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O60941

- DTNB_HUMAN

UniProt

O60941 - DTNB_HUMAN

Protein

Dystrobrevin beta

Gene

DTNB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • Format
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri237 – 28448ZZ-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dystrobrevin beta
    Short name:
    DTN-B
    Alternative name(s):
    Beta-dystrobrevin
    Gene namesi
    Name:DTNB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:3058. DTNB.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. synapse Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27511.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 627627Dystrobrevin betaPRO_0000086878Add
    BLAST

    Proteomic databases

    MaxQBiO60941.
    PaxDbiO60941.
    PRIDEiO60941.

    PTM databases

    PhosphoSiteiO60941.

    Expressioni

    Tissue specificityi

    Highly expressed in brain, kidney and pancreas.

    Gene expression databases

    ArrayExpressiO60941.
    BgeeiO60941.
    CleanExiHS_DTNB.
    GenevestigatoriO60941.

    Interactioni

    Subunit structurei

    Interacts with dystrophin short form DP71 and syntrophins SNTG1 and SNTG2. Binds dystrobrevin binding protein 1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi108171. 14 interactions.
    IntActiO60941. 15 interactions.
    MINTiMINT-109678.
    STRINGi9606.ENSP00000384084.

    Structurei

    3D structure databases

    ProteinModelPortaliO60941.
    SMRiO60941. Positions 26-235, 237-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni399 – 44850Syntrophin-binding regionAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili428 – 529102Sequence AnalysisAdd
    BLAST

    Domaini

    The coiled coil domain may mediate the interaction with dystrophin.

    Sequence similaritiesi

    Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri237 – 28448ZZ-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG251970.
    HOGENOMiHOG000230684.
    HOVERGENiHBG005539.
    InParanoidiO60941.
    OMAiPQELTHT.
    OrthoDBiEOG7N8ZV0.
    PhylomeDBiO60941.
    TreeFamiTF343849.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR017432. Distrobrevin.
    IPR011992. EF-hand-dom_pair.
    IPR015153. EF-hand_dom_typ1.
    IPR015154. EF-hand_dom_typ2.
    IPR000433. Znf_ZZ.
    [Graphical view]
    PfamiPF09068. EF-hand_2. 1 hit.
    PF09069. EF-hand_3. 1 hit.
    PF00569. ZZ. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038204. Distrobrevin. 1 hit.
    SMARTiSM00291. ZnF_ZZ. 1 hit.
    [Graphical view]
    PROSITEiPS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: O60941-1) [UniParc]FASTAAdd to Basket

    Also known as: DTN-B1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIEESGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL    50
    HLVDIWNMIE AFRDNGLNTL DHTTEISVSR LETVISSIYY QLNKRLPSTH 100
    QISVEQSISL LLNFMIAAYD SEGRGKLTVF SVKAMLATMC GGKMLDKLRY 150
    VFSQMSDSNG LMIFSKFDQF LKEVLKLPTA VFEGPSFGYT EHSVRTCFPQ 200
    QRKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP VECSYCRCES 250
    MMGFRYRCQQ CHNYQLCQNC FWRGHAGGPH SNQHQMKEHS SWKSPAKKLS 300
    HAISKSLGCV PTREPPHPVF PEQPEKPLDL AHIVPPRPLT NMNDTMVSHM 350
    SSGVPTPTKR LQYSQDIPSH LADEHALIAS YVARLQHCAR VLDSPSRLDE 400
    EHRLIARYAA RLAAEAGNVT RPPTDLSFNF DANKQQRQLI AELENKNREI 450
    LQEIQRLRLE HEQASQPTPE KAQQNPTLLA ELRLLRQRKD ELEQRMSALQ 500
    ESRRELMVQL EELMKLLKEE EQKQAAQATG SPHTSPTHGG GRPMPMPVRS 550
    TSAGSTPTHC PQDSLSGVGG DVQEAFAQGT RRNLRNDLLV AADSITNTMS 600
    SLVKELHSAE EGAEEEEEKM QNGKDRG 627
    Length:627
    Mass (Da):71,356
    Last modified:August 1, 1998 - v1
    Checksum:i6927EC0BD86D375C
    GO
    Isoform 2 (identifier: O60941-2) [UniParc]FASTAAdd to Basket

    Also known as: Dystrophin-associated protein A0

    The sequence of this isoform differs from the canonical sequence as follows:
         360-390: RLQYSQDIPSHLADEHALIASYVARLQHCAR → S
         579-608: Missing.

