Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zymogen granule membrane protein 16

Gene

ZG16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.1 Publication

GO - Molecular functioni

GO - Biological processi

  • protein transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174992-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zymogen granule membrane protein 16
Short name:
Zymogen granule protein 16
Short name:
hZG16
Alternative name(s):
Secretory lectin ZG16
Gene namesi
Name:ZG16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:30961. ZG16.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic membrane-bounded vesicle lumen Source: UniProtKB-SubCell
  • extracellular matrix Source: UniProtKB
  • Golgi lumen Source: UniProtKB
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
  • zymogen granule membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Extracellular matrix, Golgi apparatus, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164727719.

Polymorphism and mutation databases

BioMutaiZG16.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 161 PublicationAdd BLAST16
ChainiPRO_000001757017 – 167Zymogen granule membrane protein 16Add BLAST151

Proteomic databases

PaxDbiO60844.
PeptideAtlasiO60844.
PRIDEiO60844.

PTM databases

iPTMnetiO60844.
PhosphoSitePlusiO60844.

Expressioni

Tissue specificityi

Highly expressed in liver. Detected at lower levels in colon, ileum and jejunum.1 Publication

Gene expression databases

BgeeiENSG00000174992.
GenevisibleiO60844. HS.

Organism-specific databases

HPAiHPA052066.
HPA052512.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PUF60Q9UHX13EBI-746479,EBI-1053259
SGTAO437656EBI-746479,EBI-347996
UBQLN1Q9UMX06EBI-746479,EBI-741480
UBQLN1Q9UMX0-23EBI-746479,EBI-10173939

Protein-protein interaction databases

BioGridi576089. 4 interactors.
IntActiO60844. 7 interactors.
MINTiMINT-1481896.
STRINGi9606.ENSP00000383563.

Structurei

Secondary structure

1167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 31Combined sources7
Beta strandi35 – 39Combined sources5
Helixi41 – 46Combined sources6
Beta strandi48 – 56Combined sources9
Beta strandi58 – 68Combined sources11
Beta strandi79 – 87Combined sources9
Beta strandi94 – 112Combined sources19
Beta strandi117 – 121Combined sources5
Beta strandi125 – 130Combined sources6
Beta strandi138 – 158Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3APAX-ray1.65A21-159[»]
3VY6X-ray2.00A21-159[»]
3VY7X-ray2.14A21-159[»]
3VZEX-ray1.90A21-159[»]
3VZFX-ray2.80A21-159[»]
3VZGX-ray2.70A21-159[»]
ProteinModelPortaliO60844.
SMRiO60844.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60844.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 159Jacalin-type lectinPROSITE-ProRule annotationAdd BLAST136

Sequence similaritiesi

Belongs to the jacalin lectin family.PROSITE-ProRule annotationCurated
Contains 1 jacalin-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IE5W. Eukaryota.
ENOG41122DQ. LUCA.
HOGENOMiHOG000015245.
HOVERGENiHBG079379.
InParanoidiO60844.
OrthoDBiEOG091G0Y3H.
PhylomeDBiO60844.
TreeFamiTF333440.

Family and domain databases

Gene3Di2.100.10.30. 1 hit.
InterProiIPR001229. Jacalin-like_lectin_dom.
IPR033563. ZG16.
[Graphical view]
PANTHERiPTHR33589:SF3. PTHR33589:SF3. 1 hit.
PfamiPF01419. Jacalin. 1 hit.
[Graphical view]
SMARTiSM00915. Jacalin. 1 hit.
[Graphical view]
SUPFAMiSSF51101. SSF51101. 1 hit.
PROSITEiPS51752. JACALIN_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTVALLALL CASASGNAIQ ARSSSYSGEY GGGGGKRFSH SGNQLDGPIT
60 70 80 90 100
ALRVRVNTYY IVGLQVRYGK VWSDYVGGRN GDLEEIFLHP GESVIQVSGK
110 120 130 140 150
YKWYLKKLLF VTDKGRYLSF GKDSGTSFNA VPLHPNTVLR FISGRSGSLI
160
DAIGLHWDVY PSSCSRC
Length:167
Mass (Da):18,147
Last modified:April 16, 2014 - v2
Checksum:i247AE2FB4FC180A3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03458732G → S.1 PublicationCorresponds to variant rs235636dbSNPEnsembl.1
Natural variantiVAR_070695109L → V.5 Publications1
Natural variantiVAR_034588162S → T.Corresponds to variant rs235638dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB092813 mRNA. Translation: BAC20361.1.
AK312002 mRNA. Translation: BAG34940.1.
AK125559 mRNA. Translation: BAG54214.1.
AC009133 Genomic DNA. No translation available.
AC002301 Genomic DNA. Translation: AAC08708.1.
CH471238 Genomic DNA. Translation: EAW80011.1.
BC029149 mRNA. Translation: AAH29149.1.
BC150656 mRNA. Translation: AAI50657.1.
CCDSiCCDS54000.1.
RefSeqiNP_689551.2. NM_152338.3.
UniGeneiHs.632195.

