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O60883

- ETBR2_HUMAN

UniProt

O60883 - ETBR2_HUMAN

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Protein

Prosaposin receptor GPR37L1

Gene

GPR37L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of astrocyte differentiation Source: Ensembl
  2. negative regulation of neuron differentiation Source: Ensembl
  3. negative regulation of smoothened signaling pathway Source: Ensembl
  4. positive regulation of cerebellar granule cell precursor proliferation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prosaposin receptor GPR37L1
Alternative name(s):
Endothelin B receptor-like protein 2
Short name:
ETBR-LP-2
G-protein coupled receptor 37-like 1
Gene namesi
Name:GPR37L1
Synonyms:ETBRLP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14923. GPR37L1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-KW
  3. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28883.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 481456Prosaposin receptor GPR37L1PRO_0000012796Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231O-linked (GalNAc...)1 Publication
Glycosylationi79 – 791O-linked (GalNAc...)1 Publication
Glycosylationi85 – 851O-linked (GalNAc...)1 Publication
Glycosylationi86 – 861O-linked (GalNAc...)1 Publication
Glycosylationi95 – 951O-linked (GalNAc...)1 Publication
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi107 – 1071O-linked (GalNAc...)1 Publication
Disulfide bondi203 ↔ 286PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO60883.
PRIDEiO60883.

PTM databases

PhosphoSiteiO60883.

Expressioni

Tissue specificityi

Expressed in the central nervous system.

Gene expression databases

BgeeiO60883.
CleanExiHS_GPR37L1.
GenevestigatoriO60883.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRCPP427852EBI-2927498,EBI-2803892

Protein-protein interaction databases

IntActiO60883. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO60883.
SMRiO60883. Positions 123-435.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 134109ExtracellularSequence AnalysisAdd
BLAST
Topological domaini156 – 16712CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini189 – 20517ExtracellularSequence AnalysisAdd
BLAST
Topological domaini227 – 25125CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini273 – 31038ExtracellularSequence AnalysisAdd
BLAST
Topological domaini332 – 36130CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini383 – 39816ExtracellularSequence AnalysisAdd
BLAST
Topological domaini420 – 48162CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei135 – 15521Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei168 – 18821Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei252 – 27221Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei311 – 33121Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei362 – 38221Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei399 – 41921Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi418 – 43922Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG291459.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiO60883.
KOiK04244.
OMAiVWHSYYL.
OrthoDBiEOG7CVPXV.
PhylomeDBiO60883.
TreeFamiTF331292.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60883 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRWLWPLAVS LAVILAVGLS RVSGGAPLHL GRHRAETQEQ QSRSKRGTED
60 70 80 90 100
EEAKGVQQYV PEEWAEYPRP IHPAGLQPTK PLVATSPNPG KDGGTPDSGQ
110 120 130 140 150
ELRGNLTGAP GQRLQIQNPL YPVTESSYSA YAIMLLALVV FAVGIVGNLS
160 170 180 190 200
VMCIVWHSYY LKSAWNSILA SLALWDFLVL FFCLPIVIFN EITKQRLLGD
210 220 230 240 250
VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR PIERCQSILA
260 270 280 290 300
KLAVIWVGSM TLAVPELLLW QLAQEPAPTM GTLDSCIMKP SASLPESLYS
310 320 330 340 350
LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKSECRASKH
360 370 380 390 400
EQCESQLNST VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI
410 420 430 440 450
NQFSTFFKGA ITPVLLLCIC RPLGQAFLDC CCCCCCEECG GASEASAANG
460 470 480
SDNKLKTEVS SSIYFHKPRE SPPLLPLGTP C
Length:481
Mass (Da):52,771
Last modified:November 2, 2010 - v2
Checksum:iEE9DFE0446E3AF24
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti204 – 2041R → S in BAG35876. (PubMed:14702039)Curated
Sequence conflicti433 – 4331C → F in BAG35876. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811P → A.
Corresponds to variant rs3795594 [ dbSNP | Ensembl ].
VAR_047455
Natural varianti90 – 901G → D.2 Publications
Corresponds to variant rs3795595 [ dbSNP | Ensembl ].
VAR_047456
Natural varianti91 – 911K → R.1 Publication
Corresponds to variant rs17854616 [ dbSNP | Ensembl ].
VAR_047457

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16280 mRNA. Translation: CAA76153.1.
AK313044 mRNA. Translation: BAG35876.1.
AK222639 mRNA. Translation: BAD96359.1.
AL592300 Genomic DNA. Translation: CAI13106.1.
BC050334 mRNA. Translation: AAH50334.1.
CCDSiCCDS1420.1.
RefSeqiNP_004758.3. NM_004767.3.
UniGeneiHs.132049.

Genome annotation databases

EnsembliENST00000367282; ENSP00000356251; ENSG00000170075.
GeneIDi9283.
KEGGihsa:9283.
UCSCiuc001gxj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16280 mRNA. Translation: CAA76153.1 .
AK313044 mRNA. Translation: BAG35876.1 .
AK222639 mRNA. Translation: BAD96359.1 .
AL592300 Genomic DNA. Translation: CAI13106.1 .
BC050334 mRNA. Translation: AAH50334.1 .
CCDSi CCDS1420.1.
RefSeqi NP_004758.3. NM_004767.3.
UniGenei Hs.132049.

3D structure databases

ProteinModelPortali O60883.
SMRi O60883. Positions 123-435.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O60883. 1 interaction.

Chemistry

BindingDBi O60883.
ChEMBLi CHEMBL5892.
GuidetoPHARMACOLOGYi 104.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O60883.

Proteomic databases

PaxDbi O60883.
PRIDEi O60883.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367282 ; ENSP00000356251 ; ENSG00000170075 .
GeneIDi 9283.
KEGGi hsa:9283.
UCSCi uc001gxj.3. human.

Organism-specific databases

CTDi 9283.
GeneCardsi GC01P202091.
H-InvDB HIX0200009.
HGNCi HGNC:14923. GPR37L1.
neXtProti NX_O60883.
PharmGKBi PA28883.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG291459.
GeneTreei ENSGT00760000119177.
HOGENOMi HOG000252922.
HOVERGENi HBG051808.
InParanoidi O60883.
KOi K04244.
OMAi VWHSYYL.
OrthoDBi EOG7CVPXV.
PhylomeDBi O60883.
TreeFami TF331292.

Miscellaneous databases

ChiTaRSi GPR37L1. human.
GeneWikii GPR37L1.
GenomeRNAii 9283.
NextBioi 34789.
PROi O60883.

Gene expression databases

Bgeei O60883.
CleanExi HS_GPR37L1.
Genevestigatori O60883.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new family of orphan G protein-coupled receptors predominantly expressed in the brain."
    Valdenaire O., Giller T., Breu V., Ardati A., Schweizer A., Richards J.G.
    FEBS Lett. 424:193-196(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-90.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-90.
    Tissue: Brain.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-91.
    Tissue: Brain.
  6. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
    Halim A., Ruetschi U., Larson G., Nilsson J.
    J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT SER-23; THR-79; THR-85; SER-86; THR-95 AND THR-107, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin."
    Meyer R.C., Giddens M.M., Schaefer S.A., Hall R.A.
    Proc. Natl. Acad. Sci. U.S.A. 110:9529-9534(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiETBR2_HUMAN
AccessioniPrimary (citable) accession number: O60883
Secondary accession number(s): B2R7M9, Q5SXP7, Q86VP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3