    Show »
    Length:567
    Mass (Da):64,603
    Checksum:iFCE6EA264E0288AC
    GO
    Isoform 3 (identifier: O60941-3) [UniParc]FASTAAdd to Basket

    Also known as: DTN-B2

    The sequence of this isoform differs from the canonical sequence as follows:
         526-558: AQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPT → VSELRNFPPDSRSFARSSFPHINVSPLLPAHHL
         559-627: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:558
    Mass (Da):64,424
    Checksum:i503AE1161728764C
    GO
    Isoform 4 (identifier: O60941-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         579-608: Missing.

    Show »
    Length:597
    Mass (Da):68,061
    Checksum:iD6B8F6824D9ADA5E
    GO
    Isoform 5 (identifier: O60941-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         360-390: RLQYSQDIPSHLADEHALIASYVARLQHCAR → S
         519-525: Missing.
         579-608: Missing.

    Show »
    Length:560
    Mass (Da):63,760
    Checksum:i7E690DC33BBC1CE2
    GO
    Isoform 6 (identifier: O60941-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-57: Missing.
         519-525: Missing.
         609-626: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:545
    Mass (Da):61,538
    Checksum:iE80E4844A6FE8689
    GO
    Isoform 7 (identifier: O60941-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         609-626: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:609
    Mass (Da):69,294
    Checksum:iF1FE02EF941A8F9D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti102 – 1021I → T in BAH13469. (PubMed:14702039)Curated
    Sequence conflicti172 – 1721K → T in BAH13469. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti97 – 971P → H.1 Publication
    Corresponds to variant rs17854576 [ dbSNP | Ensembl ].
    VAR_069146
    Natural varianti116 – 1161I → T.1 Publication
    Corresponds to variant rs17854577 [ dbSNP | Ensembl ].
    VAR_069147

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5757Missing in isoform 6. 1 PublicationVSP_045534Add
    BLAST
    Alternative sequencei360 – 39031RLQYS…QHCAR → S in isoform 2 and isoform 5. 3 PublicationsVSP_004223Add
    BLAST
    Alternative sequencei519 – 5257Missing in isoform 5 and isoform 6. 3 PublicationsVSP_043445
    Alternative sequencei526 – 55833AQATG…GSTPT → VSELRNFPPDSRSFARSSFP HINVSPLLPAHHL in isoform 3. 1 PublicationVSP_004224Add
    BLAST
    Alternative sequencei559 – 62769Missing in isoform 3. 1 PublicationVSP_004225Add
    BLAST
    Alternative sequencei579 – 60830Missing in isoform 2, isoform 4 and isoform 5. 4 PublicationsVSP_004226Add
    BLAST
    Alternative sequencei609 – 62618Missing in isoform 6 and isoform 7. 2 PublicationsVSP_045535Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022728 mRNA. Translation: AAC05082.1.
    Y15722 mRNA. Translation: CAA75737.1.
    Y12712 mRNA. Translation: CAA73249.1.
    Y15718 mRNA. Translation: CAA75733.1.
    Y15719 mRNA. Translation: CAA75734.1.
    Y15720 mRNA. Translation: CAA75735.1.
    Y15721 mRNA. Translation: CAA75736.1.
    BT009805 mRNA. Translation: AAP88807.1.
    AK301386 mRNA. Translation: BAH13469.1.
    AC010150 Genomic DNA. No translation available.
    AC012074 Genomic DNA. No translation available.
    AC019144 Genomic DNA. No translation available.
    AC104699 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00719.1.
    CH471053 Genomic DNA. Translation: EAX00722.1.
    BC016655 mRNA. Translation: AAH16655.1.
    BC049366 mRNA. Translation: AAH49366.1.
    AF070567 mRNA. Translation: AAC28643.1.
    CCDSiCCDS46233.1. [O60941-5]
    CCDS46234.1. [O60941-2]
    CCDS46235.1. [O60941-4]
    CCDS46236.1. [O60941-7]
    CCDS46237.1. [O60941-1]
    CCDS58702.1. [O60941-6]
    RefSeqiNP_001243232.1. NM_001256303.1.
    NP_001243233.1. NM_001256304.1.
    NP_001243237.1. NM_001256308.1. [O60941-6]
    NP_068707.1. NM_021907.4. [O60941-1]
    NP_149159.2. NM_033147.3. [O60941-4]
    NP_149160.1. NM_033148.3. [O60941-2]
    NP_899204.1. NM_183360.2. [O60941-7]
    NP_899205.1. NM_183361.2. [O60941-5]
    UniGeneiHs.307720.

