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Protein

Growth arrest-specific protein 7

Gene

GAS7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in promoting maturation and morphological differentiation of cerebellar neurons.

GO - Molecular functioni

  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • cell cycle arrest Source: ProtInc
  • cell differentiation Source: UniProtKB-KW
  • nervous system development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000007237-MONOMER.
SignaLinkiO60861.
SIGNORiO60861.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 7
Short name:
GAS-7
Gene namesi
Name:GAS7
Synonyms:KIAA0394
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:4169. GAS7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving GAS7 is found in acute myeloid leukemia. Translocation t(11;17)(q23;p13) with KMT2A/MLL1.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi8522.
OpenTargetsiENSG00000007237.
PharmGKBiPA28583.

Polymorphism and mutation databases

BioMutaiGAS7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760571 – 476Growth arrest-specific protein 7Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphoserineCombined sources1
Modified residuei163PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO60861.
PeptideAtlasiO60861.
PRIDEiO60861.

PTM databases

iPTMnetiO60861.
PhosphoSitePlusiO60861.

Expressioni

Gene expression databases

BgeeiENSG00000007237.
CleanExiHS_GAS7.
ExpressionAtlasiO60861. baseline and differential.
GenevisibleiO60861. HS.

Organism-specific databases

HPAiHPA004838.
HPA064678.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
WDYHV1Q96HA84EBI-11745923,EBI-741158

Protein-protein interaction databases

BioGridi114094. 23 interactors.
IntActiO60861. 19 interactors.
MINTiMINT-1577125.
STRINGi9606.ENSP00000407552.

Structurei

Secondary structure

1476
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 9Combined sources5
Beta strandi28 – 32Combined sources5
Beta strandi40 – 43Combined sources4
Beta strandi49 – 52Combined sources4
Helixi54 – 56Combined sources3
Beta strandi57 – 59Combined sources3
Beta strandi84 – 87Combined sources4
Beta strandi93 – 96Combined sources4
Beta strandi98 – 100Combined sources3
Beta strandi103 – 107Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LX7NMR-A1-60[»]
2YSHNMR-A79-111[»]
ProteinModelPortaliO60861.
SMRiO60861.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60861.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 62SH3PROSITE-ProRule annotationAdd BLAST62
Domaini77 – 110WWPROSITE-ProRule annotationAdd BLAST34
Domaini196 – 456F-BARPROSITE-ProRule annotationAdd BLAST261

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili309 – 419Sequence analysisAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi67 – 70Poly-Pro4

Sequence similaritiesi

Contains 1 F-BAR domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
KOG2398. Eukaryota.
ENOG410Z5NV. LUCA.
GeneTreeiENSGT00860000133756.
HOGENOMiHOG000294146.
HOVERGENiHBG001320.
InParanoidiO60861.
KOiK18618.
OMAiSYMSPQG.
OrthoDBiEOG091G077K.
PhylomeDBiO60861.
TreeFamiTF328986.

Family and domain databases

InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR001452. SH3_domain.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF14604. SH3_9. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00055. FCH. 1 hit.
SM00326. SH3. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS50002. SH3. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: O60861-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGARCRTLY PFSGERHGQG LRFAAGELIT LLQVPDGGWW EGEKEDGLRG
60 70 80 90 100
WFPASYVQLL EKPGMVPPPP GEESQTVILP PGWQSYLSPQ GRRYYVNTTT
110 120 130 140 150
NETTWERPSS SPGIPASPGS HRSSLPPTVN GYHASGTPAH PPETAHMSVR
160 170 180 190 200
KSTGDSQNLG SSSPSKKQSK ENTITINCVT FPHPDTMPEQ QLLKPTEWSY
210 220 230 240 250
CDYFWADKKD PQGNGTVAGF ELLLQKQLKG KQMQKEMSEF IRERIKIEED
260 270 280 290 300
YAKNLAKLSQ NSLASQEEGS LGEAWAQVKK SLADEAEVHL KFSAKLHSEV
310 320 330 340 350
EKPLMNFREN FKKDMKKCDH HIADLRKQLA SRYASVEKAR KALTERQRDL
360 370 380 390 400
EMKTQQLEIK LSNKTEEDIK KARRKSTQAG DDLMRCVDLY NQAQSKWFEE
410 420 430 440 450
MVTTTLELER LEVERVEMIR QHLCQYTQLR HETDMFNQST VEPVDQLLRK
460 470
VDPAKDRELW VREHKTGNIR PVDMEI
Length:476
Mass (Da):54,371
Last modified:December 16, 2008 - v3
Checksum:i57BFB99907652745
GO
Isoform 1 (identifier: O60861-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Show »
Length:412
Mass (Da):47,266
Checksum:iB65049D5F18254A7
GO
Isoform 2 (identifier: O60861-2) [UniParc]FASTAAdd to basket
Also known as: GAS7-CB

