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O60884

- DNJA2_HUMAN

UniProt

O60884 - DNJA2_HUMAN

Protein

DnaJ homolog subfamily A member 2

Gene

DNAJA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Co-chaperone of Hsc70.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi143 – 1431Zinc 1By similarity
    Metal bindingi146 – 1461Zinc 1By similarity
    Metal bindingi159 – 1591Zinc 2By similarity
    Metal bindingi162 – 1621Zinc 2By similarity
    Metal bindingi186 – 1861Zinc 2By similarity
    Metal bindingi189 – 1891Zinc 2By similarity
    Metal bindingi202 – 2021Zinc 1By similarity
    Metal bindingi205 – 2051Zinc 1By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri130 – 21485CR-typeAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. chaperone binding Source: UniProt
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: IntAct
    5. unfolded protein binding Source: UniProt

    GO - Biological processi

    1. positive regulation of cell proliferation Source: ProtInc
    2. protein refolding Source: UniProt
    3. response to heat Source: InterPro

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DnaJ homolog subfamily A member 2
    Alternative name(s):
    Cell cycle progression restoration gene 3 protein
    Dnj3
    Short name:
    Dj3
    HIRA-interacting protein 4
    Renal carcinoma antigen NY-REN-14
    Gene namesi
    Name:DNAJA2
    Synonyms:CPR3, HIRIP4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:14884. DNAJA2.

    Subcellular locationi

    Membrane Curated; Lipid-anchor Curated

    GO - Cellular componenti

    1. cytosol Source: UniProt
    2. extracellular vesicular exosome Source: UniProt
    3. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27409.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 409409DnaJ homolog subfamily A member 2PRO_0000071011Add
    BLAST
    Propeptidei410 – 4123Removed in mature formCuratedPRO_0000393942

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei39 – 391N6-acetyllysineBy similarity
    Modified residuei78 – 781Phosphoserine3 Publications
    Modified residuei152 – 1521N6-acetyllysineBy similarity
    Modified residuei409 – 4091Cysteine methyl esterCurated
    Lipidationi409 – 4091S-farnesyl cysteine1 Publication

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    MaxQBiO60884.
    PaxDbiO60884.
    PeptideAtlasiO60884.
    PRIDEiO60884.

    PTM databases

    PhosphoSiteiO60884.

    Expressioni

    Gene expression databases

    ArrayExpressiO60884.
    BgeeiO60884.
    CleanExiHS_DNAJA2.
    GenevestigatoriO60884.

    Organism-specific databases

    HPAiHPA049789.
    HPA060538.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AICDAQ9GZX73EBI-352957,EBI-3834328
    DNAJA4Q8WW222EBI-352957,EBI-2555157
    NUDCQ9Y2662EBI-352957,EBI-357298

    Protein-protein interaction databases

    BioGridi115582. 34 interactions.
    IntActiO60884. 31 interactions.
    MINTiMINT-5005885.
    STRINGi9606.ENSP00000314030.

    Structurei

    3D structure databases

    ProteinModelPortaliO60884.
    SMRiO60884. Positions 4-377.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 7063JAdd
    BLAST
    Repeati143 – 1508CXXCXGXG motif
    Repeati159 – 1668CXXCXGXG motif
    Repeati186 – 1938CXXCXGXG motif
    Repeati202 – 2098CXXCXGXG motif

    Sequence similaritiesi

    Contains 1 CR-type zinc finger.Curated
    Contains 1 J domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri130 – 21485CR-typeAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0484.
    HOGENOMiHOG000226718.
    HOVERGENiHBG066727.
    InParanoidiO60884.
    KOiK09503.
    OMAiKEHETYR.
    OrthoDBiEOG7XM2XK.
    PhylomeDBiO60884.
    TreeFamiTF105141.

