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Protein

PRAME family member 2

Gene

PRAMEF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PRAME family member 2
Gene namesi
Name:PRAMEF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componentsi: Chromosome 1, Chromosome 2

Organism-specific databases

HGNCiHGNC:28841. PRAMEF2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671139.

Polymorphism and mutation databases

BioMutaiPRAMEF2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474PRAME family member 2PRO_0000156976Add
BLAST

Proteomic databases

PaxDbiO60811.
PeptideAtlasiO60811.
PRIDEiO60811.

PTM databases

iPTMnetiO60811.
PhosphoSiteiO60811.

Expressioni

Gene expression databases

BgeeiO60811.
CleanExiHS_PRAMEF2.
GenevisibleiO60811. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000240189.

Structurei

3D structure databases

ProteinModelPortaliO60811.
SMRiO60811. Positions 228-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati319 – 34224LRR 1Add
BLAST
Repeati348 – 37528LRR 2Add
BLAST

Sequence similaritiesi

Belongs to the PRAME family.Curated
Contains 2 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KC9V. Eukaryota.
ENOG4110P6P. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000231112.
HOVERGENiHBG006326.
InParanoidiO60811.
OMAiLEIHNTC.
OrthoDBiEOG7ZPNPR.
PhylomeDBiO60811.
TreeFamiTF332708.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR026271. PRAME_family.
[Graphical view]
PIRSFiPIRSF038286. PRAME. 1 hit.

Sequencei

Sequence statusi: Complete.

O60811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIQAPPRLL ELAGQSLLRD QALSISAMEE LPRVLYLPLF REAFSRRHFQ
60 70 80 90 100
TLTVMVQAWP FTCLPLVSLM KTLHLEPLKA LLEGLHMLLT QKDRPRRWKL
110 120 130 140 150
QVLDLRDVDE NFWARWPGAW ALSCFPEAMS KRQTAEDCPR TGEHQPLKVF
160 170 180 190 200
IDICLKEIPQ DECLRYLFQW VYQRRGLVHL CCSKLVNYLT PIKYLRKSLK
210 220 230 240 250
IIYINSIGEL EIHNTCWPHL IRKLYCYLKE MKTLCKLVFS RCHHYTSDNE
260 270 280 290 300
LEGWLVTRFT SVFLRLEHLQ LLKIKLITFF SGHLEQLIRC LQNPLENLEL
310 320 330 340 350
TCGNLLEEDL KCLSQFPSLG YLKHLNLSYV LLFRISLEPL GALLEKIAAS
360 370 380 390 400
LETLVLEGCQ IHYSQLSAIL PGLSCCSQLT TFYFGSNCMS IDALKDLLRH
410 420 430 440 450
TSGLSKLSLE TYPAPEESLN SLVRVNWEIF TPLRAELMCT LREFRQPKRI
460 470
FIGPTPCPSC GSSPSEELEL HLCC
Length:474
Mass (Da):54,872
Last modified:January 1, 1999 - v2
Checksum:i77EEACD6FE68594E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331R → S.
Corresponds to variant rs9661554 [ dbSNP | Ensembl ].
VAR_060093
Natural varianti67 – 671V → G.
Corresponds to variant rs3204790 [ dbSNP | Ensembl ].
VAR_034400
Natural varianti68 – 681S → W.
Corresponds to variant rs17038657 [ dbSNP | Ensembl ].
VAR_034401
Natural varianti72 – 721T → R.
Corresponds to variant rs9659529 [ dbSNP | Ensembl ].
VAR_034402
Natural varianti83 – 831E → K.
Corresponds to variant rs9728577 [ dbSNP | Ensembl ].
VAR_053606
Natural varianti128 – 1281A → T.
Corresponds to variant rs142476002 [ dbSNP | Ensembl ].
VAR_034403
Natural varianti141 – 1411T → M.
Corresponds to variant rs202143308 [ dbSNP | Ensembl ].
VAR_034404
Natural varianti225 – 2251Y → C.
Corresponds to variant rs3204805 [ dbSNP | Ensembl ].
VAR_034405
Natural varianti233 – 2331T → N.
Corresponds to variant rs17038692 [ dbSNP | Ensembl ].
VAR_034406
Natural varianti301 – 3011T → A.
Corresponds to variant rs12139546 [ dbSNP | Ensembl ].
VAR_034407
Natural varianti302 – 3021C → Y.
Corresponds to variant rs17404799 [ dbSNP | Ensembl ].
VAR_034408
Natural varianti304 – 3041N → Y.
Corresponds to variant rs17404806 [ dbSNP | Ensembl ].
VAR_034409
Natural varianti308 – 3081E → G.
Corresponds to variant rs12139550 [ dbSNP | Ensembl ].
VAR_034410
Natural varianti310 – 3101L → M.
Corresponds to variant rs17039283 [ dbSNP | Ensembl ].
VAR_034411
Natural varianti316 – 3161F → Y.
Corresponds to variant rs17039293 [ dbSNP | Ensembl ].
VAR_034412
Natural varianti375 – 3751C → R.
Corresponds to variant rs17039307 [ dbSNP | Ensembl ].
VAR_034413

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049674 mRNA. Translation: CAB41247.1.
AL022101 Genomic DNA. Translation: CAA17878.1.
BC075008 mRNA. Translation: AAH75008.1.
BC075009 mRNA. Translation: AAH75009.1.
CCDSiCCDS149.1.
RefSeqiNP_075390.1. NM_023014.1.
UniGeneiHs.104991.

Genome annotation databases

EnsembliENST00000240189; ENSP00000240189; ENSG00000120952.
ENST00000632257; ENSP00000487743; ENSG00000282817.
GeneIDi65122.
KEGGihsa:65122.
UCSCiuc001aum.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049674 mRNA. Translation: CAB41247.1.
AL022101 Genomic DNA. Translation: CAA17878.1.
BC075008 mRNA. Translation: AAH75008.1.
BC075009 mRNA. Translation: AAH75009.1.
CCDSiCCDS149.1.
RefSeqiNP_075390.1. NM_023014.1.
UniGeneiHs.104991.

3D structure databases

ProteinModelPortaliO60811.
SMRiO60811. Positions 228-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000240189.

PTM databases

iPTMnetiO60811.
PhosphoSiteiO60811.

Polymorphism and mutation databases

BioMutaiPRAMEF2.

Proteomic databases

PaxDbiO60811.
PeptideAtlasiO60811.
PRIDEiO60811.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240189; ENSP00000240189; ENSG00000120952.
ENST00000632257; ENSP00000487743; ENSG00000282817.
GeneIDi65122.
KEGGihsa:65122.
UCSCiuc001aum.1. human.

Organism-specific databases

CTDi65122.
GeneCardsiPRAMEF2.
HGNCiHGNC:28841. PRAMEF2.
neXtProtiNX_O60811.
PharmGKBiPA142671139.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KC9V. Eukaryota.
ENOG4110P6P. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000231112.
HOVERGENiHBG006326.
InParanoidiO60811.
OMAiLEIHNTC.
OrthoDBiEOG7ZPNPR.
PhylomeDBiO60811.
TreeFamiTF332708.

Miscellaneous databases

GenomeRNAii65122.
PROiO60811.

Gene expression databases

BgeeiO60811.
CleanExiHS_PRAMEF2.
GenevisibleiO60811. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR026271. PRAME_family.
[Graphical view]
PIRSFiPIRSF038286. PRAME. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Rhodes S.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiPRAM2_HUMAN
AccessioniPrimary (citable) accession number: O60811
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1999
Last modified: July 6, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.