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Protein

Target of Myb protein 1

Gene

TOM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in intracellular trafficking. Probable association with membranes.

GO - Molecular functioni

  • clathrin binding Source: UniProtKB

GO - Biological processi

  • endocytosis Source: UniProtKB
  • endosomal transport Source: UniProtKB
  • intracellular protein transport Source: InterPro
  • protein transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100284-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Target of Myb protein 1
Gene namesi
Name:TOM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:11982. TOM1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • early endosome Source: UniProtKB
  • endosome Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10043.
OpenTargetsiENSG00000100284.
PharmGKBiPA36666.

Polymorphism and mutation databases

BioMutaiTOM1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000726281 – 492Target of Myb protein 1Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei164PhosphothreonineCombined sources1
Modified residuei176PhosphoserineBy similarity1
Modified residuei180PhosphoserineBy similarity1
Modified residuei355PhosphoserineCombined sources1
Modified residuei376PhosphoserineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei462PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60784.
MaxQBiO60784.
PaxDbiO60784.
PeptideAtlasiO60784.
PRIDEiO60784.
TopDownProteomicsiO60784-2. [O60784-2]

PTM databases

iPTMnetiO60784.
PhosphoSitePlusiO60784.

Miscellaneous databases

PMAP-CutDBO60784.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in skeletal muscle, heart, placenta and liver.1 Publication

Gene expression databases

BgeeiENSG00000100284.
CleanExiHS_TOM1.
ExpressionAtlasiO60784. baseline and differential.
GenevisibleiO60784. HS.

Organism-specific databases

HPAiHPA000818.
HPA001749.

Interactioni

Subunit structurei

Interacts with ZFYVE16; interaction is required to target it to endosomes.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TOLLIPQ6FIE93EBI-74634,EBI-10249783
TOLLIPQ9H0E24EBI-74634,EBI-74615
TOM1L1O756742EBI-74634,EBI-712991
ZFYVE16Q7Z3T85EBI-74634,EBI-298055

GO - Molecular functioni

  • clathrin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115354. 35 interactors.
DIPiDIP-30844N.
IntActiO60784. 20 interactors.
MINTiMINT-275660.
STRINGi9606.ENSP00000413697.

Structurei

Secondary structure

1492
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 10Combined sources3
Helixi12 – 20Combined sources9
Helixi30 – 42Combined sources13
Beta strandi43 – 45Combined sources3
Helixi46 – 58Combined sources13
Helixi64 – 80Combined sources17
Helixi83 – 89Combined sources7
Helixi92 – 98Combined sources7
Helixi100 – 103Combined sources4
Turni105 – 107Combined sources3
Helixi111 – 128Combined sources18
Helixi135 – 147Combined sources13
Helixi217 – 240Combined sources24
Turni243 – 245Combined sources3
Helixi248 – 274Combined sources27
Helixi278 – 305Combined sources28

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ELKX-ray1.50A/B1-153[»]
1WRDX-ray1.75A215-312[»]
2N2NNMR-A215-309[»]
2N9DNMR-A215-309[»]
ProteinModelPortaliO60784.
SMRiO60784.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60784.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 152VHSPROSITE-ProRule annotationAdd BLAST133
Domaini215 – 303GATPROSITE-ProRule annotationAdd BLAST89

Sequence similaritiesi

Belongs to the TOM1 family.Curated
Contains 1 GAT domain.PROSITE-ProRule annotation
Contains 1 VHS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1087. Eukaryota.
ENOG410Y26G. LUCA.
GeneTreeiENSGT00860000133703.
HOGENOMiHOG000285970.
HOVERGENiHBG025068.
InParanoidiO60784.
OMAiQRKGVKY.
OrthoDBiEOG091G08M1.
PhylomeDBiO60784.
TreeFamiTF314105.