    Family and domain databases

    Gene3Di1.10.287.110. 1 hit.
    2.10.230.10. 1 hit.
    HAMAPiMF_01152. DnaJ.
    InterProiIPR012724. DnaJ.
    IPR002939. DnaJ_C.
    IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    IPR008971. HSP40/DnaJ_pept-bd.
    IPR001305. HSP_DnaJ_Cys-rich_dom.
    [Graphical view]
    PfamiPF01556. CTDII. 1 hit.
    PF00226. DnaJ. 1 hit.
    PF00684. DnaJ_CXXCXGXG. 1 hit.
    [Graphical view]
    PRINTSiPR00625. JDOMAIN.
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    SSF49493. SSF49493. 3 hits.
    SSF57938. SSF57938. 1 hit.
    PROSITEiPS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    PS51188. ZF_CR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O60884-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANVADTKLY DILGVPPGAS ENELKKAYRK LAKEYHPDKN PNAGDKFKEI    50
    SFAYEVLSNP EKRELYDRYG EQGLREGSGG GGGMDDIFSH IFGGGLFGFM 100
    GNQSRSRNGR RRGEDMMHPL KVSLEDLYNG KTTKLQLSKN VLCSACSGQG 150
    GKSGAVQKCS ACRGRGVRIM IRQLAPGMVQ QMQSVCSDCN GEGEVINEKD 200
    RCKKCEGKKV IKEVKILEVH VDKGMKHGQR ITFTGEADQA PGVEPGDIVL 250
    LLQEKEHEVF QRDGNDLHMT YKIGLVEALC GFQFTFKHLD GRQIVVKYPP 300
    GKVIEPGCVR VVRGEGMPQY RNPFEKGDLY IKFDVQFPEN NWINPDKLSE 350
    LEDLLPSRPE VPNIIGETEE VELQEFDSTR GSGGGQRREA YNDSSDEESS 400
    SHHGPGVQCA HQ 412
    Length:412
    Mass (Da):45,746
    Last modified:August 1, 1998 - v1
    Checksum:i8F1BC367425CB428
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti17 – 171P → A in AAB69313. (PubMed:9383053)Curated
    Sequence conflicti42 – 465NAGDK → QMQETN in AAB69313. (PubMed:9383053)Curated
    Sequence conflicti83 – 9311GMDDIFSHIFG → WHGLIFSLTVFC in AAB69313. (PubMed:9383053)CuratedAdd
    BLAST
    Sequence conflicti242 – 25716GVEPG…QEKEH → EWNPETLFFLLPGEKNM in AAB69313. (PubMed:9383053)CuratedAdd
    BLAST
    Sequence conflicti286 – 2872FK → LS in AAB69313. (PubMed:9383053)Curated
    Sequence conflicti328 – 3281D → G in AAB69313. (PubMed:9383053)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001309 mRNA. Translation: CAA04669.1.
    Y13350 mRNA. Translation: CAA73791.1.
    AF011793 mRNA. Translation: AAB69313.1.
    AK313031 mRNA. Translation: BAG35864.1.
    CH471092 Genomic DNA. Translation: EAW82693.1.
    BC013044 mRNA. Translation: AAH13044.1.
    BC015809 mRNA. Translation: AAH15809.1.
    CCDSiCCDS10726.1.
    RefSeqiNP_005871.1. NM_005880.3.
    UniGeneiHs.368078.

    Genome annotation databases

    EnsembliENST00000317089; ENSP00000314030; ENSG00000069345.
    GeneIDi10294.
    KEGGihsa:10294.
    UCSCiuc002eeo.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001309 mRNA. Translation: CAA04669.1 .
    Y13350 mRNA. Translation: CAA73791.1 .
    AF011793 mRNA. Translation: AAB69313.1 .
    AK313031 mRNA. Translation: BAG35864.1 .
    CH471092 Genomic DNA. Translation: EAW82693.1 .
    BC013044 mRNA. Translation: AAH13044.1 .
    BC015809 mRNA. Translation: AAH15809.1 .
    CCDSi CCDS10726.1.
    RefSeqi NP_005871.1. NM_005880.3.
    UniGenei Hs.368078.

