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O60879

- DIAP2_HUMAN

UniProt

O60879 - DIAP2_HUMAN

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Protein
Protein diaphanous homolog 2
Gene
DIAPH2, DIA
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.1 Publication

GO - Molecular functioni

  1. receptor binding Source: ProtInc

GO - Biological processi

  1. actin filament polymerization Source: Ensembl
  2. cytokinesis Source: ProtInc
  3. female gamete generation Source: ProtInc
  4. multicellular organismal development Source: UniProtKB-KW
  5. oogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Oogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein diaphanous homolog 2
Alternative name(s):
Diaphanous-related formin-2
Short name:
DRF2
Gene namesi
Name:DIAPH2
Synonyms:DIA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:2877. DIAPH2.

Subcellular locationi

Isoform 3 : Cytoplasmcytosol. Early endosome
Note: Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.1 Publication

GO - Cellular componenti

  1. cytosol Source: UniProtKB-SubCell
  2. early endosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome

Pathology & Biotechi

Involvement in diseasei

Premature ovarian failure 2A (POF2A) [MIM:300511]: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Keywords - Diseasei

Premature ovarian failure

Organism-specific databases

MIMi300511. phenotype.
Orphaneti619. Primary ovarian failure.
PharmGKBiPA27334.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11011101Protein diaphanous homolog 2
PRO_0000194895Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO60879.
PaxDbiO60879.
PRIDEiO60879.

PTM databases

PhosphoSiteiO60879.

Expressioni

Tissue specificityi

Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes.

Developmental stagei

Expressed from E16 in ovary and testis and during P6-P16 during differentiation of ovarian follicles.

Gene expression databases

ArrayExpressiO60879.
BgeeiO60879.
CleanExiHS_DIAPH2.
GenevestigatoriO60879.

Organism-specific databases

HPAiCAB015461.
HPA005647.

Interactioni

Subunit structurei

Isoform 3 interacts with RHOD in the GTP-bound form.1 Publication

Protein-protein interaction databases

BioGridi108074. 7 interactions.
DIPiDIP-47261N.
IntActiO60879. 3 interactions.
STRINGi9606.ENSP00000321348.

Structurei

3D structure databases

ProteinModelPortaliO60879.
SMRiO60879. Positions 106-477, 630-1070.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 464367GBD/FH3
Add
BLAST
Domaini549 – 62375FH1
Add
BLAST
Domaini628 – 1028401FH2
Add
BLAST
Domaini1051 – 108131DAD
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili366 – 41853 Reviewed prediction
Add
BLAST
Coiled coili487 – 54761 Reviewed prediction
Add
BLAST
Coiled coili903 – 1053151 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi257 – 2604Poly-Leu
Compositional biasi543 – 5464Poly-Ser
Compositional biasi562 – 57211Poly-Pro
Add
BLAST
Compositional biasi576 – 58510Poly-Pro
Compositional biasi591 – 5977Poly-Pro
Compositional biasi603 – 6086Poly-Pro
Compositional biasi613 – 6164Poly-Pro
Compositional biasi1038 – 10414Poly-Lys
Compositional biasi1072 – 10754Arg/Lys-rich (basic)

Domaini

The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments By similarity.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG149898.
HOGENOMiHOG000293231.
HOVERGENiHBG051357.
KOiK05741.
OrthoDBiEOG7G1V5D.
PhylomeDBiO60879.
TreeFamiTF315383.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR027644. DIAPH2.
IPR014767. Diaphanous_autoregulatory.
IPR010465. Drf_DAD.
IPR015425. FH2_Formin.
IPR010472. FH3_dom.
IPR010473. GTPase-bd.
IPR014768. GTPase-bd/formin_homology_3.
[Graphical view]
PANTHERiPTHR23213:SF174. PTHR23213:SF174. 1 hit.
PfamiPF06345. Drf_DAD. 1 hit.
PF06367. Drf_FH3. 1 hit.
PF06371. Drf_GBD. 1 hit.
PF02181. FH2. 1 hit.
[Graphical view]
SMARTiSM00498. FH2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51231. DAD. 1 hit.
PS51444. FH2. 1 hit.
PS51232. GBD_FH3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O60879-1) [UniParc]FASTAAdd to Basket

