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Protein

Receptor activity-modifying protein 1

Gene

RAMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.1 Publication

GO - Molecular functioni

  • calcitonin gene-related peptide binding Source: UniProtKB
  • calcitonin gene-related peptide receptor activity Source: UniProtKB
  • coreceptor activity Source: Ensembl
  • protein transporter activity Source: UniProtKB
  • signaling receptor activity Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  • amylin receptor signaling pathway Source: ARUK-UCL
  • angiogenesis Source: UniProtKB
  • calcitonin gene-related peptide receptor signaling pathway Source: UniProtKB
  • calcium ion transport Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: Reactome
  • intracellular protein transport Source: InterPro
  • positive regulation of cAMP metabolic process Source: ARUK-UCL
  • positive regulation of protein glycosylation Source: UniProtKB
  • protein localization to plasma membrane Source: UniProtKB
  • protein transport Source: UniProtKB
  • receptor internalization Source: UniProtKB
  • regulation of G-protein coupled receptor protein signaling pathway Source: InterPro

Keywordsi

Molecular functionReceptor
Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor activity-modifying protein 1
Alternative name(s):
Calcitonin-receptor-like receptor activity-modifying protein 1
Short name:
CRLR activity-modifying protein 1
Gene namesi
Name:RAMP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000132329.10
HGNCiHGNC:9843 RAMP1
MIMi605153 gene
neXtProtiNX_O60894

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 117ExtracellularSequence analysisAdd BLAST91
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 148CytoplasmicSequence analysis10

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10267
OpenTargetsiENSG00000132329
PharmGKBiPA34202

Chemistry databases

ChEMBLiCHEMBL2107838
DrugBankiDB01278 Pramlintide
GuidetoPHARMACOLOGYi51

Polymorphism and mutation databases

BioMutaiRAMP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000003016827 – 148Receptor activity-modifying protein 1Add BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 82
Disulfide bondi40 ↔ 72
Disulfide bondi57 ↔ 104

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO60894
PeptideAtlasiO60894
PRIDEiO60894

PTM databases

iPTMnetiO60894
PhosphoSitePlusiO60894

Expressioni

Tissue specificityi

Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract.1 Publication

Gene expression databases

BgeeiENSG00000132329
CleanExiHS_RAMP1
ExpressionAtlasiO60894 baseline and differential
GenevisibleiO60894 HS

Organism-specific databases

HPAiHPA057814

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCRLQ166023EBI-962893,EBI-962878

Protein-protein interaction databases

BioGridi115558, 22 interactors
CORUMiO60894
DIPiDIP-37675N
IntActiO60894, 1 interactor
STRINGi9606.ENSP00000254661

Chemistry databases

BindingDBiO60894

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 28Combined sources3
Helixi29 – 39Combined sources11
Helixi41 – 51Combined sources11
Helixi53 – 55Combined sources3
Helixi59 – 80Combined sources22
Helixi87 – 100Combined sources14
Beta strandi101 – 103Combined sources3
Beta strandi111 – 113Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YX8X-ray2.40A27-112[»]
3N7PX-ray2.80D/E/F/R26-117[»]
3N7RX-ray2.90C/D26-117[»]
3N7SX-ray2.10C/D26-117[»]
4RWGX-ray2.44A/B/C24-108[»]
5V6YX-ray2.80A/B/C/D24-111[»]
ProteinModelPortaliO60894
SMRiO60894
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60894

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZHQ Eukaryota
ENOG4111NGJ LUCA
GeneTreeiENSGT00390000016200
HOGENOMiHOG000253018
HOVERGENiHBG061268
InParanoidiO60894
KOiK08447
OMAiWRSKRPE
OrthoDBiEOG091G0KY6
PhylomeDBiO60894
TreeFamiTF333286

Family and domain databases

Gene3Di1.10.150.510, 1 hit
InterProiView protein in InterPro
IPR006985 RAMP
IPR038126 RAMP_sf
PANTHERiPTHR14076 PTHR14076, 1 hit
PfamiView protein in Pfam
PF04901 RAMP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARALCRLPR RGLWLLLAHH LFMTTACQEA NYGALLRELC LTQFQVDMEA
60 70 80 90 100
VGETLWCDWG RTIRSYRELA DCTWHMAEKL GCFWPNAEVD RFFLAVHGRY
110 120 130 140
FRSCPISGRA VRDPPGSILY PFIVVPITVT LLVTALVVWQ SKRTEGIV
Length:148
Mass (Da):16,988
Last modified:August 1, 1998 - v1
Checksum:i8530DD590BAEBE5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001014 mRNA Translation: CAA04472.1
AY265457 mRNA Translation: AAP23298.1
CR542032 mRNA Translation: CAG46829.1
CR542044 mRNA Translation: CAG46841.1
CH471063 Genomic DNA Translation: EAW71127.1
BC000548 mRNA Translation: AAH00548.1
CCDSiCCDS2522.1
RefSeqiNP_005846.1, NM_005855.3
UniGeneiHs.471783

Genome annotation databases

EnsembliENST00000254661; ENSP00000254661; ENSG00000132329
GeneIDi10267
KEGGihsa:10267
UCSCiuc002vxj.4 human

Similar proteinsi

Entry informationi

Entry nameiRAMP1_HUMAN
AccessioniPrimary (citable) accession number: O60894
Secondary accession number(s): Q6FGS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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