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Protein

Growth arrest-specific protein 7

Gene

GAS7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in promoting maturation and morphological differentiation of cerebellar neurons.

GO - Molecular functioni

  • DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  • cell cycle arrest Source: ProtInc
  • cell differentiation Source: UniProtKB-KW
  • nervous system development Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

SignaLinkiO60861
SIGNORiO60861

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 7
Short name:
GAS-7
Gene namesi
Name:GAS7
Synonyms:KIAA0394
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000007237.18
HGNCiHGNC:4169 GAS7
MIMi603127 gene
neXtProtiNX_O60861

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving GAS7 is found in acute myeloid leukemia. Translocation t(11;17)(q23;p13) with KMT2A/MLL1.1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi8522
OpenTargetsiENSG00000007237
PharmGKBiPA28583

Polymorphism and mutation databases

BioMutaiGAS7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760571 – 476Growth arrest-specific protein 7Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphoserineCombined sources1
Modified residuei163PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO60861
PeptideAtlasiO60861
PRIDEiO60861

PTM databases

iPTMnetiO60861
PhosphoSitePlusiO60861

Expressioni

Gene expression databases

BgeeiENSG00000007237
CleanExiHS_GAS7
ExpressionAtlasiO60861 baseline and differential
GenevisibleiO60861 HS

Organism-specific databases

HPAiHPA004838
HPA064678

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114094, 23 interactors
IntActiO60861, 21 interactors
MINTiO60861
STRINGi9606.ENSP00000407552

Structurei

Secondary structure

1476
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 9Combined sources5
Beta strandi28 – 32Combined sources5
Beta strandi40 – 43Combined sources4
Beta strandi49 – 52Combined sources4
Helixi54 – 56Combined sources3
Beta strandi57 – 59Combined sources3
Beta strandi84 – 87Combined sources4
Beta strandi93 – 96Combined sources4
Beta strandi98 – 100Combined sources3
Beta strandi103 – 107Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LX7NMR-A1-60[»]
2YSHNMR-A79-111[»]
ProteinModelPortaliO60861
SMRiO60861
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60861

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 62SH3PROSITE-ProRule annotationAdd BLAST62
Domaini77 – 110WWPROSITE-ProRule annotationAdd BLAST34
Domaini196 – 456F-BARPROSITE-ProRule annotationAdd BLAST261

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili309 – 419Sequence analysisAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi67 – 70Poly-Pro4

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG0940 Eukaryota
KOG2398 Eukaryota
ENOG410Z5NV LUCA
GeneTreeiENSGT00860000133756
HOGENOMiHOG000294146
HOVERGENiHBG001320
InParanoidiO60861
KOiK18618
OMAiHMSLRKS
OrthoDBiEOG091G077K
PhylomeDBiO60861
TreeFamiTF328986

Family and domain databases

CDDicd07649 F-BAR_GAS7, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR037957 GAS7_F-BAR
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF14604 SH3_9, 1 hit
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 1 hit
SM00456 WW, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: O60861-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGARCRTLY PFSGERHGQG LRFAAGELIT LLQVPDGGWW EGEKEDGLRG
60 70 80 90 100
WFPASYVQLL EKPGMVPPPP GEESQTVILP PGWQSYLSPQ GRRYYVNTTT
110 120 130 140 150
NETTWERPSS SPGIPASPGS HRSSLPPTVN GYHASGTPAH PPETAHMSVR
160 170 180 190 200
KSTGDSQNLG SSSPSKKQSK ENTITINCVT FPHPDTMPEQ QLLKPTEWSY
210 220 230 240 250
CDYFWADKKD PQGNGTVAGF ELLLQKQLKG KQMQKEMSEF IRERIKIEED
260 270 280 290 300
YAKNLAKLSQ NSLASQEEGS LGEAWAQVKK SLADEAEVHL KFSAKLHSEV
310 320 330 340 350
EKPLMNFREN FKKDMKKCDH HIADLRKQLA SRYASVEKAR KALTERQRDL
360 370 380 390 400
EMKTQQLEIK LSNKTEEDIK KARRKSTQAG DDLMRCVDLY NQAQSKWFEE
410 420 430 440 450
MVTTTLELER LEVERVEMIR QHLCQYTQLR HETDMFNQST VEPVDQLLRK
460 470
VDPAKDRELW VREHKTGNIR PVDMEI
Length:476
Mass (Da):54,371
Last modified:December 16, 2008 - v3
Checksum:i57BFB99907652745
GO
Isoform 1 (identifier: O60861-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Show »
Length:412
Mass (Da):47,266
Checksum:iB65049D5F18254A7
GO
Isoform 2 (identifier: O60861-2) [UniParc]FASTAAdd to basket
Also known as: GAS7-CB

