Reviewed, UniProtKB/Swiss-Prot O60927 (PP1RB_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein phosphatase 1 regulatory subunit 11
Alternative name(s):
    Protein phosphatase inhibitor 3
    Hemochromatosis candidate protein V
    HCG V
    HCG-V

Gene names

Name:	PPP1R11
Synonyms:	HCGV, TCTE5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	126 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Inhibitor of protein phosphatase 1. Ref.7
Tissue specificity	Widely expressed. Ref.1

Ontologies

Keywords
Molecular function	Protein phosphatase inhibitor
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	soluble fraction Ref.7 Traceable author statement. Source: ProtInc
Molecular function	phosphoprotein phosphatase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PPP1CB	P62140	1	EBI-1048104,EBI-352350

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 126	126	Protein phosphatase 1 regulatory subunit 11		PRO_0000239619
Regions
	Compositional bias	105 – 123	19	Pro-rich
Amino acid modifications
	Modified residue	64	1	Phosphotyrosine Ref.8
	Modified residue	73	1	Phosphoserine Ref.9 Ref.10
	Modified residue	74	1	Phosphoserine Ref.9 Ref.10
	Modified residue	75	1	Phosphothreonine Ref.9 Ref.10
	Modified residue	77	1	Phosphoserine Ref.9 Ref.10
	Modified residue	109	1	Phosphothreonine Ref.10

Sequences

	Sequence		Length	Mass (Da)
	O60927-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: D6788A5AAC073549	FASTA	126	13,953
	10 20 30 40 50 60 MAEAGAGLSE TVTETTVTVT TEPENRSLTI KLRKRKPEKK VEWTSDTVDN EHMGRRSSKC 70 80 90 100 110 120 CCIYEKPRAF GESSTESDEE EEEGCGHTHC VRGHRKGRRR ATLGPTPTTP PQPPDPSQPP PGPMQH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region." Giffon T., Lepourcelet M., Pichon L., Jezequel P., Bouric P., Carn G., Pontarotti P., Gall J.-Y., David V. Immunogenetics 44:331-339(1996) [PubMed: 8781118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY. Tissue: Duodenal mucosa.
[2]	"Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence." Lepourcelet M., Andrieux N., Giffon T., Pichon L., Hampe A., Galibert F., Mosser J. Genomics 37:316-326(1996) [PubMed: 8938444] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Shiina S., Tamiya G., Oka A., Inoko H. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions." Shiina T., Ota M., Takasu M., Katsuyama Y., Hashimoto N., Tokunaga K., Inoko H. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Tissue: Peripheral blood leukocyte.
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1." Zhang J., Zhang L., Zhao S., Lee E.Y.C. Biochemistry 37:16728-16734(1998) [PubMed: 9843442] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-126, FUNCTION. Tissue: Brain.
[8]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-64, MASS SPECTROMETRY.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-74; THR-75 AND SER-77, MASS SPECTROMETRY. Tissue: Epithelium.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-74; THR-75; SER-77 AND THR-109, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X81003 mRNA. Translation: CAC16920.1. X89902 Genomic DNA. Translation: CAC16919.1. U53588 Genomic DNA. Translation: AAC52082.1. BA000025 Genomic DNA. Translation: BAB63334.1. AB088087 Genomic DNA. Translation: BAC54919.1. AB202082 Genomic DNA. Translation: BAE78601.1. AL669914 Genomic DNA. Translation: CAI18177.1. AL671859 Genomic DNA. Translation: CAI17578.1. AL845439 Genomic DNA. Translation: CAI18539.1. BC102010 mRNA. Translation: AAI02011.1. BC102011 mRNA. Translation: AAI02012.1. BC104750 mRNA. Translation: AAI04751.1.
IPI	IPI00030355.
RefSeq	NP_068778.1.
UniGene	Hs.82887
3D structure databases
DisProt	DP00219.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60927. 1 interaction.
PTM databases
PhosphoSite	O60927.
Proteomic databases
PeptideAtlas	O60927.
PRIDE	O60927.
Genome annotation databases
Ensembl	ENSG00000112498. Homo sapiens. [Contig view] ENSG00000204619. Homo sapiens. [Contig view] ENSG00000206501. Homo sapiens. [Contig view]
GeneID	6992.
KEGG	hsa:6992.
Organism-specific databases
GeneCards	GC06P030142.
H-InvDB	HIX0029604. HIX0058266.
HGNC	HGNC:9285. PPP1R11.
MIM	606670. gene.
PharmGKB	PA33614.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O60927.
HOVERGEN	O60927.
OMA	O60927. EKKVEWS.
Gene expression databases
ArrayExpress	O60927.
Bgee	O60927.
CleanEx	HS_PPP1R11.
GermOnline	ENSG00000204619. Homo sapiens.
Family and domain databases
InterPro	IPR011107. PPI_Ypi1. [Graphical view]
PANTHER	PTHR20835. PPI_Ypi1. 1 hit.
Pfam	PF07491. PPI_Ypi1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	27317.
PMAP-CutDB	O60927.
SOURCE	Search...

Entry information

Entry name

PP1RB_HUMAN

Accession

Primary (citable) accession number: O60927

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	August 1, 1998
Last modified:	June 16, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)