Reviewed, UniProtKB/Swiss-Prot O60858 (TRI13_HUMAN)

Names and origin

Protein names

Recommended name:
    Tripartite motif-containing protein 13
Alternative name(s):
    Ret finger protein 2
    Putative tumor suppressor RFP2
    Leukemia-associated protein 5
    B-cell chronic lymphocytic leukemia tumor suppressor Leu5
    RING finger protein 77

Gene names

Name:	TRIM13
Synonyms:	LEU5, RFP2, RNF77

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May act as a tumor suppressor.
Involvement in disease	May be involved in B-cell chronic lymphocytic leukemia (B-CLL) with a 13q14 region deletion.
Sequence similarities	Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 RING-type zinc finger.

Ontologies

Keywords
Biological process	Cell cycle
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Anti-oncogene
Gene Ontology (GO)
Biological process	anatomical structure morphogenesis Ref.1 Traceable author statement. Source: ProtInc negative regulation of cell cycle Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from mutant phenotype. Source: UniProtKB
Cellular component	centrosome Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from mutant phenotype. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Alpha (identifier: O60858-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Beta (identifier: O60858-2)

The sequence of this isoform differs from the canonical sequence as follows:
     175-175: L → D
     176-407: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 407	407	Tripartite motif-containing protein 13		PRO_0000056028
Regions
	Zinc finger	10 – 58	49	RING-type
	Zinc finger	89 – 131	43	B box-type
	Coiled coil	172 – 200	29	Potential
Natural variations
	Alternative sequence	175	1	L → D in isoform Beta.		VSP_005746
	Alternative sequence	176 – 407	232	Missing in isoform Beta.		VSP_005747
	Natural variant	355	1	S → T: dbSNP rs1056543.		VAR_013512

