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O60879

- DIAP2_HUMAN

UniProt

O60879 - DIAP2_HUMAN

Protein

Protein diaphanous homolog 2

Gene

DIAPH2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.1 Publication

    GO - Molecular functioni

    1. receptor binding Source: ProtInc

    GO - Biological processi

    1. actin filament polymerization Source: Ensembl
    2. cytokinesis Source: ProtInc
    3. female gamete generation Source: ProtInc
    4. multicellular organismal development Source: UniProtKB-KW
    5. oogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Oogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein diaphanous homolog 2
    Alternative name(s):
    Diaphanous-related formin-2
    Short name:
    DRF2
    Gene namesi
    Name:DIAPH2
    Synonyms:DIA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:2877. DIAPH2.

    Subcellular locationi

    Isoform 3 : Cytoplasmcytosol. Early endosome
    Note: Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell
    2. early endosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Endosome

    Pathology & Biotechi

    Involvement in diseasei

    Premature ovarian failure 2A (POF2A) [MIM:300511]: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Premature ovarian failure

    Organism-specific databases

    MIMi300511. phenotype.
    Orphaneti619. Primary ovarian failure.
    PharmGKBiPA27334.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11011101Protein diaphanous homolog 2PRO_0000194895Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO60879.
    PaxDbiO60879.
    PRIDEiO60879.

    PTM databases

    PhosphoSiteiO60879.

    Expressioni

    Tissue specificityi

    Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes.

    Developmental stagei

    Expressed from E16 in ovary and testis and during P6-P16 during differentiation of ovarian follicles.

    Gene expression databases

    ArrayExpressiO60879.
    BgeeiO60879.
    CleanExiHS_DIAPH2.
    GenevestigatoriO60879.

    Organism-specific databases

    HPAiCAB015461.
    HPA005647.

    Interactioni

    Subunit structurei

    Isoform 3 interacts with RHOD in the GTP-bound form.1 Publication

    Protein-protein interaction databases

    BioGridi108074. 7 interactions.
    DIPiDIP-47261N.
    IntActiO60879. 4 interactions.
    STRINGi9606.ENSP00000321348.

    Structurei

    3D structure databases

    ProteinModelPortaliO60879.
    SMRiO60879. Positions 106-477, 630-1070.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini98 – 464367GBD/FH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini549 – 62375FH1Add
    BLAST
    Domaini628 – 1028401FH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1051 – 108131DADPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili366 – 41853Sequence AnalysisAdd
    BLAST
    Coiled coili487 – 54761Sequence AnalysisAdd
    BLAST
    Coiled coili903 – 1053151Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi257 – 2604Poly-Leu
    Compositional biasi543 – 5464Poly-Ser
    Compositional biasi562 – 57211Poly-ProAdd
    BLAST
    Compositional biasi576 – 58510Poly-Pro
    Compositional biasi591 – 5977Poly-Pro
    Compositional biasi603 – 6086Poly-Pro
    Compositional biasi613 – 6164Poly-Pro
    Compositional biasi1038 – 10414Poly-Lys
    Compositional biasi1072 – 10754Arg/Lys-rich (basic)

    Domaini

    The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments By similarity.By similarity

    Sequence similaritiesi

    Contains 1 DAD (diaphanous autoregulatory) domain.PROSITE-ProRule annotation
    Contains 1 FH2 (formin homology 2) domain.PROSITE-ProRule annotation
    Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG149898.
    HOGENOMiHOG000293231.
    HOVERGENiHBG051357.
    KOiK05741.
    OrthoDBiEOG7G1V5D.
    PhylomeDBiO60879.
    TreeFamiTF315383.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR027644. DIAPH2.
    IPR014767. Diaphanous_autoregulatory.
    IPR010465. Drf_DAD.
    IPR015425. FH2_Formin.
    IPR010472. FH3_dom.
    IPR010473. GTPase-bd.
    IPR014768. GTPase-bd/formin_homology_3.
    [Graphical view]
    PANTHERiPTHR23213:SF174. PTHR23213:SF174. 1 hit.
    PfamiPF06345. Drf_DAD. 1 hit.
    PF06367. Drf_FH3. 1 hit.
    PF06371. Drf_GBD. 1 hit.
    PF02181. FH2. 1 hit.
    [Graphical view]
    SMARTiSM00498. FH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS51231. DAD. 1 hit.
    PS51444. FH2. 1 hit.
    PS51232. GBD_FH3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60879-1) [UniParc]FASTAAdd to Basket

