O60927 (PP1RB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein phosphatase 1 regulatory subunit 11

Alternative name(s):
Hemochromatosis candidate gene V protein
Short name=HCG V
Protein phosphatase inhibitor 3

Gene names

Name:	PPP1R11
Synonyms:	HCGV, TCTE5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	126 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibitor of protein phosphatase 1. Ref.7
Tissue specificity	Widely expressed. Ref.1

Ontologies

Keywords
Molecular function	Protein phosphatase inhibitor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	protein phosphatase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 126	126	Protein phosphatase 1 regulatory subunit 11		PRO_0000239619
Regions
	Compositional bias	105 – 123	19	Pro-rich
Amino acid modifications
	Modified residue	73	1	Phosphoserine Ref.8
	Modified residue	74	1	Phosphoserine Ref.8
	Modified residue	75	1	Phosphothreonine Ref.8
	Modified residue	77	1	Phosphoserine Ref.8
	Modified residue	109	1	Phosphothreonine Ref.8

Sequences

	Sequence		Length	Mass (Da)
	O60927 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: D6788A5AAC073549	FASTA	126	13,953
	10 20 30 40 50 60 MAEAGAGLSE TVTETTVTVT TEPENRSLTI KLRKRKPEKK VEWTSDTVDN EHMGRRSSKC 70 80 90 100 110 120 CCIYEKPRAF GESSTESDEE EEEGCGHTHC VRGHRKGRRR ATLGPTPTTP PQPPDPSQPP PGPMQH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region." Giffon T., Lepourcelet M., Pichon L., Jezequel P., Bouric P., Carn G., Pontarotti P., Gall J.-Y., David V. Immunogenetics 44:331-339(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY. Tissue: Duodenal mucosa.
[2]	"Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence." Lepourcelet M., Andrieux N., Giffon T., Pichon L., Hampe A., Galibert F., Mosser J. Genomics 37:316-326(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Shiina S., Tamiya G., Oka A., Inoko H. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions." Shiina T., Ota M., Takasu M., Katsuyama Y., Hashimoto N., Tokunaga K., Inoko H. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Tissue: Peripheral blood leukocyte.
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1." Zhang J., Zhang L., Zhao S., Lee E.Y.C. Biochemistry 37:16728-16734(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-126, FUNCTION. Tissue: Brain.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-74; THR-75; SER-77 AND THR-109, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X81003 mRNA. Translation: CAC16920.1. X89902 Genomic DNA. Translation: CAC16919.1. U53588 Genomic DNA. Translation: AAC52082.1. BA000025 Genomic DNA. Translation: BAB63334.1. AB088087 Genomic DNA. Translation: BAC54919.1. AB202082 Genomic DNA. Translation: BAE78601.1. AL669914 Genomic DNA. Translation: CAI18177.1. AL671859 Genomic DNA. Translation: CAI17578.1. AL845439 Genomic DNA. Translation: CAI18539.1. BC102010 mRNA. Translation: AAI02011.1. BC102011 mRNA. Translation: AAI02012.1. BC104750 mRNA. Translation: AAI04751.1.
IPI	IPI00030355.
RefSeq	NP_068778.1. NM_021959.2.
UniGene	Hs.82887.
3D structure databases
DisProt	DP00219.
ProteinModelPortal	O60927.
ModBase	Search...
PTM databases
PhosphoSite	O60927.
Proteomic databases
PaxDb	O60927.
PeptideAtlas	O60927.
PRIDE	O60927.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376772; ENSP00000365963; ENSG00000204619. ENST00000383612; ENSP00000373107; ENSG00000206501. ENST00000431424; ENSP00000411038; ENSG00000236560. ENST00000431977; ENSP00000407981; ENSG00000237829. ENST00000436591; ENSP00000414808; ENSG00000234058. ENST00000437937; ENSP00000394056; ENSG00000233314. ENST00000448378; ENSP00000403557; ENSG00000237403. ENST00000452679; ENSP00000412297; ENSG00000227720.
GeneID	6992.
KEGG	hsa:6992.
UCSC	uc003npb.3. human.
Organism-specific databases
CTD	6992.
GeneCards	GC06P030038.
HGNC	HGNC:9285. PPP1R11.
HPA	HPA043266.
MIM	606670. gene.
neXtProt	NX_O60927.
PharmGKB	PA33614.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG77393.
HOGENOM	HOG000232107.
HOVERGEN	HBG080560.
InParanoid	O60927.
OMA	CGSAHCI.
OrthoDB	EOG4VT5ZT.
PhylomeDB	O60927.
Gene expression databases
ArrayExpress	O60927.
Bgee	O60927.
CleanEx	HS_PPP1R11.
Genevestigator	O60927.
GermOnline	ENSG00000204619. Homo sapiens.
Family and domain databases
InterPro	IPR011107. PPI_Ypi1. [Graphical view]
PANTHER	PTHR20835. PTHR20835. 1 hit.
Pfam	PF07491. PPI_Ypi1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PPP1R11. human.
GenomeRNAi	6992.
NextBio	27317.
PMAP-CutDB	O60927.
SOURCE	Search...

Entry information

Entry name

PP1RB_HUMAN

Accession

Primary (citable) accession number: O60927

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	August 1, 1998
Last modified:	April 3, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.