Sequences

	Sequence		Length	Mass (Da)
	Isoform Alpha [UniParc]. Last modified July 19, 2005. Version 2. Checksum: 94B624345124AEBF	FASTA	407	46,988
	10 20 30 40 50 60 MELLEEDLTC PICCSLFDDP RVLPCSHNFC KKCLEGILEG SVRNSLWRPA PFKCPTCRKE 70 80 90 100 110 120 TSATGINSLQ VNYSLKGIVE KYNKIKISPK MPVCKGHLGQ PLNIFCLTDM QLICGICATR 130 140 150 160 170 180 GEHTKHVFCS IEDAYAQERD AFESLFQSFE TWRRGDALSR LDTLETSKRK SLQLLTKDSD 190 200 210 220 230 240 KVKEFFEKLQ HTLDQKKNEI LSDFETMKLA VMQAYDPEIN KLNTILQEQR MAFNIAEAFK 250 260 270 280 290 300 DVSEPIVFLQ QMQEFREKIK VIKETPLPPS NLPASPLMKN FDTSQWEDIK LVDVDKLSLP 310 320 330 340 350 360 QDTGTFISKI PWSFYKLFLL ILLLGLVIVF GPTMFLEWSL FDDLATWKGC LSNFSSYLTK 370 380 390 400 TADFIEQSVF YWEQVTDGFF IFNERFKNFT LVVLNNVAEF VCKYKLL
	Isoform Beta [UniParc]. Checksum: 006850E437E0D9B9		175	19,841
	10 20 30 40 50 60 MELLEEDLTC PICCSLFDDP RVLPCSHNFC KKCLEGILEG SVRNSLWRPA PFKCPTCRKE 70 80 90 100 110 120 TSATGINSLQ VNYSLKGIVE KYNKIKISPK MPVCKGHLGQ PLNIFCLTDM QLICGICATR 130 140 150 160 170 GEHTKHVFCS IEDAYAQERD AFESLFQSFE TWRRGDALSR LDTLETSKRK SLQLD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A cosmid and cDNA fine physical map of a human chromosome 13q14 region frequently lost in B-cell chronic lymphocytic leukemia and identification of a new putative tumor suppressor gene, Leu5." Kapanadze B., Kashuba V., Baranova A., Rasool O., van Everdink W.J., Liu Y., Syomov A., Corcoran M., Poltaraus A., Brodyansky V., Syomova N., Kazakov A., Ibbotson R., van den Berg A., Gizatullin R., Fedorova L., Sulimova G., Zelenin A. , Deaven L., Lehrach H., Grander D., Buys C., Oscier D., Zabarovsky E.R., Einhorn S., Yankovsky N. FEBS Lett. 426:266-270(1998) [PubMed: 9599022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), VARIANT THR-355. Tissue: Leukemia.
[2]	"Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14." Kapanadze B., Makeeva N., Corcoran M., Jareborg N., Hammarsund M., Baranova A., Zabarovsky E., Vorontsova O., Merup M., Gahrton G., Jansson M., Yankovsky N., Einhorn S., Oscier D., Grander D., Sangfelt O. Genomics 70:327-334(2000) [PubMed: 11161783] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORM ALPHA), VARIANT THR-355.
[3]	"The tripartite motif family identifies cell compartments." Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., Riganelli D., Zanaria E., Messali S., Cainarca S., Guffanti A., Minucci S., Pelicci P.G., Ballabio A. EMBO J. 20:2140-2151(2001) [PubMed: 11331580] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS ALPHA AND BETA), VARIANT THR-355.
[4]	"Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia." Migliazza A., Bosch F., Komatsu H., Cayanis E., Martinotti S., Toniato E., Guccione E., Qu X., Chien M., Murty V.V., Gaidano G., Inghirami G., Zhang P., Fischer S., Kalachikov S.M., Russo J., Edelman I., Efstratiadis A., Dalla-Favera R. Blood 97:2098-2104(2001) [PubMed: 11264177] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM ALPHA), VARIANT THR-355.
[5]	"RFP2, c13ORF1, and FAM10A4 are the most likely tumor suppressor gene candidates for B-cell chronic lymphocytic leukemia." van Everdink W.J., Baranova A., Lummen C., Tyazhelova T., Looman M.W., Ivanov D., Verlind E., Pestova A., Faber H., van der Veen A.Y., Yankovsky N., Vellenga E., Buys C.H. Cancer Genet. Cytogenet. 146:48-57(2003) [PubMed: 14499696] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORM ALPHA).
[6]	Corcoran M.M., Hammarsund M., Grander D., Oscier D., Kapanadze B., Einhorn S., Sangfelt O. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM ALPHA).
[7]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-355.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA). Tissue: Blood and Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ224819 mRNA. Translation: CAA12136.1. AF241849 Genomic DNA. Translation: AAK51624.1. AF241850 mRNA. Translation: AAF91315.1. AF220127 mRNA. Translation: AAG53500.1. AF220128 mRNA. Translation: AAG53501.1. AF279660 Genomic DNA. Translation: AAK13059.1. AY191002 mRNA. Translation: AAO38979.1. AY455758 mRNA. Translation: AAR31110.1. AL137060 Genomic DNA. Translation: CAC43391.1. BC003579 mRNA. Translation: AAH03579.1. BC063407 mRNA. Translation: AAH63407.1.
RefSeq	NP_005789.2. NP_434698.1. NP_998755.1.
UniGene	Hs.436922
3D structure databases
HSSP	HSSP built from PDB template 1JM7 based on UniProtKB P38398.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000204977. Homo sapiens. [Contig view]
GeneID	10206.
Organism-specific databases
HGNC	HGNC:9976. TRIM13.
HPA	HPA000367.
MIM	605661. gene.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	O60858.
Gene expression databases
ArrayExpress	O60858.
CleanEx	HS_TRIM13.
GermOnline	ENSG00000204977. Homo sapiens.
Family and domain databases
InterPro	IPR000315. Znf_B-box. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Gene3D	G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
Pfam	PF00643. zf-B_box. 1 hit. PF00097. zf-C3HC4. 1 hit. [Graphical view]
PRINTS	PR01406. BBOXZNFINGER.
SMART	SM00336. BBOX. 1 hit. SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS50119. ZF_BBOX. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	38634.
SOURCE	Search...

Entry information

Entry name

TRI13_HUMAN

Accession

Primary (citable) accession number: O60858
Secondary accession number(s): Q9BQ47, Q9C021

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	July 19, 2005
Last modified:	November 25, 2008
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)