    Genome annotation databases

    EnsembliENST00000404103; ENSP00000385482; ENSG00000138101. [O60941-4]
    ENST00000405222; ENSP00000384787; ENSG00000138101. [O60941-5]
    ENST00000406818; ENSP00000384084; ENSG00000138101. [O60941-1]
    ENST00000407038; ENSP00000384767; ENSG00000138101. [O60941-2]
    ENST00000407661; ENSP00000385193; ENSG00000138101. [O60941-7]
    ENST00000496972; ENSP00000444463; ENSG00000138101. [O60941-6]
    GeneIDi1838.
    KEGGihsa:1838.
    UCSCiuc002rgh.4. human. [O60941-1]
    uc002rgi.4. human.
    uc002rgj.4. human. [O60941-4]
    uc002rgk.4. human. [O60941-2]
    uc002rgl.4. human. [O60941-5]
    uc002rgr.1. human. [O60941-3]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022728 mRNA. Translation: AAC05082.1 .
    Y15722 mRNA. Translation: CAA75737.1 .
    Y12712 mRNA. Translation: CAA73249.1 .
    Y15718 mRNA. Translation: CAA75733.1 .
    Y15719 mRNA. Translation: CAA75734.1 .
    Y15720 mRNA. Translation: CAA75735.1 .
    Y15721 mRNA. Translation: CAA75736.1 .
    BT009805 mRNA. Translation: AAP88807.1 .
    AK301386 mRNA. Translation: BAH13469.1 .
    AC010150 Genomic DNA. No translation available.
    AC012074 Genomic DNA. No translation available.
    AC019144 Genomic DNA. No translation available.
    AC104699 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00719.1 .
    CH471053 Genomic DNA. Translation: EAX00722.1 .
    BC016655 mRNA. Translation: AAH16655.1 .
    BC049366 mRNA. Translation: AAH49366.1 .
    AF070567 mRNA. Translation: AAC28643.1 .
    CCDSi CCDS46233.1. [O60941-5 ]
    CCDS46234.1. [O60941-2 ]
    CCDS46235.1. [O60941-4 ]
    CCDS46236.1. [O60941-7 ]
    CCDS46237.1. [O60941-1 ]
    CCDS58702.1. [O60941-6 ]
    RefSeqi NP_001243232.1. NM_001256303.1.
    NP_001243233.1. NM_001256304.1.
    NP_001243237.1. NM_001256308.1. [O60941-6 ]
    NP_068707.1. NM_021907.4. [O60941-1 ]
    NP_149159.2. NM_033147.3. [O60941-4 ]
    NP_149160.1. NM_033148.3. [O60941-2 ]
    NP_899204.1. NM_183360.2. [O60941-7 ]
    NP_899205.1. NM_183361.2. [O60941-5 ]
    UniGenei Hs.307720.

    3D structure databases

    ProteinModelPortali O60941.
    SMRi O60941. Positions 26-235, 237-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108171. 14 interactions.
    IntActi O60941. 15 interactions.
    MINTi MINT-109678.
    STRINGi 9606.ENSP00000384084.

