O60941 (DTNB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dystrobrevin beta
Short name=DTN-B

Alternative name(s):
Beta-dystrobrevin

Gene names

Name:

DTNB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	627 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with dystrophin short form DP71 and syntrophins SNTG1 and SNTG2. Binds dystrobrevin binding protein 1 By similarity. Ref.9
Subcellular location	Cytoplasm.
Tissue specificity	Highly expressed in brain, kidney and pancreas.
Domain	The coiled coil domain may mediate the interaction with dystrophin.
Sequence similarities	Belongs to the dystrophin family. Dystrobrevin subfamily. Contains 1 ZZ-type zinc finger.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell synapse Inferred from electronic annotation. Source: Compara
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: O60941-1)

Also known as: DTN-B1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O60941-2)

Also known as: Dystrophin-associated protein A0;

The sequence of this isoform differs from the canonical sequence as follows:
     360-390: RLQYSQDIPSHLADEHALIASYVARLQHCAR → S
     579-608: Missing.

Isoform 3 (identifier: O60941-3)

Also known as: DTN-B2;

The sequence of this isoform differs from the canonical sequence as follows:
     526-558: AQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPT → VSELRNFPPDSRSFARSSFPHINVSPLLPAHHL
     559-627: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 4 (identifier: O60941-4)

The sequence of this isoform differs from the canonical sequence as follows:
     579-608: Missing.

Isoform 5 (identifier: O60941-5)

The sequence of this isoform differs from the canonical sequence as follows:
     360-390: RLQYSQDIPSHLADEHALIASYVARLQHCAR → S
     519-525: Missing.
     579-608: Missing.

Isoform 6 (identifier: O60941-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.
     519-525: Missing.
     609-626: Missing.

Note: No experimental confirmation available.

Isoform 7 (identifier: O60941-7)

