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O60927

- PP1RB_HUMAN

UniProt

O60927 - PP1RB_HUMAN

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Protein
Protein phosphatase 1 regulatory subunit 11
Gene
PPP1R11, HCGV, TCTE5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibitor of protein phosphatase 1.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein phosphatase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Protein phosphatase inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1 regulatory subunit 11
    Alternative name(s):
    Hemochromatosis candidate gene V protein
    Short name:
    HCG V
    Protein phosphatase inhibitor 3
    Gene namesi
    Name:PPP1R11
    Synonyms:HCGV, TCTE5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:9285. PPP1R11.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    Complete GO annotation...

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33614.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 126125Protein phosphatase 1 regulatory subunit 11
    PRO_0000239619Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei73 – 731Phosphoserine1 Publication
    Modified residuei74 – 741Phosphoserine1 Publication
    Modified residuei75 – 751Phosphothreonine1 Publication
    Modified residuei77 – 771Phosphoserine1 Publication
    Modified residuei109 – 1091Phosphothreonine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO60927.
    PaxDbiO60927.
    PeptideAtlasiO60927.
    PRIDEiO60927.

    PTM databases

    PhosphoSiteiO60927.

    Miscellaneous databases

    PMAP-CutDBiO60927.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiO60927.
    BgeeiO60927.
    CleanExiHS_PPP1R11.
    GenevestigatoriO60927.

    Organism-specific databases

    HPAiHPA043266.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PPP1CAP621392EBI-1048104,EBI-2008988From a different organism.

    Protein-protein interaction databases

    BioGridi112852. 4 interactions.
    IntActiO60927. 2 interactions.
    MINTiMINT-3000724.
    STRINGi9606.ENSP00000394056.

    Structurei

    3D structure databases

    DisProtiDP00219.
    ProteinModelPortaliO60927.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi105 – 12319Pro-rich
    Add
    BLAST

    Phylogenomic databases

    eggNOGiNOG77393.
    HOGENOMiHOG000232107.
    HOVERGENiHBG080560.
    InParanoidiO60927.
    KOiK17553.
    OMAiIYEKPRQ.
    PhylomeDBiO60927.
    TreeFamiTF352541.

    Family and domain databases

    InterProiIPR011107. PPI_Ypi1.
    [Graphical view]
    PANTHERiPTHR20835. PTHR20835. 1 hit.
    PfamiPF07491. PPI_Ypi1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O60927-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEAGAGLSE TVTETTVTVT TEPENRSLTI KLRKRKPEKK VEWTSDTVDN    50
    EHMGRRSSKC CCIYEKPRAF GESSTESDEE EEEGCGHTHC VRGHRKGRRR 100
    ATLGPTPTTP PQPPDPSQPP PGPMQH 126
    Length:126
    Mass (Da):13,953
    Last modified:August 1, 1998 - v1
    Checksum:iD6788A5AAC073549
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81003 mRNA. Translation: CAC16920.1.
    X89902 Genomic DNA. Translation: CAC16919.1.
    U53588 Genomic DNA. Translation: AAC52082.1.
    BA000025 Genomic DNA. Translation: BAB63334.1.
    AB088087 Genomic DNA. Translation: BAC54919.1.
    AB202082 Genomic DNA. Translation: BAE78601.1.
    AL669914 Genomic DNA. Translation: CAI18177.1.
    AL671859 Genomic DNA. Translation: CAI17578.1.
    AL845439 Genomic DNA. Translation: CAI18539.1.
    BC102010 mRNA. Translation: AAI02011.1.
    BC102011 mRNA. Translation: AAI02012.1.
    BC104750 mRNA. Translation: AAI04751.1.
    CCDSiCCDS4671.1.
    RefSeqiNP_068778.1. NM_021959.2.
    UniGeneiHs.82887.