Family and domain databases

Gene3Di1.20.58.160. 1 hit.
1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR014645. TOM1.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PIRSFiPIRSF036948. TOM1. 1 hit.
SMARTiSM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60784-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFLLGNPFS SPVGQRIEKA TDGSLQSEDW ALNMEICDII NETEEGPKDA
60 70 80 90 100
LRAVKKRIVG NKNFHEVMLA LTVLETCVKN CGHRFHVLVA SQDFVESVLV
110 120 130 140 150
RTILPKNNPP TIVHDKVLNL IQSWADAFRS SPDLTGVVTI YEDLRRKGLE
160 170 180 190 200
FPMTDLDMLS PIHTPQRTVF NSETQSGQDS VGTDSSQQED SGQHAAPLPA
210 220 230 240 250
PPILSGDTPI APTPEQIGKL RSELEMVSGN VRVMSEMLTE LVPTQAEPAD
260 270 280 290 300
LELLQELNRT CRAMQQRVLE LIPQIANEQL TEELLIVNDN LNNVFLRHER
310 320 330 340 350
FERFRTGQTT KAPSEAEPAA DLIDMGPDPA ATGNLSSQLA GMNLGSSSVR
360 370 380 390 400
AGLQSLEASG RLEDEFDMFA LTRGSSLADQ RKEVKYEAPQ ATDGLAGALD
410 420 430 440 450
ARQQSTGAIP VTQACLMEDI EQWLSTDVGN DAEEPKGVTS EEFDKFLEER
460 470 480 490
AKAADRLPNL SSPSAEGPPG PPSGPAPRKK TQEKDDDMLF AL
Length:492
Mass (Da):53,818
Last modified:August 1, 1999 - v2
Checksum:iC7D77B5669476242
GO
Isoform 2 (identifier: O60784-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     441-442: EE → EGK

Note: No experimental confirmation available.
Show »
Length:493
Mass (Da):53,875
Checksum:i01BB90C04783CC89
GO
Isoform 3 (identifier: O60784-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-167: Missing.

Note: No experimental confirmation available.
Show »
Length:447
Mass (Da):48,673
Checksum:i457262C1877D9580
GO
Isoform 4 (identifier: O60784-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     441-442: EE → EGK

Note: No experimental confirmation available.
Show »
Length:460
Mass (Da):50,269
Checksum:i2203E9E4F1835281
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti215E → G in BAG60163 (PubMed:14702039).Curated1
Sequence conflicti249A → V in BAG57130 (PubMed:14702039).Curated1
Sequence conflicti346S → P in BAG60163 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05384584R → H.Corresponds to variant rs11558473dbSNPEnsembl.1
Natural variantiVAR_034567264M → V.Corresponds to variant rs34371697dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0383641 – 33Missing in isoform 4. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_038365123 – 167Missing in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_038366441 – 442EE → EGK in isoform 2 and isoform 4. 2 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006973 mRNA. Translation: CAA07362.1.
CR456595 mRNA. Translation: CAG30481.1.
AK293694 mRNA. Translation: BAG57130.1.
AK297827 mRNA. Translation: BAG60163.1.
AL008635, Z82244 Genomic DNA. Translation: CAI21633.1.
Z82244, AL008635 Genomic DNA. Translation: CAI17951.1.
CH471095 Genomic DNA. Translation: EAW60055.1.
BC046151 mRNA. Translation: AAH46151.1.
CCDSiCCDS13913.1. [O60784-1]
CCDS46696.1. [O60784-2]
CCDS46697.1. [O60784-3]
CCDS46698.1. [O60784-4]
RefSeqiNP_001129201.1. NM_001135729.1. [O60784-4]
NP_001129202.1. NM_001135730.1. [O60784-3]
NP_001129204.1. NM_001135732.1. [O60784-2]
NP_005479.1. NM_005488.2. [O60784-1]
UniGeneiHs.474705.

