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Protein

Receptor activity-modifying protein 3

Gene

RAMP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.2 Publications

GO - Molecular functioni

  • coreceptor activity Source: Ensembl
  • protein transporter activity Source: UniProtKB
  • receptor activity Source: UniProtKB

GO - Biological processi

  • calcium ion transport Source: UniProtKB
  • cellular response to estradiol stimulus Source: UniProtKB
  • G-protein coupled receptor signaling pathway involved in heart process Source: UniProtKB
  • intracellular protein transport Source: InterPro
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of establishment of protein localization to plasma membrane Source: UniProtKB
  • positive regulation of receptor recycling Source: UniProtKB
  • protein localization to plasma membrane Source: UniProtKB
  • protein transport Source: UniProtKB
  • receptor internalization Source: UniProtKB
  • regulation of G-protein coupled receptor protein signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122679-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.
R-HSA-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor activity-modifying protein 3
Alternative name(s):
Calcitonin-receptor-like receptor activity-modifying protein 3
Short name:
CRLR activity-modifying protein 3
Gene namesi
Name:RAMP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:9845. RAMP3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 118ExtracellularSequence analysisAdd BLAST95
Transmembranei119 – 138HelicalSequence analysisAdd BLAST20
Topological domaini139 – 148CytoplasmicSequence analysis10

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • intracellular Source: UniProtKB
  • lysosome Source: ProtInc
  • plasma membrane Source: UniProtKB
  • receptor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10268.
OpenTargetsiENSG00000122679.
PharmGKBiPA34204.

Chemistry databases

ChEMBLiCHEMBL2111191.
DrugBankiDB01278. Pramlintide.

Polymorphism and mutation databases

BioMutaiRAMP3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003017624 – 148Receptor activity-modifying protein 3Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi40 ↔ 72By similarity
Disulfide bondi57 ↔ 104By similarity
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO60896.
PeptideAtlasiO60896.
PRIDEiO60896.

Expressioni

Tissue specificityi

Strongly expressed in lung, breast, immune system and fetal tissues.1 Publication

Gene expression databases

BgeeiENSG00000122679.
CleanExiHS_RAMP3.
ExpressionAtlasiO60896. baseline and differential.
GenevisibleiO60896. HS.

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP3 (By similarity). Interacts with GPER1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP5-9P263713EBI-720447,EBI-3958099
NOTCH2NLQ7Z3S95EBI-720447,EBI-945833

Protein-protein interaction databases

BioGridi115559. 7 interactors.
IntActiO60896. 6 interactors.
MINTiMINT-1384016.
STRINGi9606.ENSP00000242249.

Chemistry databases

BindingDBiO60896.

Structurei

3D structure databases

ProteinModelPortaliO60896.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXGF. Eukaryota.
ENOG4111U8C. LUCA.
GeneTreeiENSGT00390000016200.
HOGENOMiHOG000253018.
HOVERGENiHBG061268.
InParanoidiO60896.
KOiK08449.
PhylomeDBiO60896.
TreeFamiTF333286.

Family and domain databases

InterProiIPR006985. RAMP.
[Graphical view]
PANTHERiPTHR14076. PTHR14076. 1 hit.
PfamiPF04901. RAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METGALRRPQ LLPLLLLLCG GCPRAGGCNE TGMLERLPLC GKAFADMMGK
60 70 80 90 100
VDVWKWCNLS EFIVYYESFT NCTEMEANVV GCYWPNPLAQ GFITGIHRQF
110 120 130 140
FSNCTVDRVH LEDPPDEVLI PLIVIPVVLT VAMAGLVVWR SKRTDTLL
Length:148
Mass (Da):16,518
Last modified:August 1, 1998 - v1
Checksum:iEEEE312496EF513C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03443726G → D.Corresponds to variant rs10272187dbSNPEnsembl.1
Natural variantiVAR_05362833M → L.1 PublicationCorresponds to variant rs11550711dbSNPEnsembl.1
Natural variantiVAR_02460256W → R.Corresponds to variant rs2074654dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001016 mRNA. Translation: CAA04474.1.
AY265459 mRNA. Translation: AAP23300.1.
AC004844 Genomic DNA. No translation available.
BC022304 mRNA. Translation: AAH22304.1.
BC053852 mRNA. Translation: AAH53852.1.
CCDSiCCDS5503.1.
RefSeqiNP_005847.1. NM_005856.2.
UniGeneiHs.25691.

Genome annotation databases

EnsembliENST00000242249; ENSP00000242249; ENSG00000122679.
ENST00000481345; ENSP00000419012; ENSG00000122679.
GeneIDi10268.
KEGGihsa:10268.
UCSCiuc003tnb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001016 mRNA. Translation: CAA04474.1.
AY265459 mRNA. Translation: AAP23300.1.
AC004844 Genomic DNA. No translation available.
BC022304 mRNA. Translation: AAH22304.1.
BC053852 mRNA. Translation: AAH53852.1.
CCDSiCCDS5503.1.
RefSeqiNP_005847.1. NM_005856.2.
UniGeneiHs.25691.

3D structure databases

ProteinModelPortaliO60896.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115559. 7 interactors.
IntActiO60896. 6 interactors.
MINTiMINT-1384016.
STRINGi9606.ENSP00000242249.

Chemistry databases

BindingDBiO60896.
ChEMBLiCHEMBL2111191.
DrugBankiDB01278. Pramlintide.

Polymorphism and mutation databases

BioMutaiRAMP3.

Proteomic databases

PaxDbiO60896.
PeptideAtlasiO60896.
PRIDEiO60896.

Protocols and materials databases

DNASUi10268.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242249; ENSP00000242249; ENSG00000122679.
ENST00000481345; ENSP00000419012; ENSG00000122679.
GeneIDi10268.
KEGGihsa:10268.
UCSCiuc003tnb.4. human.

Organism-specific databases

CTDi10268.
DisGeNETi10268.
GeneCardsiRAMP3.
HGNCiHGNC:9845. RAMP3.
MIMi605155. gene.
neXtProtiNX_O60896.
OpenTargetsiENSG00000122679.
PharmGKBiPA34204.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXGF. Eukaryota.
ENOG4111U8C. LUCA.
GeneTreeiENSGT00390000016200.
HOGENOMiHOG000253018.
HOVERGENiHBG061268.
InParanoidiO60896.
KOiK08449.
PhylomeDBiO60896.
TreeFamiTF333286.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122679-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.
R-HSA-419812. Calcitonin-like ligand receptors.

Miscellaneous databases

ChiTaRSiRAMP3. human.
GeneWikiiRAMP3.
GenomeRNAii10268.
PROiO60896.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122679.
CleanExiHS_RAMP3.
ExpressionAtlasiO60896. baseline and differential.
GenevisibleiO60896. HS.

Family and domain databases

InterProiIPR006985. RAMP.
[Graphical view]
PANTHERiPTHR14076. PTHR14076. 1 hit.
PfamiPF04901. RAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAMP3_HUMAN
AccessioniPrimary (citable) accession number: O60896
Secondary accession number(s): Q7Z2Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.