SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O60896

- RAMP3_HUMAN

UniProt

O60896 - RAMP3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Receptor activity-modifying protein 3
Gene
RAMP3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.2 Publications

GO - Molecular functioni

  1. coreceptor activity Source: Ensembl
  2. protein binding Source: UniProtKB
  3. protein transporter activity Source: UniProtKB
  4. receptor activity Source: UniProtKB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway involved in heart process Source: UniProtKB
  2. calcium ion transport Source: UniProtKB
  3. cellular response to estradiol stimulus Source: UniProtKB
  4. intracellular protein transport Source: InterPro
  5. negative regulation of transcription, DNA-templated Source: UniProtKB
  6. positive regulation of establishment of protein localization to plasma membrane Source: UniProtKB
  7. positive regulation of receptor recycling Source: UniProtKB
  8. protein localization to plasma membrane Source: UniProtKB
  9. protein transport Source: UniProtKB
  10. receptor internalization Source: UniProtKB
  11. regulation of G-protein coupled receptor protein signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_18290. Calcitonin-like ligand receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor activity-modifying protein 3
Alternative name(s):
Calcitonin-receptor-like receptor activity-modifying protein 3
Short name:
CRLR activity-modifying protein 3
Gene namesi
Name:RAMP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:9845. RAMP3.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein
Note: Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 11895Extracellular Reviewed prediction
Add
BLAST
Transmembranei119 – 13820Helical; Reviewed prediction
Add
BLAST
Topological domaini139 – 14810Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
  3. intracellular Source: UniProtKB
  4. lysosome Source: ProtInc
  5. plasma membrane Source: UniProtKB
  6. receptor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34204.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 148125Receptor activity-modifying protein 3
PRO_0000030176Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi40 ↔ 72 By similarity
Disulfide bondi57 ↔ 104 By similarity
Glycosylationi58 – 581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO60896.
PRIDEiO60896.

Expressioni

Tissue specificityi

Strongly expressed in lung, breast, immune system and fetal tissues.1 Publication

Gene expression databases

ArrayExpressiO60896.
BgeeiO60896.
CleanExiHS_RAMP3.
GenevestigatoriO60896.

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP3 By similarity. Interacts with GPER1.1 Publication

Protein-protein interaction databases

BioGridi115559. 4 interactions.
IntActiO60896. 2 interactions.
MINTiMINT-1384016.
STRINGi9606.ENSP00000242249.

Structurei

3D structure databases

ProteinModelPortaliO60896.
SMRiO60896. Positions 39-104.

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39494.
HOGENOMiHOG000253018.
HOVERGENiHBG061268.
InParanoidiO60896.
KOiK08449.
OrthoDBiEOG7ZKSD3.
PhylomeDBiO60896.
TreeFamiTF333286.

Family and domain databases

InterProiIPR006985. RAMP.
[Graphical view]
PANTHERiPTHR14076. PTHR14076. 1 hit.
PfamiPF04901. RAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60896-1 [UniParc]FASTAAdd to Basket

« Hide

METGALRRPQ LLPLLLLLCG GCPRAGGCNE TGMLERLPLC GKAFADMMGK    50
VDVWKWCNLS EFIVYYESFT NCTEMEANVV GCYWPNPLAQ GFITGIHRQF 100
FSNCTVDRVH LEDPPDEVLI PLIVIPVVLT VAMAGLVVWR SKRTDTLL 148
Length:148
Mass (Da):16,518
Last modified:August 1, 1998 - v1
Checksum:iEEEE312496EF513C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261G → D.
Corresponds to variant rs10272187 [ dbSNP | Ensembl ].
VAR_034437
Natural varianti33 – 331M → L.1 Publication
Corresponds to variant rs11550711 [ dbSNP | Ensembl ].
VAR_053628
Natural varianti56 – 561W → R.
Corresponds to variant rs2074654 [ dbSNP | Ensembl ].
VAR_024602

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001016 mRNA. Translation: CAA04474.1.
AY265459 mRNA. Translation: AAP23300.1.
AC004844 Genomic DNA. No translation available.
BC022304 mRNA. Translation: AAH22304.1.
BC053852 mRNA. Translation: AAH53852.1.
CCDSiCCDS5503.1.
RefSeqiNP_005847.1. NM_005856.2.
UniGeneiHs.25691.

Genome annotation databases

EnsembliENST00000242249; ENSP00000242249; ENSG00000122679.
ENST00000481345; ENSP00000419012; ENSG00000122679.
GeneIDi10268.
KEGGihsa:10268.
UCSCiuc003tnb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001016 mRNA. Translation: CAA04474.1 .
AY265459 mRNA. Translation: AAP23300.1 .
AC004844 Genomic DNA. No translation available.
BC022304 mRNA. Translation: AAH22304.1 .
BC053852 mRNA. Translation: AAH53852.1 .
CCDSi CCDS5503.1.
RefSeqi NP_005847.1. NM_005856.2.
UniGenei Hs.25691.

3D structure databases

ProteinModelPortali O60896.
SMRi O60896. Positions 39-104.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115559. 4 interactions.
IntActi O60896. 2 interactions.
MINTi MINT-1384016.
STRINGi 9606.ENSP00000242249.

Chemistry

ChEMBLi CHEMBL2111191.
DrugBanki DB01278. Pramlintide.

Proteomic databases

PaxDbi O60896.
PRIDEi O60896.

Protocols and materials databases

DNASUi 10268.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000242249 ; ENSP00000242249 ; ENSG00000122679 .
ENST00000481345 ; ENSP00000419012 ; ENSG00000122679 .
GeneIDi 10268.
KEGGi hsa:10268.
UCSCi uc003tnb.3. human.

Organism-specific databases

CTDi 10268.
GeneCardsi GC07P045163.
HGNCi HGNC:9845. RAMP3.
MIMi 605155. gene.
neXtProti NX_O60896.
PharmGKBi PA34204.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39494.
HOGENOMi HOG000253018.
HOVERGENi HBG061268.
InParanoidi O60896.
KOi K08449.
OrthoDBi EOG7ZKSD3.
PhylomeDBi O60896.
TreeFami TF333286.

Enzyme and pathway databases

Reactomei REACT_18290. Calcitonin-like ligand receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikii RAMP3.
GenomeRNAii 10268.
NextBioi 38902.
PROi O60896.
SOURCEi Search...

Gene expression databases

ArrayExpressi O60896.
Bgeei O60896.
CleanExi HS_RAMP3.
Genevestigatori O60896.

Family and domain databases

InterProi IPR006985. RAMP.
[Graphical view ]
PANTHERi PTHR14076. PTHR14076. 1 hit.
Pfami PF04901. RAMP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor."
    McLatchie L.M., Fraser N.J., Main M.J., Wise A., Brown J., Thompson N., Solari R., Lee M.G., Foord S.M.
    Nature 393:333-339(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-33.
    Tissue: Lung and PNS.
  5. "G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection."
    Lenhart P.M., Broselid S., Barrick C.J., Leeb-Lundberg L.M., Caron K.M.
    J. Mol. Endocrinol. 51:191-202(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GPER1, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRAMP3_HUMAN
AccessioniPrimary (citable) accession number: O60896
Secondary accession number(s): Q7Z2Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi