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Protein

Cathepsin L2

Gene

CTSV

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cysteine protease. May have an important role in corneal physiology.2 Publications

Catalytic activityi

The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1381 Publication1
Active sitei2771 Publication1
Active sitei3011 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.43 2681
ReactomeiR-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-1679131 Trafficking and processing of endosomal TLR
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-2132295 MHC class II antigen presentation
R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
SABIO-RKiO60911

Protein family/group databases

MEROPSiI29.010

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin L2 (EC:3.4.22.43)
Alternative name(s):
Cathepsin U
Cathepsin V
Gene namesi
Name:CTSV
Synonyms:CATL2, CTSL2, CTSU
ORF Names:UNQ268/PRO305
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136943.10
HGNCiHGNC:2538 CTSV
MIMi603308 gene
neXtProtiNX_O60911

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1515
OpenTargetsiENSG00000136943
PharmGKBiPA27036

Chemistry databases

ChEMBLiCHEMBL3272
DrugBankiDB02869 3-amino-5-phenylpentane
DB04451 4-Methylpiperazin-1-Yl Carbonyl Group
GuidetoPHARMACOLOGYi2352

Polymorphism and mutation databases

BioMutaiCTSV

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000002627718 – 113Activation peptideAdd BLAST96
ChainiPRO_0000026278114 – 334Cathepsin L2Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi135 ↔ 178Combined sources1 Publication
Disulfide bondi169 ↔ 211Combined sources1 Publication
Glycosylationi221N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi270 ↔ 323Combined sources1 Publication
Glycosylationi292N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiO60911
MaxQBiO60911
PaxDbiO60911
PeptideAtlasiO60911
PRIDEiO60911

PTM databases

iPTMnetiO60911
PhosphoSitePlusiO60911

Expressioni

Tissue specificityi

Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.3 Publications

Gene expression databases

BgeeiENSG00000136943
CleanExiHS_CTSL2
ExpressionAtlasiO60911 baseline and differential
GenevisibleiO60911 HS

Organism-specific databases

HPAiCAB017112

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107895, 31 interactors
IntActiO60911, 15 interactors
MINTiO60911
STRINGi9606.ENSP00000259470

Chemistry databases

BindingDBiO60911

Structurei

Secondary structure

1334
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi120 – 123Combined sources4
Helixi138 – 155Combined sources18
Helixi163 – 169Combined sources7
Helixi171 – 173Combined sources3
Helixi177 – 179Combined sources3
Helixi183 – 193Combined sources11
Beta strandi196 – 198Combined sources3
Turni199 – 201Combined sources3
Helixi215 – 217Combined sources3
Beta strandi218 – 220Combined sources3
Beta strandi225 – 227Combined sources3
Helixi233 – 242Combined sources10
Beta strandi246 – 250Combined sources5
Helixi255 – 258Combined sources4
Beta strandi262 – 265Combined sources4
Beta strandi272 – 274Combined sources3
Beta strandi277 – 289Combined sources13
Beta strandi293 – 300Combined sources8
Beta strandi312 – 316Combined sources5
Beta strandi318 – 321Combined sources4
Helixi322 – 324Combined sources3
Turni325 – 327Combined sources3
Beta strandi330 – 332Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FH0X-ray1.60A/B114-334[»]
3H6SX-ray2.22A/B/C/D114-334[»]
3KFQX-ray1.99A/B114-334[»]
ProteinModelPortaliO60911
SMRiO60911
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60911

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00900000140823
HOGENOMiHOG000230774
HOVERGENiHBG011513
InParanoidiO60911
KOiK01375
OMAiPKFDQNL
OrthoDBiEOG091G0AKT
PhylomeDBiO60911
TreeFamiTF313739

Family and domain databases

InterProiView protein in InterPro
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLSLVLAAF CLGIASAVPK FDQNLDTKWY QWKATHRRLY GANEEGWRRA
60 70 80 90 100
VWEKNMKMIE LHNGEYSQGK HGFTMAMNAF GDMTNEEFRQ MMGCFRNQKF
110 120 130 140 150
RKGKVFREPL FLDLPKSVDW RKKGYVTPVK NQKQCGSCWA FSATGALEGQ
160 170 180 190 200
MFRKTGKLVS LSEQNLVDCS RPQGNQGCNG GFMARAFQYV KENGGLDSEE
210 220 230 240 250
SYPYVAVDEI CKYRPENSVA NDTGFTVVAP GKEKALMKAV ATVGPISVAM
260 270 280 290 300
DAGHSSFQFY KSGIYFEPDC SSKNLDHGVL VVGYGFEGAN SNNSKYWLVK
310 320 330
NSWGPEWGSN GYVKIAKDKN NHCGIATAAS YPNV
Length:334
Mass (Da):37,329
Last modified:December 1, 2000 - v2
Checksum:iCD2DE51AC5F242C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81G → P in CAA75029 (PubMed:9563472).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14734 mRNA Translation: CAA75029.1
AB001928 mRNA Translation: BAA25909.1
AF070448 mRNA Translation: AAC23598.1
AB019534 Genomic DNA Translation: BAA34365.1
AY358641 mRNA Translation: AAQ89004.1
AL445670 Genomic DNA No translation available.
BC023504 mRNA Translation: AAH23504.1
BC110512 mRNA Translation: AAI10513.1
CCDSiCCDS6723.1
RefSeqiNP_001188504.1, NM_001201575.1
NP_001324.2, NM_001333.3
UniGeneiHs.610096

Genome annotation databases

EnsembliENST00000259470; ENSP00000259470; ENSG00000136943
ENST00000538255; ENSP00000445052; ENSG00000136943
GeneIDi1515
KEGGihsa:1515
UCSCiuc004awt.4 human

Similar proteinsi

Entry informationi

Entry nameiCATL2_HUMAN
AccessioniPrimary (citable) accession number: O60911
Secondary accession number(s): O60233, Q2TB86, Q5T1U0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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