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Protein

PRAME family member 10

Gene

PRAMEF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PRAME family member 10Imported
Gene namesi
Name:PRAMEF10Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:27997. PRAMEF10.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187545.
PharmGKBiPA142671147.

Polymorphism and mutation databases

BioMutaiPRAMEF10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001569841 – 474PRAME family member 10Add BLAST474

Proteomic databases

EPDiO60809.
PaxDbiO60809.
PRIDEiO60809.

PTM databases

iPTMnetiO60809.
PhosphoSitePlusiO60809.

Expressioni

Gene expression databases

BgeeiENSG00000187545.
CleanExiHS_PRAMEF10.
GenevisibleiO60809. HS.

Structurei

3D structure databases

ProteinModelPortaliO60809.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati97 – 124LRR 1; degenerateBy similarityAdd BLAST28
Repeati179 – 203LRR 2; degenerateBy similarityAdd BLAST25
Repeati204 – 230LRR 3; degenerateBy similarityAdd BLAST27
Repeati231 – 265LRR 4; degenerateBy similarityAdd BLAST35
Repeati266 – 291LRR 5By similarityAdd BLAST26
Repeati292 – 323LRR 6By similarityAdd BLAST32
Repeati324 – 342LRR 7By similarityAdd BLAST19
Repeati348 – 375LRR 8By similarityAdd BLAST28
Repeati376 – 400LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KCAS. Eukaryota.
ENOG4110P5P. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000231112.
HOVERGENiHBG006326.
InParanoidiO60809.
OMAiSPFLCLY.
OrthoDBiEOG091G05PP.
TreeFamiTF332708.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR032675. L_dom-like.
IPR026271. PRAME_family.
PIRSFiPIRSF038286. PRAME. 1 hit.

Sequencei

Sequence statusi: Complete.

O60809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQAPSRLL ELAGQSLLRN QFLTIFTLDE LPREVFPLMF MEAFSMRRFE
60 70 80 90 100
ALKLMVQAWP FLRLPLGSLM KTPHLETLQA VLRGLDTLVA QKVRPRRWKL
110 120 130 140 150
QVLDLRDVDE NFWTIWSGAR VLSCSPEAMS KRQTVEDCPR MGERQPLKVF
160 170 180 190 200
IDLCLKESTL DECLSYLFGW IHYRRGLVHL CCSKVQNYSM PTSSFRNLLE
210 220 230 240 250
RIYPDSIQEL EVWKKCSLNK TGKFAPYLSQ MSNLRELFLA FGYERELYVS
260 270 280 290 300
VQWPCIPDLD SPFLCLYYPQ MLYIKKISNI KEHLEHLLRY LKNPLGAFIF
310 320 330 340 350
SDAYLTDRDM ECLSQYPSLS QLKELRLIHI LMWTTNLEPL GVLLEKVAAT
360 370 380 390 400
LKTLVLKDCR IQDPQLRVLL PALSHCSQLT TFNFHGNETS MNALKDLLRH
410 420 430 440 450
TRGLSKLGLE LYPAPLESLD YKGHVNWEIL TPIRAELMRT LREVRQPKRI
460 470
FFGPVPCPNC GSWPSEKVDF HLCS
Length:474
Mass (Da):55,211
Last modified:January 20, 2016 - v4
Checksum:i55DEAAD7962DC5E0
GO

Sequence cautioni

The sequence CAA17876 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63R → S in AAI12209 (PubMed:15489334).Curated1
Sequence conflicti63R → S in AAI12211 (PubMed:15489334).Curated1
Sequence conflicti63R → S in CAB41254 (Ref. 3) Curated1
Sequence conflicti73P → L in AAI12209 (PubMed:15489334).Curated1
Sequence conflicti73P → L in AAI12211 (PubMed:15489334).Curated1
Sequence conflicti73P → L in CAB41254 (Ref. 3) Curated1
Sequence conflicti336N → H in AAI12209 (PubMed:15489334).Curated1
Sequence conflicti336N → H in AAI12211 (PubMed:15489334).Curated1
Sequence conflicti336N → H in CAB41254 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02910499K → I. Corresponds to variant dbSNP:rs3121398Ensembl.1
Natural variantiVAR_029105144R → H2 PublicationsCorresponds to variant dbSNP:rs2797709Ensembl.1
Natural variantiVAR_029106306T → A1 PublicationCorresponds to variant dbSNP:rs848424Ensembl.1
Natural variantiVAR_029107402R → G1 PublicationCorresponds to variant dbSNP:rs1736772Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245034 Genomic DNA. No translation available.
AL022101 Genomic DNA. Translation: CAA17876.1. Sequence problems.
BC112208 mRNA. Translation: AAI12209.1.
BC112210 mRNA. Translation: AAI12211.1.
AL049682 mRNA. Translation: CAB41254.1.
CCDSiCCDS41255.1.
RefSeqiNP_001034450.3. NM_001039361.4.
UniGeneiHs.684629.

Genome annotation databases

EnsembliENST00000235347; ENSP00000235347; ENSG00000187545.
ENST00000632873; ENSP00000488485; ENSG00000282663.
GeneIDi343071.
KEGGihsa:343071.
UCSCiuc031tpi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPRA10_HUMAN
AccessioniPrimary (citable) accession number: O60809
Secondary accession number(s): Q2M1V2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 20, 2016
Last modified: August 30, 2017
This is version 121 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families