The sequence of this isoform differs from the canonical sequence as follows:
     609-626: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 627	627	Dystrobrevin beta		PRO_0000086878
Regions
	Zinc finger	237 – 284	48	ZZ-type
	Region	399 – 448	50	Syntrophin-binding region
	Coiled coil	428 – 529	102	Potential
Natural variations
	Alternative sequence	1 – 57	57	Missing in isoform 6.		VSP_045534
	Alternative sequence	360 – 390	31	RLQYS…QHCAR → S in isoform 2 and isoform 5.		VSP_004223
	Alternative sequence	519 – 525	7	Missing in isoform 5 and isoform 6.		VSP_043445
	Alternative sequence	526 – 558	33	AQATG…GSTPT → VSELRNFPPDSRSFARSSFP HINVSPLLPAHHL in isoform 3.		VSP_004224
	Alternative sequence	559 – 627	69	Missing in isoform 3.		VSP_004225
	Alternative sequence	579 – 608	30	Missing in isoform 2, isoform 4 and isoform 5.		VSP_004226
	Alternative sequence	609 – 626	18	Missing in isoform 6 and isoform 7.		VSP_045535
	Natural variant	97	1	P → H. Ref.7 Corresponds to variant rs17854576 [ dbSNP | Ensembl ].		VAR_069146
	Natural variant	116	1	I → T. Ref.7 Corresponds to variant rs17854577 [ dbSNP | Ensembl ].		VAR_069147
Experimental info
	Sequence conflict	102	1	I → T in BAH13469. Ref.4
	Sequence conflict	172	1	K → T in BAH13469. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (DTN-B1) [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 6927EC0BD86D375C	FASTA	627	71,356
	10 20 30 40 50 60 MIEESGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL HLVDIWNMIE 70 80 90 100 110 120 AFRDNGLNTL DHTTEISVSR LETVISSIYY QLNKRLPSTH QISVEQSISL LLNFMIAAYD 130 140 150 160 170 180 SEGRGKLTVF SVKAMLATMC GGKMLDKLRY VFSQMSDSNG LMIFSKFDQF LKEVLKLPTA 190 200 210 220 230 240 VFEGPSFGYT EHSVRTCFPQ QRKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP 250 260 270 280 290 300 VECSYCRCES MMGFRYRCQQ CHNYQLCQNC FWRGHAGGPH SNQHQMKEHS SWKSPAKKLS 310 320 330 340 350 360 HAISKSLGCV PTREPPHPVF PEQPEKPLDL AHIVPPRPLT NMNDTMVSHM SSGVPTPTKR 370 380 390 400 410 420 LQYSQDIPSH LADEHALIAS YVARLQHCAR VLDSPSRLDE EHRLIARYAA RLAAEAGNVT 430 440 450 460 470 480 RPPTDLSFNF DANKQQRQLI AELENKNREI LQEIQRLRLE HEQASQPTPE KAQQNPTLLA 490 500 510 520 530 540 ELRLLRQRKD ELEQRMSALQ ESRRELMVQL EELMKLLKEE EQKQAAQATG SPHTSPTHGG 550 560 570 580 590 600 GRPMPMPVRS TSAGSTPTHC PQDSLSGVGG DVQEAFAQGT RRNLRNDLLV AADSITNTMS 610 620 SLVKELHSAE EGAEEEEEKM QNGKDRG
	Isoform 2 (Dystrophin-associated protein A0) [UniParc]. Checksum: FCE6EA264E0288AC	FASTA	567	64,603
	10 20 30 40 50 60 MIEESGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL HLVDIWNMIE 70 80 90 100 110 120 AFRDNGLNTL DHTTEISVSR LETVISSIYY QLNKRLPSTH QISVEQSISL LLNFMIAAYD 130 140 150 160 170 180 SEGRGKLTVF SVKAMLATMC GGKMLDKLRY VFSQMSDSNG LMIFSKFDQF LKEVLKLPTA 190 200 210 220 230 240 VFEGPSFGYT EHSVRTCFPQ QRKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP 250 260 270 280 290 300 VECSYCRCES MMGFRYRCQQ CHNYQLCQNC FWRGHAGGPH SNQHQMKEHS SWKSPAKKLS 310 320 330 340 350 360 HAISKSLGCV PTREPPHPVF PEQPEKPLDL AHIVPPRPLT NMNDTMVSHM SSGVPTPTKS 370 380 390 400 410 420 VLDSPSRLDE EHRLIARYAA RLAAEAGNVT RPPTDLSFNF DANKQQRQLI AELENKNREI 430 440 450 460 470 480 LQEIQRLRLE HEQASQPTPE KAQQNPTLLA ELRLLRQRKD ELEQRMSALQ ESRRELMVQL 490 500 510 520 530 540 EELMKLLKEE EQKQAAQATG SPHTSPTHGG GRPMPMPVRS TSAGSTPTHC PQDSLSGVGG 550 560 DVQEAFAQAE EGAEEEEEKM QNGKDRG
