Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DnaJ homolog subfamily A member 2

Gene

DNAJA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Co-chaperone of Hsc70.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi143Zinc 1By similarity1
Metal bindingi146Zinc 1By similarity1
Metal bindingi159Zinc 2By similarity1
Metal bindingi162Zinc 2By similarity1
Metal bindingi186Zinc 2By similarity1
Metal bindingi189Zinc 2By similarity1
Metal bindingi202Zinc 1By similarity1
Metal bindingi205Zinc 1By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 214CR-typeAdd BLAST85

GO - Molecular functioni

  • ATP binding Source: InterPro
  • chaperone binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • unfolded protein binding Source: UniProtKB

GO - Biological processi

  • positive regulation of cell proliferation Source: ProtInc
  • protein refolding Source: UniProtKB
  • response to heat Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000069345-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily A member 2
Alternative name(s):
Cell cycle progression restoration gene 3 protein
Dnj3
Short name:
Dj3
HIRA-interacting protein 4
Renal carcinoma antigen NY-REN-14
Gene namesi
Name:DNAJA2
Synonyms:CPR3, HIRIP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14884. DNAJA2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10294.
OpenTargetsiENSG00000069345.
PharmGKBiPA27409.

Polymorphism and mutation databases

BioMutaiDNAJA2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710111 – 409DnaJ homolog subfamily A member 2Add BLAST409
PropeptideiPRO_0000393942410 – 412Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39N6-acetyllysineBy similarity1
Modified residuei78PhosphoserineCombined sources1
Modified residuei123PhosphoserineBy similarity1
Modified residuei152N6-acetyllysineBy similarity1
Modified residuei391PhosphotyrosineCombined sources1
Modified residuei394PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1
Modified residuei409Cysteine methyl esterCurated1
Lipidationi409S-farnesyl cysteine1 Publication1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiO60884.
MaxQBiO60884.
PaxDbiO60884.
PeptideAtlasiO60884.
PRIDEiO60884.

PTM databases

iPTMnetiO60884.
PhosphoSitePlusiO60884.
SwissPalmiO60884.

Expressioni

Gene expression databases

BgeeiENSG00000069345.
CleanExiHS_DNAJA2.
ExpressionAtlasiO60884. baseline and differential.
GenevisibleiO60884. HS.

Organism-specific databases

HPAiHPA049789.
HPA060538.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AICDAQ9GZX73EBI-352957,EBI-3834328
DNAJA4Q8WW222EBI-352957,EBI-2555157
NUDCQ9Y2662EBI-352957,EBI-357298

GO - Molecular functioni

  • chaperone binding Source: UniProtKB
  • unfolded protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115582. 86 interactors.
IntActiO60884. 54 interactors.
MINTiMINT-5005885.
STRINGi9606.ENSP00000314030.

Structurei

3D structure databases

ProteinModelPortaliO60884.
SMRiO60884.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 70JAdd BLAST63
Repeati143 – 150CXXCXGXG motif8
Repeati159 – 166CXXCXGXG motif8
Repeati186 – 193CXXCXGXG motif8
Repeati202 – 209CXXCXGXG motif8

Sequence similaritiesi

Contains 1 CR-type zinc finger.Curated
Contains 1 J domain.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 214CR-typeAdd BLAST85