Also known as: DIA-156

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEQPGAAASG AGGGSEEPGG GRSNKRSAGN RAANEEETKN KPKLNIQIKT     50
LADDVRDRIT SFRKSTVKKE KPLIQHPIDS QVAMSEFPAA QPLYDERSLN 100
LSEKEVLDLF EKMMEDMNLN EEKKAPLRNK DFTTKREMVV QYISATAKSG 150
GLKNSKHECT LSSQEYVHEL RSGISDEKLL NCLESLRVSL TSNPVSWVNN 200
FGHEGLGLLL DELEKLLDKK QQENIDKKNQ YKLIQCLKAF MNNKFGLQRI 250
LGDERSLLLL ARAIDPKQPN MMTEIVKILS AICIVGEENI LDKLLGAITT 300
AAERNNRERF SPIVEGLENQ EALQLQVACM QFINALVTSP YELDFRIHLR 350
NEFLRSGLKT MLPDLKEKEN DELDIQLKVF DENKEDDLTE LSHRLNDIRA 400
EMDDMNEVYH LLYNMLKDTA AENYFLSILQ HFLLIRNDYY IRPQYYKIIE 450
ECVSQIVLHC SGMDPDFKYR QRLDIDLTHL IDSCVNKAKV EESEQKAAEF 500
SKKFDEEFTA RQEAQAELQK RDEKIKELEA EIQQLRTQAQ VLSSSSGIPG 550
PPAAPPLPGV GPPPPPPAPP LPGGAPLPPP PPPLPGMMGI PPPPPPPLLF 600
GGPPPPPPLG GVPPPPGISL NLPYGMKQKK MYKPEVSMKR INWSKIEPTE 650
LSENCFWLRV KEDKFENPDL FAKLALNFAT QIKVQKNAEA LEEKKTGPTK 700
KKVKELRILD PKTAQNLSIF LGSYRMPYED IRNVILEVNE DMLSEALIQN 750
LVKHLPEQKI LNELAELKNE YDDLCEPEQF GVVMSSVKML QPRLSSILFK 800
LTFEEHINNI KPSIIAVTLA CEELKKSESF NRLLELVLLV GNYMNSGSRN 850
AQSLGFKINF LCKIRDTKSA DQKTTLLHFI ADICEEKYRD ILKFPEELEH 900
VESASKVSAQ ILKSNLASME QQIVHLERDI KKFPQAENQH DKFVEKMTSF 950
TKTAREQYEK LSTMHNNMMK LYENLGEYFI FDSKTVSIEE FFGDLNNFRT 1000
LFLEAVRENN KRREMEEKTR RAKLAKEKAE QEKLERQKKK KQLIDINKEG 1050
DETGVMDNLL EALQSGAAFR DRRKRIPRNP DNRRVPLERS RSRHNGAISS 1100
K 1101
Length:1,101
Mass (Da):125,569
Last modified:August 1, 1998 - v1
Checksum:i399F1C292D79188B
GO
Isoform 2 (identifier: O60879-2) [UniParc]FASTAAdd to Basket

Also known as: DIA-12C, DIA2B

The sequence of this isoform differs from the canonical sequence as follows:
     1081-1101: DNRRVPLERSRSRHNGAISSK → VVNHPCATRANPRSAT

Show »
Length:1,096
Mass (Da):124,827
Checksum:iD43A61A84A4B937F
GO
Isoform 3 (identifier: O60879-3) [UniParc]FASTAAdd to Basket

Also known as: DIA2C

The sequence of this isoform differs from the canonical sequence as follows:
     45-55: Missing.
     149-149: S → SIVGSKVT

Show »
Length:1,097
Mass (Da):125,043
Checksum:iEE15E9AC8C949229
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti425 – 4251F → L.
Corresponds to variant rs20361 [ dbSNP | Ensembl ].
VAR_049095
Natural varianti426 – 4261L → V.
Corresponds to variant rs20361 [ dbSNP | Ensembl ].
VAR_049096