	Isoform 3 (DTN-B2) [UniParc]. Checksum: 503AE1161728764C	FASTA	558	64,424
	10 20 30 40 50 60 MIEESGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL HLVDIWNMIE 70 80 90 100 110 120 AFRDNGLNTL DHTTEISVSR LETVISSIYY QLNKRLPSTH QISVEQSISL LLNFMIAAYD 130 140 150 160 170 180 SEGRGKLTVF SVKAMLATMC GGKMLDKLRY VFSQMSDSNG LMIFSKFDQF LKEVLKLPTA 190 200 210 220 230 240 VFEGPSFGYT EHSVRTCFPQ QRKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP 250 260 270 280 290 300 VECSYCRCES MMGFRYRCQQ CHNYQLCQNC FWRGHAGGPH SNQHQMKEHS SWKSPAKKLS 310 320 330 340 350 360 HAISKSLGCV PTREPPHPVF PEQPEKPLDL AHIVPPRPLT NMNDTMVSHM SSGVPTPTKR 370 380 390 400 410 420 LQYSQDIPSH LADEHALIAS YVARLQHCAR VLDSPSRLDE EHRLIARYAA RLAAEAGNVT 430 440 450 460 470 480 RPPTDLSFNF DANKQQRQLI AELENKNREI LQEIQRLRLE HEQASQPTPE KAQQNPTLLA 490 500 510 520 530 540 ELRLLRQRKD ELEQRMSALQ ESRRELMVQL EELMKLLKEE EQKQAVSELR NFPPDSRSFA 550 RSSFPHINVS PLLPAHHL
	Isoform 4 [UniParc]. Checksum: D6B8F6824D9ADA5E	FASTA	597	68,061
	10 20 30 40 50 60 MIEESGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL HLVDIWNMIE 70 80 90 100 110 120 AFRDNGLNTL DHTTEISVSR LETVISSIYY QLNKRLPSTH QISVEQSISL LLNFMIAAYD 130 140 150 160 170 180 SEGRGKLTVF SVKAMLATMC GGKMLDKLRY VFSQMSDSNG LMIFSKFDQF LKEVLKLPTA 190 200 210 220 230 240 VFEGPSFGYT EHSVRTCFPQ QRKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP 250 260 270 280 290 300 VECSYCRCES MMGFRYRCQQ CHNYQLCQNC FWRGHAGGPH SNQHQMKEHS SWKSPAKKLS 310 320 330 340 350 360 HAISKSLGCV PTREPPHPVF PEQPEKPLDL AHIVPPRPLT NMNDTMVSHM SSGVPTPTKR 370 380 390 400 410 420 LQYSQDIPSH LADEHALIAS YVARLQHCAR VLDSPSRLDE EHRLIARYAA RLAAEAGNVT 430 440 450 460 470 480 RPPTDLSFNF DANKQQRQLI AELENKNREI LQEIQRLRLE HEQASQPTPE KAQQNPTLLA 490 500 510 520 530 540 ELRLLRQRKD ELEQRMSALQ ESRRELMVQL EELMKLLKEE EQKQAAQATG SPHTSPTHGG 550 560 570 580 590 GRPMPMPVRS TSAGSTPTHC PQDSLSGVGG DVQEAFAQAE EGAEEEEEKM QNGKDRG
	Isoform 5 [UniParc]. Checksum: 7E690DC33BBC1CE2	FASTA	560	63,760
	10 20 30 40 50 60 MIEESGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL HLVDIWNMIE 70 80 90 100 110 120 AFRDNGLNTL DHTTEISVSR LETVISSIYY QLNKRLPSTH QISVEQSISL LLNFMIAAYD 130 140 150 160 170 180 SEGRGKLTVF SVKAMLATMC GGKMLDKLRY VFSQMSDSNG LMIFSKFDQF LKEVLKLPTA 190 200 210 220 230 240 VFEGPSFGYT EHSVRTCFPQ QRKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP 250 260 270 280 290 300 VECSYCRCES MMGFRYRCQQ CHNYQLCQNC FWRGHAGGPH SNQHQMKEHS SWKSPAKKLS 310 320 330 340 350 360 HAISKSLGCV PTREPPHPVF PEQPEKPLDL AHIVPPRPLT NMNDTMVSHM SSGVPTPTKS 370 380 390 400 410 420 VLDSPSRLDE EHRLIARYAA RLAAEAGNVT RPPTDLSFNF DANKQQRQLI AELENKNREI 430 440 450 460 470 480 LQEIQRLRLE HEQASQPTPE KAQQNPTLLA ELRLLRQRKD ELEQRMSALQ ESRRELMVQL 490 500 510 520 530 540 EELMKLLKAQ ATGSPHTSPT HGGGRPMPMP VRSTSAGSTP THCPQDSLSG VGGDVQEAFA 550 560 QAEEGAEEEE EKMQNGKDRG
	Isoform 6 [UniParc]. Checksum: E80E4844A6FE8689	FASTA	545	61,538
