length:545
Mass (Da):61,538
Checksum:iE80E4844A6FE8689
GO
Isoform 7 (identifier: O60941-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     609-626: Missing.

Note: No experimental confirmation available.
Show »
Length:609
Mass (Da):69,294
Checksum:iF1FE02EF941A8F9D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102I → T in BAH13469 (PubMed:14702039).Curated1
Sequence conflicti172K → T in BAH13469 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06914697P → H1 PublicationCorresponds to variant dbSNP:rs17854576Ensembl.1
Natural variantiVAR_069147116I → T1 PublicationCorresponds to variant dbSNP:rs17854577Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0455341 – 57Missing in isoform 6. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_004223360 – 390RLQYS…QHCAR → S in isoform 2 and isoform 5. 3 PublicationsAdd BLAST31
Alternative sequenceiVSP_043445519 – 525Missing in isoform 5 and isoform 6. 3 Publications7
Alternative sequenceiVSP_004224526 – 558AQATG…GSTPT → VSELRNFPPDSRSFARSSFP HINVSPLLPAHHL in isoform 3. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_004225559 – 627Missing in isoform 3. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_004226579 – 608Missing in isoform 2, isoform 4 and isoform 5. 4 PublicationsAdd BLAST30
Alternative sequenceiVSP_045535609 – 626Missing in isoform 6 and isoform 7. 2 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022728 mRNA Translation: AAC05082.1
Y15722 mRNA Translation: CAA75737.1
Y12712 mRNA Translation: CAA73249.1
Y15718 mRNA Translation: CAA75733.1
Y15719 mRNA Translation: CAA75734.1
Y15720 mRNA Translation: CAA75735.1
Y15721 mRNA Translation: CAA75736.1
BT009805 mRNA Translation: AAP88807.1
AK301386 mRNA Translation: BAH13469.1
AC010150 Genomic DNA No translation available.
AC012074 Genomic DNA No translation available.
AC019144 Genomic DNA No translation available.
AC104699 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00719.1
CH471053 Genomic DNA Translation: EAX00722.1
BC016655 mRNA Translation: AAH16655.1
BC049366 mRNA Translation: AAH49366.1
AF070567 mRNA Translation: AAC28643.1
CCDSiCCDS46233.1 [O60941-5]
CCDS46234.1 [O60941-2]
CCDS46235.1 [O60941-4]
CCDS46236.1 [O60941-7]
CCDS46237.1 [O60941-1]
CCDS58702.1 [O60941-6]
RefSeqiNP_001243232.1, NM_001256303.1
NP_001243237.1, NM_001256308.2 [O60941-6]
NP_001307861.1, NM_001320932.1
NP_001307862.1, NM_001320933.1
NP_001307863.1, NM_001320934.1
NP_001307864.1, NM_001320935.1
NP_001307865.1, NM_001320936.1
NP_068707.1, NM_021907.4 [O60941-1]
NP_149159.2, NM_033147.3 [O60941-4]
NP_149160.1, NM_033148.3 [O60941-2]
NP_899204.1, NM_183360.2 [O60941-7]
NP_899205.1, NM_183361.2 [O60941-5]
UniGeneiHs.307720

Genome annotation databases

EnsembliENST00000404103; ENSP00000385482; ENSG00000138101 [O60941-4]
ENST00000405222; ENSP00000384787; ENSG00000138101 [O60941-5]
ENST00000406818; ENSP00000384084; ENSG00000138101 [O60941-1]
ENST00000407038; ENSP00000384767; ENSG00000138101 [O60941-2]
ENST00000407661; ENSP00000385193; ENSG00000138101 [O60941-7]
ENST00000496972; ENSP00000444463; ENSG00000138101 [O60941-6]
GeneIDi1838
KEGGihsa:1838
UCSCiuc002rgh.5 human [O60941-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDTNB_HUMAN
AccessioniPrimary (citable) accession number: O60941
Secondary accession number(s): B7Z733
, F5GZG4, G5E9F6, O43782, O60881, O75538, Q86VR4, Q96AW0, Q9UE14, Q9UE15, Q9UE16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: June 20, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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