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Protein

PRAME family member 2

Gene

PRAMEF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PRAME family member 2Imported
Gene namesi
Name:PRAMEF2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28841. PRAMEF2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120952.
PharmGKBiPA142671139.

Polymorphism and mutation databases

BioMutaiPRAMEF2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001569761 – 474PRAME family member 2Add BLAST474

Proteomic databases

MaxQBiO60811.
PaxDbiO60811.
PeptideAtlasiO60811.
PRIDEiO60811.

PTM databases

iPTMnetiO60811.
PhosphoSitePlusiO60811.

Expressioni

Gene expression databases

BgeeiENSG00000120952.
CleanExiHS_PRAMEF2.
GenevisibleiO60811. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000240189.

Structurei

3D structure databases

ProteinModelPortaliO60811.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati97 – 124LRR 1; degenerateBy similarityAdd BLAST28
Repeati179 – 203LRR 2; degenerateBy similarityAdd BLAST25
Repeati204 – 230LRR 3; degenerateBy similarityAdd BLAST27
Repeati231 – 265LRR 4; degenerateBy similarityAdd BLAST35
Repeati266 – 291LRR 5By similarityAdd BLAST26
Repeati292 – 323LRR 6By similarityAdd BLAST32
Repeati324 – 342LRR 7By similarityAdd BLAST19
Repeati348 – 375LRR 8By similarityAdd BLAST28
Repeati376 – 400LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KC9V. Eukaryota.
ENOG4110P6P. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000231112.
HOVERGENiHBG006326.
InParanoidiO60811.
OMAiLEIHNTC.
OrthoDBiEOG091G05PP.
PhylomeDBiO60811.
TreeFamiTF332708.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR032675. L_dom-like.
IPR026271. PRAME_family.
PIRSFiPIRSF038286. PRAME. 1 hit.

Sequencei

Sequence statusi: Complete.

O60811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIQAPPRLL ELAGQSLLRD QALSISAMEE LPRVLYLPLF REAFSRRHFQ
60 70 80 90 100
TLTVMVQAWP FTCLPLVSLM KTLHLEPLKA LLEGLHMLLT QKDRPRRWKL
110 120 130 140 150
QVLDLRDVDE NFWARWPGAW ALSCFPEAMS KRQTAEDCPR TGEHQPLKVF
160 170 180 190 200
IDICLKEIPQ DECLRYLFQW VYQRRGLVHL CCSKLVNYLT PIKYLRKSLK
210 220 230 240 250
IIYINSIGEL EIHNTCWPHL IRKLYCYLKE MKTLCKLVFS RCHHYTSDNE
260 270 280 290 300
LEGWLVTRFT SVFLRLEHLQ LLKIKLITFF SGHLEQLIRC LQNPLENLEL
310 320 330 340 350
TCGNLLEEDL KCLSQFPSLG YLKHLNLSYV LLFRISLEPL GALLEKIAAS
360 370 380 390 400
LETLVLEGCQ IHYSQLSAIL PGLSCCSQLT TFYFGSNCMS IDALKDLLRH
410 420 430 440 450
TSGLSKLSLE TYPAPEESLN SLVRVNWEIF TPLRAELMCT LREFRQPKRI
460 470
FIGPTPCPSC GSSPSEELEL HLCC
Length:474
Mass (Da):54,872
Last modified:January 1, 1999 - v2
Checksum:i77EEACD6FE68594E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06009333R → S. Corresponds to variant dbSNP:rs9661554Ensembl.1
Natural variantiVAR_03440067V → G. Corresponds to variant dbSNP:rs3204790Ensembl.1
Natural variantiVAR_03440168S → W. Corresponds to variant dbSNP:rs17038657Ensembl.1
Natural variantiVAR_03440272T → R. Corresponds to variant dbSNP:rs9659529Ensembl.1
Natural variantiVAR_05360683E → K. Corresponds to variant dbSNP:rs9728577Ensembl.1
Natural variantiVAR_034403128A → T. Corresponds to variant dbSNP:rs142476002Ensembl.1
Natural variantiVAR_034404141T → M. Corresponds to variant dbSNP:rs202143308Ensembl.1
Natural variantiVAR_034405225Y → C. Corresponds to variant dbSNP:rs3204805Ensembl.1
Natural variantiVAR_034406233T → N. Corresponds to variant dbSNP:rs17038692Ensembl.1
Natural variantiVAR_034407301T → A. Corresponds to variant dbSNP:rs12139546Ensembl.1
Natural variantiVAR_034408302C → Y. Corresponds to variant dbSNP:rs17404799Ensembl.1
Natural variantiVAR_034409304N → Y. Corresponds to variant dbSNP:rs17404806Ensembl.1
Natural variantiVAR_034410308E → G. Corresponds to variant dbSNP:rs12139550Ensembl.1
Natural variantiVAR_034411310L → M. Corresponds to variant dbSNP:rs17039283Ensembl.1
Natural variantiVAR_034412316F → Y. Corresponds to variant dbSNP:rs17039293Ensembl.1
Natural variantiVAR_034413375C → R. Corresponds to variant dbSNP:rs17039307Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049674 mRNA. Translation: CAB41247.1.
AL022101 Genomic DNA. No translation available.
BC075008 mRNA. Translation: AAH75008.1.
BC075009 mRNA. Translation: AAH75009.1.
CCDSiCCDS149.1.
RefSeqiNP_075390.1. NM_023014.1.
UniGeneiHs.104991.

Genome annotation databases

EnsembliENST00000240189; ENSP00000240189; ENSG00000120952.
ENST00000632257; ENSP00000487743; ENSG00000282817.
GeneIDi65122.
KEGGihsa:65122.
UCSCiuc001aum.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPRAM2_HUMAN
AccessioniPrimary (citable) accession number: O60811
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1999
Last modified: July 5, 2017
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families