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O60927

- PP1RB_HUMAN

UniProt

O60927 - PP1RB_HUMAN

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Protein

Protein phosphatase 1 regulatory subunit 11

Gene

PPP1R11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Inhibitor of protein phosphatase 1.1 Publication

GO - Molecular functioni

  1. protein phosphatase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 11
Alternative name(s):
Hemochromatosis candidate gene V protein
Short name:
HCG V
Protein phosphatase inhibitor 3
Gene namesi
Name:PPP1R11
Synonyms:HCGV, TCTE5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:9285. PPP1R11.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33614.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 126125Protein phosphatase 1 regulatory subunit 11PRO_0000239619Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei73 – 731Phosphoserine1 Publication
Modified residuei74 – 741Phosphoserine1 Publication
Modified residuei75 – 751Phosphothreonine1 Publication
Modified residuei77 – 771Phosphoserine1 Publication
Modified residuei109 – 1091Phosphothreonine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO60927.
PaxDbiO60927.
PeptideAtlasiO60927.
PRIDEiO60927.

PTM databases

PhosphoSiteiO60927.

Miscellaneous databases

PMAP-CutDBO60927.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiO60927.
CleanExiHS_PPP1R11.
ExpressionAtlasiO60927. baseline and differential.
GenevestigatoriO60927.

Organism-specific databases

HPAiHPA043266.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621392EBI-1048104,EBI-2008988From a different organism.

Protein-protein interaction databases

BioGridi112852. 8 interactions.
IntActiO60927. 2 interactions.
MINTiMINT-3000724.
STRINGi9606.ENSP00000394056.

Structurei

3D structure databases

DisProtiDP00219.
ProteinModelPortaliO60927.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi105 – 12319Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG77393.
GeneTreeiENSGT00390000001153.
HOGENOMiHOG000232107.
HOVERGENiHBG080560.
InParanoidiO60927.
KOiK17553.
OMAiIYEKPRQ.
PhylomeDBiO60927.
TreeFamiTF352541.

Family and domain databases

InterProiIPR011107. PPI_Ypi1.
[Graphical view]
PANTHERiPTHR20835. PTHR20835. 1 hit.
PfamiPF07491. PPI_Ypi1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60927-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEAGAGLSE TVTETTVTVT TEPENRSLTI KLRKRKPEKK VEWTSDTVDN
60 70 80 90 100
EHMGRRSSKC CCIYEKPRAF GESSTESDEE EEEGCGHTHC VRGHRKGRRR
110 120
ATLGPTPTTP PQPPDPSQPP PGPMQH
Length:126
Mass (Da):13,953
Last modified:August 1, 1998 - v1
Checksum:iD6788A5AAC073549
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81003 mRNA. Translation: CAC16920.1.
X89902 Genomic DNA. Translation: CAC16919.1.
U53588 Genomic DNA. Translation: AAC52082.1.
BA000025 Genomic DNA. Translation: BAB63334.1.
AB088087 Genomic DNA. Translation: BAC54919.1.
AB202082 Genomic DNA. Translation: BAE78601.1.
AL669914 Genomic DNA. Translation: CAI18177.1.
AL671859 Genomic DNA. Translation: CAI17578.1.
AL845439 Genomic DNA. Translation: CAI18539.1.
BC102010 mRNA. Translation: AAI02011.1.
BC102011 mRNA. Translation: AAI02012.1.
BC104750 mRNA. Translation: AAI04751.1.
CCDSiCCDS4671.1.
RefSeqiNP_068778.1. NM_021959.2.
UniGeneiHs.82887.

Genome annotation databases

EnsembliENST00000376772; ENSP00000365963; ENSG00000204619.
ENST00000383612; ENSP00000373107; ENSG00000206501.
ENST00000431424; ENSP00000411038; ENSG00000236560.
ENST00000431977; ENSP00000407981; ENSG00000237829.
ENST00000436591; ENSP00000414808; ENSG00000234058.
ENST00000437937; ENSP00000394056; ENSG00000233314.
ENST00000448378; ENSP00000403557; ENSG00000237403.
ENST00000452679; ENSP00000412297; ENSG00000227720.
GeneIDi6992.
KEGGihsa:6992.
UCSCiuc003npb.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81003 mRNA. Translation: CAC16920.1 .
X89902 Genomic DNA. Translation: CAC16919.1 .
U53588 Genomic DNA. Translation: AAC52082.1 .
BA000025 Genomic DNA. Translation: BAB63334.1 .
AB088087 Genomic DNA. Translation: BAC54919.1 .
AB202082 Genomic DNA. Translation: BAE78601.1 .
AL669914 Genomic DNA. Translation: CAI18177.1 .
AL671859 Genomic DNA. Translation: CAI17578.1 .
AL845439 Genomic DNA. Translation: CAI18539.1 .
BC102010 mRNA. Translation: AAI02011.1 .
BC102011 mRNA. Translation: AAI02012.1 .
BC104750 mRNA. Translation: AAI04751.1 .
CCDSi CCDS4671.1.
RefSeqi NP_068778.1. NM_021959.2.
UniGenei Hs.82887.

3D structure databases

DisProti DP00219.
ProteinModelPortali O60927.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112852. 8 interactions.
IntActi O60927. 2 interactions.
MINTi MINT-3000724.
STRINGi 9606.ENSP00000394056.

PTM databases

PhosphoSitei O60927.

Proteomic databases

MaxQBi O60927.
PaxDbi O60927.
PeptideAtlasi O60927.
PRIDEi O60927.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376772 ; ENSP00000365963 ; ENSG00000204619 .
ENST00000383612 ; ENSP00000373107 ; ENSG00000206501 .
ENST00000431424 ; ENSP00000411038 ; ENSG00000236560 .
ENST00000431977 ; ENSP00000407981 ; ENSG00000237829 .
ENST00000436591 ; ENSP00000414808 ; ENSG00000234058 .
ENST00000437937 ; ENSP00000394056 ; ENSG00000233314 .
ENST00000448378 ; ENSP00000403557 ; ENSG00000237403 .
ENST00000452679 ; ENSP00000412297 ; ENSG00000227720 .
GeneIDi 6992.
KEGGi hsa:6992.
UCSCi uc003npb.3. human.

Organism-specific databases

CTDi 6992.
GeneCardsi GC06P030192.
GC06Pi29971.
GC06Pj30024.
GC06Pk30024.
GC06Pl30029.
GC06Pm30112.
GC06Pn30024.
GC06Po30024.
HGNCi HGNC:9285. PPP1R11.
HPAi HPA043266.
MIMi 606670. gene.
neXtProti NX_O60927.
PharmGKBi PA33614.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG77393.
GeneTreei ENSGT00390000001153.
HOGENOMi HOG000232107.
HOVERGENi HBG080560.
InParanoidi O60927.
KOi K17553.
OMAi IYEKPRQ.
PhylomeDBi O60927.
TreeFami TF352541.

Miscellaneous databases

ChiTaRSi PPP1R11. human.
GeneWikii PPP1R11.
GenomeRNAii 6992.
NextBioi 27317.
PMAP-CutDB O60927.
PROi O60927.
SOURCEi Search...

Gene expression databases

Bgeei O60927.
CleanExi HS_PPP1R11.
ExpressionAtlasi O60927. baseline and differential.
Genevestigatori O60927.

Family and domain databases

InterProi IPR011107. PPI_Ypi1.
[Graphical view ]
PANTHERi PTHR20835. PTHR20835. 1 hit.
Pfami PF07491. PPI_Ypi1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region."
    Giffon T., Lepourcelet M., Pichon L., Jezequel P., Bouric P., Carn G., Pontarotti P., Gall J.-Y., David V.
    Immunogenetics 44:331-339(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Tissue: Duodenal mucosa.
  2. "Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence."
    Lepourcelet M., Andrieux N., Giffon T., Pichon L., Hampe A., Galibert F., Mosser J.
    Genomics 37:316-326(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions."
    Shiina T., Ota M., Takasu M., Katsuyama Y., Hashimoto N., Tokunaga K., Inoko H.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Tissue: Peripheral blood leukocyte.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1."
    Zhang J., Zhang L., Zhao S., Lee E.Y.C.
    Biochemistry 37:16728-16734(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-126, FUNCTION.
    Tissue: Brain.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-74; THR-75; SER-77 AND THR-109, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPP1RB_HUMAN
AccessioniPrimary (citable) accession number: O60927
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3