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Protein

Heterogeneous nuclear ribonucleoprotein C-like 1

Gene

HNRNPCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs.By similarity

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein C-like 1
Short name:
hnRNP C-like-1
Alternative name(s):
hnRNP core protein C-like 1
Gene namesi
Name:HNRNPCL1
Synonyms:HNRPCL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componentsi: Chromosome 1, Chromosome 2

Organism-specific databases

HGNCiHGNC:29295. HNRNPCL1.

Subcellular locationi

  • Nucleus By similarity

  • Note: Component of ribonucleosomes.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162391240.

Polymorphism and mutation databases

BioMutaiHNRNPCL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293Heterogeneous nuclear ribonucleoprotein C-like 1PRO_0000081848Add
BLAST

Proteomic databases

EPDiO60812.
MaxQBiO60812.
PaxDbiO60812.
PRIDEiO60812.

PTM databases

iPTMnetiO60812.
PhosphoSiteiO60812.
SwissPalmiO60812.

Expressioni

Gene expression databases

CleanExiHS_HNRNPCL1.
GenevisibleiO60812. HS.

Interactioni

Protein-protein interaction databases

BioGridi131227. 29 interactions.
IntActiO60812. 16 interactions.
MINTiMINT-6733038.
STRINGi9606.ENSP00000365370.

Structurei

3D structure databases

ProteinModelPortaliO60812.
SMRiO60812. Positions 2-106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 8772RRMPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili177 – 22549Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the RRM HNRPC family. RALY subfamily.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00390000006718.
HOGENOMiHOG000231958.
HOVERGENiHBG002302.
InParanoidiO60812.
OMAiMECEGGA.
OrthoDBiEOG7KWSK9.
PhylomeDBiO60812.
TreeFamiTF330974.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR017347. hnRNP_C.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037992. hnRNP-C_Raly. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNVTNKMD PHSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIAGCSVHK
60 70 80 90 100
GFAFVQYDKE KNARAAVAGE DGRMIASQVV DINLAAEPKV NRGNAGVKRS
110 120 130 140 150
AAEMYGSSFD LDYGFQRDYY DGMYSFPARV PPPPPIALAV VPSKRQRLSG
160 170 180 190 200
NTSRRGKSGF NSKSGKRGSS KSGKLKGDDL QAIKQELTQI KQKVDSLLEN
210 220 230 240 250
LEKIEKEQSK QEVEVKNAKS EEEQSSSSMK KDETHVKMES EGGAEDSAEE
260 270 280 290
GDPLDDDVNE DQGDDQLELI KDDEKEAEEG EDDRDSTNGQ DDS
Length:293
Mass (Da):32,142
Last modified:August 1, 1998 - v1
Checksum:iC87938AE3189D8E2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811D → V.
Corresponds to variant rs2982092 [ dbSNP | Ensembl ].
VAR_059824
Natural varianti208 – 2081Q → H.
Corresponds to variant rs6702447 [ dbSNP | Ensembl ].
VAR_052225
Natural varianti258 – 2581V → D.
Corresponds to variant rs2076063 [ dbSNP | Ensembl ].
VAR_033723

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022101 Genomic DNA. Translation: CAA17879.1.
CH471130 Genomic DNA. Translation: EAW71752.1.
BC137258 mRNA. Translation: AAI37259.1.
BC171866 mRNA. Translation: AAI71866.1.
CCDSiCCDS30591.1.
RefSeqiNP_001013653.1. NM_001013631.2.
UniGeneiHs.502617.

Genome annotation databases

EnsembliENST00000317869; ENSP00000365370; ENSG00000179172.
ENST00000617044; ENSP00000479365; ENSG00000179172.
ENST00000633387; ENSP00000488781; ENSG00000282175.
ENST00000634171; ENSP00000488130; ENSG00000282175.
GeneIDi343069.
KEGGihsa:343069.
UCSCiuc010obf.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022101 Genomic DNA. Translation: CAA17879.1.
CH471130 Genomic DNA. Translation: EAW71752.1.
BC137258 mRNA. Translation: AAI37259.1.
BC171866 mRNA. Translation: AAI71866.1.
CCDSiCCDS30591.1.
RefSeqiNP_001013653.1. NM_001013631.2.
UniGeneiHs.502617.

3D structure databases

ProteinModelPortaliO60812.
SMRiO60812. Positions 2-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131227. 29 interactions.
IntActiO60812. 16 interactions.
MINTiMINT-6733038.
STRINGi9606.ENSP00000365370.

PTM databases

iPTMnetiO60812.
PhosphoSiteiO60812.
SwissPalmiO60812.

Polymorphism and mutation databases

BioMutaiHNRNPCL1.

Proteomic databases

EPDiO60812.
MaxQBiO60812.
PaxDbiO60812.
PRIDEiO60812.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317869; ENSP00000365370; ENSG00000179172.
ENST00000617044; ENSP00000479365; ENSG00000179172.
ENST00000633387; ENSP00000488781; ENSG00000282175.
ENST00000634171; ENSP00000488130; ENSG00000282175.
GeneIDi343069.
KEGGihsa:343069.
UCSCiuc010obf.2. human.

Organism-specific databases

CTDi343069.
GeneCardsiHNRNPCL1.
H-InvDBHIX0028700.
HIX0159705.
HGNCiHGNC:29295. HNRNPCL1.
neXtProtiNX_O60812.
PharmGKBiPA162391240.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00390000006718.
HOGENOMiHOG000231958.
HOVERGENiHBG002302.
InParanoidiO60812.
OMAiMECEGGA.
OrthoDBiEOG7KWSK9.
PhylomeDBiO60812.
TreeFamiTF330974.

Miscellaneous databases

GenomeRNAii343069.
PROiO60812.

Gene expression databases

CleanExiHS_HNRNPCL1.
GenevisibleiO60812. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR017347. hnRNP_C.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037992. hnRNP-C_Raly. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiHNRC1_HUMAN
AccessioniPrimary (citable) accession number: O60812
Secondary accession number(s): B2RP44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.