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei45 – 5511Missing in isoform 3.
VSP_012955Add
BLAST
Alternative sequencei149 – 1491S → SIVGSKVT in isoform 3.
VSP_012956
Alternative sequencei1081 – 110121DNRRV…AISSK → VVNHPCATRANPRSAT in isoform 2.
VSP_001573Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15909 mRNA. Translation: CAA75870.1.
Y15908 mRNA. Translation: CAA75869.1.
AL139809
, AL031053, AL161624, AL391821, AL592157, AL606530, AL669876, Z86061 Genomic DNA. Translation: CAI39928.1.
AL161624
, AL031053, AL139809, AL391821, AL592157, AL606530, AL669876, Z86061 Genomic DNA. Translation: CAI40915.1.
AL592157
, AL031053, AL139809, AL161624, AL391821, AL606530, AL669876, Z86061 Genomic DNA. Translation: CAI40544.1.
AL606530
, AL031053, AL139809, AL161624, AL391821, AL592157, AL669876, Z86061 Genomic DNA. Translation: CAI39841.1.
Z86061
, AL031053, AL139809, AL161624, AL391821, AL592157, AL606530, AL669876 Genomic DNA. Translation: CAI42257.1.
AL031053
, AL139809, AL161624, AL391821, AL592157, AL606530, AL669876, Z86061 Genomic DNA. Translation: CAI42515.1.
AL669876
, AL031053, AL139809, AL161624, AL391821, AL592157, AL606530, Z86061 Genomic DNA. Translation: CAH71113.1.
AL669876
, AL031053, AL139809, AL161624, AL592157, AL606530, Z86061 Genomic DNA. Translation: CAH71114.1.
AL391821
, AL031053, AL139809, AL161624, AL592157, AL606530, AL669876, Z86061 Genomic DNA. Translation: CAH71361.1.
AL592157
, AL031053, AL139809, AL161624, AL606530, AL669876, Z86061 Genomic DNA. Translation: CAI40545.1.
AL606530
, AL031053, AL139809, AL161624, AL592157, AL669876, Z86061 Genomic DNA. Translation: CAI39842.1.
Z86061
, AL031053, AL139809, AL161624, AL592157, AL606530, AL669876 Genomic DNA. Translation: CAI42258.1.
AL161624
, AL031053, AL139809, AL592157, AL606530, AL669876, Z86061 Genomic DNA. Translation: CAI40916.1.
AL031053 Genomic DNA. Translation: CAB39108.2.
AL139809 Genomic DNA. Translation: CAD13477.2.
CCDSiCCDS14467.1. [O60879-1]
CCDS14468.1. [O60879-2]
RefSeqiNP_006720.1. NM_006729.4. [O60879-1]
NP_009293.1. NM_007309.3. [O60879-2]
UniGeneiHs.226483.

Genome annotation databases

EnsembliENST00000324765; ENSP00000321348; ENSG00000147202. [O60879-1]
ENST00000373049; ENSP00000362140; ENSG00000147202. [O60879-2]
GeneIDi1730.
KEGGihsa:1730.
UCSCiuc004eft.4. human. [O60879-2]
uc004efu.4. human. [O60879-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15909 mRNA. Translation: CAA75870.1 .
Y15908 mRNA. Translation: CAA75869.1 .
AL139809
, AL031053 , AL161624 , AL391821 , AL592157 , AL606530 , AL669876 , Z86061 Genomic DNA. Translation: CAI39928.1 .
AL161624
, AL031053 , AL139809 , AL391821 , AL592157 , AL606530 , AL669876 , Z86061 Genomic DNA. Translation: CAI40915.1 .
AL592157
, AL031053 , AL139809 , AL161624 , AL391821 , AL606530 , AL669876 , Z86061 Genomic DNA. Translation: CAI40544.1 .
AL606530
, AL031053 , AL139809 , AL161624 , AL391821 , AL592157 , AL669876 , Z86061 Genomic DNA. Translation: CAI39841.1 .
Z86061
, AL031053 , AL139809 , AL161624 , AL391821 , AL592157 , AL606530 , AL669876 Genomic DNA. Translation: CAI42257.1 .
AL031053
, AL139809 , AL161624 , AL391821 , AL592157 , AL606530 , AL669876 , Z86061 Genomic DNA. Translation: CAI42515.1 .
AL669876
, AL031053 , AL139809 , AL161624 , AL391821 , AL592157 , AL606530 , Z86061 Genomic DNA. Translation: CAH71113.1 .
AL669876
, AL031053 , AL139809 , AL161624 , AL592157 , AL606530 , Z86061 Genomic DNA. Translation: CAH71114.1 .
AL391821
, AL031053 , AL139809 , AL161624 , AL592157 , AL606530 , AL669876 , Z86061 Genomic DNA. Translation: CAH71361.1 .
AL592157
, AL031053 , AL139809 , AL161624 , AL606530 , AL669876 , Z86061 Genomic DNA. Translation: CAI40545.1 .
AL606530
, AL031053 , AL139809 , AL161624 , AL592157 , AL669876 , Z86061 Genomic DNA. Translation: CAI39842.1 .
Z86061
, AL031053 , AL139809 , AL161624 , AL592157 , AL606530 , AL669876 Genomic DNA. Translation: CAI42258.1 .
AL161624
, AL031053 , AL139809 , AL592157 , AL606530 , AL669876 , Z86061 Genomic DNA. Translation: CAI40916.1 .
AL031053 Genomic DNA. Translation: CAB39108.2 .
AL139809 Genomic DNA. Translation: CAD13477.2 .
CCDSi CCDS14467.1. [O60879-1 ]
CCDS14468.1. [O60879-2 ]
RefSeqi NP_006720.1. NM_006729.4. [O60879-1 ]
NP_009293.1. NM_007309.3. [O60879-2 ]
UniGenei Hs.226483.