    Also known as: DIA-156

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEQPGAAASG AGGGSEEPGG GRSNKRSAGN RAANEEETKN KPKLNIQIKT     50
    LADDVRDRIT SFRKSTVKKE KPLIQHPIDS QVAMSEFPAA QPLYDERSLN 100
    LSEKEVLDLF EKMMEDMNLN EEKKAPLRNK DFTTKREMVV QYISATAKSG 150
    GLKNSKHECT LSSQEYVHEL RSGISDEKLL NCLESLRVSL TSNPVSWVNN 200
    FGHEGLGLLL DELEKLLDKK QQENIDKKNQ YKLIQCLKAF MNNKFGLQRI 250
    LGDERSLLLL ARAIDPKQPN MMTEIVKILS AICIVGEENI LDKLLGAITT 300
    AAERNNRERF SPIVEGLENQ EALQLQVACM QFINALVTSP YELDFRIHLR 350
    NEFLRSGLKT MLPDLKEKEN DELDIQLKVF DENKEDDLTE LSHRLNDIRA 400
    EMDDMNEVYH LLYNMLKDTA AENYFLSILQ HFLLIRNDYY IRPQYYKIIE 450
    ECVSQIVLHC SGMDPDFKYR QRLDIDLTHL IDSCVNKAKV EESEQKAAEF 500
    SKKFDEEFTA RQEAQAELQK RDEKIKELEA EIQQLRTQAQ VLSSSSGIPG 550
    PPAAPPLPGV GPPPPPPAPP LPGGAPLPPP PPPLPGMMGI PPPPPPPLLF 600
    GGPPPPPPLG GVPPPPGISL NLPYGMKQKK MYKPEVSMKR INWSKIEPTE 650
    LSENCFWLRV KEDKFENPDL FAKLALNFAT QIKVQKNAEA LEEKKTGPTK 700
    KKVKELRILD PKTAQNLSIF LGSYRMPYED IRNVILEVNE DMLSEALIQN 750
    LVKHLPEQKI LNELAELKNE YDDLCEPEQF GVVMSSVKML QPRLSSILFK 800
    LTFEEHINNI KPSIIAVTLA CEELKKSESF NRLLELVLLV GNYMNSGSRN 850
    AQSLGFKINF LCKIRDTKSA DQKTTLLHFI ADICEEKYRD ILKFPEELEH 900
    VESASKVSAQ ILKSNLASME QQIVHLERDI KKFPQAENQH DKFVEKMTSF 950
    TKTAREQYEK LSTMHNNMMK LYENLGEYFI FDSKTVSIEE FFGDLNNFRT 1000
    LFLEAVRENN KRREMEEKTR RAKLAKEKAE QEKLERQKKK KQLIDINKEG 1050
    DETGVMDNLL EALQSGAAFR DRRKRIPRNP DNRRVPLERS RSRHNGAISS 1100
    K 1101
    Length:1,101
    Mass (Da):125,569
    Last modified:August 1, 1998 - v1
    Checksum:i399F1C292D79188B
    GO
    Isoform 2 (identifier: O60879-2) [UniParc]FASTAAdd to Basket

    Also known as: DIA-12C, DIA2B

    The sequence of this isoform differs from the canonical sequence as follows:
         1081-1101: DNRRVPLERSRSRHNGAISSK → VVNHPCATRANPRSAT

    Show »
    Length:1,096
    Mass (Da):124,827
    Checksum:iD43A61A84A4B937F
    GO
    Isoform 3 (identifier: O60879-3) [UniParc]FASTAAdd to Basket

    Also known as: DIA2C

    The sequence of this isoform differs from the canonical sequence as follows:
         45-55: Missing.
         149-149: S → SIVGSKVT

    Show »
    Length:1,097
    Mass (Da):125,043
    Checksum:iEE15E9AC8C949229
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti425 – 4251F → L.
    Corresponds to variant rs20361 [ dbSNP | Ensembl ].
    VAR_049095
    Natural varianti426 – 4261L → V.
    Corresponds to variant rs20361 [ dbSNP | Ensembl ].
    VAR_049096

