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O60896

- RAMP3_HUMAN

UniProt

O60896 - RAMP3_HUMAN

Protein

Receptor activity-modifying protein 3

Gene

RAMP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.2 Publications

    GO - Molecular functioni

    1. coreceptor activity Source: Ensembl
    2. protein binding Source: UniProtKB
    3. protein transporter activity Source: UniProtKB
    4. receptor activity Source: UniProtKB

    GO - Biological processi

    1. calcium ion transport Source: UniProtKB
    2. cellular response to estradiol stimulus Source: UniProtKB
    3. G-protein coupled receptor signaling pathway involved in heart process Source: UniProtKB
    4. intracellular protein transport Source: InterPro
    5. negative regulation of transcription, DNA-templated Source: UniProtKB
    6. positive regulation of establishment of protein localization to plasma membrane Source: UniProtKB
    7. positive regulation of receptor recycling Source: UniProtKB
    8. protein localization to plasma membrane Source: UniProtKB
    9. protein transport Source: UniProtKB
    10. receptor internalization Source: UniProtKB
    11. regulation of G-protein coupled receptor protein signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_18290. Calcitonin-like ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor activity-modifying protein 3
    Alternative name(s):
    Calcitonin-receptor-like receptor activity-modifying protein 3
    Short name:
    CRLR activity-modifying protein 3
    Gene namesi
    Name:RAMP3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:9845. RAMP3.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Membrane 1 Publication; Single-pass type I membrane protein 1 Publication
    Note: Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. integral component of plasma membrane Source: ProtInc
    3. intracellular Source: UniProtKB
    4. lysosome Source: ProtInc
    5. plasma membrane Source: UniProtKB
    6. receptor complex Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34204.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 148125Receptor activity-modifying protein 3PRO_0000030176Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi40 ↔ 72By similarity
    Disulfide bondi57 ↔ 104By similarity
    Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO60896.
    PRIDEiO60896.

    Expressioni

    Tissue specificityi

    Strongly expressed in lung, breast, immune system and fetal tissues.1 Publication

    Gene expression databases

    ArrayExpressiO60896.
    BgeeiO60896.
    CleanExiHS_RAMP3.
    GenevestigatoriO60896.

    Interactioni

    Subunit structurei

    Heterodimer of CALCRL and RAMP3 By similarity. Interacts with GPER1.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi115559. 4 interactions.
    IntActiO60896. 2 interactions.
    MINTiMINT-1384016.
    STRINGi9606.ENSP00000242249.

    Structurei

    3D structure databases

    ProteinModelPortaliO60896.
    SMRiO60896. Positions 39-104.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 11895ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini139 – 14810CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei119 – 13820HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RAMP family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39494.
    HOGENOMiHOG000253018.
    HOVERGENiHBG061268.
    InParanoidiO60896.
    KOiK08449.
    OrthoDBiEOG7ZKSD3.
    PhylomeDBiO60896.
    TreeFamiTF333286.

    Family and domain databases

    InterProiIPR006985. RAMP.
    [Graphical view]
    PANTHERiPTHR14076. PTHR14076. 1 hit.
    PfamiPF04901. RAMP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O60896-1 [UniParc]FASTAAdd to Basket

    « Hide

    METGALRRPQ LLPLLLLLCG GCPRAGGCNE TGMLERLPLC GKAFADMMGK    50
    VDVWKWCNLS EFIVYYESFT NCTEMEANVV GCYWPNPLAQ GFITGIHRQF 100
    FSNCTVDRVH LEDPPDEVLI PLIVIPVVLT VAMAGLVVWR SKRTDTLL 148
    Length:148
    Mass (Da):16,518
    Last modified:August 1, 1998 - v1
    Checksum:iEEEE312496EF513C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti26 – 261G → D.
    Corresponds to variant rs10272187 [ dbSNP | Ensembl ].
    VAR_034437
    Natural varianti33 – 331M → L.1 Publication
    Corresponds to variant rs11550711 [ dbSNP | Ensembl ].
    VAR_053628
    Natural varianti56 – 561W → R.
    Corresponds to variant rs2074654 [ dbSNP | Ensembl ].
    VAR_024602

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001016 mRNA. Translation: CAA04474.1.
    AY265459 mRNA. Translation: AAP23300.1.
    AC004844 Genomic DNA. No translation available.
    BC022304 mRNA. Translation: AAH22304.1.
    BC053852 mRNA. Translation: AAH53852.1.
    CCDSiCCDS5503.1.
    RefSeqiNP_005847.1. NM_005856.2.
    UniGeneiHs.25691.

    Genome annotation databases

    EnsembliENST00000242249; ENSP00000242249; ENSG00000122679.
    ENST00000481345; ENSP00000419012; ENSG00000122679.
    GeneIDi10268.
    KEGGihsa:10268.
    UCSCiuc003tnb.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001016 mRNA. Translation: CAA04474.1 .
    AY265459 mRNA. Translation: AAP23300.1 .
    AC004844 Genomic DNA. No translation available.
    BC022304 mRNA. Translation: AAH22304.1 .
    BC053852 mRNA. Translation: AAH53852.1 .
    CCDSi CCDS5503.1.
    RefSeqi NP_005847.1. NM_005856.2.
    UniGenei Hs.25691.

    3D structure databases

    ProteinModelPortali O60896.
    SMRi O60896. Positions 39-104.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115559. 4 interactions.
    IntActi O60896. 2 interactions.
    MINTi MINT-1384016.
    STRINGi 9606.ENSP00000242249.

    Chemistry

    ChEMBLi CHEMBL2111191.
    DrugBanki DB01278. Pramlintide.

    Proteomic databases

    PaxDbi O60896.
    PRIDEi O60896.

    Protocols and materials databases

    DNASUi 10268.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000242249 ; ENSP00000242249 ; ENSG00000122679 .
    ENST00000481345 ; ENSP00000419012 ; ENSG00000122679 .
    GeneIDi 10268.
    KEGGi hsa:10268.
    UCSCi uc003tnb.3. human.

    Organism-specific databases

    CTDi 10268.
    GeneCardsi GC07P045163.
    HGNCi HGNC:9845. RAMP3.
    MIMi 605155. gene.
    neXtProti NX_O60896.
    PharmGKBi PA34204.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39494.
    HOGENOMi HOG000253018.
    HOVERGENi HBG061268.
    InParanoidi O60896.
    KOi K08449.
    OrthoDBi EOG7ZKSD3.
    PhylomeDBi O60896.
    TreeFami TF333286.

    Enzyme and pathway databases

    Reactomei REACT_18290. Calcitonin-like ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GeneWikii RAMP3.
    GenomeRNAii 10268.
    NextBioi 38902.
    PROi O60896.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60896.
    Bgeei O60896.
    CleanExi HS_RAMP3.
    Genevestigatori O60896.

    Family and domain databases

    InterProi IPR006985. RAMP.
    [Graphical view ]
    PANTHERi PTHR14076. PTHR14076. 1 hit.
    Pfami PF04901. RAMP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor."
      McLatchie L.M., Fraser N.J., Main M.J., Wise A., Brown J., Thompson N., Solari R., Lee M.G., Foord S.M.
      Nature 393:333-339(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-33.
      Tissue: Lung and PNS.
    5. "G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection."
      Lenhart P.M., Broselid S., Barrick C.J., Leeb-Lundberg L.M., Caron K.M.
      J. Mol. Endocrinol. 51:191-202(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GPER1, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiRAMP3_HUMAN
    AccessioniPrimary (citable) accession number: O60896
    Secondary accession number(s): Q7Z2Y1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3