Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O60907

- TBL1X_HUMAN

UniProt

O60907 - TBL1X_HUMAN

Protein

F-box-like/WD repeat-containing protein TBL1X

Gene

TBL1X

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 3 (14 Apr 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.1 Publication

    GO - Molecular functioni

    1. beta-catenin binding Source: UniProtKB
    2. histone binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. protein C-terminus binding Source: UniProtKB
    5. protein domain specific binding Source: UniProtKB
    6. transcription corepressor activity Source: UniProtKB
    7. transcription factor binding Source: UniProtKB
    8. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. canonical Wnt signaling pathway Source: UniProtKB
    2. cellular lipid metabolic process Source: Reactome
    3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. Notch signaling pathway Source: Reactome
    5. positive regulation of transcription, DNA-templated Source: UniProtKB
    6. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    7. proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
    8. proteolysis Source: UniProtKB
    9. sensory perception of sound Source: UniProtKB
    10. small molecule metabolic process Source: Reactome
    11. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation, Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_116145. PPARA activates gene expression.
    REACT_118659. RORA activates circadian gene expression.
    REACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_118789. REV-ERBA represses gene expression.
    REACT_147904. Activation of gene expression by SREBF (SREBP).
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_19241. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
    REACT_200608. Transcriptional activation of mitochondrial biogenesis.
    REACT_24941. Circadian Clock.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinkiO60907.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box-like/WD repeat-containing protein TBL1X
    Alternative name(s):
    SMAP55
    Transducin beta-like protein 1X
    Transducin-beta-like protein 1, X-linked
    Gene namesi
    Name:TBL1X
    Synonyms:TBL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:11585. TBL1X.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. nucleus Source: UniProtKB
    3. spindle microtubule Source: UniProtKB
    4. transcriptional repressor complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Deafness

    Organism-specific databases

    PharmGKBiPA36349.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 577577F-box-like/WD repeat-containing protein TBL1XPRO_0000051263Add
    BLAST

    Proteomic databases

    MaxQBiO60907.
    PaxDbiO60907.
    PRIDEiO60907.

    PTM databases

    PhosphoSiteiO60907.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiO60907.
    BgeeiO60907.
    CleanExiHS_TBL1X.
    GenevestigatoriO60907.

    Organism-specific databases

    HPAiCAB005363.

    Interactioni

    Subunit structurei

    Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Probably part of other corepressor complexes, that do not contain NCOR1 and NCOR2. Interacts with histones H2B, H3a and H4.1 Publication

    Protein-protein interaction databases

    BioGridi112770. 40 interactions.
    DIPiDIP-60532N.
    IntActiO60907. 10 interactions.
    STRINGi9606.ENSP00000217964.

    Structurei

    Secondary structure

    1
    577
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi56 – 6914
    Helixi73 – 8210
    Helixi85 – 873
    Helixi92 – 943
    Helixi99 – 11618

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2XTCX-ray2.22A/B52-141[»]
    2XTDX-ray3.20A/B52-122[»]
    2XTEX-ray3.90A/B/C/D/E/F/G/H/I/J/K/L52-141[»]
    ProteinModelPortaliO60907.
    SMRiO60907. Positions 53-126, 205-576.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO60907.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 8733LisHPROSITE-ProRule annotationAdd
    BLAST
    Domaini92 – 13746F-box-likeAdd
    BLAST
    Repeati230 – 26940WD 1Add
    BLAST
    Repeati286 – 32540WD 2Add
    BLAST
    Repeati327 – 36640WD 3Add
    BLAST
    Repeati369 – 40941WD 4Add
    BLAST
    Repeati410 – 44940WD 5Add
    BLAST
    Repeati452 – 50049WD 6Add
    BLAST
    Repeati503 – 54240WD 7Add
    BLAST
    Repeati544 – 57633WD 8Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi159 – 17517Poly-AlaAdd
    BLAST

    Domaini

    The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.By similarity

    Sequence similaritiesi

    Belongs to the WD repeat EBI family.Curated
    Contains 1 F-box-like domain.Curated
    Contains 1 LisH domain.PROSITE-ProRule annotation
    Contains 8 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000220902.
    HOVERGENiHBG050240.
    InParanoidiO60907.
    KOiK04508.
    OMAiSMKQEVC.
    OrthoDBiEOG79CXZ3.
    PhylomeDBiO60907.
    TreeFamiTF323190.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR006594. LisH_dimerisation.
    IPR013720. LisH_dimerisation_subgr.
    IPR011047. Quinonprotein_ADH-like_supfam.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF08513. LisH. 1 hit.
    PF00400. WD40. 7 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00667. LisH. 1 hit.
    SM00320. WD40. 8 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    SSF50998. SSF50998. 1 hit.
    PROSITEiPS50896. LISH. 1 hit.
    PS00678. WD_REPEATS_1. 4 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60907-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTELAGASSS CCHRPAGRGA MQSVLHHFQR LRGREGGSHF INTSSPRGEA    50
    KMSITSDEVN FLVYRYLQES GFSHSAFTFG IESHISQSNI NGTLVPPAAL 100
    ISILQKGLQY VEAEISINED GTVFDGRPIE SLSLIDAVMP DVVQTRQQAF 150
    REKLAQQQAS AAAAAAAATA AATAATTTSA GVSHQNPSKN REATVNGEEN 200
    RAHSVNNHAK PMEIDGEVEI PSSKATVLRG HESEVFICAW NPVSDLLASG 250
    SGDSTARIWN LNENSNGGST QLVLRHCIRE GGHDVPSNKD VTSLDWNTNG 300
    TLLATGSYDG FARIWTEDGN LASTLGQHKG PIFALKWNRK GNYILSAGVD 350
    KTTIIWDAHT GEAKQQFPFH SAPALDVDWQ NNTTFASCST DMCIHVCRLG 400
    CDRPVKTFQG HTNEVNAIKW DPSGMLLASC SDDMTLKIWS MKQEVCIHDL 450
    QAHNKEIYTI KWSPTGPATS NPNSNIMLAS ASFDSTVRLW DIERGVCTHT 500
    LTKHQEPVYS VAFSPDGKYL ASGSFDKCVH IWNTQSGNLV HSYRGTGGIF 550
    EVCWNARGDK VGASASDGSV CVLDLRK 577
    Length:577
    Mass (Da):62,496
    Last modified:April 14, 2009 - v3
    Checksum:iD830A37781E2A15C
    GO
    Isoform 2 (identifier: O60907-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-51: Missing.

    Show »
    Length:526
    Mass (Da):57,049
    Checksum:i98922F88EC42F6E9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti316 – 3161T → A in BAF82098. (PubMed:14702039)Curated
    Sequence conflicti390 – 3901T → A in BAF83651. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5151Missing in isoform 2. 2 PublicationsVSP_036905Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12781 mRNA. Translation: CAA73319.1.
    AK289409 mRNA. Translation: BAF82098.1.
    AK290962 mRNA. Translation: BAF83651.1.
    AC003036 Genomic DNA. No translation available.
    BC032708 mRNA. Translation: AAH32708.1.
    BC052304 mRNA. Translation: AAH52304.1.
    CCDSiCCDS14133.1. [O60907-1]
    CCDS48078.1. [O60907-2]
    RefSeqiNP_001132938.1. NM_001139466.1. [O60907-1]
    NP_001132939.1. NM_001139467.1. [O60907-2]
    NP_001132940.1. NM_001139468.1. [O60907-2]
    NP_005638.1. NM_005647.3. [O60907-1]
    UniGeneiHs.495656.

    Genome annotation databases

    EnsembliENST00000217964; ENSP00000217964; ENSG00000101849. [O60907-1]
    ENST00000380961; ENSP00000370348; ENSG00000101849. [O60907-2]
    ENST00000407597; ENSP00000385988; ENSG00000101849. [O60907-1]
    ENST00000424279; ENSP00000394097; ENSG00000101849. [O60907-2]
    GeneIDi6907.
    KEGGihsa:6907.
    UCSCiuc004csq.4. human. [O60907-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12781 mRNA. Translation: CAA73319.1 .
    AK289409 mRNA. Translation: BAF82098.1 .
    AK290962 mRNA. Translation: BAF83651.1 .
    AC003036 Genomic DNA. No translation available.
    BC032708 mRNA. Translation: AAH32708.1 .
    BC052304 mRNA. Translation: AAH52304.1 .
    CCDSi CCDS14133.1. [O60907-1 ]
    CCDS48078.1. [O60907-2 ]
    RefSeqi NP_001132938.1. NM_001139466.1. [O60907-1 ]
    NP_001132939.1. NM_001139467.1. [O60907-2 ]
    NP_001132940.1. NM_001139468.1. [O60907-2 ]
    NP_005638.1. NM_005647.3. [O60907-1 ]
    UniGenei Hs.495656.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2XTC X-ray 2.22 A/B 52-141 [» ]
    2XTD X-ray 3.20 A/B 52-122 [» ]
    2XTE X-ray 3.90 A/B/C/D/E/F/G/H/I/J/K/L 52-141 [» ]
    ProteinModelPortali O60907.
    SMRi O60907. Positions 53-126, 205-576.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112770. 40 interactions.
    DIPi DIP-60532N.
    IntActi O60907. 10 interactions.
    STRINGi 9606.ENSP00000217964.

