Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zymogen granule membrane protein 16

Gene

ZG16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.1 Publication

GO - Molecular functioni

GO - Biological processi

  • protein transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Zymogen granule membrane protein 16
Short name:
Zymogen granule protein 16
Short name:
hZG16
Alternative name(s):
Secretory lectin ZG16
Gene namesi
Name:ZG16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:30961. ZG16.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic membrane-bounded vesicle lumen Source: UniProtKB-SubCell
  • extracellular matrix Source: UniProtKB
  • Golgi lumen Source: UniProtKB
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
  • zymogen granule membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Extracellular matrix, Golgi apparatus, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164727719.

Polymorphism and mutation databases

BioMutaiZG16.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 16161 PublicationAdd
BLAST
Chaini17 – 167151Zymogen granule membrane protein 16PRO_0000017570Add
BLAST

Proteomic databases

PaxDbiO60844.
PRIDEiO60844.

PTM databases

iPTMnetiO60844.
PhosphoSiteiO60844.

Expressioni

Tissue specificityi

Highly expressed in liver. Detected at lower levels in colon, ileum and jejunum.1 Publication

Gene expression databases

BgeeiO60844.
GenevisibleiO60844. HS.

Organism-specific databases

HPAiHPA052066.
HPA052512.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PUF60Q9UHX13EBI-746479,EBI-1053259
SGTAO437654EBI-746479,EBI-347996
UBQLN1Q9UMX04EBI-746479,EBI-741480
UBQLN1Q9UMX0-23EBI-746479,EBI-10173939

Protein-protein interaction databases

BioGridi576089. 4 interactions.
IntActiO60844. 5 interactions.
MINTiMINT-1481896.
STRINGi9606.ENSP00000383563.

Structurei

Secondary structure

1
167
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi25 – 317Combined sources
Beta strandi35 – 395Combined sources
Helixi41 – 466Combined sources
Beta strandi48 – 569Combined sources
Beta strandi58 – 6811Combined sources
Beta strandi79 – 879Combined sources
Beta strandi94 – 11219Combined sources
Beta strandi117 – 1215Combined sources
Beta strandi125 – 1306Combined sources
Beta strandi138 – 15821Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3APAX-ray1.65A21-159[»]
3VY6X-ray2.00A21-159[»]
3VY7X-ray2.14A21-159[»]
3VZEX-ray1.90A21-159[»]
3VZFX-ray2.80A21-159[»]
3VZGX-ray2.70A21-159[»]
ProteinModelPortaliO60844.
SMRiO60844. Positions 36-159.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60844.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 159136Jacalin-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the jacalin lectin family.PROSITE-ProRule annotationCurated
Contains 1 jacalin-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IE5W. Eukaryota.
ENOG41122DQ. LUCA.
HOGENOMiHOG000015245.
HOVERGENiHBG079379.
InParanoidiO60844.
OrthoDBiEOG73FQQ7.
PhylomeDBiO60844.
TreeFamiTF333440.

Family and domain databases

Gene3Di2.100.10.30. 1 hit.
InterProiIPR001229. Jacalin-like_lectin_dom.
[Graphical view]
PfamiPF01419. Jacalin. 1 hit.
[Graphical view]
SMARTiSM00915. Jacalin. 1 hit.
[Graphical view]
SUPFAMiSSF51101. SSF51101. 1 hit.
PROSITEiPS51752. JACALIN_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTVALLALL CASASGNAIQ ARSSSYSGEY GGGGGKRFSH SGNQLDGPIT
60 70 80 90 100
ALRVRVNTYY IVGLQVRYGK VWSDYVGGRN GDLEEIFLHP GESVIQVSGK
110 120 130 140 150
YKWYLKKLLF VTDKGRYLSF GKDSGTSFNA VPLHPNTVLR FISGRSGSLI
160
DAIGLHWDVY PSSCSRC
Length:167
Mass (Da):18,147
Last modified:April 16, 2014 - v2
Checksum:i247AE2FB4FC180A3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti32 – 321G → S.1 Publication
Corresponds to variant rs235636 [ dbSNP | Ensembl ].
VAR_034587
Natural varianti109 – 1091L → V.5 Publications
VAR_070695
Natural varianti162 – 1621S → T.
Corresponds to variant rs235638 [ dbSNP | Ensembl ].
VAR_034588

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB092813 mRNA. Translation: BAC20361.1.
AK312002 mRNA. Translation: BAG34940.1.
AK125559 mRNA. Translation: BAG54214.1.
AC009133 Genomic DNA. No translation available.
AC002301 Genomic DNA. Translation: AAC08708.1.
CH471238 Genomic DNA. Translation: EAW80011.1.
BC029149 mRNA. Translation: AAH29149.1.
BC150656 mRNA. Translation: AAI50657.1.
CCDSiCCDS54000.1.
RefSeqiNP_689551.2. NM_152338.3.
UniGeneiHs.632195.

