Reviewed,
UniProtKB/Swiss-Prot O60832 (DKC1_HUMAN)
Last modified
June 16, 2009.
Version 108.
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90%,
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Names and origin
| Protein names | Recommended name: H/ACA ribonucleoprotein complex subunit 4 EC=5.4.99.- Alternative name(s): Dyskerin Nucleolar protein family A member 4 snoRNP protein DKC1 Nopp140-associated protein of 57 kDa Nucleolar protein NAP57 CBF5 homolog | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 514 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. |
| Catalytic activity | RNA uridine = RNA pseudouridine. |
| Subunit structure | Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which contains NHP2/NOLA2, GAR1/NOLA1, NOP10/NOLA3, and DKC1/NOLA4, which is presumed to be the catalytic subunit. The complex contains a stable core formed by binding of one or two NOP10-DKC1 heterodimers to NHP2; GAR1 subsequently binds to this core via DKC1. The complex binds a box H/ACA small nucleolar RNA (snoRNA), which may target the specific site of modification within the RNA substrate. During assembly, the complex contains NAF1 instead of GAR1/NOLA1. The complex also interacts with TERC, which contains a 3'-terminal domain related to the box H/ACA snoRNAs. Specific interactions with snoRNAs or TERC are mediated by GAR1 and NHP2. Associates with NOLC1/NOPP140. H/ACA snoRNPs interact with the SMN complex, consisting of SMN1 or SMN2, SIP1/GEMIN2, DDX20/GEMIN3, and GEMIN4. This is mediated by interaction between GAR1 and SMN1 or SMN2. The SMN complex may be required for correct assembly of the H/ACA snoRNP complex. Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WDR79/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Ref.10 Ref.16 Ref.19 |
| Subcellular location | Nucleus › nucleolus. Nucleus › Cajal body. Note: Also localized to Cajal bodies (coiled bodies). Ref.7 Ref.8 Ref.11 |
| Tissue specificity | Ubiquitously expressed. Ref.9 |
| Involvement in disease | Defects in DKC1 are a cause of dyskeratosis congenita X-linked recessive (XDKC) [MIM:305000]. XDKC is a rare, progressive bone marrow failure syndrome characterized by the triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy. Ref.1 Ref.2 Defects in DKC1 are the cause of Hoyeraal-Hreidarsson syndrome (HHS) [MIM:300240]. HHS is a multisystem disorder affecting males and is characterized by aplastic anemia, immunodeficiency, microcephaly, cerebellar hypoplasia, and growth retardation. Ref.29 Ref.30 |
| Sequence similarities | Belongs to the pseudouridine synthase truB family. Contains 1 PUA domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.6 | ||||||
| Chain | 2 – 514 | 513 | H/ACA ribonucleoprotein complex subunit 4 | PRO_0000121983 | |||||
Regions | |||||||||
| Domain | 296 – 371 | 76 | PUA | ||||||
| Region | 2 – 21 | 20 | Nucleolar localization | ||||||
| Region | 446 – 514 | 69 | Nuclear and nucleolar localization | ||||||
| Compositional bias | 11 – 17 | 7 | Poly-Lys | ||||||
Sites | |||||||||
| Active site | 125 | 1 | Nucleophile By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylalanine Ref.6 | ||||||
| Modified residue | 21 | 1 | Phosphoserine Ref.15 Ref.18 Ref.21 Ref.24 Ref.25 | ||||||
| Modified residue | 451 | 1 | Phosphoserine Ref.15 Ref.25 Ref.20 Ref.22 | ||||||
| Modified residue | 453 | 1 | Phosphoserine Ref.15 Ref.25 Ref.22 Ref.14 | ||||||
| Modified residue | 455 | 1 | Phosphoserine Ref.15 Ref.25 Ref.20 Ref.14 Ref.23 | ||||||
