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Protein

PRAME family member 11

Gene

PRAMEF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PRAME family member 11Imported
Gene namesi
Name:PRAMEF11Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000239810.3
HGNCiHGNC:14086 PRAMEF11
neXtProtiNX_O60813

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000239810
PharmGKBiPA142671148

Polymorphism and mutation databases

BioMutaiPRAMEF11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001569851 – 478PRAME family member 11Add BLAST478

Proteomic databases

PaxDbiO60813
PeptideAtlasiO60813
PRIDEiO60813

PTM databases

iPTMnetiO60813
PhosphoSitePlusiO60813

Expressioni

Gene expression databases

BgeeiENSG00000239810

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000439551

Structurei

3D structure databases

ProteinModelPortaliO60813
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati99 – 126LRR 1; degenerateBy similarityAdd BLAST28
Repeati181 – 205LRR 2; degenerateBy similarityAdd BLAST25
Repeati206 – 232LRR 3; degenerateBy similarityAdd BLAST27
Repeati233 – 268LRR 4; degenerateBy similarityAdd BLAST36
Repeati269 – 294LRR 5By similarityAdd BLAST26
Repeati295 – 326LRR 6By similarityAdd BLAST32
Repeati327 – 347LRR 7By similarityAdd BLAST21
Repeati351 – 378LRR 8By similarityAdd BLAST28
Repeati379 – 403LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KDY5 Eukaryota
ENOG4111EBM LUCA
GeneTreeiENSGT00760000119028
HOGENOMiHOG000231112
HOVERGENiHBG006326
InParanoidiO60813
OMAiERTMNEF
OrthoDBiEOG091G05PP
TreeFamiTF332708

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit

Sequencei

Sequence statusi: Complete.

O60813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMSIRIPPR LLELAGRSLL RDQALAVSTL EELPTELFPP LFMEAFSRRR
60 70 80 90 100
CEALKLMVQA WPFRRLPLRP LIKMPCLEAF QAVLDGLDAL LTQGVRPRRW
110 120 130 140 150
KLQVLDLQDV CENFWMVWSE AMAHGCFLNA KRNKKPVQDC PRMRGRQPLT
160 170 180 190 200
VFVELWLKNR TLDEYLTCLL LWVKQRRDLL HLCCKKLKIL GMPFRNIRSI
210 220 230 240 250
LKMVNLDCIQ EVEVNCKWIL PILTQFTPYL GHLRNLQKLV LSHMDVSRYV
260 270 280 290 300
SPEQKKEIVT QFTTQFLKLR CLQKLYMNSV SFLEGHLDQL LSCLKTSLKV
310 320 330 340 350
LTITNCVLLE SDLKHLSQCP SISQLKTLDL SGIRLTNYSL VPLQILLEKV
360 370 380 390 400
AATLEYLDLD DCGIIDSQVN AILPALSRCF ELNTFSFCGN PICMATLENL
410 420 430 440 450
LSHTIILKNL CLELYPAPQE SYGADGTLCW SRFAQIRAEL MKKVRHLRHP
460 470
KRILFCTDNC PDHGDRSFYD LEADQYCC
Length:478
Mass (Da):55,344
Last modified:March 28, 2018 - v5
Checksum:iC22EF55879C975C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135K → T in CAB41252 (Ref. 3) Curated1
Sequence conflicti135K → T in AAI44427 (PubMed:15489334).Curated1
Sequence conflicti145G → E in CAB41252 (Ref. 3) Curated1
Sequence conflicti233L → M in AAI44427 (PubMed:15489334).Curated1
Sequence conflicti412L → V in AAI44427 (PubMed:15489334).Curated1
Sequence conflicti419Q → R in AAI44427 (PubMed:15489334).Curated1
Sequence conflicti442 – 443KK → NR in AAI44427 (PubMed:15489334).Curated2
Sequence conflicti446H → D in AAI44427 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245034 Genomic DNA No translation available.
BC144426 mRNA Translation: AAI44427.1
AL049680 mRNA Translation: CAB41252.1
CCDSiCCDS53268.2
RefSeqiNP_001139816.2, NM_001146344.2
XP_011539781.1, XM_011541479.2
UniGeneiHs.551617

Genome annotation databases

EnsembliENST00000619922; ENSP00000480027; ENSG00000239810
ENST00000633392; ENSP00000488512; ENSG00000281934
GeneIDi440560
KEGGihsa:440560
UCSCiuc031tph.2 human

Similar proteinsi

Entry informationi

Entry nameiPRA11_HUMAN
AccessioniPrimary (citable) accession number: O60813
Secondary accession number(s): A0A087WW85, B7ZMC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 116 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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