Genome annotation databases

EnsembliENST00000400752; ENSP00000383563; ENSG00000174992.
GeneIDi653808.
KEGGihsa:653808.
UCSCiuc002dtr.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB092813 mRNA. Translation: BAC20361.1.
AK312002 mRNA. Translation: BAG34940.1.
AK125559 mRNA. Translation: BAG54214.1.
AC009133 Genomic DNA. No translation available.
AC002301 Genomic DNA. Translation: AAC08708.1.
CH471238 Genomic DNA. Translation: EAW80011.1.
BC029149 mRNA. Translation: AAH29149.1.
BC150656 mRNA. Translation: AAI50657.1.
CCDSiCCDS54000.1.
RefSeqiNP_689551.2. NM_152338.3.
UniGeneiHs.632195.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3APAX-ray1.65A21-159[»]
3VY6X-ray2.00A21-159[»]
3VY7X-ray2.14A21-159[»]
3VZEX-ray1.90A21-159[»]
3VZFX-ray2.80A21-159[»]
3VZGX-ray2.70A21-159[»]
ProteinModelPortaliO60844.
SMRiO60844. Positions 36-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi576089. 4 interactions.
IntActiO60844. 5 interactions.
MINTiMINT-1481896.
STRINGi9606.ENSP00000383563.

PTM databases

iPTMnetiO60844.
PhosphoSiteiO60844.

Polymorphism and mutation databases

BioMutaiZG16.

Proteomic databases

PaxDbiO60844.
PRIDEiO60844.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400752; ENSP00000383563; ENSG00000174992.
GeneIDi653808.
KEGGihsa:653808.
UCSCiuc002dtr.5. human.

Organism-specific databases

CTDi653808.
GeneCardsiZG16.
H-InvDBHIX0012923.
HGNCiHGNC:30961. ZG16.
HPAiHPA052066.
HPA052512.
neXtProtiNX_O60844.
PharmGKBiPA164727719.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE5W. Eukaryota.
ENOG41122DQ. LUCA.
HOGENOMiHOG000015245.
HOVERGENiHBG079379.
InParanoidiO60844.
OrthoDBiEOG73FQQ7.
PhylomeDBiO60844.
TreeFamiTF333440.

Miscellaneous databases

EvolutionaryTraceiO60844.
GeneWikiiZG16.
GenomeRNAii653808.
PROiO60844.

Gene expression databases

BgeeiO60844.
GenevisibleiO60844. HS.

Family and domain databases

Gene3Di2.100.10.30. 1 hit.
InterProiIPR001229. Jacalin-like_lectin_dom.
[Graphical view]
PfamiPF01419. Jacalin. 1 hit.
[Graphical view]
SMARTiSM00915. Jacalin. 1 hit.
[Graphical view]
SUPFAMiSSF51101. SSF51101. 1 hit.
PROSITEiPS51752. JACALIN_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Carbohydrate-binding activity of ZG16p."
    Hosokawa S., Kojima-Aikawa K.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-109.
    Tissue: Colon adenocarcinoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-109.
    Tissue: Colon and Rectum.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-109.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-109.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-32 AND VAL-109.
    Tissue: Colon.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 17-31.
  8. "hZG16, a novel human secreted protein expressed in liver, was down-regulated in hepatocellular carcinoma."
    Zhou Y.B., Cao J.B., Yang H.M., Zhu H., Xu Z.G., Wang K.S., Zhang X., Wang Z.Q., Han Z.G.
    Biochem. Biophys. Res. Commun. 355:679-686(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  9. "Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related beta-prism fold."
    Kanagawa M., Satoh T., Ikeda A., Nakano Y., Yagi H., Kato K., Kojima-Aikawa K., Yamaguchi Y.
    Biochem. Biophys. Res. Commun. 404:201-205(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 21-159.

Entry informationi

Entry nameiZG16_HUMAN
AccessioniPrimary (citable) accession number: O60844
Secondary accession number(s): B2R4Z3, B9EK72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: April 16, 2014
Last modified: June 8, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.