The sequence of this isoform differs from the canonical sequence as follows:
     1-140: Missing.
     141-156: PPETAHMSVRKSTGDS → MSNMENSFDDVSCLSP

Show »
Length:336
Mass (Da):39,206
Checksum:iB57E482E417B5F39
GO
Isoform 4 (identifier: O60861-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.
     61-61: E → M

Show »
Length:416
Mass (Da):47,680
Checksum:i56CCB6E52CC680F5
GO

Sequence cautioni

The sequence BAA23690 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti301E → D in CAA12177 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0068021 – 140Missing in isoform 2. 2 PublicationsAdd BLAST140
Alternative sequenceiVSP_0359881 – 64Missing in isoform 1. 3 PublicationsAdd BLAST64
Alternative sequenceiVSP_0442941 – 60Missing in isoform 4. 2 PublicationsAdd BLAST60
Alternative sequenceiVSP_04429561E → M in isoform 4. 2 Publications1
Alternative sequenceiVSP_006803141 – 156PPETA…STGDS → MSNMENSFDDVSCLSP in isoform 2. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224876 mRNA. Translation: CAA12177.1.
AB007854 mRNA. Translation: BAA23690.2. Different initiation.
AY327406 mRNA. Translation: AAP92798.1.
BT006891 mRNA. Translation: AAP35537.1.
AK292987 mRNA. Translation: BAF85676.1.
AK315162 mRNA. Translation: BAG37606.1.
AC000003 Genomic DNA. No translation available.
AC005747 Genomic DNA. No translation available.
AC026591 Genomic DNA. No translation available.
AC083783 Genomic DNA. No translation available.
AC107938 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90013.1.
CH471108 Genomic DNA. Translation: EAW90011.1.
CH471108 Genomic DNA. Translation: EAW90012.1.
BC001152 mRNA. Translation: AAH01152.1.
BC006454 mRNA. Translation: AAH06454.2.
AF231998 mRNA. Translation: AAG26332.2. Sequence problems.
CCDSiCCDS11152.1. [O60861-3]
CCDS42263.1. [O60861-4]
CCDS45611.1. [O60861-2]
CCDS58518.1. [O60861-1]
RefSeqiNP_001124303.1. NM_001130831.1. [O60861-1]
NP_003635.2. NM_003644.2. [O60861-2]
NP_958836.1. NM_201432.1. [O60861-4]
NP_958839.1. NM_201433.1. [O60861-3]
XP_005256888.1. XM_005256831.3. [O60861-1]
XP_005256889.1. XM_005256832.3. [O60861-1]
XP_011522346.1. XM_011524044.2. [O60861-1]
XP_016880728.1. XM_017025239.1. [O60861-1]
UniGeneiHs.462214.