Genome annotation databases

EnsembliENST00000411850; ENSP00000413697; ENSG00000100284. [O60784-2]
ENST00000425375; ENSP00000394924; ENSG00000100284. [O60784-3]
ENST00000447733; ENSP00000398876; ENSG00000100284. [O60784-4]
ENST00000449058; ENSP00000394466; ENSG00000100284. [O60784-1]
GeneIDi10043.
KEGGihsa:10043.
UCSCiuc003ann.3. human. [O60784-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006973 mRNA. Translation: CAA07362.1.
CR456595 mRNA. Translation: CAG30481.1.
AK293694 mRNA. Translation: BAG57130.1.
AK297827 mRNA. Translation: BAG60163.1.
AL008635, Z82244 Genomic DNA. Translation: CAI21633.1.
Z82244, AL008635 Genomic DNA. Translation: CAI17951.1.
CH471095 Genomic DNA. Translation: EAW60055.1.
BC046151 mRNA. Translation: AAH46151.1.
CCDSiCCDS13913.1. [O60784-1]
CCDS46696.1. [O60784-2]
CCDS46697.1. [O60784-3]
CCDS46698.1. [O60784-4]
RefSeqiNP_001129201.1. NM_001135729.1. [O60784-4]
NP_001129202.1. NM_001135730.1. [O60784-3]
NP_001129204.1. NM_001135732.1. [O60784-2]
NP_005479.1. NM_005488.2. [O60784-1]
UniGeneiHs.474705.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ELKX-ray1.50A/B1-153[»]
1WRDX-ray1.75A215-312[»]
2N2NNMR-A215-309[»]
2N9DNMR-A215-309[»]
ProteinModelPortaliO60784.
SMRiO60784.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115354. 35 interactors.
DIPiDIP-30844N.
IntActiO60784. 20 interactors.
MINTiMINT-275660.
STRINGi9606.ENSP00000413697.

PTM databases

iPTMnetiO60784.
PhosphoSitePlusiO60784.

Polymorphism and mutation databases

BioMutaiTOM1.

Proteomic databases

EPDiO60784.
MaxQBiO60784.
PaxDbiO60784.
PeptideAtlasiO60784.
PRIDEiO60784.
TopDownProteomicsiO60784-2. [O60784-2]

Protocols and materials databases

DNASUi10043.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000411850; ENSP00000413697; ENSG00000100284. [O60784-2]
ENST00000425375; ENSP00000394924; ENSG00000100284. [O60784-3]
ENST00000447733; ENSP00000398876; ENSG00000100284. [O60784-4]
ENST00000449058; ENSP00000394466; ENSG00000100284. [O60784-1]
GeneIDi10043.
KEGGihsa:10043.
UCSCiuc003ann.3. human. [O60784-1]

Organism-specific databases

CTDi10043.
DisGeNETi10043.
GeneCardsiTOM1.
H-InvDBHIX0175450.
HGNCiHGNC:11982. TOM1.
HPAiHPA000818.
HPA001749.
MIMi604700. gene.
neXtProtiNX_O60784.
OpenTargetsiENSG00000100284.
PharmGKBiPA36666.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1087. Eukaryota.
ENOG410Y26G. LUCA.
GeneTreeiENSGT00860000133703.
HOGENOMiHOG000285970.
HOVERGENiHBG025068.
InParanoidiO60784.
OMAiQRKGVKY.
OrthoDBiEOG091G08M1.
PhylomeDBiO60784.
TreeFamiTF314105.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100284-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiTOM1. human.
EvolutionaryTraceiO60784.
GeneWikiiTOM1.
GenomeRNAii10043.
PMAP-CutDBO60784.
PROiO60784.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100284.
CleanExiHS_TOM1.
ExpressionAtlasiO60784. baseline and differential.
GenevisibleiO60784. HS.

Family and domain databases

Gene3Di1.20.58.160. 1 hit.
1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR014645. TOM1.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PIRSFiPIRSF036948. TOM1. 1 hit.
SMARTiSM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOM1_HUMAN
AccessioniPrimary (citable) accession number: O60784
Secondary accession number(s): B4DEL9
, B4DNA1, Q5TIJ6, Q86X74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: August 1, 1999
Last modified: November 30, 2016
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.