    PTM databases

    PhosphoSitei O60907.

    Proteomic databases

    MaxQBi O60907.
    PaxDbi O60907.
    PRIDEi O60907.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000217964 ; ENSP00000217964 ; ENSG00000101849 . [O60907-1 ]
    ENST00000380961 ; ENSP00000370348 ; ENSG00000101849 . [O60907-2 ]
    ENST00000407597 ; ENSP00000385988 ; ENSG00000101849 . [O60907-1 ]
    ENST00000424279 ; ENSP00000394097 ; ENSG00000101849 . [O60907-2 ]
    GeneIDi 6907.
    KEGGi hsa:6907.
    UCSCi uc004csq.4. human. [O60907-1 ]

    Organism-specific databases

    CTDi 6907.
    GeneCardsi GC0XP009431.
    HGNCi HGNC:11585. TBL1X.
    HPAi CAB005363.
    MIMi 300196. gene.
    neXtProti NX_O60907.
    PharmGKBi PA36349.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000220902.
    HOVERGENi HBG050240.
    InParanoidi O60907.
    KOi K04508.
    OMAi SMKQEVC.
    OrthoDBi EOG79CXZ3.
    PhylomeDBi O60907.
    TreeFami TF323190.

    Enzyme and pathway databases

    Reactomei REACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_116145. PPARA activates gene expression.
    REACT_118659. RORA activates circadian gene expression.
    REACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_118789. REV-ERBA represses gene expression.
    REACT_147904. Activation of gene expression by SREBF (SREBP).
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_19241. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
    REACT_200608. Transcriptional activation of mitochondrial biogenesis.
    REACT_24941. Circadian Clock.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinki O60907.

    Miscellaneous databases

    ChiTaRSi TBL1X. human.
    EvolutionaryTracei O60907.
    GeneWikii TBL1X.
    GenomeRNAii 6907.
    NextBioi 27011.
    PROi O60907.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60907.
    Bgeei O60907.
    CleanExi HS_TBL1X.
    Genevestigatori O60907.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR006594. LisH_dimerisation.
    IPR013720. LisH_dimerisation_subgr.
    IPR011047. Quinonprotein_ADH-like_supfam.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF08513. LisH. 1 hit.
    PF00400. WD40. 7 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00667. LisH. 1 hit.
    SM00320. WD40. 8 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    SSF50998. SSF50998. 1 hit.
    PROSITEi PS50896. LISH. 1 hit.
    PS00678. WD_REPEATS_1. 4 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats."
      Bassi M.T., Ramesar R.S., Caciotti B., Winship I.M., De Grandi A., Riboni M., Townes P.L., Beighton P., Ballabio A., Borsani G.
      Am. J. Hum. Genet. 64:1604-1616(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Lymph and Pancreas.
    5. "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness."
      Guenther M.G., Lane W.S., Fischle W., Verdin E., Lazar M.A., Shiekhattar R.
      Genes Dev. 14:1048-1057(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, COMPONENT OF THE N-COR COMPLEX WITH NCOR2 AND HDAC3.
    6. "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3."
      Li J., Wang J., Wang J., Nawaz Z., Liu J.M., Qin J., Wong J.
      EMBO J. 19:4342-4350(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPONENT OF THE N-COR COMPLEX WITH NCOR2 AND HDAC3.
    7. "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses."
      Matsuzawa S., Reed J.C.
      Mol. Cell 7:915-926(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT OF A COMPLEX WITH UBE2D1; CACYBP; SIAH1 AND APC.
    8. "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2."
      Zhang J., Kalkum M., Chait B.T., Roeder R.G.
      Mol. Cell 9:611-623(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPONENT OF THE N-COR COMPLEX WITH NCOR1; NCOR2; GPS2; TBL1R AND HDAC3.
    9. "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1."
      Yoon H.-G., Chan D.W., Huang Z.-Q., Li J., Fondell J.D., Qin J., Wong J.
      EMBO J. 22:1336-1346(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPONENT OF THE N-COR COMPLEX WITH TBL1R; CORO2A AND HDAC3, HISTONE-BINDING.
    10. "A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors."
      Perissi V., Aggarwal A., Glass C.K., Rose D.W., Rosenfeld M.G.
      Cell 116:511-526(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, RECRUITMENT OF 19S PROTEASOME COMPLEX.

    Entry informationi

    Entry nameiTBL1X_HUMAN
    AccessioniPrimary (citable) accession number: O60907
    Secondary accession number(s): A8K044, A8K4J7, Q86UY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: April 14, 2009
    Last modified: October 1, 2014
    This is version 141 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3