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O60927 (PP1RB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 1 regulatory subunit 11
Alternative name(s):
Hemochromatosis candidate gene V protein
Short name=HCG V
Protein phosphatase inhibitor 3
Gene names
Name:PPP1R11
Synonyms:HCGV, TCTE5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length126 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibitor of protein phosphatase 1. Ref.7

Tissue specificity

Widely expressed. Ref.1

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PPP1CAP621392EBI-1048104,EBI-2008988From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.10
Chain2 – 126125Protein phosphatase 1 regulatory subunit 11
PRO_0000239619

Regions

Compositional bias105 – 12319Pro-rich

Amino acid modifications

Modified residue21N-acetylalanine Ref.10
Modified residue731Phosphoserine Ref.8
Modified residue741Phosphoserine Ref.8
Modified residue751Phosphothreonine Ref.8
Modified residue771Phosphoserine Ref.8
Modified residue1091Phosphothreonine Ref.8

Sequences

Sequence LengthMass (Da)Tools
O60927 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: D6788A5AAC073549

FASTA12613,953
        10         20         30         40         50         60 
MAEAGAGLSE TVTETTVTVT TEPENRSLTI KLRKRKPEKK VEWTSDTVDN EHMGRRSSKC 

        70         80         90        100        110        120 
CCIYEKPRAF GESSTESDEE EEEGCGHTHC VRGHRKGRRR ATLGPTPTTP PQPPDPSQPP 


PGPMQH 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region."
Giffon T., Lepourcelet M., Pichon L., Jezequel P., Bouric P., Carn G., Pontarotti P., Gall J.-Y., David V.
Immunogenetics 44:331-339(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
Tissue: Duodenal mucosa.
[2]"Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence."
Lepourcelet M., Andrieux N., Giffon T., Pichon L., Hampe A., Galibert F., Mosser J.
Genomics 37:316-326(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
Shiina S., Tamiya G., Oka A., Inoko H.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions."
Shiina T., Ota M., Takasu M., Katsuyama Y., Hashimoto N., Tokunaga K., Inoko H.
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Tissue: Peripheral blood leukocyte.
[5]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]"Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1."
Zhang J., Zhang L., Zhao S., Lee E.Y.C.
Biochemistry 37:16728-16734(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-126, FUNCTION.
Tissue: Brain.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-74; THR-75; SER-77 AND THR-109, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X81003 mRNA. Translation: CAC16920.1.
X89902 Genomic DNA. Translation: CAC16919.1.
U53588 Genomic DNA. Translation: AAC52082.1.
BA000025 Genomic DNA. Translation: BAB63334.1.
AB088087 Genomic DNA. Translation: BAC54919.1.
AB202082 Genomic DNA. Translation: BAE78601.1.
AL669914 Genomic DNA. Translation: CAI18177.1.
AL671859 Genomic DNA. Translation: CAI17578.1.
AL845439 Genomic DNA. Translation: CAI18539.1.
BC102010 mRNA. Translation: AAI02011.1.
BC102011 mRNA. Translation: AAI02012.1.
BC104750 mRNA. Translation: AAI04751.1.
CCDSCCDS4671.1.
RefSeqNP_068778.1. NM_021959.2.
UniGeneHs.82887.

3D structure databases

DisProtDP00219.
ProteinModelPortalO60927.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112852. 4 interactions.
IntActO60927. 2 interactions.
MINTMINT-3000724.
STRING9606.ENSP00000394056.

PTM databases

PhosphoSiteO60927.

Proteomic databases

MaxQBO60927.
PaxDbO60927.
PeptideAtlasO60927.
PRIDEO60927.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376772; ENSP00000365963; ENSG00000204619.
ENST00000383612; ENSP00000373107; ENSG00000206501.
ENST00000431424; ENSP00000411038; ENSG00000236560.
ENST00000431977; ENSP00000407981; ENSG00000237829.
ENST00000436591; ENSP00000414808; ENSG00000234058.
ENST00000437937; ENSP00000394056; ENSG00000233314.
ENST00000448378; ENSP00000403557; ENSG00000237403.
ENST00000452679; ENSP00000412297; ENSG00000227720.
GeneID6992.
KEGGhsa:6992.
UCSCuc003npb.3. human.

Organism-specific databases

CTD6992.
GeneCardsGC06P030047.
GC06Pi29971.
GC06Pj30024.
GC06Pk30024.
GC06Pl30029.
GC06Pm30112.
GC06Pn30024.
GC06Po30024.
HGNCHGNC:9285. PPP1R11.
HPAHPA043266.
MIM606670. gene.
neXtProtNX_O60927.
PharmGKBPA33614.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG77393.
HOGENOMHOG000232107.
HOVERGENHBG080560.
InParanoidO60927.
KOK17553.
OMAIYEKPRQ.
PhylomeDBO60927.
TreeFamTF352541.

Gene expression databases

ArrayExpressO60927.
BgeeO60927.
CleanExHS_PPP1R11.
GenevestigatorO60927.

Family and domain databases

InterProIPR011107. PPI_Ypi1.
[Graphical view]
PANTHERPTHR20835. PTHR20835. 1 hit.
PfamPF07491. PPI_Ypi1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPPP1R11. human.
GeneWikiPPP1R11.
GenomeRNAi6992.
NextBio27317.
PMAP-CutDBO60927.
PROO60927.
SOURCESearch...

Entry information

Entry namePP1RB_HUMAN
AccessionPrimary (citable) accession number: O60927
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM