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Protein

Prefoldin subunit 1

Gene

PFDN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

GO - Molecular functioni

  • protein binding involved in protein folding Source: AgBase
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • cell cycle Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113068-MONOMER.
ReactomeiR-HSA-389957. Prefoldin mediated transfer of substrate to CCT/TriC.

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 1
Gene namesi
Name:PFDN1
Synonyms:PFD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8866. PFDN1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113068.
PharmGKBiPA33207.

Polymorphism and mutation databases

BioMutaiPFDN1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001248302 – 122Prefoldin subunit 1Add BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO60925.
MaxQBiO60925.
PaxDbiO60925.
PeptideAtlasiO60925.
PRIDEiO60925.
TopDownProteomicsiO60925.

2D gel databases

OGPiO60925.

PTM databases

iPTMnetiO60925.
PhosphoSitePlusiO60925.

Expressioni

Gene expression databases

BgeeiENSG00000113068.
CleanExiHS_PFDN1.
ExpressionAtlasiO60925. baseline and differential.
GenevisibleiO60925. HS.

Organism-specific databases

HPAiHPA006499.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

GO - Molecular functioni

  • protein binding involved in protein folding Source: AgBase

Protein-protein interaction databases

BioGridi111223. 96 interactors.
IntActiO60925. 58 interactors.
MINTiMINT-1143999.
STRINGi9606.ENSP00000261813.

Structurei

3D structure databases

ProteinModelPortaliO60925.
SMRiO60925.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiENOG410ISJS. Eukaryota.
ENOG4111Q46. LUCA.
GeneTreeiENSGT00390000009786.
HOGENOMiHOG000005946.
HOVERGENiHBG031813.
InParanoidiO60925.
KOiK09548.
OMAiDKCDKAI.
OrthoDBiEOG091G0X1V.
PhylomeDBiO60925.
TreeFamiTF106490.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view]
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60925-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPVDLELK KAFTELQAKV IDTQQKVKLA DIQIEQLNRT KKHAHLTDTE
60 70 80 90 100
IMTLVDETNM YEGVGRMFIL QSKEAIHSQL LEKQKIAEEK IKELEQKKSY
110 120
LERSVKEAED NIREMLMARR AQ
Length:122
Mass (Da):14,210
Last modified:August 13, 2002 - v2
Checksum:i4C88216612864F87
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86I → V in BAD97114 (Ref. 3) Curated1
Sequence conflicti104 – 105SV → RL in CAA76759 (PubMed:9630229).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17392 mRNA. Translation: CAA76759.1.
AK223394 mRNA. Translation: BAD97114.1.
AK315353 mRNA. Translation: BAG37749.1.
CH471062 Genomic DNA. Translation: EAW62071.1.
BC003620 mRNA. Translation: AAH03620.1.
BC006202 mRNA. Translation: AAH06202.1.
BC011869 mRNA. Translation: AAH11869.1.
CCDSiCCDS4222.1.
RefSeqiNP_002613.2. NM_002622.4.
UniGeneiHs.483564.

Genome annotation databases

EnsembliENST00000261813; ENSP00000261813; ENSG00000113068.
GeneIDi5201.
KEGGihsa:5201.
UCSCiuc003lff.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17392 mRNA. Translation: CAA76759.1.
AK223394 mRNA. Translation: BAD97114.1.
AK315353 mRNA. Translation: BAG37749.1.
CH471062 Genomic DNA. Translation: EAW62071.1.
BC003620 mRNA. Translation: AAH03620.1.
BC006202 mRNA. Translation: AAH06202.1.
BC011869 mRNA. Translation: AAH11869.1.
CCDSiCCDS4222.1.
RefSeqiNP_002613.2. NM_002622.4.
UniGeneiHs.483564.

3D structure databases

ProteinModelPortaliO60925.
SMRiO60925.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111223. 96 interactors.
IntActiO60925. 58 interactors.
MINTiMINT-1143999.
STRINGi9606.ENSP00000261813.

PTM databases

iPTMnetiO60925.
PhosphoSitePlusiO60925.

Polymorphism and mutation databases

BioMutaiPFDN1.

2D gel databases

OGPiO60925.

Proteomic databases

EPDiO60925.
MaxQBiO60925.
PaxDbiO60925.
PeptideAtlasiO60925.
PRIDEiO60925.
TopDownProteomicsiO60925.

Protocols and materials databases

DNASUi5201.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261813; ENSP00000261813; ENSG00000113068.
GeneIDi5201.
KEGGihsa:5201.
UCSCiuc003lff.2. human.

Organism-specific databases

CTDi5201.
GeneCardsiPFDN1.
HGNCiHGNC:8866. PFDN1.
HPAiHPA006499.
MIMi604897. gene.
neXtProtiNX_O60925.
OpenTargetsiENSG00000113068.
PharmGKBiPA33207.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISJS. Eukaryota.
ENOG4111Q46. LUCA.
GeneTreeiENSGT00390000009786.
HOGENOMiHOG000005946.
HOVERGENiHBG031813.
InParanoidiO60925.
KOiK09548.
OMAiDKCDKAI.
OrthoDBiEOG091G0X1V.
PhylomeDBiO60925.
TreeFamiTF106490.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113068-MONOMER.
ReactomeiR-HSA-389957. Prefoldin mediated transfer of substrate to CCT/TriC.

Miscellaneous databases

GeneWikiiPFDN1.
GenomeRNAii5201.
PROiO60925.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113068.
CleanExiHS_PFDN1.
ExpressionAtlasiO60925. baseline and differential.
GenevisibleiO60925. HS.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view]
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPFD1_HUMAN
AccessioniPrimary (citable) accession number: O60925
Secondary accession number(s): B2RD02, Q53F95, Q96EX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 13, 2002
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.