Reviewed,
UniProtKB/Swiss-Prot O60927 (PP1RB_HUMAN)
Last modified
June 16, 2009.
Version 63.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Protein phosphatase 1 regulatory subunit 11 Alternative name(s): Protein phosphatase inhibitor 3 Hemochromatosis candidate protein V HCG V HCG-V | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 126 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
Ontologies
| Keywords | |
|---|---|
| Molecular function | Protein phosphatase inhibitor |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Cellular component | soluble fraction Ref.7 Traceable author statement. Source: ProtInc |
| Molecular function | phosphoprotein phosphatase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 126 | 126 | Protein phosphatase 1 regulatory subunit 11 | PRO_0000239619 | |||||
Regions | |||||||||
| Compositional bias | 105 – 123 | 19 | Pro-rich | ||||||
Amino acid modifications | |||||||||
| Modified residue | 64 | 1 | Phosphotyrosine Ref.8 | ||||||
| Modified residue | 73 | 1 | Phosphoserine Ref.9 Ref.10 | ||||||
| Modified residue | 74 | 1 | Phosphoserine Ref.9 Ref.10 | ||||||
| Modified residue | 75 | 1 | Phosphothreonine Ref.9 Ref.10 | ||||||
| Modified residue | 77 | 1 | Phosphoserine Ref.9 Ref.10 | ||||||
| Modified residue | 109 | 1 | Phosphothreonine Ref.10 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region." Giffon T., Lepourcelet M., Pichon L., Jezequel P., Bouric P., Carn G., Pontarotti P., Gall J.-Y., David V. Immunogenetics 44:331-339(1996) [PubMed: 8781118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY. Tissue: Duodenal mucosa. |
| [2] | "Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence." Lepourcelet M., Andrieux N., Giffon T., Pichon L., Hampe A., Galibert F., Mosser J. Genomics 37:316-326(1996) [PubMed: 8938444] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Shiina S., Tamiya G., Oka A., Inoko H. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions." Shiina T., Ota M., Takasu M., Katsuyama Y., Hashimoto N., Tokunaga K., Inoko H. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Tissue: Peripheral blood leukocyte. |
| [5] | "The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. Beck S.Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [7] | "Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1." Zhang J., Zhang L., Zhao S., Lee E.Y.C. Biochemistry 37:16728-16734(1998) [PubMed: 9843442] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-126, FUNCTION. Tissue: Brain. |
| [8] | "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-64, MASS SPECTROMETRY. |
| [9] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-74; THR-75 AND SER-77, MASS SPECTROMETRY. Tissue: Epithelium. |
| [10] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-74; THR-75; SER-77 AND THR-109, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X81003 mRNA. Translation: CAC16920.1. X89902 Genomic DNA. Translation: CAC16919.1. U53588 Genomic DNA. Translation: AAC52082.1. BA000025 Genomic DNA. Translation: BAB63334.1. AB088087 Genomic DNA. Translation: BAC54919.1. AB202082 Genomic DNA. Translation: BAE78601.1. AL669914 Genomic DNA. Translation: CAI18177.1. AL671859 Genomic DNA. Translation: CAI17578.1. AL845439 Genomic DNA. Translation: CAI18539.1. BC102010 mRNA. Translation: AAI02011.1. BC102011 mRNA. Translation: AAI02012.1. BC104750 mRNA. Translation: AAI04751.1. | |
| IPI | IPI00030355. |
| RefSeq | NP_068778.1. |
| UniGene | Hs.82887 |
3D structure databases | |
| DisProt | DP00219. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O60927. 1 interaction. |
PTM databases | |
| PhosphoSite | O60927. |
Proteomic databases | |
| PeptideAtlas | O60927. |
| PRIDE | O60927. |
Genome annotation databases | |
| Ensembl | ENSG00000112498. Homo sapiens. [Contig view] ENSG00000204619. Homo sapiens. [Contig view] ENSG00000206501. Homo sapiens. [Contig view] |
| GeneID | 6992. |
| KEGG | hsa:6992. |
Organism-specific databases | |
| GeneCards | GC06P030142. |
| H-InvDB | HIX0029604. HIX0058266. |
| HGNC | HGNC:9285. PPP1R11. |
| MIM | 606670. gene. |
| PharmGKB | PA33614. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | O60927. |
| HOVERGEN | O60927. |
| OMA | O60927. EKKVEWS. |
Gene expression databases | |
| ArrayExpress | O60927. |
| Bgee | O60927. |
| CleanEx | HS_PPP1R11. |
| GermOnline | ENSG00000204619. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR011107. PPI_Ypi1. [Graphical view] |
| PANTHER | PTHR20835. PPI_Ypi1. 1 hit. |
| Pfam | PF07491. PPI_Ypi1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 27317. |
| PMAP-CutDB | O60927. |
| SOURCE | Search... |
Entry information
| Entry name | PP1RB_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O60927 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 6 Human chromosome 6: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |

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