    3D structure databases

    ProteinModelPortali O60884.
    SMRi O60884. Positions 4-377.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115582. 34 interactions.
    IntActi O60884. 31 interactions.
    MINTi MINT-5005885.
    STRINGi 9606.ENSP00000314030.

    PTM databases

    PhosphoSitei O60884.

    Proteomic databases

    MaxQBi O60884.
    PaxDbi O60884.
    PeptideAtlasi O60884.
    PRIDEi O60884.

    Protocols and materials databases

    DNASUi 10294.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317089 ; ENSP00000314030 ; ENSG00000069345 .
    GeneIDi 10294.
    KEGGi hsa:10294.
    UCSCi uc002eeo.2. human.

    Organism-specific databases

    CTDi 10294.
    GeneCardsi GC16M046931.
    H-InvDB HIX0173287.
    HGNCi HGNC:14884. DNAJA2.
    HPAi HPA049789.
    HPA060538.
    MIMi 611322. gene.
    neXtProti NX_O60884.
    PharmGKBi PA27409.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0484.
    HOGENOMi HOG000226718.
    HOVERGENi HBG066727.
    InParanoidi O60884.
    KOi K09503.
    OMAi KEHETYR.
    OrthoDBi EOG7XM2XK.
    PhylomeDBi O60884.
    TreeFami TF105141.

    Miscellaneous databases

    ChiTaRSi DNAJA2. human.
    GeneWikii DNAJA2.
    GenomeRNAii 10294.
    NextBioi 39010.
    PROi O60884.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60884.
    Bgeei O60884.
    CleanExi HS_DNAJA2.
    Genevestigatori O60884.

    Family and domain databases

    Gene3Di 1.10.287.110. 1 hit.
    2.10.230.10. 1 hit.
    HAMAPi MF_01152. DnaJ.
    InterProi IPR012724. DnaJ.
    IPR002939. DnaJ_C.
    IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    IPR008971. HSP40/DnaJ_pept-bd.
    IPR001305. HSP_DnaJ_Cys-rich_dom.
    [Graphical view ]
    Pfami PF01556. CTDII. 1 hit.
    PF00226. DnaJ. 1 hit.
    PF00684. DnaJ_CXXCXGXG. 1 hit.
    [Graphical view ]
    PRINTSi PR00625. JDOMAIN.
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    SSF49493. SSF49493. 3 hits.
    SSF57938. SSF57938. 1 hit.
    PROSITEi PS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    PS51188. ZF_CR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "HIRIP4, a new human DnaJ, is a nuclear protein that interacts with the product of the DiGeorge syndrome gene candidate HIRA."
      Lorain S., Brendel C., Scamps C., Lecluse Y., Lipinski M.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Human CPR (cell cycle progression restoration) genes impart a Far-phenotype on yeast cells."
      Edwards M.C., Liegeois N., Horecka J., DePinho R.A., Sprague G.F. Jr., Tyers M., Elledge S.J.
      Genetics 147:1063-1076(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta and Skin.
    6. Cited for: IDENTIFICATION AS A RENAL CANCER ANTIGEN.
      Tissue: Renal cell carcinoma.
    7. "Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70."
      Terada K., Mori M.
      J. Biol. Chem. 275:24728-24734(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    8. "A tagging-via-substrate technology for detection and proteomics of farnesylated proteins."
      Kho Y., Kim S.C., Jiang C., Barma D., Kwon S.W., Cheng J., Jaunbergs J., Weinbaum C., Tamanoi F., Falck J., Zhao Y.
      Proc. Natl. Acad. Sci. U.S.A. 101:12479-12484(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: ISOPRENYLATION AT CYS-409.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDNJA2_HUMAN
    AccessioniPrimary (citable) accession number: O60884
    Secondary accession number(s): B2R7L7, O14711
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2001
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 144 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3