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei45 – 5511Missing in isoform 3. CuratedVSP_012955Add
    BLAST
    Alternative sequencei149 – 1491S → SIVGSKVT in isoform 3. CuratedVSP_012956
    Alternative sequencei1081 – 110121DNRRV…AISSK → VVNHPCATRANPRSAT in isoform 2. CuratedVSP_001573Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y15909 mRNA. Translation: CAA75870.1.
    Y15908 mRNA. Translation: CAA75869.1.
    AL139809
    , AL031053, AL161624, AL391821, AL592157, AL606530, AL669876, Z86061 Genomic DNA. Translation: CAI39928.1.
    AL161624
    , AL031053, AL139809, AL391821, AL592157, AL606530, AL669876, Z86061 Genomic DNA. Translation: CAI40915.1.
    AL592157
    , AL031053, AL139809, AL161624, AL391821, AL606530, AL669876, Z86061 Genomic DNA. Translation: CAI40544.1.
    AL606530
    , AL031053, AL139809, AL161624, AL391821, AL592157, AL669876, Z86061 Genomic DNA. Translation: CAI39841.1.
    Z86061
    , AL031053, AL139809, AL161624, AL391821, AL592157, AL606530, AL669876 Genomic DNA. Translation: CAI42257.1.
    AL031053
    , AL139809, AL161624, AL391821, AL592157, AL606530, AL669876, Z86061 Genomic DNA. Translation: CAI42515.1.
    AL669876
    , AL031053, AL139809, AL161624, AL391821, AL592157, AL606530, Z86061 Genomic DNA. Translation: CAH71113.1.
    AL669876
    , AL031053, AL139809, AL161624, AL592157, AL606530, Z86061 Genomic DNA. Translation: CAH71114.1.
    AL391821
    , AL031053, AL139809, AL161624, AL592157, AL606530, AL669876, Z86061 Genomic DNA. Translation: CAH71361.1.
    AL592157
    , AL031053, AL139809, AL161624, AL606530, AL669876, Z86061 Genomic DNA. Translation: CAI40545.1.
    AL606530
    , AL031053, AL139809, AL161624, AL592157, AL669876, Z86061 Genomic DNA. Translation: CAI39842.1.
    Z86061
    , AL031053, AL139809, AL161624, AL592157, AL606530, AL669876 Genomic DNA. Translation: CAI42258.1.
    AL161624
    , AL031053, AL139809, AL592157, AL606530, AL669876, Z86061 Genomic DNA. Translation: CAI40916.1.
    AL031053 Genomic DNA. Translation: CAB39108.2.
    AL139809 Genomic DNA. Translation: CAD13477.2.
    CCDSiCCDS14467.1. [O60879-1]
    CCDS14468.1. [O60879-2]
    RefSeqiNP_006720.1. NM_006729.4. [O60879-1]
    NP_009293.1. NM_007309.3. [O60879-2]
    UniGeneiHs.226483.

    Genome annotation databases

    EnsembliENST00000324765; ENSP00000321348; ENSG00000147202. [O60879-1]
    ENST00000373049; ENSP00000362140; ENSG00000147202. [O60879-2]
    GeneIDi1730.
    KEGGihsa:1730.
    UCSCiuc004eft.4. human. [O60879-2]
    uc004efu.4. human. [O60879-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y15909 mRNA. Translation: CAA75870.1 .
    Y15908 mRNA. Translation: CAA75869.1 .
    AL139809
    , AL031053 , AL161624 , AL391821 , AL592157 , AL606530 , AL669876 , Z86061 Genomic DNA. Translation: CAI39928.1 .
    AL161624
    , AL031053 , AL139809 , AL391821 , AL592157 , AL606530 , AL669876 , Z86061 Genomic DNA. Translation: CAI40915.1 .
    AL592157
    , AL031053 , AL139809 , AL161624 , AL391821 , AL606530 , AL669876 , Z86061 Genomic DNA. Translation: CAI40544.1 .
    AL606530
    , AL031053 , AL139809 , AL161624 , AL391821 , AL592157 , AL669876 , Z86061 Genomic DNA. Translation: CAI39841.1 .
    Z86061
    , AL031053 , AL139809 , AL161624 , AL391821 , AL592157 , AL606530 , AL669876 Genomic DNA. Translation: CAI42257.1 .
    AL031053
    , AL139809 , AL161624 , AL391821 , AL592157 , AL606530 , AL669876 , Z86061 Genomic DNA. Translation: CAI42515.1 .
    AL669876
    , AL031053 , AL139809 , AL161624 , AL391821 , AL592157 , AL606530 , Z86061 Genomic DNA. Translation: CAH71113.1 .
    AL669876
    , AL031053 , AL139809 , AL161624 , AL592157 , AL606530 , Z86061 Genomic DNA. Translation: CAH71114.1 .
    AL391821
    , AL031053 , AL139809 , AL161624 , AL592157 , AL606530 , AL669876 , Z86061 Genomic DNA. Translation: CAH71361.1 .
    AL592157
    , AL031053 , AL139809 , AL161624 , AL606530 , AL669876 , Z86061 Genomic DNA. Translation: CAI40545.1 .
    AL606530
    , AL031053 , AL139809 , AL161624 , AL592157 , AL669876 , Z86061 Genomic DNA. Translation: CAI39842.1 .
    Z86061
    , AL031053 , AL139809 , AL161624 , AL592157 , AL606530 , AL669876 Genomic DNA. Translation: CAI42258.1 .
    AL161624
    , AL031053 , AL139809 , AL592157 , AL606530 , AL669876 , Z86061 Genomic DNA. Translation: CAI40916.1 .
    AL031053 Genomic DNA. Translation: CAB39108.2 .
    AL139809 Genomic DNA. Translation: CAD13477.2 .
    CCDSi CCDS14467.1. [O60879-1 ]
    CCDS14468.1. [O60879-2 ]
    RefSeqi NP_006720.1. NM_006729.4. [O60879-1 ]
    NP_009293.1. NM_007309.3. [O60879-2 ]
    UniGenei Hs.226483.

