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Protein

PRA1 family protein 2

Gene

PRAF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:G66-31176-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
PRA1 family protein 2
Gene namesi
Name:PRAF2
ORF Names:JM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:28911. PRAF2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 64ExtracellularSequence analysis2
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 96CytoplasmicSequence analysisAdd BLAST11
Transmembranei97 – 119HelicalSequence analysisAdd BLAST23
Topological domaini120 – 122ExtracellularSequence analysis3
Transmembranei123 – 140HelicalSequence analysisAdd BLAST18
Topological domaini141 – 178CytoplasmicSequence analysisAdd BLAST38

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11230.
OpenTargetsiENSG00000243279.
PharmGKBiPA134955002.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002208811 – 178PRA1 family protein 2Add BLAST178

Proteomic databases

EPDiO60831.
MaxQBiO60831.
PaxDbiO60831.
PeptideAtlasiO60831.
PRIDEiO60831.

PTM databases

iPTMnetiO60831.
PhosphoSitePlusiO60831.
SwissPalmiO60831.

Expressioni

Tissue specificityi

Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in tumor tissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same patient. High expression in neuroblastic tumors. Strongly expressed in Purkinje cells and more moderately in cells of the molecular and the granular layers in the cerebellum. Detected in neuronal cells, but not in non-neuronal cells in the cerebral cortex, hippocampus, and lateral ventricles.3 Publications

Gene expression databases

BgeeiENSG00000243279.
CleanExiHS_PRAF2.
ExpressionAtlasiO60831. baseline and differential.
GenevisibleiO60831. HS.

Organism-specific databases

HPAiCAB011655.
HPA002859.

Interactioni

Subunit structurei

Interacts with CCR5 and GDE1.2 Publications

Protein-protein interaction databases

BioGridi116396. 18 interactors.
IntActiO60831. 18 interactors.
MINTiMINT-1339907.
STRINGi9606.ENSP00000365570.

Structurei

3D structure databases

ProteinModelPortaliO60831.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PRA1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4050. Eukaryota.
ENOG4111MUC. LUCA.
GeneTreeiENSGT00390000008631.
HOGENOMiHOG000231363.
HOVERGENiHBG053661.
InParanoidiO60831.
KOiK20392.
OMAiERWNNRI.
OrthoDBiEOG091G0QS5.
PhylomeDBiO60831.
TreeFamiTF105479.

Family and domain databases

InterProiIPR004895. Prenylated_rab_accept_PRA1.
[Graphical view]
PfamiPF03208. PRA1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60831-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEVRLPPLR ALDDFVLGSA RLAAPDPCDP QRWCHRVINN LLYYQTNYLL
60 70 80 90 100
CFGIGLALAG YVRPLHTLLS ALVVAVALGV LVWAAETRAA VRRCRRSHPA
110 120 130 140 150
ACLAAVLAVG LLVLWVAGGA CTFLFSIAGP VLLILVHASL RLRNLKNKIE
160 170
NKIESIGLKR TPMGLLLEAL GQEQEAGS
Length:178
Mass (Da):19,258
Last modified:August 1, 1998 - v1
Checksum:iE62695D7DC40550A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05062856L → F.Corresponds to variant rs34565429dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005896 mRNA. Translation: CAA06753.1.
CR457023 mRNA. Translation: CAG33304.1.
AK315374 mRNA. Translation: BAG37767.1.
CH471224 Genomic DNA. Translation: EAW50706.1.
BC021213 mRNA. Translation: AAH21213.1.
CCDSiCCDS14317.1.
RefSeqiNP_009144.1. NM_007213.2.
UniGeneiHs.29595.

Genome annotation databases

EnsembliENST00000553851; ENSP00000451962; ENSG00000243279.
GeneIDi11230.
KEGGihsa:11230.
UCSCiuc033ecu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005896 mRNA. Translation: CAA06753.1.
CR457023 mRNA. Translation: CAG33304.1.
AK315374 mRNA. Translation: BAG37767.1.
CH471224 Genomic DNA. Translation: EAW50706.1.
BC021213 mRNA. Translation: AAH21213.1.
CCDSiCCDS14317.1.
RefSeqiNP_009144.1. NM_007213.2.
UniGeneiHs.29595.

3D structure databases

ProteinModelPortaliO60831.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116396. 18 interactors.
IntActiO60831. 18 interactors.
MINTiMINT-1339907.
STRINGi9606.ENSP00000365570.

PTM databases

iPTMnetiO60831.
PhosphoSitePlusiO60831.
SwissPalmiO60831.

Proteomic databases

EPDiO60831.
MaxQBiO60831.
PaxDbiO60831.
PeptideAtlasiO60831.
PRIDEiO60831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000553851; ENSP00000451962; ENSG00000243279.
GeneIDi11230.
KEGGihsa:11230.
UCSCiuc033ecu.2. human.

Organism-specific databases

CTDi11230.
DisGeNETi11230.
GeneCardsiPRAF2.
HGNCiHGNC:28911. PRAF2.
HPAiCAB011655.
HPA002859.
MIMi300840. gene.
neXtProtiNX_O60831.
OpenTargetsiENSG00000243279.
PharmGKBiPA134955002.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4050. Eukaryota.
ENOG4111MUC. LUCA.
GeneTreeiENSGT00390000008631.
HOGENOMiHOG000231363.
HOVERGENiHBG053661.
InParanoidiO60831.
KOiK20392.
OMAiERWNNRI.
OrthoDBiEOG091G0QS5.
PhylomeDBiO60831.
TreeFamiTF105479.

Enzyme and pathway databases

BioCyciZFISH:G66-31176-MONOMER.

Miscellaneous databases

ChiTaRSiPRAF2. human.
GenomeRNAii11230.
PROiO60831.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000243279.
CleanExiHS_PRAF2.
ExpressionAtlasiO60831. baseline and differential.
GenevisibleiO60831. HS.

Family and domain databases

InterProiIPR004895. Prenylated_rab_accept_PRA1.
[Graphical view]
PfamiPF03208. PRA1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRAF2_HUMAN
AccessioniPrimary (citable) accession number: O60831
Secondary accession number(s): B2RD20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.