3D structure databases

ProteinModelPortali O60879.
SMRi O60879. Positions 106-477, 630-1070.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108074. 7 interactions.
DIPi DIP-47261N.
IntActi O60879. 3 interactions.
STRINGi 9606.ENSP00000321348.

PTM databases

PhosphoSitei O60879.

Proteomic databases

MaxQBi O60879.
PaxDbi O60879.
PRIDEi O60879.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000324765 ; ENSP00000321348 ; ENSG00000147202 . [O60879-1 ]
ENST00000373049 ; ENSP00000362140 ; ENSG00000147202 . [O60879-2 ]
GeneIDi 1730.
KEGGi hsa:1730.
UCSCi uc004eft.4. human. [O60879-2 ]
uc004efu.4. human. [O60879-1 ]

Organism-specific databases

CTDi 1730.
GeneCardsi GC0XP095939.
HGNCi HGNC:2877. DIAPH2.
HPAi CAB015461.
HPA005647.
MIMi 300108. gene.
300511. phenotype.
neXtProti NX_O60879.
Orphaneti 619. Primary ovarian failure.
PharmGKBi PA27334.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149898.
HOGENOMi HOG000293231.
HOVERGENi HBG051357.
KOi K05741.
OrthoDBi EOG7G1V5D.
PhylomeDBi O60879.
TreeFami TF315383.

Miscellaneous databases

GeneWikii DIAPH2.
GenomeRNAii 1730.
NextBioi 7003.
PROi O60879.
SOURCEi Search...

Gene expression databases

ArrayExpressi O60879.
Bgeei O60879.
CleanExi HS_DIAPH2.
Genevestigatori O60879.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR027644. DIAPH2.
IPR014767. Diaphanous_autoregulatory.
IPR010465. Drf_DAD.
IPR015425. FH2_Formin.
IPR010472. FH3_dom.
IPR010473. GTPase-bd.
IPR014768. GTPase-bd/formin_homology_3.
[Graphical view ]
PANTHERi PTHR23213:SF174. PTHR23213:SF174. 1 hit.
Pfami PF06345. Drf_DAD. 1 hit.
PF06367. Drf_FH3. 1 hit.
PF06371. Drf_GBD. 1 hit.
PF02181. FH2. 1 hit.
[Graphical view ]
SMARTi SM00498. FH2. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS51231. DAD. 1 hit.
PS51444. FH2. 1 hit.
PS51232. GBD_FH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: evidence for conserved function in oogenesis and implications for human sterility."
    Bione S., Sala C., Manzini C., Arrigo G., Zuffardi O., Banfi S., Borsani G., Jonveaux P., Philippe C., Zuccotti M., Ballabio A., Toniolo D.
    Am. J. Hum. Genet. 62:533-541(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, INVOLVEMENT IN POF2A.
  2. "RhoD regulates endosome dynamics through diaphanous-related formin and Src tyrosine kinase."
    Gasman S., Kalaidzidis Y., Zerial M.
    Nat. Cell Biol. 5:195-204(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 3), INTERACTION WITH RHOD, SUBCELLULAR LOCATION, FUNCTION.
  3. Erratum
    Gasman S., Kalaidzidis Y., Zerial M.
    Nat. Cell Biol. 5:680-680(2003)
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDIAP2_HUMAN
AccessioniPrimary (citable) accession number: O60879
Secondary accession number(s): A6NG19
, O60878, Q8WX06, Q8WX48, Q9UJL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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