| Modified residue | 458 | 1 | Phosphothreonine Ref.15 Ref.25 | ||||||
| Modified residue | 485 | 1 | Phosphoserine Ref.25 | ||||||
| Modified residue | 494 | 1 | Phosphoserine Ref.25 Ref.13 Ref.17 Ref.26 | ||||||
| Modified residue | 513 | 1 | Phosphoserine Ref.15 Ref.18 Ref.25 Ref.13 Ref.17 | ||||||
Natural variations | |||||||||
| Natural variant | 2 | 1 | A → V in XDKC. Ref.2 | VAR_010076 | |||||
| Natural variant | 36 | 1 | F → V in XDKC. Ref.1 | VAR_006811 | |||||
| Natural variant | 37 | 1 | Missing in XDKC. Ref.1 | VAR_006812 | |||||
| Natural variant | 38 | 1 | I → T in HHS. Ref.30 | VAR_015674 | |||||
| Natural variant | 39 | 1 | K → E in XDKC. Ref.2 | VAR_010077 | |||||
| Natural variant | 40 | 1 | P → R in XDKC. Ref.1 | VAR_006813 | |||||
| Natural variant | 41 | 1 | E → K in XDKC. Ref.2 | VAR_010078 | |||||
| Natural variant | 49 | 1 | T → M in HHS. Ref.29 | VAR_015675 | |||||
| Natural variant | 65 | 1 | R → T in XDKC. Ref.2 | VAR_010079 | |||||
| Natural variant | 66 | 1 | T → A in XDKC. Ref.2 | VAR_010080 | |||||
| Natural variant | 72 | 1 | L → Y in XDKC; requires 2 nucleotide substitutions. Ref.1 Ref.2 | VAR_006814 | |||||
| Natural variant | 121 | 1 | S → G in HHS. Ref.29 | VAR_015676 | |||||
| Natural variant | 223 | 1 | G → D: dbSNP rs2728533. | VAR_022553 | |||||
| Natural variant | 321 | 1 | L → V in XDKC. Ref.2 | VAR_010081 | |||||
| Natural variant | 350 | 1 | M → I in XDKC. Ref.2 | VAR_010082 | |||||
| Natural variant | 350 | 1 | M → T in XDKC. Ref.2 | VAR_010083 | |||||
| Natural variant | 353 | 1 | A → V in XDKC and HHS. | VAR_009264 | |||||
| Natural variant | 402 | 1 | G → E in XDKC. Ref.1 Ref.2 | VAR_006815 | |||||
| Natural variant | 402 | 1 | G → R in XDKC. Ref.1 Ref.2 | VAR_010084 | |||||
Experimental info | |||||||||
| Sequence conflict | 37 | 1 | L → F in AAB94299. Ref.4 | ||||||
| Sequence conflict | 285 | 1 | V → F in AAH09928. Ref.5 | ||||||
| Sequence conflict | 446 | 1 | K → KVSGMLSSVWN in CAB51168. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions." Heiss N.S., Knight S.W., Vulliamy T.J., Klauck S.M., Wiemann S., Mason P.J., Poustka A., Dokal I. Nat. Genet. 19:32-38(1998) [PubMed: 9590285] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS XDKC VAL-36; LEU-37 DEL; ARG-40; TYR-72 AND GLU-402. |
| [2] | "X-linked dyskeratosis congenita is predominantly caused by missense mutations in the DKC1 gene." Knight S.W., Heiss N.S., Vulliamy T.J., Greschner S., Stavrides G., Pai G.S., Lestringant G., Varma N., Mason P.J., Dokal I., Poustka A. Am. J. Hum. Genet. 65:50-58(1999) [PubMed: 10364516] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS XDKC VAL-2; GLU-39; LYS-41; THR-65; ALA-66; VAL-321; ILE-350; THR-350; VAL-353 AND ARG-402. |
| [3] | "Mapping and characterization of the X-linked dyskeratosis congenita (DKC) gene." Hassock S., Vetrie D., Giannelli F. Genomics 55:21-27(1999) [PubMed: 9888995] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. |
| [4] | "A highly conserved nucleolar protein from human interacts with a HMG-like protein." Jiang W., Clifford J., Koltin Y. Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus. |
| [6] | Bienvenut W.V. Submitted (OCT-2004) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-11; 118-127; 159-191; 284-291; 303-322 AND 426-443, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [7] | "Dyskerin localizes to the nucleolus and its mislocalization is unlikely to play a role in the pathogenesis of dyskeratosis congenita." Heiss N.S., Girod A., Salowsky R., Wiemann S., Pepperkok R., Poustka A. Hum. Mol. Genet. 8:2515-2524(1999) [PubMed: 10556300] [Abstract] Cited for: SUBCELLULAR LOCATION, DOMAIN NUCLEOLAR LOCALIZATION. |
