Reviewed,
UniProtKB/Swiss-Prot O60858 (TRI13_HUMAN)
Last modified
November 25, 2008.
Version 83.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Tripartite motif-containing protein 13 Alternative name(s): Ret finger protein 2 Putative tumor suppressor RFP2 Leukemia-associated protein 5 B-cell chronic lymphocytic leukemia tumor suppressor Leu5 RING finger protein 77 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 407 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | May act as a tumor suppressor. |
| Involvement in disease | May be involved in B-cell chronic lymphocytic leukemia (B-CLL) with a 13q14 region deletion. |
| Sequence similarities | Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 RING-type zinc finger. |
Ontologies
Keywords | |
|---|---|
| Biological process | Cell cycle |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Coiled coil Zinc-finger |
| Ligand | Metal-binding Zinc |
| Molecular function | Anti-oncogene |
Gene Ontology (GO) | |
| Biological process | anatomical structure morphogenesis Ref.1 Traceable author statement. Source: ProtInc negative regulation of cell cycleInferred from electronic annotation. Source: UniProtKB-KW positive regulation of I-kappaB kinase/NF-kappaB cascadeInferred from mutant phenotype. Source: UniProtKB |
| Cellular component | centrosome Inferred from direct assay. Source: HPA nucleusInferred from direct assay. Source: HPA |
| Molecular function | protein binding Inferred from electronic annotation. Source: InterPro signal transducer activityInferred from mutant phenotype. Source: UniProtKB zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform Alpha (identifier: O60858-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform Beta (identifier: O60858-2) The sequence of this isoform differs from the canonical sequence as follows: 175-175: L → D 176-407: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 407 | 407 | Tripartite motif-containing protein 13 | PRO_0000056028 | |||||
Regions | |||||||||
| Zinc finger | 10 – 58 | 49 | RING-type | ||||||
| Zinc finger | 89 – 131 | 43 | B box-type | ||||||
| Coiled coil | 172 – 200 | 29 | Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 175 | 1 | L → D in isoform Beta. | VSP_005746 | |||||
| Alternative sequence | 176 – 407 | 232 | Missing in isoform Beta. | VSP_005747 | |||||
| Natural variant | 355 | 1 | S → T: dbSNP rs1056543. | VAR_013512 | |||||
Sequences
| ||||||||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "A cosmid and cDNA fine physical map of a human chromosome 13q14 region frequently lost in B-cell chronic lymphocytic leukemia and identification of a new putative tumor suppressor gene, Leu5." Kapanadze B., Kashuba V., Baranova A., Rasool O., van Everdink W.J., Liu Y., Syomov A., Corcoran M., Poltaraus A., Brodyansky V., Syomova N., Kazakov A., Ibbotson R., van den Berg A., Gizatullin R., Fedorova L., Sulimova G., Zelenin A. Yankovsky N.FEBS Lett. 426:266-270(1998) [PubMed: 9599022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), VARIANT THR-355. Tissue: Leukemia. |
| [2] | "Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14." Kapanadze B., Makeeva N., Corcoran M., Jareborg N., Hammarsund M., Baranova A., Zabarovsky E., Vorontsova O., Merup M., Gahrton G., Jansson M., Yankovsky N., Einhorn S., Oscier D., Grander D., Sangfelt O. Genomics 70:327-334(2000) [PubMed: 11161783] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORM ALPHA), VARIANT THR-355. |
| [3] | "The tripartite motif family identifies cell compartments." Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., Riganelli D., Zanaria E., Messali S., Cainarca S., Guffanti A., Minucci S., Pelicci P.G., Ballabio A. EMBO J. 20:2140-2151(2001) [PubMed: 11331580] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS ALPHA AND BETA), VARIANT THR-355. |
| [4] | "Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia." Migliazza A., Bosch F., Komatsu H., Cayanis E., Martinotti S., Toniato E., Guccione E., Qu X., Chien M., Murty V.V., Gaidano G., Inghirami G., Zhang P., Fischer S., Kalachikov S.M., Russo J., Edelman I., Efstratiadis A., Dalla-Favera R. Blood 97:2098-2104(2001) [PubMed: 11264177] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM ALPHA), VARIANT THR-355. |
| [5] | "RFP2, c13ORF1, and FAM10A4 are the most likely tumor suppressor gene candidates for B-cell chronic lymphocytic leukemia." van Everdink W.J., Baranova A., Lummen C., Tyazhelova T., Looman M.W., Ivanov D., Verlind E., Pestova A., Faber H., van der Veen A.Y., Yankovsky N., Vellenga E., Buys C.H. Cancer Genet. Cytogenet. 146:48-57(2003) [PubMed: 14499696] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORM ALPHA). |
| [6] | Corcoran M.M., Hammarsund M., Grander D., Oscier D., Kapanadze B., Einhorn S., Sangfelt O. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM ALPHA). |
| [7] | "The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. Ross M.T.Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-355. |
| [8] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA). Tissue: Blood and Lung. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AJ224819 mRNA. Translation: CAA12136.1. AF241849 Genomic DNA. Translation: AAK51624.1. AF241850 mRNA. Translation: AAF91315.1. AF220127 mRNA. Translation: AAG53500.1. AF220128 mRNA. Translation: AAG53501.1. AF279660 Genomic DNA. Translation: AAK13059.1. AY191002 mRNA. Translation: AAO38979.1. AY455758 mRNA. Translation: AAR31110.1. AL137060 Genomic DNA. Translation: CAC43391.1. BC003579 mRNA. Translation: AAH03579.1. BC063407 mRNA. Translation: AAH63407.1. | |
| RefSeq | NP_005789.2. NP_434698.1. NP_998755.1. |
| UniGene | Hs.436922 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1JM7 based on UniProtKB P38398. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000204977. Homo sapiens. [Contig view] |
| GeneID | 10206. |
Organism-specific databases | |
| HGNC | HGNC:9976. TRIM13. |
| HPA | HPA000367. |
| MIM | 605661. gene. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | O60858. |
Gene expression databases | |
| ArrayExpress | O60858. |
| CleanEx | HS_TRIM13. |
| GermOnline | ENSG00000204977. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000315. Znf_B-box. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view] |
| Gene3D | G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit. |
| Pfam | PF00643. zf-B_box. 1 hit. PF00097. zf-C3HC4. 1 hit. [Graphical view] |
| PRINTS | PR01406. BBOXZNFINGER. |
| SMART | SM00336. BBOX. 1 hit. SM00184. RING. 1 hit. [Graphical view] |
| PROSITE | PS50119. ZF_BBOX. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 38634. |
| SOURCE | Search... |
Entry information
| Entry name | TRI13_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O60858 Secondary accession number(s): Q9BQ47, Q9C021 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 13 Human chromosome 13: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