	10 20 30 40 50 60 MIEAFRDNGL NTLDHTTEIS VSRLETVISS IYYQLNKRLP STHQISVEQS ISLLLNFMIA 70 80 90 100 110 120 AYDSEGRGKL TVFSVKAMLA TMCGGKMLDK LRYVFSQMSD SNGLMIFSKF DQFLKEVLKL 130 140 150 160 170 180 PTAVFEGPSF GYTEHSVRTC FPQQRKIMLN MFLDTMMADP PPQCLVWLPL MHRLAHVENV 190 200 210 220 230 240 FHPVECSYCR CESMMGFRYR CQQCHNYQLC QNCFWRGHAG GPHSNQHQMK EHSSWKSPAK 250 260 270 280 290 300 KLSHAISKSL GCVPTREPPH PVFPEQPEKP LDLAHIVPPR PLTNMNDTMV SHMSSGVPTP 310 320 330 340 350 360 TKRLQYSQDI PSHLADEHAL IASYVARLQH CARVLDSPSR LDEEHRLIAR YAARLAAEAG 370 380 390 400 410 420 NVTRPPTDLS FNFDANKQQR QLIAELENKN REILQEIQRL RLEHEQASQP TPEKAQQNPT 430 440 450 460 470 480 LLAELRLLRQ RKDELEQRMS ALQESRRELM VQLEELMKLL KAQATGSPHT SPTHGGGRPM 490 500 510 520 530 540 PMPVRSTSAG STPTHCPQDS LSGVGGDVQE AFAQGTRRNL RNDLLVAADS ITNTMSSLVK ELHSG
	Isoform 7 [UniParc]. Checksum: F1FE02EF941A8F9D	FASTA	609	69,294
	10 20 30 40 50 60 MIEESGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL HLVDIWNMIE 70 80 90 100 110 120 AFRDNGLNTL DHTTEISVSR LETVISSIYY QLNKRLPSTH QISVEQSISL LLNFMIAAYD 130 140 150 160 170 180 SEGRGKLTVF SVKAMLATMC GGKMLDKLRY VFSQMSDSNG LMIFSKFDQF LKEVLKLPTA 190 200 210 220 230 240 VFEGPSFGYT EHSVRTCFPQ QRKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP 250 260 270 280 290 300 VECSYCRCES MMGFRYRCQQ CHNYQLCQNC FWRGHAGGPH SNQHQMKEHS SWKSPAKKLS 310 320 330 340 350 360 HAISKSLGCV PTREPPHPVF PEQPEKPLDL AHIVPPRPLT NMNDTMVSHM SSGVPTPTKR 370 380 390 400 410 420 LQYSQDIPSH LADEHALIAS YVARLQHCAR VLDSPSRLDE EHRLIARYAA RLAAEAGNVT 430 440 450 460 470 480 RPPTDLSFNF DANKQQRQLI AELENKNREI LQEIQRLRLE HEQASQPTPE KAQQNPTLLA 490 500 510 520 530 540 ELRLLRQRKD ELEQRMSALQ ESRRELMVQL EELMKLLKEE EQKQAAQATG SPHTSPTHGG 550 560 570 580 590 600 GRPMPMPVRS TSAGSTPTHC PQDSLSGVGG DVQEAFAQGT RRNLRNDLLV AADSITNTMS SLVKELHSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Beta-dystrobrevin, a new member of the dystrophin family. Identification, cloning, and protein associations." Peters M.F., O'Brien K.F., Sadoulet-Puccio H.M., Kunkel L.M., Adams M.E., Froehner S.C. J. Biol. Chem. 272:31561-31569(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Identification and characterization of a novel member of the dystrobrevin gene family." Puca A.A., Piluso V.N.G., Belsito A., Sampaolo S., Quaderi N., Rossi E., Di Iorio G., Ballabio A., Franco B. FEBS Lett. 425:7-13(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Skeletal muscle.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Synovium.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 7), VARIANTS HIS-97 AND THR-116. Tissue: Brain and Eye.
[8]	Yu W., Gibbs R.A. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 200-627 (ISOFORM 4). Tissue: Brain.
[9]	"Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells." Piluso G., Mirabella M., Ricci E., Belsito A., Abbondanza C., Servidei S., Puca A.A., Tonali P., Puca G.A., Nigro V. J. Biol. Chem. 275:15851-15860(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SNTG1 AND SNTG2.
