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Protein

Prosaposin receptor GPR37L1

Gene

GPR37L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.1 Publication

GO - Molecular functioni

  • G-protein coupled peptide receptor activity Source: ParkinsonsUK-UCL
  • peptide binding Source: ParkinsonsUK-UCL
  • prosaposin receptor activity Source: ParkinsonsUK-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170075-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Prosaposin receptor GPR37L1
Alternative name(s):
Endothelin B receptor-like protein 2
Short name:
ETBR-LP-2
G-protein coupled receptor 37-like 1
Gene namesi
Name:GPR37L1
Synonyms:ETBRLP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14923. GPR37L1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 134ExtracellularSequence analysisAdd BLAST109
Transmembranei135 – 155Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini156 – 167CytoplasmicSequence analysisAdd BLAST12
Transmembranei168 – 188Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini189 – 205ExtracellularSequence analysisAdd BLAST17
Transmembranei206 – 226Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini227 – 251CytoplasmicSequence analysisAdd BLAST25
Transmembranei252 – 272Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini273 – 310ExtracellularSequence analysisAdd BLAST38
Transmembranei311 – 331Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini332 – 361CytoplasmicSequence analysisAdd BLAST30
Transmembranei362 – 382Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini383 – 398ExtracellularSequence analysisAdd BLAST16
Transmembranei399 – 419Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini420 – 481CytoplasmicSequence analysisAdd BLAST62

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9283.
OpenTargetsiENSG00000170075.
PharmGKBiPA28883.

Chemistry databases

ChEMBLiCHEMBL5892.
GuidetoPHARMACOLOGYi104.

Polymorphism and mutation databases

BioMutaiGPR37L1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001279626 – 481Prosaposin receptor GPR37L1Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79O-linked (GalNAc...)1 Publication1
Glycosylationi85O-linked (GalNAc...)1 Publication1
Glycosylationi86O-linked (GalNAc...)1 Publication1
Glycosylationi95O-linked (GalNAc...)1 Publication1
Glycosylationi105N-linked (GlcNAc...)Sequence analysis1
Glycosylationi107O-linked (GalNAc...)1 Publication1
Disulfide bondi203 ↔ 286PROSITE-ProRule annotation
Modified residuei471PhosphoserineBy similarity1
Modified residuei479PhosphothreonineBy similarity1

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO60883.
PeptideAtlasiO60883.
PRIDEiO60883.

PTM databases

iPTMnetiO60883.
PhosphoSitePlusiO60883.
UniCarbKBiO60883.

Expressioni

Tissue specificityi

Expressed in the central nervous system.

Gene expression databases

BgeeiENSG00000170075.
CleanExiHS_GPR37L1.
GenevisibleiO60883. HS.

Organism-specific databases

HPAiHPA064454.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRCPP427852EBI-2927498,EBI-2803892

Protein-protein interaction databases

IntActiO60883. 1 interactor.
STRINGi9606.ENSP00000356251.

Chemistry databases

BindingDBiO60883.

Structurei

3D structure databases

ProteinModelPortaliO60883.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi418 – 439Cys-richAdd BLAST22

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiO60883.
KOiK04244.
OMAiTVVYALC.
OrthoDBiEOG091G053G.
PhylomeDBiO60883.
TreeFamiTF331292.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWLWPLAVS LAVILAVGLS RVSGGAPLHL GRHRAETQEQ QSRSKRGTED
60 70 80 90 100
EEAKGVQQYV PEEWAEYPRP IHPAGLQPTK PLVATSPNPG KDGGTPDSGQ
110 120 130 140 150
ELRGNLTGAP GQRLQIQNPL YPVTESSYSA YAIMLLALVV FAVGIVGNLS
160 170 180 190 200
VMCIVWHSYY LKSAWNSILA SLALWDFLVL FFCLPIVIFN EITKQRLLGD
210 220 230 240 250
VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR PIERCQSILA
260 270 280 290 300
KLAVIWVGSM TLAVPELLLW QLAQEPAPTM GTLDSCIMKP SASLPESLYS
310 320 330 340 350
LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKSECRASKH
360 370 380 390 400
EQCESQLNST VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI
410 420 430 440 450
NQFSTFFKGA ITPVLLLCIC RPLGQAFLDC CCCCCCEECG GASEASAANG
460 470 480
SDNKLKTEVS SSIYFHKPRE SPPLLPLGTP C
Length:481
Mass (Da):52,771
Last modified:November 2, 2010 - v2
Checksum:iEE9DFE0446E3AF24
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204R → S in BAG35876 (PubMed:14702039).Curated1
Sequence conflicti433C → F in BAG35876 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04745581P → A.Corresponds to variant rs3795594dbSNPEnsembl.1
Natural variantiVAR_04745690G → D.2 PublicationsCorresponds to variant rs3795595dbSNPEnsembl.1
Natural variantiVAR_04745791K → R.1 PublicationCorresponds to variant rs17854616dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16280 mRNA. Translation: CAA76153.1.
AK313044 mRNA. Translation: BAG35876.1.
AK222639 mRNA. Translation: BAD96359.1.
AL592300 Genomic DNA. Translation: CAI13106.1.
BC050334 mRNA. Translation: AAH50334.1.
CCDSiCCDS1420.1.
RefSeqiNP_004758.3. NM_004767.3.
UniGeneiHs.132049.
Hs.604697.

Genome annotation databases

EnsembliENST00000367282; ENSP00000356251; ENSG00000170075.
GeneIDi9283.
KEGGihsa:9283.
UCSCiuc001gxj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16280 mRNA. Translation: CAA76153.1.
AK313044 mRNA. Translation: BAG35876.1.
AK222639 mRNA. Translation: BAD96359.1.
AL592300 Genomic DNA. Translation: CAI13106.1.
BC050334 mRNA. Translation: AAH50334.1.
CCDSiCCDS1420.1.
RefSeqiNP_004758.3. NM_004767.3.
UniGeneiHs.132049.
Hs.604697.

3D structure databases

ProteinModelPortaliO60883.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO60883. 1 interactor.
STRINGi9606.ENSP00000356251.

Chemistry databases

BindingDBiO60883.
ChEMBLiCHEMBL5892.
GuidetoPHARMACOLOGYi104.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO60883.
PhosphoSitePlusiO60883.
UniCarbKBiO60883.

Polymorphism and mutation databases

BioMutaiGPR37L1.

Proteomic databases

PaxDbiO60883.
PeptideAtlasiO60883.
PRIDEiO60883.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367282; ENSP00000356251; ENSG00000170075.
GeneIDi9283.
KEGGihsa:9283.
UCSCiuc001gxj.4. human.

Organism-specific databases

CTDi9283.
DisGeNETi9283.
GeneCardsiGPR37L1.
H-InvDBHIX0200009.
HGNCiHGNC:14923. GPR37L1.
HPAiHPA064454.
neXtProtiNX_O60883.
OpenTargetsiENSG00000170075.
PharmGKBiPA28883.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiO60883.
KOiK04244.
OMAiTVVYALC.
OrthoDBiEOG091G053G.
PhylomeDBiO60883.
TreeFamiTF331292.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170075-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.

Miscellaneous databases

ChiTaRSiGPR37L1. human.
GeneWikiiGPR37L1.
GenomeRNAii9283.
PROiO60883.

Gene expression databases

BgeeiENSG00000170075.
CleanExiHS_GPR37L1.
GenevisibleiO60883. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiETBR2_HUMAN
AccessioniPrimary (citable) accession number: O60883
Secondary accession number(s): B2R7M9, Q5SXP7, Q86VP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 2, 2010
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.