    PTM databases

    PhosphoSitei O60941.

    Proteomic databases

    MaxQBi O60941.
    PaxDbi O60941.
    PRIDEi O60941.

    Protocols and materials databases

    DNASUi 1838.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000404103 ; ENSP00000385482 ; ENSG00000138101 . [O60941-4 ]
    ENST00000405222 ; ENSP00000384787 ; ENSG00000138101 . [O60941-5 ]
    ENST00000406818 ; ENSP00000384084 ; ENSG00000138101 . [O60941-1 ]
    ENST00000407038 ; ENSP00000384767 ; ENSG00000138101 . [O60941-2 ]
    ENST00000407661 ; ENSP00000385193 ; ENSG00000138101 . [O60941-7 ]
    ENST00000496972 ; ENSP00000444463 ; ENSG00000138101 . [O60941-6 ]
    GeneIDi 1838.
    KEGGi hsa:1838.
    UCSCi uc002rgh.4. human. [O60941-1 ]
    uc002rgi.4. human.
    uc002rgj.4. human. [O60941-4 ]
    uc002rgk.4. human. [O60941-2 ]
    uc002rgl.4. human. [O60941-5 ]
    uc002rgr.1. human. [O60941-3 ]

    Organism-specific databases

    CTDi 1838.
    GeneCardsi GC02M025600.
    HGNCi HGNC:3058. DTNB.
    MIMi 602415. gene.
    neXtProti NX_O60941.
    PharmGKBi PA27511.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG251970.
    HOGENOMi HOG000230684.
    HOVERGENi HBG005539.
    InParanoidi O60941.
    OMAi PQELTHT.
    OrthoDBi EOG7N8ZV0.
    PhylomeDBi O60941.
    TreeFami TF343849.

    Miscellaneous databases

    ChiTaRSi DTNB. human.
    GeneWikii DTNB.
    GenomeRNAii 1838.
    NextBioi 7517.
    PROi O60941.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60941.
    Bgeei O60941.
    CleanExi HS_DTNB.
    Genevestigatori O60941.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR017432. Distrobrevin.
    IPR011992. EF-hand-dom_pair.
    IPR015153. EF-hand_dom_typ1.
    IPR015154. EF-hand_dom_typ2.
    IPR000433. Znf_ZZ.
    [Graphical view ]
    Pfami PF09068. EF-hand_2. 1 hit.
    PF09069. EF-hand_3. 1 hit.
    PF00569. ZZ. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038204. Distrobrevin. 1 hit.
    SMARTi SM00291. ZnF_ZZ. 1 hit.
    [Graphical view ]
    PROSITEi PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Beta-dystrobrevin, a new member of the dystrophin family. Identification, cloning, and protein associations."
      Peters M.F., O'Brien K.F., Sadoulet-Puccio H.M., Kunkel L.M., Adams M.E., Froehner S.C.
      J. Biol. Chem. 272:31561-31569(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Identification and characterization of a novel member of the dystrobrevin gene family."
      Puca A.A., Piluso V.N.G., Belsito A., Sampaolo S., Quaderi N., Rossi E., Di Iorio G., Ballabio A., Franco B.
      FEBS Lett. 425:7-13(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Skeletal muscle.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
      Tissue: Synovium.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 7), VARIANTS HIS-97 AND THR-116.
      Tissue: Brain and Eye.
    8. Yu W., Gibbs R.A.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 200-627 (ISOFORM 4).
      Tissue: Brain.
    9. "Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells."
      Piluso G., Mirabella M., Ricci E., Belsito A., Abbondanza C., Servidei S., Puca A.A., Tonali P., Puca G.A., Nigro V.
      J. Biol. Chem. 275:15851-15860(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SNTG1 AND SNTG2.
    10. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDTNB_HUMAN
    AccessioniPrimary (citable) accession number: O60941
    Secondary accession number(s): B7Z733
    , F5GZG4, G5E9F6, O43782, O60881, O75538, Q86VR4, Q96AW0, Q9UE14, Q9UE15, Q9UE16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3