Genome annotation databases

EnsembliENST00000323816; ENSP00000322608; ENSG00000007237. [O60861-4]
ENST00000432992; ENSP00000407552; ENSG00000007237. [O60861-3]
ENST00000437099; ENSP00000410108; ENSG00000007237. [O60861-1]
ENST00000542249; ENSP00000443265; ENSG00000007237. [O60861-1]
ENST00000579158; ENSP00000463527; ENSG00000007237. [O60861-1]
ENST00000580865; ENSP00000463873; ENSG00000007237. [O60861-2]
ENST00000585266; ENSP00000464240; ENSG00000007237. [O60861-4]
GeneIDi8522.
KEGGihsa:8522.
UCSCiuc002gmg.2. human. [O60861-3]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224876 mRNA. Translation: CAA12177.1.
AB007854 mRNA. Translation: BAA23690.2. Different initiation.
AY327406 mRNA. Translation: AAP92798.1.
BT006891 mRNA. Translation: AAP35537.1.
AK292987 mRNA. Translation: BAF85676.1.
AK315162 mRNA. Translation: BAG37606.1.
AC000003 Genomic DNA. No translation available.
AC005747 Genomic DNA. No translation available.
AC026591 Genomic DNA. No translation available.
AC083783 Genomic DNA. No translation available.
AC107938 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90013.1.
CH471108 Genomic DNA. Translation: EAW90011.1.
CH471108 Genomic DNA. Translation: EAW90012.1.
BC001152 mRNA. Translation: AAH01152.1.
BC006454 mRNA. Translation: AAH06454.2.
AF231998 mRNA. Translation: AAG26332.2. Sequence problems.
CCDSiCCDS11152.1. [O60861-3]
CCDS42263.1. [O60861-4]
CCDS45611.1. [O60861-2]
CCDS58518.1. [O60861-1]
RefSeqiNP_001124303.1. NM_001130831.1. [O60861-1]
NP_003635.2. NM_003644.2. [O60861-2]
NP_958836.1. NM_201432.1. [O60861-4]
NP_958839.1. NM_201433.1. [O60861-3]
XP_005256888.1. XM_005256831.3. [O60861-1]
XP_005256889.1. XM_005256832.3. [O60861-1]
XP_011522346.1. XM_011524044.2. [O60861-1]
XP_016880728.1. XM_017025239.1. [O60861-1]
UniGeneiHs.462214.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LX7NMR-A1-60[»]
2YSHNMR-A79-111[»]
ProteinModelPortaliO60861.
SMRiO60861.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114094. 23 interactors.
IntActiO60861. 19 interactors.
MINTiMINT-1577125.
STRINGi9606.ENSP00000407552.

PTM databases

iPTMnetiO60861.
PhosphoSitePlusiO60861.

Polymorphism and mutation databases

BioMutaiGAS7.

Proteomic databases

PaxDbiO60861.
PeptideAtlasiO60861.
PRIDEiO60861.

Protocols and materials databases

DNASUi8522.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323816; ENSP00000322608; ENSG00000007237. [O60861-4]
ENST00000432992; ENSP00000407552; ENSG00000007237. [O60861-3]
ENST00000437099; ENSP00000410108; ENSG00000007237. [O60861-1]
ENST00000542249; ENSP00000443265; ENSG00000007237. [O60861-1]
ENST00000579158; ENSP00000463527; ENSG00000007237. [O60861-1]
ENST00000580865; ENSP00000463873; ENSG00000007237. [O60861-2]
ENST00000585266; ENSP00000464240; ENSG00000007237. [O60861-4]
GeneIDi8522.
KEGGihsa:8522.
UCSCiuc002gmg.2. human. [O60861-3]

Organism-specific databases

CTDi8522.
DisGeNETi8522.
GeneCardsiGAS7.
HGNCiHGNC:4169. GAS7.
HPAiHPA004838.
HPA064678.
MIMi603127. gene.
neXtProtiNX_O60861.
OpenTargetsiENSG00000007237.
PharmGKBiPA28583.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
KOG2398. Eukaryota.
ENOG410Z5NV. LUCA.
GeneTreeiENSGT00860000133756.
HOGENOMiHOG000294146.
HOVERGENiHBG001320.
InParanoidiO60861.
KOiK18618.
OMAiSYMSPQG.
OrthoDBiEOG091G077K.
PhylomeDBiO60861.
TreeFamiTF328986.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000007237-MONOMER.
SignaLinkiO60861.
SIGNORiO60861.

Miscellaneous databases

ChiTaRSiGAS7. human.
EvolutionaryTraceiO60861.
GeneWikiiGAS7.
GenomeRNAii8522.
PROiO60861.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000007237.
CleanExiHS_GAS7.
ExpressionAtlasiO60861. baseline and differential.
GenevisibleiO60861. HS.

Family and domain databases

InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR001452. SH3_domain.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF14604. SH3_9. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00055. FCH. 1 hit.
SM00326. SH3. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS50002. SH3. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAS7_HUMAN
AccessioniPrimary (citable) accession number: O60861
Secondary accession number(s): A8KAC2
, B2RCK9, O43144, Q53Y77, Q7Z571
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: December 16, 2008
Last modified: November 30, 2016
This is version 159 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.