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O60883

- ETBR2_HUMAN

UniProt

O60883 - ETBR2_HUMAN

Protein

Prosaposin receptor GPR37L1

Gene

GPR37L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. protein binding Source: IntAct

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prosaposin receptor GPR37L1
    Alternative name(s):
    Endothelin B receptor-like protein 2
    Short name:
    ETBR-LP-2
    G-protein coupled receptor 37-like 1
    Gene namesi
    Name:GPR37L1
    Synonyms:ETBRLP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14923. GPR37L1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB-SubCell
    3. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28883.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 481456Prosaposin receptor GPR37L1PRO_0000012796Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi23 – 231O-linked (GalNAc...)1 Publication
    Glycosylationi79 – 791O-linked (GalNAc...)1 Publication
    Glycosylationi85 – 851O-linked (GalNAc...)1 Publication
    Glycosylationi86 – 861O-linked (GalNAc...)1 Publication
    Glycosylationi95 – 951O-linked (GalNAc...)1 Publication
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi107 – 1071O-linked (GalNAc...)1 Publication
    Disulfide bondi203 ↔ 286PROSITE-ProRule annotation

    Post-translational modificationi

    O-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO60883.
    PRIDEiO60883.

    PTM databases

    PhosphoSiteiO60883.

    Expressioni

    Tissue specificityi

    Expressed in the central nervous system.

    Gene expression databases

    BgeeiO60883.
    CleanExiHS_GPR37L1.
    GenevestigatoriO60883.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PRCPP427852EBI-2927498,EBI-2803892

    Protein-protein interaction databases

    IntActiO60883. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO60883.
    SMRiO60883. Positions 123-435.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 134109ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini156 – 16712CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini189 – 20517ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 25125CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini273 – 31038ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini332 – 36130CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini383 – 39816ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini420 – 48162CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei135 – 15521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei252 – 27221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei362 – 38221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei399 – 41921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi418 – 43922Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG291459.
    HOGENOMiHOG000252922.
    HOVERGENiHBG051808.
    InParanoidiO60883.
    KOiK04244.
    OMAiVWHSYYL.
    OrthoDBiEOG7CVPXV.
    PhylomeDBiO60883.
    TreeFamiTF331292.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003909. GPR37_orph.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01421. GPR37ORPHANR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O60883-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRWLWPLAVS LAVILAVGLS RVSGGAPLHL GRHRAETQEQ QSRSKRGTED    50
    EEAKGVQQYV PEEWAEYPRP IHPAGLQPTK PLVATSPNPG KDGGTPDSGQ 100
    ELRGNLTGAP GQRLQIQNPL YPVTESSYSA YAIMLLALVV FAVGIVGNLS 150
    VMCIVWHSYY LKSAWNSILA SLALWDFLVL FFCLPIVIFN EITKQRLLGD 200
    VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR PIERCQSILA 250
    KLAVIWVGSM TLAVPELLLW QLAQEPAPTM GTLDSCIMKP SASLPESLYS 300
    LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKSECRASKH 350
    EQCESQLNST VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI 400
    NQFSTFFKGA ITPVLLLCIC RPLGQAFLDC CCCCCCEECG GASEASAANG 450
    SDNKLKTEVS SSIYFHKPRE SPPLLPLGTP C 481
    Length:481
    Mass (Da):52,771
    Last modified:November 2, 2010 - v2
    Checksum:iEE9DFE0446E3AF24
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti204 – 2041R → S in BAG35876. (PubMed:14702039)Curated
    Sequence conflicti433 – 4331C → F in BAG35876. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti81 – 811P → A.
    Corresponds to variant rs3795594 [ dbSNP | Ensembl ].
    VAR_047455
    Natural varianti90 – 901G → D.2 Publications
    Corresponds to variant rs3795595 [ dbSNP | Ensembl ].
    VAR_047456
    Natural varianti91 – 911K → R.1 Publication
    Corresponds to variant rs17854616 [ dbSNP | Ensembl ].
    VAR_047457

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16280 mRNA. Translation: CAA76153.1.
    AK313044 mRNA. Translation: BAG35876.1.
    AK222639 mRNA. Translation: BAD96359.1.
    AL592300 Genomic DNA. Translation: CAI13106.1.
    BC050334 mRNA. Translation: AAH50334.1.
    CCDSiCCDS1420.1.
    RefSeqiNP_004758.3. NM_004767.3.
    UniGeneiHs.132049.

    Genome annotation databases

    EnsembliENST00000367282; ENSP00000356251; ENSG00000170075.
    GeneIDi9283.
    KEGGihsa:9283.
    UCSCiuc001gxj.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16280 mRNA. Translation: CAA76153.1 .
    AK313044 mRNA. Translation: BAG35876.1 .
    AK222639 mRNA. Translation: BAD96359.1 .
    AL592300 Genomic DNA. Translation: CAI13106.1 .
    BC050334 mRNA. Translation: AAH50334.1 .
    CCDSi CCDS1420.1.
    RefSeqi NP_004758.3. NM_004767.3.
    UniGenei Hs.132049.

    3D structure databases

    ProteinModelPortali O60883.
    SMRi O60883. Positions 123-435.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O60883. 1 interaction.

    Chemistry

    BindingDBi O60883.
    ChEMBLi CHEMBL5892.
    GuidetoPHARMACOLOGYi 104.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O60883.

    Proteomic databases

    PaxDbi O60883.
    PRIDEi O60883.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367282 ; ENSP00000356251 ; ENSG00000170075 .
    GeneIDi 9283.
    KEGGi hsa:9283.
    UCSCi uc001gxj.3. human.

    Organism-specific databases

    CTDi 9283.
    GeneCardsi GC01P202091.
    H-InvDB HIX0200009.
    HGNCi HGNC:14923. GPR37L1.
    neXtProti NX_O60883.
    PharmGKBi PA28883.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG291459.
    HOGENOMi HOG000252922.
    HOVERGENi HBG051808.
    InParanoidi O60883.
    KOi K04244.
    OMAi VWHSYYL.
    OrthoDBi EOG7CVPXV.
    PhylomeDBi O60883.
    TreeFami TF331292.

    Miscellaneous databases

    ChiTaRSi GPR37L1. human.
    GeneWikii GPR37L1.
    GenomeRNAii 9283.
    NextBioi 34789.
    PROi O60883.

    Gene expression databases

    Bgeei O60883.
    CleanExi HS_GPR37L1.
    Genevestigatori O60883.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003909. GPR37_orph.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01421. GPR37ORPHANR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new family of orphan G protein-coupled receptors predominantly expressed in the brain."
      Valdenaire O., Giller T., Breu V., Ardati A., Schweizer A., Richards J.G.
      FEBS Lett. 424:193-196(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-90.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-90.
      Tissue: Brain.
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-91.
      Tissue: Brain.
    6. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
      Halim A., Ruetschi U., Larson G., Nilsson J.
      J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT SER-23; THR-79; THR-85; SER-86; THR-95 AND THR-107, IDENTIFICATION BY MASS SPECTROMETRY.
    7. "GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin."
      Meyer R.C., Giddens M.M., Schaefer S.A., Hall R.A.
      Proc. Natl. Acad. Sci. U.S.A. 110:9529-9534(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiETBR2_HUMAN
    AccessioniPrimary (citable) accession number: O60883
    Secondary accession number(s): B2R7M9, Q5SXP7, Q86VP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3