Genome annotation databases

EnsembliENST00000400752; ENSP00000383563; ENSG00000174992.
GeneIDi653808.
KEGGihsa:653808.
UCSCiuc002dtr.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB092813 mRNA. Translation: BAC20361.1.
AK312002 mRNA. Translation: BAG34940.1.
AK125559 mRNA. Translation: BAG54214.1.
AC009133 Genomic DNA. No translation available.
AC002301 Genomic DNA. Translation: AAC08708.1.
CH471238 Genomic DNA. Translation: EAW80011.1.
BC029149 mRNA. Translation: AAH29149.1.
BC150656 mRNA. Translation: AAI50657.1.
CCDSiCCDS54000.1.
RefSeqiNP_689551.2. NM_152338.3.
UniGeneiHs.632195.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3APAX-ray1.65A21-159[»]
3VY6X-ray2.00A21-159[»]
3VY7X-ray2.14A21-159[»]
3VZEX-ray1.90A21-159[»]
3VZFX-ray2.80A21-159[»]
3VZGX-ray2.70A21-159[»]
ProteinModelPortaliO60844.
SMRiO60844.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi576089. 4 interactors.
IntActiO60844. 7 interactors.
MINTiMINT-1481896.
STRINGi9606.ENSP00000383563.

PTM databases

iPTMnetiO60844.
PhosphoSitePlusiO60844.

Polymorphism and mutation databases

BioMutaiZG16.

Proteomic databases

PaxDbiO60844.
PeptideAtlasiO60844.
PRIDEiO60844.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400752; ENSP00000383563; ENSG00000174992.
GeneIDi653808.
KEGGihsa:653808.
UCSCiuc002dtr.5. human.

Organism-specific databases

CTDi653808.
GeneCardsiZG16.
H-InvDBHIX0012923.
HGNCiHGNC:30961. ZG16.
HPAiHPA052066.
HPA052512.
neXtProtiNX_O60844.
PharmGKBiPA164727719.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE5W. Eukaryota.
ENOG41122DQ. LUCA.
HOGENOMiHOG000015245.
HOVERGENiHBG079379.
InParanoidiO60844.
OrthoDBiEOG091G0Y3H.
PhylomeDBiO60844.
TreeFamiTF333440.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174992-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO60844.
GeneWikiiZG16.
GenomeRNAii653808.
PROiO60844.

Gene expression databases

BgeeiENSG00000174992.
GenevisibleiO60844. HS.

Family and domain databases

Gene3Di2.100.10.30. 1 hit.
InterProiIPR001229. Jacalin-like_lectin_dom.
IPR033563. ZG16.
[Graphical view]
PANTHERiPTHR33589:SF3. PTHR33589:SF3. 1 hit.
PfamiPF01419. Jacalin. 1 hit.
[Graphical view]
SMARTiSM00915. Jacalin. 1 hit.
[Graphical view]
SUPFAMiSSF51101. SSF51101. 1 hit.
PROSITEiPS51752. JACALIN_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZG16_HUMAN
AccessioniPrimary (citable) accession number: O60844
Secondary accession number(s): B2R4Z3, B9EK72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: April 16, 2014
Last modified: November 30, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.