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Protein

PRAME family member 11

Gene

PRAMEF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PRAME family member 11Curated
Gene namesi
Name:PRAMEF11Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14086. PRAMEF11.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671148.

Polymorphism and mutation databases

BioMutaiPRAMEF11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436PRAME family member 11PRO_0000156985Add
BLAST

Proteomic databases

PaxDbiO60813.
PRIDEiO60813.

Structurei

3D structure databases

ProteinModelPortaliO60813.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati193 – 21422LRR 1Add
BLAST
Repeati226 – 24823LRR 2Add
BLAST
Repeati255 – 27521LRR 3Add
BLAST
Repeati282 – 30524LRR 4Add
BLAST
Repeati311 – 33222LRR 5Add
BLAST
Repeati339 – 35921LRR 6Add
BLAST

Sequence similaritiesi

Belongs to the PRAME family.Curated
Contains 6 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

HOGENOMiHOG000231112.
HOVERGENiHBG006326.
InParanoidiO60813.
OrthoDBiEOG7KSX88.
TreeFamiTF332708.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR026271. PRAME_family.
[Graphical view]
PIRSFiPIRSF038286. PRAME. 1 hit.

Sequencei

Sequence statusi: Complete.

O60813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAFSRRRCE ALKLMVQAWP FRRLPLRPLI KMPCLEAFQA VLDGLDALLT
60 70 80 90 100
QGVRPRRWKL QVLDLQDVCE NFWMVWSEAM AHGCFLNAKR NKKPVQDCPR
110 120 130 140 150
MRGRQPLTVF VELWLKNRTL DEYLTCLLLW VKQRRDLLHL CCKKLKILGM
160 170 180 190 200
PFRNIRSILK MVNLDCIQEV EVNCKWILPI LTQFTPYLGH LRNLQKLVLS
210 220 230 240 250
HMDVSRYVSP EQKKEIVTQF TTQFLKLRCL QKLYMNSVSF LEGHLDQLLS
260 270 280 290 300
CLKTSLKVLT ITNCVLLESD LKHLSQCPSI SQLKTLDLSG IRLTNYSLVP
310 320 330 340 350
LQILLEKVAA TLEYLDLDDC GIIDSQVNAI LPALSRCFEL NTFSFCGNPI
360 370 380 390 400
CMATLENLLS HTIILKNLCL ELYPAPQESY GADGTLCWSR FAQIRAELMK
410 420 430
KVRHLRHPKR ILFCTDNCPD HGDRSFYDLE ADQYCC
Length:436
Mass (Da):50,598
Last modified:January 20, 2016 - v4
Checksum:iF9A261E543E69F2F
GO

Sequence cautioni

The sequence CAA17880.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931K → T in CAB41252 (Ref. 2) Curated
Sequence conflicti103 – 1031G → E in CAB41252 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245034 Genomic DNA. No translation available.
AL022101 Genomic DNA. Translation: CAA17880.1. Sequence problems.
AL049680 mRNA. Translation: CAB41252.1.
UniGeneiHs.551617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245034 Genomic DNA. No translation available.
AL022101 Genomic DNA. Translation: CAA17880.1. Sequence problems.
AL049680 mRNA. Translation: CAB41252.1.
UniGeneiHs.551617.

3D structure databases

ProteinModelPortaliO60813.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiPRAMEF11.

Proteomic databases

PaxDbiO60813.
PRIDEiO60813.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiPRAMEF11.
HGNCiHGNC:14086. PRAMEF11.
neXtProtiNX_O60813.
PharmGKBiPA142671148.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000231112.
HOVERGENiHBG006326.
InParanoidiO60813.
OrthoDBiEOG7KSX88.
TreeFamiTF332708.

Miscellaneous databases

NextBioi109352.
PROiO60813.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR026271. PRAME_family.
[Graphical view]
PIRSFiPIRSF038286. PRAME. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Rhodes S.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-435.

Entry informationi

Entry nameiPRA11_HUMAN
AccessioniPrimary (citable) accession number: O60813
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 20, 2016
Last modified: April 13, 2016
This is version 104 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.