| [8] | "A telomerase component is defective in the human disease dyskeratosis congenita." Mitchell J.R., Wood E., Collins K. Nature 402:551-555(1999) [PubMed: 10591218] [Abstract] Cited for: SUBCELLULAR LOCATION, ASSOCIATION WITH TELOMERASE. |
| [9] | "Gene structure and expression of the mouse dyskeratosis congenita gene, dkc1." Heiss N.S., Baechner D., Salowsky R., Kolb A., Kioschis P., Poustka A. Genomics 67:153-163(2000) [PubMed: 10903840] [Abstract] Cited for: TISSUE SPECIFICITY. |
| [10] | "Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10." Pogacic V., Dragon F., Filipowicz W. Mol. Cell. Biol. 20:9028-9040(2000) [PubMed: 11074001] [Abstract] Cited for: INTERACTION WITH NHP2. |
| [11] | "Functional proteomic analysis of human nucleolus." Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J. Mol. Biol. Cell 13:4100-4109(2002) [PubMed: 12429849] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [12] | "Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins." Wang C., Meier U.T. EMBO J. 23:1857-1867(2004) [PubMed: 15044956] [Abstract] Cited for: CHARACTERIZATION OF THE H/ACA SNORNP COMPLEX. |
| [13] | "Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-494 AND SER-513, MASS SPECTROMETRY. Tissue: Epithelium. |
| [14] | "Global phosphoproteome of HT-29 human colon adenocarcinoma cells." Kim J.-E., Tannenbaum S.R., White F.M. J. Proteome Res. 4:1339-1346(2005) [PubMed: 16083285] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-453 AND SER-455, MASS SPECTROMETRY. |
| [15] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; SER-451; SER-453; SER-455; THR-458 AND SER-513, MASS SPECTROMETRY. Tissue: Epithelium. |
| [16] | "Stepwise RNP assembly at the site of H/ACA RNA transcription in human cells." Darzacq X., Kittur N., Roy S., Shav-Tal Y., Singer R.H., Meier U.T. J. Cell Biol. 173:207-218(2006) [PubMed: 16618814] [Abstract] Cited for: INTERACTION WITH NAF1. |
| [17] | "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-494 AND SER-513, MASS SPECTROMETRY. Tissue: Epithelium. |
| [18] | "Phosphoproteome analysis of the human mitotic spindle." Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006) [PubMed: 16565220] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21 AND SER-513, MASS SPECTROMETRY. Tissue: Epithelium. |
| [19] | "hNaf1 is required for accumulation of human box H/ACA snoRNPs, scaRNPs, and telomerase." Hoareau-Aveilla C., Bonoli M., Caizergues-Ferrer M., Henry Y. RNA 12:832-840(2006) [PubMed: 16601202] [Abstract] Cited for: INTERACTION WITH NAF1. |
| [20] | "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line." Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S. Electrophoresis 28:2027-2034(2007) [PubMed: 17487921] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-451 AND SER-455, MASS SPECTROMETRY. |
| [21] | "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, MASS SPECTROMETRY. Tissue: Epithelium. |
| [22] | "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-451 AND SER-453, MASS SPECTROMETRY. |
| [23] | "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455, MASS SPECTROMETRY. |
| [24] | "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, MASS SPECTROMETRY. |
| [25] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; SER-451; SER-453; SER-455; THR-458; SER-485; SER-494 AND SER-513, MASS SPECTROMETRY. |