    3D structure databases

    ProteinModelPortali O60879.
    SMRi O60879. Positions 106-477, 630-1070.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108074. 7 interactions.
    DIPi DIP-47261N.
    IntActi O60879. 4 interactions.
    STRINGi 9606.ENSP00000321348.

    PTM databases

    PhosphoSitei O60879.

    Proteomic databases

    MaxQBi O60879.
    PaxDbi O60879.
    PRIDEi O60879.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324765 ; ENSP00000321348 ; ENSG00000147202 . [O60879-1 ]
    ENST00000373049 ; ENSP00000362140 ; ENSG00000147202 . [O60879-2 ]
    GeneIDi 1730.
    KEGGi hsa:1730.
    UCSCi uc004eft.4. human. [O60879-2 ]
    uc004efu.4. human. [O60879-1 ]

    Organism-specific databases

    CTDi 1730.
    GeneCardsi GC0XP095939.
    HGNCi HGNC:2877. DIAPH2.
    HPAi CAB015461.
    HPA005647.
    MIMi 300108. gene.
    300511. phenotype.
    neXtProti NX_O60879.
    Orphaneti 619. Primary ovarian failure.
    PharmGKBi PA27334.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149898.
    HOGENOMi HOG000293231.
    HOVERGENi HBG051357.
    KOi K05741.
    OrthoDBi EOG7G1V5D.
    PhylomeDBi O60879.
    TreeFami TF315383.

    Miscellaneous databases

    GeneWikii DIAPH2.
    GenomeRNAii 1730.
    NextBioi 7003.
    PROi O60879.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60879.
    Bgeei O60879.
    CleanExi HS_DIAPH2.
    Genevestigatori O60879.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR027644. DIAPH2.
    IPR014767. Diaphanous_autoregulatory.
    IPR010465. Drf_DAD.
    IPR015425. FH2_Formin.
    IPR010472. FH3_dom.
    IPR010473. GTPase-bd.
    IPR014768. GTPase-bd/formin_homology_3.
    [Graphical view ]
    PANTHERi PTHR23213:SF174. PTHR23213:SF174. 1 hit.
    Pfami PF06345. Drf_DAD. 1 hit.
    PF06367. Drf_FH3. 1 hit.
    PF06371. Drf_GBD. 1 hit.
    PF02181. FH2. 1 hit.
    [Graphical view ]
    SMARTi SM00498. FH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS51231. DAD. 1 hit.
    PS51444. FH2. 1 hit.
    PS51232. GBD_FH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: evidence for conserved function in oogenesis and implications for human sterility."
      Bione S., Sala C., Manzini C., Arrigo G., Zuffardi O., Banfi S., Borsani G., Jonveaux P., Philippe C., Zuccotti M., Ballabio A., Toniolo D.
      Am. J. Hum. Genet. 62:533-541(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, INVOLVEMENT IN POF2A.
    2. "RhoD regulates endosome dynamics through diaphanous-related formin and Src tyrosine kinase."
      Gasman S., Kalaidzidis Y., Zerial M.
      Nat. Cell Biol. 5:195-204(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 3), INTERACTION WITH RHOD, SUBCELLULAR LOCATION, FUNCTION.
    3. Erratum
      Gasman S., Kalaidzidis Y., Zerial M.
      Nat. Cell Biol. 5:680-680(2003)
    4. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDIAP2_HUMAN
    AccessioniPrimary (citable) accession number: O60879
    Secondary accession number(s): A6NG19
    , O60878, Q8WX06, Q8WX48, Q9UJL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 142 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3