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O60883 (ETBR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prosaposin receptor GPR37L1
Alternative name(s):
Endothelin B receptor-like protein 2
Short name=ETBR-LP-2
G-protein coupled receptor 37-like 1
Gene names
Name:GPR37L1
Synonyms:ETBRLP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade. Ref.7

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in the central nervous system.

Post-translational modification

O-glycosylated. Ref.6

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PRCPP427852EBI-2927498,EBI-2803892

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 481456Prosaposin receptor GPR37L1
PRO_0000012796

Regions

Topological domain26 – 134109Extracellular Potential
Transmembrane135 – 15521Helical; Name=1; Potential
Topological domain156 – 16712Cytoplasmic Potential
Transmembrane168 – 18821Helical; Name=2; Potential
Topological domain189 – 20517Extracellular Potential
Transmembrane206 – 22621Helical; Name=3; Potential
Topological domain227 – 25125Cytoplasmic Potential
Transmembrane252 – 27221Helical; Name=4; Potential
Topological domain273 – 31038Extracellular Potential
Transmembrane311 – 33121Helical; Name=5; Potential
Topological domain332 – 36130Cytoplasmic Potential
Transmembrane362 – 38221Helical; Name=6; Potential
Topological domain383 – 39816Extracellular Potential
Transmembrane399 – 41921Helical; Name=7; Potential
Topological domain420 – 48162Cytoplasmic Potential
Compositional bias418 – 43922Cys-rich

Amino acid modifications

Glycosylation231O-linked (GalNAc...) Ref.6
Glycosylation791O-linked (GalNAc...) Ref.6
Glycosylation851O-linked (GalNAc...) Ref.6
Glycosylation861O-linked (GalNAc...) Ref.6
Glycosylation951O-linked (GalNAc...) Ref.6
Glycosylation1051N-linked (GlcNAc...) Potential
Glycosylation1071O-linked (GalNAc...) Ref.6
Disulfide bond203 ↔ 286 By similarity

Natural variations

Natural variant811P → A.
Corresponds to variant rs3795594 [ dbSNP | Ensembl ].
VAR_047455
Natural variant901G → D. Ref.1 Ref.2
Corresponds to variant rs3795595 [ dbSNP | Ensembl ].
VAR_047456
Natural variant911K → R. Ref.5
Corresponds to variant rs17854616 [ dbSNP | Ensembl ].
VAR_047457

Experimental info

Sequence conflict2041R → S in BAG35876. Ref.2
Sequence conflict4331C → F in BAG35876. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O60883 [UniParc].

Last modified November 2, 2010. Version 2.
Checksum: EE9DFE0446E3AF24

FASTA48152,771
        10         20         30         40         50         60 
MRWLWPLAVS LAVILAVGLS RVSGGAPLHL GRHRAETQEQ QSRSKRGTED EEAKGVQQYV 

        70         80         90        100        110        120 
PEEWAEYPRP IHPAGLQPTK PLVATSPNPG KDGGTPDSGQ ELRGNLTGAP GQRLQIQNPL 

       130        140        150        160        170        180 
YPVTESSYSA YAIMLLALVV FAVGIVGNLS VMCIVWHSYY LKSAWNSILA SLALWDFLVL 

       190        200        210        220        230        240 
FFCLPIVIFN EITKQRLLGD VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR 

       250        260        270        280        290        300 
PIERCQSILA KLAVIWVGSM TLAVPELLLW QLAQEPAPTM GTLDSCIMKP SASLPESLYS 

       310        320        330        340        350        360 
LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKSECRASKH EQCESQLNST 

       370        380        390        400        410        420 
VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI NQFSTFFKGA ITPVLLLCIC 

       430        440        450        460        470        480 
RPLGQAFLDC CCCCCCEECG GASEASAANG SDNKLKTEVS SSIYFHKPRE SPPLLPLGTP 


C 

« Hide

References

« Hide 'large scale' references
[1]"A new family of orphan G protein-coupled receptors predominantly expressed in the brain."
Valdenaire O., Giller T., Breu V., Ardati A., Schweizer A., Richards J.G.
FEBS Lett. 424:193-196(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-90.
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-90.
Tissue: Brain.
[3]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-91.
Tissue: Brain.
[6]"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
Halim A., Ruetschi U., Larson G., Nilsson J.
J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT SER-23; THR-79; THR-85; SER-86; THR-95 AND THR-107, IDENTIFICATION BY MASS SPECTROMETRY.
[7]"GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin."
Meyer R.C., Giddens M.M., Schaefer S.A., Hall R.A.
Proc. Natl. Acad. Sci. U.S.A. 110:9529-9534(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y16280 mRNA. Translation: CAA76153.1.
AK313044 mRNA. Translation: BAG35876.1.
AK222639 mRNA. Translation: BAD96359.1.
AL592300 Genomic DNA. Translation: CAI13106.1.
BC050334 mRNA. Translation: AAH50334.1.
CCDSCCDS1420.1.
RefSeqNP_004758.3. NM_004767.3.
UniGeneHs.132049.

3D structure databases

ProteinModelPortalO60883.
SMRO60883. Positions 123-435.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO60883. 1 interaction.

Chemistry

BindingDBO60883.
ChEMBLCHEMBL5892.
GuidetoPHARMACOLOGY104.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO60883.

Proteomic databases

PaxDbO60883.
PRIDEO60883.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367282; ENSP00000356251; ENSG00000170075.
GeneID9283.
KEGGhsa:9283.
UCSCuc001gxj.3. human.

Organism-specific databases

CTD9283.
GeneCardsGC01P202091.
H-InvDBHIX0200009.
HGNCHGNC:14923. GPR37L1.
neXtProtNX_O60883.
PharmGKBPA28883.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG291459.
HOGENOMHOG000252922.
HOVERGENHBG051808.
InParanoidO60883.
KOK04244.
OMAVWHSYYL.
OrthoDBEOG7CVPXV.
PhylomeDBO60883.
TreeFamTF331292.

Gene expression databases

BgeeO60883.
CleanExHS_GPR37L1.
GenevestigatorO60883.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGPR37L1. human.
GeneWikiGPR37L1.
GenomeRNAi9283.
NextBio34789.
PROO60883.

Entry information

Entry nameETBR2_HUMAN
AccessionPrimary (citable) accession number: O60883
Secondary accession number(s): B2R7M9, Q5SXP7, Q86VP7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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SIMILARITY comments

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