    Genome annotation databases

    EnsembliENST00000376772; ENSP00000365963; ENSG00000204619.
    ENST00000383612; ENSP00000373107; ENSG00000206501.
    ENST00000431424; ENSP00000411038; ENSG00000236560.
    ENST00000431977; ENSP00000407981; ENSG00000237829.
    ENST00000436591; ENSP00000414808; ENSG00000234058.
    ENST00000437937; ENSP00000394056; ENSG00000233314.
    ENST00000448378; ENSP00000403557; ENSG00000237403.
    ENST00000452679; ENSP00000412297; ENSG00000227720.
    GeneIDi6992.
    KEGGihsa:6992.
    UCSCiuc003npb.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81003 mRNA. Translation: CAC16920.1 .
    X89902 Genomic DNA. Translation: CAC16919.1 .
    U53588 Genomic DNA. Translation: AAC52082.1 .
    BA000025 Genomic DNA. Translation: BAB63334.1 .
    AB088087 Genomic DNA. Translation: BAC54919.1 .
    AB202082 Genomic DNA. Translation: BAE78601.1 .
    AL669914 Genomic DNA. Translation: CAI18177.1 .
    AL671859 Genomic DNA. Translation: CAI17578.1 .
    AL845439 Genomic DNA. Translation: CAI18539.1 .
    BC102010 mRNA. Translation: AAI02011.1 .
    BC102011 mRNA. Translation: AAI02012.1 .
    BC104750 mRNA. Translation: AAI04751.1 .
    CCDSi CCDS4671.1.
    RefSeqi NP_068778.1. NM_021959.2.
    UniGenei Hs.82887.

    3D structure databases

    DisProti DP00219.
    ProteinModelPortali O60927.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 112852. 4 interactions.
    IntActi O60927. 2 interactions.
    MINTi MINT-3000724.
    STRINGi 9606.ENSP00000394056.

    PTM databases

    PhosphoSitei O60927.

    Proteomic databases

    MaxQBi O60927.
    PaxDbi O60927.
    PeptideAtlasi O60927.
    PRIDEi O60927.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376772 ; ENSP00000365963 ; ENSG00000204619 .
    ENST00000383612 ; ENSP00000373107 ; ENSG00000206501 .
    ENST00000431424 ; ENSP00000411038 ; ENSG00000236560 .
    ENST00000431977 ; ENSP00000407981 ; ENSG00000237829 .
    ENST00000436591 ; ENSP00000414808 ; ENSG00000234058 .
    ENST00000437937 ; ENSP00000394056 ; ENSG00000233314 .
    ENST00000448378 ; ENSP00000403557 ; ENSG00000237403 .
    ENST00000452679 ; ENSP00000412297 ; ENSG00000227720 .
    GeneIDi 6992.
    KEGGi hsa:6992.
    UCSCi uc003npb.3. human.

    Organism-specific databases

    CTDi 6992.
    GeneCardsi GC06P030047.
    GC06Pi29971.
    GC06Pj30024.
    GC06Pk30024.
    GC06Pl30029.
    GC06Pm30112.
    GC06Pn30024.
    GC06Po30024.
    HGNCi HGNC:9285. PPP1R11.
    HPAi HPA043266.
    MIMi 606670. gene.
    neXtProti NX_O60927.
    PharmGKBi PA33614.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG77393.
    HOGENOMi HOG000232107.
    HOVERGENi HBG080560.
    InParanoidi O60927.
    KOi K17553.
    OMAi IYEKPRQ.
    PhylomeDBi O60927.
    TreeFami TF352541.

    Miscellaneous databases

    ChiTaRSi PPP1R11. human.
    GeneWikii PPP1R11.
    GenomeRNAii 6992.
    NextBioi 27317.
    PMAP-CutDBi O60927.
    PROi O60927.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60927.
    Bgeei O60927.
    CleanExi HS_PPP1R11.
    Genevestigatori O60927.

    Family and domain databases

    InterProi IPR011107. PPI_Ypi1.
    [Graphical view ]
    PANTHERi PTHR20835. PTHR20835. 1 hit.
    Pfami PF07491. PPI_Ypi1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region."
      Giffon T., Lepourcelet M., Pichon L., Jezequel P., Bouric P., Carn G., Pontarotti P., Gall J.-Y., David V.
      Immunogenetics 44:331-339(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
      Tissue: Duodenal mucosa.
    2. "Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence."
      Lepourcelet M., Andrieux N., Giffon T., Pichon L., Hampe A., Galibert F., Mosser J.
      Genomics 37:316-326(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Shiina S., Tamiya G., Oka A., Inoko H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions."
      Shiina T., Ota M., Takasu M., Katsuyama Y., Hashimoto N., Tokunaga K., Inoko H.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Tissue: Peripheral blood leukocyte.
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1."
      Zhang J., Zhang L., Zhao S., Lee E.Y.C.
      Biochemistry 37:16728-16734(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-126, FUNCTION.
      Tissue: Brain.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-74; THR-75; SER-77 AND THR-109, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPP1RB_HUMAN
    AccessioniPrimary (citable) accession number: O60927
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: August 1, 1998
    Last modified: July 9, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3

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