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Protein

DnaJ homolog subfamily A member 2

Gene

DNAJA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi143Zinc 1By similarity1
Metal bindingi146Zinc 1By similarity1
Metal bindingi159Zinc 2By similarity1
Metal bindingi162Zinc 2By similarity1
Metal bindingi186Zinc 2By similarity1
Metal bindingi189Zinc 2By similarity1
Metal bindingi202Zinc 1By similarity1
Metal bindingi205Zinc 1By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 214CR-typeAdd BLAST85

GO - Molecular functioni

  • ATPase activator activity Source: UniProtKB
  • ATP binding Source: InterPro
  • chaperone binding Source: UniProtKB
  • heat shock protein binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW
  • unfolded protein binding Source: UniProtKB

GO - Biological processi

  • positive regulation of cell proliferation Source: ProtInc
  • protein refolding Source: UniProtKB
  • response to heat Source: InterPro

Keywordsi

Molecular functionChaperone
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily A member 2
Alternative name(s):
Cell cycle progression restoration gene 3 protein
Dnj3
Short name:
Dj3
HIRA-interacting protein 4
Renal carcinoma antigen NY-REN-14
Gene namesi
Name:DNAJA2
Synonyms:CPR3, HIRIP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000069345.11
HGNCiHGNC:14884 DNAJA2
MIMi611322 gene
neXtProtiNX_O60884

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10294
OpenTargetsiENSG00000069345
PharmGKBiPA27409

Polymorphism and mutation databases

BioMutaiDNAJA2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710111 – 409DnaJ homolog subfamily A member 2Add BLAST409
PropeptideiPRO_0000393942410 – 412Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39N6-acetyllysineBy similarity1
Modified residuei78PhosphoserineCombined sources1
Modified residuei123PhosphoserineBy similarity1
Cross-linki134Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei152N6-acetyllysineBy similarity1
Modified residuei391PhosphotyrosineCombined sources1
Modified residuei394PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1
Modified residuei409Cysteine methyl esterCurated1
Lipidationi409S-farnesyl cysteine1 Publication1

Keywords - PTMi

Acetylation, Isopeptide bond, Lipoprotein, Methylation, Phosphoprotein, Prenylation, Ubl conjugation

Proteomic databases

EPDiO60884
MaxQBiO60884
PaxDbiO60884
PeptideAtlasiO60884
PRIDEiO60884

PTM databases

iPTMnetiO60884
PhosphoSitePlusiO60884
SwissPalmiO60884

Expressioni

Gene expression databases

BgeeiENSG00000069345
CleanExiHS_DNAJA2
ExpressionAtlasiO60884 baseline and differential
GenevisibleiO60884 HS

Organism-specific databases

HPAiHPA049789
HPA060538

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • chaperone binding Source: UniProtKB
  • heat shock protein binding Source: InterPro
  • unfolded protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115582, 99 interactors
CORUMiO60884
DIPiDIP-33143N
IntActiO60884, 60 interactors
MINTiO60884
STRINGi9606.ENSP00000314030

Structurei

3D structure databases

ProteinModelPortaliO60884
SMRiO60884
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 70JAdd BLAST63
Repeati143 – 150CXXCXGXG motif8
Repeati159 – 166CXXCXGXG motif8
Repeati186 – 193CXXCXGXG motif8
Repeati202 – 209CXXCXGXG motif8

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 214CR-typeAdd BLAST85

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0712 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00860000133716
HOGENOMiHOG000226718
HOVERGENiHBG066727
InParanoidiO60884
KOiK09503
OMAiKCKGKRT
OrthoDBiEOG091G0CAC
PhylomeDBiO60884
TreeFamiTF105141

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd10719 DnaJ_zf, 1 hit
Gene3Di1.10.287.110, 1 hit
HAMAPiMF_01152 DnaJ, 1 hit
InterProiView protein in InterPro
IPR012724 DnaJ
IPR002939 DnaJ_C
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR008971 HSP40/DnaJ_pept-bd
IPR001305 HSP_DnaJ_Cys-rich_dom
IPR036410 HSP_DnaJ_Cys-rich_dom_sf
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF01556 DnaJ_C, 1 hit
PF00684 DnaJ_CXXCXGXG, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF49493 SSF49493, 3 hits
SSF57938 SSF57938, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
PS51188 ZF_CR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANVADTKLY DILGVPPGAS ENELKKAYRK LAKEYHPDKN PNAGDKFKEI
60 70 80 90 100
SFAYEVLSNP EKRELYDRYG EQGLREGSGG GGGMDDIFSH IFGGGLFGFM
110 120 130 140 150
GNQSRSRNGR RRGEDMMHPL KVSLEDLYNG KTTKLQLSKN VLCSACSGQG
160 170 180 190 200
GKSGAVQKCS ACRGRGVRIM IRQLAPGMVQ QMQSVCSDCN GEGEVINEKD
210 220 230 240 250
RCKKCEGKKV IKEVKILEVH VDKGMKHGQR ITFTGEADQA PGVEPGDIVL
260 270 280 290 300
LLQEKEHEVF QRDGNDLHMT YKIGLVEALC GFQFTFKHLD GRQIVVKYPP
310 320 330 340 350
GKVIEPGCVR VVRGEGMPQY RNPFEKGDLY IKFDVQFPEN NWINPDKLSE
360 370 380 390 400
LEDLLPSRPE VPNIIGETEE VELQEFDSTR GSGGGQRREA YNDSSDEESS
410
SHHGPGVQCA HQ
Length:412
Mass (Da):45,746
Last modified:August 1, 1998 - v1
Checksum:i8F1BC367425CB428
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17P → A in AAB69313 (PubMed:9383053).Curated1
Sequence conflicti42 – 46NAGDK → QMQETN in AAB69313 (PubMed:9383053).Curated5
Sequence conflicti83 – 93GMDDIFSHIFG → WHGLIFSLTVFC in AAB69313 (PubMed:9383053).CuratedAdd BLAST11
Sequence conflicti242 – 257GVEPG…QEKEH → EWNPETLFFLLPGEKNM in AAB69313 (PubMed:9383053).CuratedAdd BLAST16
Sequence conflicti286 – 287FK → LS in AAB69313 (PubMed:9383053).Curated2
Sequence conflicti328D → G in AAB69313 (PubMed:9383053).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001309 mRNA Translation: CAA04669.1
Y13350 mRNA Translation: CAA73791.1
AF011793 mRNA Translation: AAB69313.1
AK313031 mRNA Translation: BAG35864.1
CH471092 Genomic DNA Translation: EAW82693.1
BC013044 mRNA Translation: AAH13044.1
BC015809 mRNA Translation: AAH15809.1
CCDSiCCDS10726.1
RefSeqiNP_005871.1, NM_005880.3
UniGeneiHs.368078

Genome annotation databases

EnsembliENST00000317089; ENSP00000314030; ENSG00000069345
GeneIDi10294
KEGGihsa:10294
UCSCiuc002eeo.3 human

Similar proteinsi

Entry informationi

Entry nameiDNJA2_HUMAN
AccessioniPrimary (citable) accession number: O60884
Secondary accession number(s): B2R7L7, O14711
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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