The sequence of this isoform differs from the canonical sequence as follows:
     1-140: Missing.
     141-156: PPETAHMSVRKSTGDS → MSNMENSFDDVSCLSP

Show »
Length:336
Mass (Da):39,206
Checksum:iB57E482E417B5F39
GO
Isoform 4 (identifier: O60861-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.
     61-61: E → M

Show »
Length:416
Mass (Da):47,680
Checksum:i56CCB6E52CC680F5
GO

Sequence cautioni

The sequence BAA23690 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti301E → D in CAA12177 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0068021 – 140Missing in isoform 2. 2 PublicationsAdd BLAST140
Alternative sequenceiVSP_0359881 – 64Missing in isoform 1. 3 PublicationsAdd BLAST64
Alternative sequenceiVSP_0442941 – 60Missing in isoform 4. 2 PublicationsAdd BLAST60
Alternative sequenceiVSP_04429561E → M in isoform 4. 2 Publications1
Alternative sequenceiVSP_006803141 – 156PPETA…STGDS → MSNMENSFDDVSCLSP in isoform 2. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224876 mRNA Translation: CAA12177.1
AB007854 mRNA Translation: BAA23690.2 Different initiation.
AY327406 mRNA Translation: AAP92798.1
BT006891 mRNA Translation: AAP35537.1
AK292987 mRNA Translation: BAF85676.1
AK315162 mRNA Translation: BAG37606.1
AC000003 Genomic DNA No translation available.
AC005747 Genomic DNA No translation available.
AC026591 Genomic DNA No translation available.
AC083783 Genomic DNA No translation available.
AC107938 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90013.1
CH471108 Genomic DNA Translation: EAW90011.1
CH471108 Genomic DNA Translation: EAW90012.1
BC001152 mRNA Translation: AAH01152.1
BC006454 mRNA Translation: AAH06454.2
AF231998 mRNA Translation: AAG26332.2 Sequence problems.
CCDSiCCDS11152.1 [O60861-3]
CCDS42263.1 [O60861-4]
CCDS45611.1 [O60861-2]
CCDS58518.1 [O60861-1]
RefSeqiNP_001124303.1, NM_001130831.1 [O60861-1]
NP_003635.2, NM_003644.2 [O60861-2]
NP_958836.1, NM_201432.1 [O60861-4]
NP_958839.1, NM_201433.1 [O60861-3]
XP_005256888.1, XM_005256831.3 [O60861-1]
XP_005256889.1, XM_005256832.3 [O60861-1]
XP_011522346.1, XM_011524044.2 [O60861-1]
XP_016880728.1, XM_017025239.1 [O60861-1]
UniGeneiHs.462214

Genome annotation databases

EnsembliENST00000323816; ENSP00000322608; ENSG00000007237 [O60861-4]
ENST00000432992; ENSP00000407552; ENSG00000007237 [O60861-3]
ENST00000437099; ENSP00000410108; ENSG00000007237 [O60861-1]
ENST00000542249; ENSP00000443265; ENSG00000007237 [O60861-1]
ENST00000579158; ENSP00000463527; ENSG00000007237 [O60861-1]
ENST00000580865; ENSP00000463873; ENSG00000007237 [O60861-2]
ENST00000585266; ENSP00000464240; ENSG00000007237 [O60861-4]
GeneIDi8522
KEGGihsa:8522
UCSCiuc002gmg.2 human [O60861-3]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiGAS7_HUMAN
AccessioniPrimary (citable) accession number: O60861
Secondary accession number(s): A8KAC2
, B2RCK9, O43144, Q53Y77, Q7Z571
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 172 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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