| [26] | "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-494, MASS SPECTROMETRY. Tissue: Liver. |
| [27] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [28] | "A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis." Venteicher A.S., Abreu E.B., Meng Z., McCann K.E., Terns R.M., Veenstra T.D., Terns M.P., Artandi S.E. Science 323:644-648(2009) [PubMed: 19179534] [Abstract] Cited for: IDENTIFICATION IN THE TELOMERASE HOLOENZYME COMPLEX. |
| [29] | "Unexplained aplastic anaemia, immunodeficiency, and cerebellar hypoplasia (Hoyeraal-Hreidarsson syndrome) due to mutations in the dyskeratosis congenita gene, DKC1." Knight S.W., Heiss N.S., Vulliamy T.J., Aalfs C.M., McMahon C., Richmond P., Jones A., Hennekam R.C.M., Poustka A., Mason P.J., Dokal I. Br. J. Haematol. 107:335-339(1999) [PubMed: 10583221] [Abstract] Cited for: VARIANTS HHS MET-49 AND GLY-121. |
| [30] | "A novel DKC1 mutation, severe combined immunodeficiency (T+B-NK-SCID) and bone marrow transplantation in an infant with Hoyeraal-Hreidarsson syndrome." Cossu F., Vulliamy T.J., Marrone A., Badiali M., Cao A., Dokal I. Br. J. Haematol. 119:765-768(2002) [PubMed: 12437656] [Abstract] Cited for: VARIANT HHS THR-38. |
| + | Additional computationally mapped references. |
Web resources
Cross-references
Sequence databases | |
|---|---|
| AJ224481 Genomic DNA. Translation: CAA11970.1. AJ010395, AJ010396 Genomic DNA. Translation: CAB51168.1. AF067008 mRNA. Translation: AAD11815.1. AF067023 AF067022 Genomic DNA. Translation: AAD20232.1. U59151 mRNA. Translation: AAB94299.1. BC009928 mRNA. Translation: AAH09928.1. BC010015 mRNA. Translation: AAH10015.1. | |
| IPI | IPI00221394. |
| RefSeq | NP_001354.1. |
| UniGene | Hs.4747 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O60832. 11 interactions. |
PTM databases | |
| PhosphoSite | O60832. |
2-D gel databases | |
| SWISS-2DPAGE | O60832. |
Proteomic databases | |
| PeptideAtlas | O60832. |
| PRIDE | O60832. |
Genome annotation databases | |
| Ensembl | ENSG00000130826. Homo sapiens. [Contig view] |
| GeneID | 1736. |
| KEGG | hsa:1736. |
| NMPDR | fig|9606.3.peg.33669. |
Organism-specific databases | |
| GeneCards | GC0XP153554. |
| H-InvDB | HIX0017164. |
| HGNC | HGNC:2890. DKC1. |
| HPA | HPA000166. HPA000447. |
| MIM | 300126. gene. 300240. phenotype. 305000. phenotype. |
| Orphanet | 1775. Dyskeratosis congenita. 3322. Progressive pancytopenia - immunodeficiency - cerebellar hypoplasia. |
| PharmGKB | PA27344. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | O60832. |
| HOVERGEN | O60832. |
Enzyme and pathway databases | |
| Pathway_Interaction_DB | telomerasepathway. Regulation of Telomerase. |
Gene expression databases | |
| ArrayExpress | O60832. |
| Bgee | O60832. |
| CleanEx | HS_DKC1. |
| GermOnline | ENSG00000130826. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR004802. Cbf5_synth. IPR012960. DKCLD. IPR002478. PUA. IPR002501. tRNA_psdUrid_synth_B_N. IPR004521. Unchar_dom_2. [Graphical view] |
| Pfam | PF08068. DKCLD. 1 hit. PF01472. PUA. 1 hit. PF01509. TruB_N. 1 hit. [Graphical view] |
| SMART | SM00359. PUA. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00425. CBF5. 1 hit. TIGR00451. unchar_dom_2. 1 hit. |
| PROSITE | PS50890. PUA. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 7039. |
| SOURCE | Search... |
Entry information
| Entry name | DKC1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O60832 Secondary accession number(s): O43845, Q96G67, Q9Y505 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