[10]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF022728 mRNA. Translation: AAC05082.1. Y15722 mRNA. Translation: CAA75737.1. Y12712 mRNA. Translation: CAA73249.1. Y15718 mRNA. Translation: CAA75733.1. Y15719 mRNA. Translation: CAA75734.1. Y15720 mRNA. Translation: CAA75735.1. Y15721 mRNA. Translation: CAA75736.1. BT009805 mRNA. Translation: AAP88807.1. AK301386 mRNA. Translation: BAH13469.1. AC010150 Genomic DNA. No translation available. AC012074 Genomic DNA. No translation available. AC019144 Genomic DNA. No translation available. AC104699 Genomic DNA. No translation available. CH471053 Genomic DNA. Translation: EAX00719.1. CH471053 Genomic DNA. Translation: EAX00722.1. BC016655 mRNA. Translation: AAH16655.1. BC049366 mRNA. Translation: AAH49366.1. AF070567 mRNA. Translation: AAC28643.1.
IPI	IPI00219529. IPI00219530. IPI00299362. IPI00373897. IPI00941442. IPI01011160.
RefSeq	NP_001243232.1. NM_001256303.1. NP_001243233.1. NM_001256304.1. NP_001243237.1. NM_001256308.1. NP_068707.1. NM_021907.4. NP_149159.2. NM_033147.3. NP_149160.1. NM_033148.3. NP_899204.1. NM_183360.2. NP_899205.1. NM_183361.2.
UniGene	Hs.307720.
3D structure databases
ProteinModelPortal	O60941.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60941. 14 interactions.
MINT	MINT-109678.
STRING	9606.ENSP00000384084.
PTM databases
PhosphoSite	O60941.
Proteomic databases
PaxDb	O60941.
PRIDE	O60941.
Protocols and materials databases
DNASU	1838.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000404103; ENSP00000385482; ENSG00000138101. ENST00000405222; ENSP00000384787; ENSG00000138101. ENST00000406818; ENSP00000384084; ENSG00000138101. ENST00000407038; ENSP00000384767; ENSG00000138101. ENST00000407661; ENSP00000385193; ENSG00000138101. ENST00000496972; ENSP00000444463; ENSG00000138101.
GeneID	1838.
KEGG	hsa:1838.
UCSC	uc002rgh.3. human. uc002rgj.3. human. uc002rgk.3. human. uc002rgr.1. human.
Organism-specific databases
CTD	1838.
GeneCards	GC02M025600.
HGNC	HGNC:3058. DTNB.
MIM	602415. gene.
neXtProt	NX_O60941.
PharmGKB	PA27511.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG251970.
HOGENOM	HOG000230684.
HOVERGEN	HBG005539.
InParanoid	O60941.
OMA	PQELTHT.
OrthoDB	EOG40GCQ7.
Gene expression databases
ArrayExpress	O60941.
Bgee	O60941.
CleanEx	HS_DTNB.
Genevestigator	O60941.
GermOnline	ENSG00000138101. Homo sapiens.
Family and domain databases
Gene3D	1.10.238.10. 2 hits.
InterPro	IPR017432. Distrobrevin. IPR011992. EF-hand-like_dom. IPR015153. EF-hand_dom_typ1. IPR015154. EF-hand_dom_typ2. IPR000433. Znf_ZZ. [Graphical view]
Pfam	PF09068. efhand_1. 1 hit. PF09069. efhand_2. 1 hit. PF00569. ZZ. 1 hit. [Graphical view]
PIRSF	PIRSF038204. Distrobrevin. 1 hit.
SMART	SM00291. ZnF_ZZ. 1 hit. [Graphical view]
PROSITE	PS01357. ZF_ZZ_1. 1 hit. PS50135. ZF_ZZ_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DTNB. human.
GenomeRNAi	1838.
NextBio	7517.
SOURCE	Search...

Entry information

Entry name

DTNB_HUMAN

Accession

Primary (citable) accession number: O60941
Secondary accession number(s): B7Z733 , F5GZG4, G5E9F6, O43782, O60881, O75538, Q86VR4, Q96AW0, Q9UE14, Q9UE15, Q9UE16

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.