O60925 (PFD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prefoldin subunit 1

Gene names

Name:	PFDN1
Synonyms:	PFD1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	122 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Subunit structure	Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
Sequence similarities	Belongs to the prefoldin subunit beta family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	'de novo' posttranslational protein folding Traceable author statement. Source: Reactome B cell activation Inferred from electronic annotation. Source: Compara actin cytoskeleton organization Inferred from electronic annotation. Source: Compara cell cycle Traceable author statement PubMed 8744932. Source: ProtInc cerebellum development Inferred from electronic annotation. Source: Compara telencephalon development Inferred from electronic annotation. Source: Compara
Cellular_component	prefoldin complex Inferred from electronic annotation. Source: InterPro
Molecular_function	sequence-specific DNA binding transcription factor activity Traceable author statement PubMed 8744932. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 122	122	Prefoldin subunit 1		PRO_0000124830
Natural variations
	Natural variant	67	1	M → R. Corresponds to variant rs1064061 [ dbSNP | Ensembl ].		VAR_014529
Experimental info
	Sequence conflict	86	1	I → V in BAD97114. Ref.3
	Sequence conflict	104 – 105	2	SV → RL in CAA76759. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O60925 [UniParc]. Last modified August 13, 2002. Version 2. Checksum: 4C88216612864F87	FASTA	122	14,210
	10 20 30 40 50 60 MAAPVDLELK KAFTELQAKV IDTQQKVKLA DIQIEQLNRT KKHAHLTDTE IMTLVDETNM 70 80 90 100 110 120 YEGVGRMFIL QSKEAIHSQL LEKQKIAEEK IKELEQKKSY LERSVKEAED NIREMLMARR AQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin." Vainberg I.E., Lewis S.A., Rommelaere H., Ampe C., Vandekerckhove J., Klein H.L., Cowan N.J. Cell 93:863-873(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y17392 mRNA. Translation: CAA76759.1. AK223394 mRNA. Translation: BAD97114.1. AK315353 mRNA. Translation: BAG37749.1. CH471062 Genomic DNA. Translation: EAW62071.1. BC003620 mRNA. Translation: AAH03620.1. BC006202 mRNA. Translation: AAH06202.1. BC011869 mRNA. Translation: AAH11869.1.
IPI	IPI00000051.
RefSeq	NP_002613.2. NM_002622.4.
UniGene	Hs.483564.
3D structure databases
ProteinModelPortal	O60925.
SMR	O60925. Positions 18-114.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60925. 14 interactions.
MINT	MINT-1143999.
STRING	9606.ENSP00000261813.
PTM databases
PhosphoSite	O60925.
2D gel databases
OGP	O60925.
Proteomic databases
PaxDb	O60925.
PeptideAtlas	O60925.
PRIDE	O60925.
Protocols and materials databases
DNASU	5201.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261813; ENSP00000261813; ENSG00000113068.
GeneID	5201.
KEGG	hsa:5201.
UCSC	uc003lff.1. human.
Organism-specific databases
CTD	5201.
GeneCards	GC05M139604.
HGNC	HGNC:8866. PFDN1.
HPA	HPA006499.
MIM	604897. gene.
neXtProt	NX_O60925.
PharmGKB	PA33207.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG261468.
HOGENOM	HOG000005946.
HOVERGEN	HBG031813.
InParanoid	O60925.
KO	K09548.
OMA	YESVGRM.
OrthoDB	EOG49CQ97.
Enzyme and pathway databases
Reactome	REACT_17015. Metabolism of proteins.
Gene expression databases
ArrayExpress	O60925.
Bgee	O60925.
CleanEx	HS_PFDN1.
Genevestigator	O60925.
GermOnline	ENSG00000113068. Homo sapiens.
Family and domain databases
InterPro	IPR002777. PFD_beta-like. IPR009053. Prefoldin. [Graphical view]
Pfam	PF01920. Prefoldin_2. 1 hit. [Graphical view]
SUPFAM	SSF46579. Prefoldin. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	5201.
NextBio	20114.
SOURCE	Search...

Entry information

Entry name

PFD1_HUMAN

Accession

Primary (citable) accession number: O60925
Secondary accession number(s): B2RD02, Q53F95, Q96EX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 13, 2002
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.