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Protein

Protein phosphatase 1 regulatory subunit 11

Gene

PPP1R11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of protein phosphatase 1.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 11
Alternative name(s):
Hemochromatosis candidate gene V protein
Short name:
HCG V
Protein phosphatase inhibitor 3
Gene namesi
Name:PPP1R11
Synonyms:HCGV, TCTE5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:9285. PPP1R11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33614.

Polymorphism and mutation databases

BioMutaiPPP1R11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 126125Protein phosphatase 1 regulatory subunit 11PRO_0000239619Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei73 – 731PhosphoserineCombined sources
Modified residuei74 – 741PhosphoserineCombined sources
Modified residuei75 – 751PhosphothreonineCombined sources
Modified residuei77 – 771PhosphoserineCombined sources
Modified residuei109 – 1091PhosphothreonineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60927.
MaxQBiO60927.
PaxDbiO60927.
PeptideAtlasiO60927.
PRIDEiO60927.
TopDownProteomicsiO60927.

PTM databases

iPTMnetiO60927.
PhosphoSiteiO60927.

Miscellaneous databases

PMAP-CutDBO60927.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000204619.
CleanExiHS_PPP1R11.
ExpressionAtlasiO60927. baseline and differential.
GenevisibleiO60927. HS.

Organism-specific databases

HPAiHPA043266.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621392EBI-1048104,EBI-2008988From a different organism.

Protein-protein interaction databases

BioGridi112852. 13 interactions.
IntActiO60927. 4 interactions.
MINTiMINT-3000724.
STRINGi9606.ENSP00000365963.

Structurei

3D structure databases

DisProtiDP00219.
ProteinModelPortaliO60927.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi105 – 12319Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiKOG4102. Eukaryota.
ENOG41126IN. LUCA.
GeneTreeiENSGT00390000001153.
HOGENOMiHOG000232107.
HOVERGENiHBG080560.
InParanoidiO60927.
KOiK17553.
OMAiYEKPRQF.
OrthoDBiEOG091G152U.
PhylomeDBiO60927.
TreeFamiTF352541.

Family and domain databases

InterProiIPR011107. PPI_Ypi1.
[Graphical view]
PANTHERiPTHR20835. PTHR20835. 1 hit.
PfamiPF07491. PPI_Ypi1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAGAGLSE TVTETTVTVT TEPENRSLTI KLRKRKPEKK VEWTSDTVDN
60 70 80 90 100
EHMGRRSSKC CCIYEKPRAF GESSTESDEE EEEGCGHTHC VRGHRKGRRR
110 120
ATLGPTPTTP PQPPDPSQPP PGPMQH
Length:126
Mass (Da):13,953
Last modified:August 1, 1998 - v1
Checksum:iD6788A5AAC073549
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81003 mRNA. Translation: CAC16920.1.
X89902 Genomic DNA. Translation: CAC16919.1.
U53588 Genomic DNA. Translation: AAC52082.1.
BA000025 Genomic DNA. Translation: BAB63334.1.
AB088087 Genomic DNA. Translation: BAC54919.1.
AB202082 Genomic DNA. Translation: BAE78601.1.
AL669914 Genomic DNA. Translation: CAI18177.1.
AL671859 Genomic DNA. Translation: CAI17578.1.
AL845439 Genomic DNA. Translation: CAI18539.1.
BC102010 mRNA. Translation: AAI02011.1.
BC102011 mRNA. Translation: AAI02012.1.
BC104750 mRNA. Translation: AAI04751.1.
CCDSiCCDS4671.1.
RefSeqiNP_068778.1. NM_021959.2.
UniGeneiHs.82887.

Genome annotation databases

EnsembliENST00000376772; ENSP00000365963; ENSG00000204619.
ENST00000383612; ENSP00000373107; ENSG00000206501.
ENST00000431424; ENSP00000411038; ENSG00000236560.
ENST00000431977; ENSP00000407981; ENSG00000237829.
ENST00000436591; ENSP00000414808; ENSG00000234058.
ENST00000437937; ENSP00000394056; ENSG00000233314.
ENST00000448378; ENSP00000403557; ENSG00000237403.
ENST00000452679; ENSP00000412297; ENSG00000227720.
GeneIDi6992.
KEGGihsa:6992.
UCSCiuc003npb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81003 mRNA. Translation: CAC16920.1.
X89902 Genomic DNA. Translation: CAC16919.1.
U53588 Genomic DNA. Translation: AAC52082.1.
BA000025 Genomic DNA. Translation: BAB63334.1.
AB088087 Genomic DNA. Translation: BAC54919.1.
AB202082 Genomic DNA. Translation: BAE78601.1.
AL669914 Genomic DNA. Translation: CAI18177.1.
AL671859 Genomic DNA. Translation: CAI17578.1.
AL845439 Genomic DNA. Translation: CAI18539.1.
BC102010 mRNA. Translation: AAI02011.1.
BC102011 mRNA. Translation: AAI02012.1.
BC104750 mRNA. Translation: AAI04751.1.
CCDSiCCDS4671.1.
RefSeqiNP_068778.1. NM_021959.2.
UniGeneiHs.82887.

3D structure databases

DisProtiDP00219.
ProteinModelPortaliO60927.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112852. 13 interactions.
IntActiO60927. 4 interactions.
MINTiMINT-3000724.
STRINGi9606.ENSP00000365963.

PTM databases

iPTMnetiO60927.
PhosphoSiteiO60927.

Polymorphism and mutation databases

BioMutaiPPP1R11.

Proteomic databases

EPDiO60927.
MaxQBiO60927.
PaxDbiO60927.
PeptideAtlasiO60927.
PRIDEiO60927.
TopDownProteomicsiO60927.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376772; ENSP00000365963; ENSG00000204619.
ENST00000383612; ENSP00000373107; ENSG00000206501.
ENST00000431424; ENSP00000411038; ENSG00000236560.
ENST00000431977; ENSP00000407981; ENSG00000237829.
ENST00000436591; ENSP00000414808; ENSG00000234058.
ENST00000437937; ENSP00000394056; ENSG00000233314.
ENST00000448378; ENSP00000403557; ENSG00000237403.
ENST00000452679; ENSP00000412297; ENSG00000227720.
GeneIDi6992.
KEGGihsa:6992.
UCSCiuc003npb.4. human.

Organism-specific databases

CTDi6992.
GeneCardsiPPP1R11.
HGNCiHGNC:9285. PPP1R11.
HPAiHPA043266.
MIMi606670. gene.
neXtProtiNX_O60927.
PharmGKBiPA33614.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4102. Eukaryota.
ENOG41126IN. LUCA.
GeneTreeiENSGT00390000001153.
HOGENOMiHOG000232107.
HOVERGENiHBG080560.
InParanoidiO60927.
KOiK17553.
OMAiYEKPRQF.
OrthoDBiEOG091G152U.
PhylomeDBiO60927.
TreeFamiTF352541.

Miscellaneous databases

ChiTaRSiPPP1R11. human.
GeneWikiiPPP1R11.
GenomeRNAii6992.
PMAP-CutDBO60927.
PROiO60927.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204619.
CleanExiHS_PPP1R11.
ExpressionAtlasiO60927. baseline and differential.
GenevisibleiO60927. HS.

Family and domain databases

InterProiIPR011107. PPI_Ypi1.
[Graphical view]
PANTHERiPTHR20835. PTHR20835. 1 hit.
PfamiPF07491. PPI_Ypi1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP1RB_HUMAN
AccessioniPrimary (citable) accession number: O60927
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.