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0712. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00860000133716.
HOGENOMiHOG000226718.
HOVERGENiHBG066727.
InParanoidiO60884.
KOiK09503.
OMAiDEESTHH.
OrthoDBiEOG091G0CAC.
PhylomeDBiO60884.
TreeFamiTF105141.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
2.10.230.10. 1 hit.
HAMAPiMF_01152. DnaJ. 1 hit.
InterProiIPR012724. DnaJ.
IPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
IPR001305. HSP_DnaJ_Cys-rich_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF01556. DnaJ_C. 1 hit.
PF00684. DnaJ_CXXCXGXG. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 3 hits.
SSF57938. SSF57938. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51188. ZF_CR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANVADTKLY DILGVPPGAS ENELKKAYRK LAKEYHPDKN PNAGDKFKEI
60 70 80 90 100
SFAYEVLSNP EKRELYDRYG EQGLREGSGG GGGMDDIFSH IFGGGLFGFM
110 120 130 140 150
GNQSRSRNGR RRGEDMMHPL KVSLEDLYNG KTTKLQLSKN VLCSACSGQG
160 170 180 190 200
GKSGAVQKCS ACRGRGVRIM IRQLAPGMVQ QMQSVCSDCN GEGEVINEKD
210 220 230 240 250
RCKKCEGKKV IKEVKILEVH VDKGMKHGQR ITFTGEADQA PGVEPGDIVL
260 270 280 290 300
LLQEKEHEVF QRDGNDLHMT YKIGLVEALC GFQFTFKHLD GRQIVVKYPP
310 320 330 340 350
GKVIEPGCVR VVRGEGMPQY RNPFEKGDLY IKFDVQFPEN NWINPDKLSE
360 370 380 390 400
LEDLLPSRPE VPNIIGETEE VELQEFDSTR GSGGGQRREA YNDSSDEESS
410
SHHGPGVQCA HQ
Length:412
Mass (Da):45,746
Last modified:August 1, 1998 - v1
Checksum:i8F1BC367425CB428
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17P → A in AAB69313 (PubMed:9383053).Curated1
Sequence conflicti42 – 46NAGDK → QMQETN in AAB69313 (PubMed:9383053).Curated5
Sequence conflicti83 – 93GMDDIFSHIFG → WHGLIFSLTVFC in AAB69313 (PubMed:9383053).CuratedAdd BLAST11
Sequence conflicti242 – 257GVEPG…QEKEH → EWNPETLFFLLPGEKNM in AAB69313 (PubMed:9383053).CuratedAdd BLAST16
Sequence conflicti286 – 287FK → LS in AAB69313 (PubMed:9383053).Curated2
Sequence conflicti328D → G in AAB69313 (PubMed:9383053).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001309 mRNA. Translation: CAA04669.1.
Y13350 mRNA. Translation: CAA73791.1.
AF011793 mRNA. Translation: AAB69313.1.
AK313031 mRNA. Translation: BAG35864.1.
CH471092 Genomic DNA. Translation: EAW82693.1.
BC013044 mRNA. Translation: AAH13044.1.
BC015809 mRNA. Translation: AAH15809.1.
CCDSiCCDS10726.1.
RefSeqiNP_005871.1. NM_005880.3.
UniGeneiHs.368078.

Genome annotation databases

EnsembliENST00000317089; ENSP00000314030; ENSG00000069345.
GeneIDi10294.
KEGGihsa:10294.
UCSCiuc002eeo.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001309 mRNA. Translation: CAA04669.1.
Y13350 mRNA. Translation: CAA73791.1.
AF011793 mRNA. Translation: AAB69313.1.
AK313031 mRNA. Translation: BAG35864.1.
CH471092 Genomic DNA. Translation: EAW82693.1.
BC013044 mRNA. Translation: AAH13044.1.
BC015809 mRNA. Translation: AAH15809.1.
CCDSiCCDS10726.1.
RefSeqiNP_005871.1. NM_005880.3.
UniGeneiHs.368078.

3D structure databases

ProteinModelPortaliO60884.
SMRiO60884.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115582. 86 interactors.
IntActiO60884. 54 interactors.
MINTiMINT-5005885.
STRINGi9606.ENSP00000314030.

PTM databases

iPTMnetiO60884.
PhosphoSitePlusiO60884.
SwissPalmiO60884.

Polymorphism and mutation databases

BioMutaiDNAJA2.

Proteomic databases

EPDiO60884.
MaxQBiO60884.
PaxDbiO60884.
PeptideAtlasiO60884.
PRIDEiO60884.

Protocols and materials databases

DNASUi10294.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317089; ENSP00000314030; ENSG00000069345.
GeneIDi10294.
KEGGihsa:10294.
UCSCiuc002eeo.3. human.

Organism-specific databases

CTDi10294.
DisGeNETi10294.
GeneCardsiDNAJA2.
H-InvDBHIX0173287.
HGNCiHGNC:14884. DNAJA2.
HPAiHPA049789.
HPA060538.
MIMi611322. gene.
neXtProtiNX_O60884.
OpenTargetsiENSG00000069345.
PharmGKBiPA27409.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0712. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00860000133716.
HOGENOMiHOG000226718.
HOVERGENiHBG066727.
InParanoidiO60884.
KOiK09503.
OMAiDEESTHH.
OrthoDBiEOG091G0CAC.
PhylomeDBiO60884.
TreeFamiTF105141.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000069345-MONOMER.

Miscellaneous databases

ChiTaRSiDNAJA2. human.
GeneWikiiDNAJA2.
GenomeRNAii10294.
PROiO60884.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000069345.
CleanExiHS_DNAJA2.
ExpressionAtlasiO60884. baseline and differential.
GenevisibleiO60884. HS.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
2.10.230.10. 1 hit.
HAMAPiMF_01152. DnaJ. 1 hit.
InterProiIPR012724. DnaJ.
IPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
IPR001305. HSP_DnaJ_Cys-rich_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF01556. DnaJ_C. 1 hit.
PF00684. DnaJ_CXXCXGXG. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 3 hits.
SSF57938. SSF57938. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51188. ZF_CR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNJA2_HUMAN
AccessioniPrimary (citable) accession number: O60884
Secondary accession number(s): B2R7L7, O14711
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 165 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.