O60883 (ETBR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Endothelin B receptor-like protein 2
Short name=ETBR-LP-2

Alternative name(s):
G-protein coupled receptor 37-like 1

Gene names

Name:	GPR37L1
Synonyms:	ETBRLP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in the central nervous system.
Post-translational modification	O-glycosylated. Ref.5
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PRCP	P42785	2	EBI-2927498,EBI-2803892

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 481	456	Endothelin B receptor-like protein 2		PRO_0000012796
Regions
	Topological domain	26 – 134	109	Extracellular Potential
	Transmembrane	135 – 155	21	Helical; Name=1; Potential
	Topological domain	156 – 167	12	Cytoplasmic Potential
	Transmembrane	168 – 188	21	Helical; Name=2; Potential
	Topological domain	189 – 205	17	Extracellular Potential
	Transmembrane	206 – 226	21	Helical; Name=3; Potential
	Topological domain	227 – 251	25	Cytoplasmic Potential
	Transmembrane	252 – 272	21	Helical; Name=4; Potential
	Topological domain	273 – 310	38	Extracellular Potential
	Transmembrane	311 – 331	21	Helical; Name=5; Potential
	Topological domain	332 – 361	30	Cytoplasmic Potential
	Transmembrane	362 – 382	21	Helical; Name=6; Potential
	Topological domain	383 – 398	16	Extracellular Potential
	Transmembrane	399 – 419	21	Helical; Name=7; Potential
	Topological domain	420 – 481	62	Cytoplasmic Potential
	Compositional bias	418 – 439	22	Cys-rich
Amino acid modifications
	Modified residue	471	1	Phosphoserine By similarity
	Glycosylation	23	1	O-linked (GalNAc...) Ref.5
	Glycosylation	79	1	O-linked (GalNAc...) Ref.5
	Glycosylation	85	1	O-linked (GalNAc...) Ref.5
	Glycosylation	86	1	O-linked (GalNAc...) Ref.5
	Glycosylation	95	1	O-linked (GalNAc...) Ref.5
	Glycosylation	105	1	N-linked (GlcNAc...) Potential
	Glycosylation	107	1	O-linked (GalNAc...) Ref.5
	Disulfide bond	203 ↔ 286		By similarity
Natural variations
	Natural variant	81	1	P → A. Corresponds to variant rs3795594 [ dbSNP | Ensembl ].		VAR_047455
	Natural variant	90	1	G → D. Ref.1 Corresponds to variant rs3795595 [ dbSNP | Ensembl ].		VAR_047456
	Natural variant	91	1	K → R. Ref.4 Corresponds to variant rs17854616 [ dbSNP | Ensembl ].		VAR_047457

Sequences

	Sequence		Length	Mass (Da)
	O60883 [UniParc]. Last modified November 2, 2010. Version 2. Checksum: EE9DFE0446E3AF24	FASTA	481	52,771
	10 20 30 40 50 60 MRWLWPLAVS LAVILAVGLS RVSGGAPLHL GRHRAETQEQ QSRSKRGTED EEAKGVQQYV 70 80 90 100 110 120 PEEWAEYPRP IHPAGLQPTK PLVATSPNPG KDGGTPDSGQ ELRGNLTGAP GQRLQIQNPL 130 140 150 160 170 180 YPVTESSYSA YAIMLLALVV FAVGIVGNLS VMCIVWHSYY LKSAWNSILA SLALWDFLVL 190 200 210 220 230 240 FFCLPIVIFN EITKQRLLGD VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR 250 260 270 280 290 300 PIERCQSILA KLAVIWVGSM TLAVPELLLW QLAQEPAPTM GTLDSCIMKP SASLPESLYS 310 320 330 340 350 360 LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKSECRASKH EQCESQLNST 370 380 390 400 410 420 VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI NQFSTFFKGA ITPVLLLCIC 430 440 450 460 470 480 RPLGQAFLDC CCCCCCEECG GASEASAANG SDNKLKTEVS SSIYFHKPRE SPPLLPLGTP C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new family of orphan G protein-coupled receptors predominantly expressed in the brain." Valdenaire O., Giller T., Breu V., Ardati A., Schweizer A., Richards J.G. FEBS Lett. 424:193-196(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-90. Tissue: Brain.
[2]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-91. Tissue: Brain.
[5]	"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins." Halim A., Ruetschi U., Larson G., Nilsson J. J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT SER-23; THR-79; THR-85; SER-86; THR-95 AND THR-107, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y16280 mRNA. Translation: CAA76153.1. AK222639 mRNA. Translation: BAD96359.1. AL592300 Genomic DNA. Translation: CAI13106.1. BC050334 mRNA. Translation: AAH50334.1.
IPI	IPI00032405.
RefSeq	NP_004758.3. NM_004767.3.
UniGene	Hs.132049.
3D structure databases
ProteinModelPortal	O60883.
SMR	O60883. Positions 127-328.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60883. 1 interaction.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O60883.
Proteomic databases
PaxDb	O60883.
PRIDE	O60883.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367282; ENSP00000356251; ENSG00000170075.
GeneID	9283.
KEGG	hsa:9283.
UCSC	uc001gxj.3. human.
Organism-specific databases
CTD	9283.
GeneCards	GC01P202091.
H-InvDB	HIX0200009.
HGNC	HGNC:14923. GPR37L1.
neXtProt	NX_O60883.
PharmGKB	PA28883.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG291459.
HOGENOM	HOG000252922.
HOVERGEN	HBG051808.
InParanoid	O60883.
KO	K04244.
OMA	VWHSYYL.
OrthoDB	EOG4CNQS6.
PhylomeDB	O60883.
Gene expression databases
ArrayExpress	O60883.
Bgee	O60883.
CleanEx	HS_GPR37L1.
Genevestigator	O60883.
GermOnline	ENSG00000170075. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR003909. GPR37_orph. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01421. GPR37ORPHANR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	O60883.
ChEMBL	CHEMBL5892.
ChiTaRS	GPR37L1. human.
GenomeRNAi	9283.
NextBio	34789.

Entry information

Entry name

ETBR2_HUMAN

Accession

Primary (citable) accession number: O60883
Secondary accession number(s): Q5SXP7, Q86VP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	November 2, 2010
Last modified:	May 1, 2013
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.